1. University of Southampton

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    1. Mentioned In 37 Articles

    2. Blood Vessel Density Measured Using Dynamic Optical Coherence Tomography is a Tool for Wound Healers

      Blood Vessel Density Measured Using Dynamic Optical Coherence Tomography is a Tool for Wound Healers
      Dynamic optical coherence tomography (D-OCT) is a relatively new technique that may be used to study the substructures in the retina, in the skin and its microcirculation. Furthermore, D-OCT is a validated method of imaging blood flow in skin microcirculation. The skin around venous and mixed arterio-venous ulcers was imaged and found to have tortuous vessels assumed to be angiogenic sprouts, and classified as dots, blobs, coils, clumps, lines, and ...
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    3. Association of ambient air pollution with age-related macular degeneration and retinal thickness in UK Biobank

      Association of ambient air pollution with age-related macular degeneration and retinal thickness in UK Biobank
      Aim To examine the associations of air pollution with both self-reported age-related macular degeneration (AMD), and in vivo measures of retinal sublayer thicknesses. Methods We included 115954 UK Biobank participants aged 4069 years old in this cross-sectional study. Ambient air pollution measures included particulate matter, nitrogen dioxide (NO 2 ) and nitrogen oxides (NO x ). Participants with self-reported ocular conditions, high refractive error ( 6 or +6 diopters) and poor spectral-domain optical ...
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    4. Comparison of plaque distribution and wire-free functional assessment in patients with stable angina and non-ST elevation myocardial infarction: an optical coherence tomography and quantitative flow ratio study

      Comparison of plaque distribution and wire-free functional assessment in patients with stable angina and non-ST elevation myocardial infarction: an optical coherence tomography and quantitative flow ratio study
      Background Data comparing plaque characteristics and wire-free physiological assessment in the target vessel in patients with stable angina versus acute coronary syndrome are sparse. Therefore, we investigated the difference in plaque distribution between stable angina and non-ST-elevation myocardial infarction (NSTEMI) and explored the relationship between target vessel vulnerability by optical coherence tomography (OCT) and wire-free functional assessment with quantitative flow ratio (QFR). Methods Patients with stable angina ( n =25) and ...
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    5. DNA Damage and Repair in Patients with Coronary Artery Disease: Correlation with Plaque Morphology Using Optical Coherence Tomography (DECODE Study)

      DNA Damage and Repair in Patients with Coronary Artery Disease: Correlation with Plaque Morphology Using Optical Coherence Tomography (DECODE Study)
      Objective The aim of this study was to examine DNA ligase activity and expression of DNA damage response pathway (DDR) genes in patients with stable angina (SA) and non-ST elevation myocardial infarction (NSTEMI) and determine whether they correlate with plaque morphology. Background Patients with coronary artery disease (CAD) have evidence of deoxyribonucleic acid (DNA) damage in peripheral blood mononuclear cells (PBMCs). It is unclear whether this represents excess damage or ...
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    6. Dynamic Optical Coherence Tomography Is a New Technique for Imaging Skin Around Lower Extremity Wounds

      Dynamic Optical Coherence Tomography Is a New Technique for Imaging Skin Around Lower Extremity Wounds
      Chronic wounds such as venous leg ulcers invariably heal slowly and recur. In the case of venous leg ulcers, poor healing of chronic wounds is variously attributed to ambulatory hypertension, impaired perfusion and diffusion, presence of chronic inflammation at wound sites, lipodermatosclerosis, and senescence. The aim of this study was to investigate whether a new technique, optical coherence tomography (OCT), which permits imaging of blood capillaries in the peri-wound skin ...
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    7. A marine biofilm flow cell for in situ screening marine fouling control coatings using optical coherence tomography

      A marine biofilm flow cell for in situ screening marine fouling control coatings using optical coherence tomography
      A novel fouling marine flow cell was designed and fitted with a clear plastic lid to allow real-time imaging of biofilms using optical coherence tomography (OCT). Marine biofilms were grown under controlled shear flow on coupons coated with 6 different biocidal antifouling coatings (SPC1, SPC2, SPC3, SPC4, CDP1 and CDP2, AkzoNobel) and one inert coating which contained no biocidal actives (NB-D) for 8 weeks. One set of coupons coated with ...
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    8. Exclusion of Traumatic Anterior Capsule Laceration Using Anterior Segment Optical Coherence Tomography

