1. University of Southern California

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    1. Mentioned In 333 Articles

    2. Novartis brolucizumab (RTH258) demonstrates superiority versus aflibercept in key secondary endpoint measures of disease activity in nAMD, a leading cause of blindness

      Novartis brolucizumab (RTH258) demonstrates superiority versus aflibercept in key secondary endpoint measures of disease activity in nAMD, a leading cause of blindness
      ...ng Partner, Retinal Consultants of Arizona; Clinical Professor, Roski Eye Institute, Keck School of Medicine, University of Southern California; and principal investigator of both trials. "HAWK and HARRIER showed that br...
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    3. Sickle cell disease and the eye

      Sickle cell disease and the eye
      Purpose of review To review recent literature pertaining to sickle cell retinopathy (SCR) and, in particular, sickle cell maculopathy. Recent findings Several recent studies suggest that macular perfusion abnormalities seen in patients with sickle cell disease of various genotypes may affect both the superficial and deep capillary plexi, with a predilection for the deep capillary plexus. Further, these changes may be associated with areas of macular thinning, as well as ...
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    4. Utility of optical coherence tomography angiography in detecting glaucomatous damage in a uveitic patient with disc congestion: A case report

      Utility of optical coherence tomography angiography in detecting glaucomatous damage in a uveitic patient with disc congestion: A case report
      Purpose To report a case of uveitic glaucoma with congested optic disc where optical coherence tomography angiography (OCT-A) provided diagnostic utility in assessing glaucomatous damage but optical coherence tomography (OCT) alone had limited utility. Observations We report a case of a 33-year-old Caucasian female referred to the USC Roski Eye Institute for uncontrolled intraocular pressure (IOP) in the left eye. She was managed by an outside provider for 6 months ...
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    5. Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field

      Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field
      Purpose To compare longitudinal glaucoma progression detection using optical coherence tomography (OCT) and visual field (VF). Design Validity assessment Method We analyzed subjects with more than 5 follow-up visits (every 6 months) in the multi-center Advanced Imaging for Glaucoma Study. Fourier-domain optical coherence tomography (OCT) was used to map the thickness of the peripapillary retinal nerve fiber layer (NFL) and ganglion cell complex (GCC). OCT-based progression detection was defined as ...
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    6. ELHnet: a convolutional neural network for classifying cochlear endolymphatic hydrops imaged with optical coherence tomography

      ELHnet: a convolutional neural network for classifying cochlear endolymphatic hydrops imaged with optical coherence tomography
      Detection of endolymphatic hydrops is important for diagnosing Menieres disease, and can be performed non-invasively using optical coherence tomography (OCT) in animal models as well as potentially in the clinic. Here, we developed ELHnet, a convolutional neural network to classify endolymphatic hydrops in a mouse model using learned features from OCT images of mice cochleae. We trained ELHnet on 2159 training and validation images from 17 mice, using only the ...
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    7. University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics

      University of Southern California Receives NIH Grant for Influence of Hair Bundle Properties on Cochlear Mechanics
      ...tro preparations where the hair bundles environment may differ considerably from that encountered in vivo.

      University of Southern California Receives a 2017 NIH Grant for $37,696 Influence of Hair Bundle Properties on...

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    8. Repeatability and Reproducibility of Superficial Macular Retinal Vessel Density Measurements Using Optical Coherence Tomography Angiography En Face Images

      Repeatability and Reproducibility of Superficial Macular Retinal Vessel Density Measurements Using Optical Coherence Tomography Angiography En Face Images
      Importance The repeatability and reproducibility of quantitative metrics from optical coherence tomographic angiography (OCTA) must be assessed before these data can be confidently interpreted in clinical research and practice. Objective To evaluate the repeatability and reproducibility of OCTA-derived retinal vascular quantitative metrics. Design, Setting and Participants In this cross-sectional study, 21 healthy volunteers (42 eyes) and 22 patients with retinal disease (22 eyes), including 14 with age-related macular degeneration, 3 ...
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    9. Optical coherence tomography (OCT) system with improved motion contrast