      Exclusion of Traumatic Anterior Capsule Laceration Using Anterior Segment Optical Coherence Tomography
      A woman in her 60s presented with a penetrating injury to the right cornea sustained on a plant. An examination revealed a small corneal laceration and a formed anterior chamber with minimal wound leakage. A possible defect of the anterior capsule was observed ( Figure , A). Anterior segment optical coherence tomography imaging was performed (SPECTRALIS; Heidelberg Engineering) that confirmed that the anterior capsule was intact ( Figure , B). She was treated with ...
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    9. Pediatric Optical Coherence Tomography in Clinical Practice—Recent Progres

      Pediatric Optical Coherence Tomography in Clinical Practice—Recent Progres
      Purpose : Optical coherence tomography (OCT) has revolutionized the diagnosis and management of adult retinal and optic nerve disease. Children were deprived of this technology until the recent development of handheld spectral-domain OCT (HH-SDOCT). In this article, we review the applications of OCT imaging in pediatric ophthalmology. Methods : This study was a review of the literature. Results : The acquisition and interpretation of pediatric tomograms differ significantly from those for adults, with ...
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    10. Optic Nerve Head Development in Healthy Infants and Children Using Handheld Spectral-Domain Optical Coherence Tomography

      Optic Nerve Head Development in Healthy Infants and Children Using Handheld Spectral-Domain Optical Coherence Tomography
      Purpose To determine feasibility of optic nerve head (ONH) imaging and to characterize ONH development in full-term infants without sedation using handheld spectral-domain optical coherence tomography (SD OCT). Design Prospective cross-sectional study. Participants Three hundred fifty-two children aged between 1 day and 13 years. Methods All participants were imaged using handheld SD OCT without sedation during a single scan session. The percentage of successful scans was calculated. Interexaminer reproducibility and ...
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    11. Pediatric Optical Coherence Tomography in Clinical Practice—Recent Progress

      Pediatric Optical Coherence Tomography in Clinical Practice—Recent Progress
      Purpose : Optical coherence tomography (OCT) has revolutionized the diagnosis and management of adult retinal and optic nerve disease. Children were deprived of this technology until the recent development of handheld spectral-domain OCT (HH-SDOCT). In this article, we review the applications of OCT imaging in pediatric ophthalmology. Methods : This study was a review of the literature. Results : The acquisition and interpretation of pediatric tomograms differ significantly from those for adults, with ...
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    12. High resolution Fourier domain Optical Coherence Tomography at 2 microns for painted objects

      High resolution Fourier domain Optical Coherence Tomography at 2 microns for painted objects
      Optical Coherence Tomography has been successfully applied to the non-invasive imaging of subsurface microstructure of a variety of materials from biological tissues to painted objects of art. One of the limitations of the technique is the low depth of penetration due to the strong scattering and absorption in the material. Previous studies found that for paint materials, the optimum window for large depth of penetration is around 2.2 microns ...
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    13. High resolution Fourier domain optical coherence tomography in the 2 um wavelength range using a broadband supercontinuum source

      High resolution Fourier domain optical coherence tomography in the 2 um wavelength range using a broadband supercontinuum source
      A 220 nm bandwidth supercontinuum source in the two-micron wavelength range has been developed for use in a Fourier domain optical coherence tomography (FDOCT) system. This long wavelength source serves to enhance probing depth in highly scattering material with low water content. We present results confirming improved penetration depth in high opacity paint samples while achieving the high axial resolution needed to resolve individual paint layers. This is the first ...
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    14. Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration: a systematic review and economic evaluation

      Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration: a systematic review and economic evaluation
      Background Age-related macular degeneration is the most common cause of sight impairment in the UK. In neovascular age-related macular degeneration (nAMD), vision worsens rapidly (over weeks) due to abnormal blood vessels developing that leak fluid and blood at the macula. Objectives To determine the optimal role of optical coherence tomography (OCT) in diagnosing people newly presenting with suspected nAMD and monitoring those previously diagnosed with the disease. Data sources Databases ...
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  2. About University of Southampton

    University of Southampton

    University of Southampton is one of the top 10 research universities in the UK and has achieved consistently high scores for its teaching and learning activities. Southampton has more than 20 Academic Schools which cover a huge range of subject areas. There are six campuses in all - five in various locations around Southampton and one in Winchester.  The Optoelectronics Research Centre (ORC) is one of the world’s leading institutes for photonics research, based at the University of Southampton. ORC is one of the schools in the Faculty of Engineering, Science and Mathematics at the University of Southampton, focusing on Photonics; the study of light. Research areas include optical fibres and materials, lasers and waveguides, and more.