      Optical coherence tomography (OCT) system with improved motion contrast
      This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system with improved motion contrast. This disclosure particularly relates to motion contrast methods for such OCT systems. The OCT system of this disclosure may have a configuration that scans a physical object, which has a surface and a depth, with a beam of light that has a beam width and a direction ...
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    10. Optical coherence tomography (OCT) system with phase-sensitive B-scan registration

      Optical coherence tomography (OCT) system with phase-sensitive B-scan registration
      This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system having a configuration that uses a phase sensitive B-scan registration method. In this disclosure, an OCT system may have a configuration that scans a physical object, acquires OCT signals to form B-scans, uses these B-scans to determine an optimal shift in an axial direction by using total phase error between B-scans ...
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    11. University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo.

      University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo.
      ...ogy developed with this grant is likely to become the new standard for making in vivo vibratory measurements. University of Southern California Receives a 2017 NIH Grant $317,544 for Optical Coherence Tomography for 3D M...
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    12. University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease

      University of Southern California Receives NIH Grant  for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease
      ... phase III clinical trials on small vessel disease to prevent and treat VCID.

      University of Southern California Receives a 2017 NIH Grant for $1,191,714 for Imaging Cerebral and Retinal Mi...

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    13. Method for quantitative assessment of retinal vessel tortuosity in optical coherence tomography angiography applied to sickle cell retinopathy

      Method for quantitative assessment of retinal vessel tortuosity in optical coherence tomography angiography applied to sickle cell retinopathy
      Tortuosity is an important geometric vessel parameter and among the first microvascular alterations observed in various retinopathies. In the current study, a quantitative vessel tortuosity index (VTI) based on a combination of local and global centerline features is presented. Performance of VTI and previously established tortuosity indices were compared against human observers evaluation of tortuosity. An imageprocessing pipeline was developed for application of VTI in retinal vessels imaged by optical ...
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    14. Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications

      Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications
      OCT has revolutionized the practice of ophthalmology over the past 1020 years. Advances in OCT technology have allowed for the creation of novel OCT-based methods. OCT-Angiography (OCTA) is one such method that has rapidly gained clinical acceptance since it was approved by the FDA in late 2016. OCTA images are based on the variable backscattering of light from the vascular and neurosensory tissue in the retina. Since the intensity and ...
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    15. Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography

      Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography
      Cardiovascular diseases are the leading cause of fatalities in the United States. Atherosclerotic plaques are one of the primary complications that can lead to strokes and heart attacks if left untreated. It is essential to diagnose the disease early and distinguish vulnerable plaques from harmless ones. Many methods focus on the structural or molecular properties of plaques. Mechanical properties have been shown to change drastically when abnormalities develop in arterial ...
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    16. Methods and systems to measure corneal epithelial thickness and power, stromal thickness, subepithelial corneal power and topography for disease diagnosis

      Methods and systems to measure corneal epithelial thickness and power, stromal thickness, subepithelial corneal power and topography for disease diagnosis
      This invention discloses methods and systems for measuring corneal epithelial thickness and power, stromal thickness, subepitheila corneal power and topography. The systems and methods disclosed herein are non-invasive, non-contact and automated imaging methods which preferably makes use of Fourier-domain optical tomography. Also disclosed herein are scanning patterns and image analysis methods for utilizing and analyzing Fourier-domain optical coherence tomography images to obtain information about conical epithelial and stromal properties as ...
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  2. About University of Southern California

    University of Southern California

    University of Southern California is located in Los Angeles, a global center for arts, technology and international trade and is one of the world’s leading private research universities. USC enrolls more international students than any other U.S. university and offers extensive opportunities for internships and study abroad. With a strong tradition of integrating liberal and professional education, USC fosters a vibrant culture of public service and encourages students to cross academic as well as geographic boundaries in their pursuit of knowledge. The Keck School of Medicine is the medical school at the University of Southern California. Founded in 1885 as the USC College of Medicine, it was closed in 1921 and reopened in 1928 as the USC School of Medicine.