1. University of Sheffield

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    1. Mentioned In 103 Articles

    4. Superparamagnetic graphene quantum dot as a dual‐modality contrast agent for confocal fluorescence microscopy and magnetomotive optical coherence tomography

      Explore Wiley Online Library Microscopy
      Superparamagnetic graphene quantum dot as a dual‐modality contrast agent for confocal fluorescence microscopy and magnetomotive optical coherence tomography
      A magnetic graphene quantum dot (MGQD) nanoparticle, synthesized by hydrothermally reducing and cutting graphene oxide‐iron oxide sheet, was demonstrated to possess the capabilities of simultaneous confocal fluorescence and magnetomotive optical coherence tomography (MMOCT) imaging. This MGQD shows low toxicity, significant tunable blue fluorescence and superparamagnetism, which can thus be used as a dual‐modality contrast agent for confocal fluorescence microscopy (CFM) and MMOCT. The feasibility of applying MGQD as ...
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      Mentions: University of Sheffield Steven J. Matcher

    5. Near-infrared and mid-infrared semiconductor broadband light emitters

      Explore Nature Publishing Group Broadband Sources
      Near-infrared and mid-infrared semiconductor broadband light emitters
      Semiconductor broadband light emitters have emerged as ideal and vital light sources for a range of biomedical sensing/imaging applications, especially for optical coherence tomography systems. Although near-infrared broadband light emitters have found increasingly wide utilization in these imaging applications, the requirement to simultaneously achieve both a high spectral bandwidth and output power is still challenging for such devices. Owing to the relatively weak amplified spontaneous emission, as a consequence ...
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      Mentions: University of Sheffield Chinese Academy of Sciences Richard A. Hogg

    6. Sub-clinical assessment of atopic dermatitis severity using angiographic optical coherence tomography

      Explore OSA | OSA Publishing Dermatology
      Sub-clinical assessment of atopic dermatitis severity using angiographic optical coherence tomography
      Measurement of sub-clinical atopic dermatitis (AD) is important for determining how long therapies should be continued after clinical clearance of visible AD lesions. An important biomarker of subclinical AD is epidermal hypertrophy, the structural measures of which often make optical coherence tomography (OCT) challenging due to the lack of a clearly delineated dermal-epidermal junction in AD patients. Alternatively, angiographic OCT measurements of vascular depth and morphology may represent a robust ...
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      Mentions: University of Sheffield Steven J. Matcher

    7. Vascular patterning of subcutaneous mouse fibrosarcomas expressing individual VEGF isoforms can be differentiated using angiographic optical coherence tomography

      Explore OSA | OSA Publishing
      Vascular patterning of subcutaneous mouse fibrosarcomas expressing individual VEGF isoforms can be differentiated using angiographic optical coherence tomography
      Subcutaneously implanted experimental tumors in mice are commonly used in cancer research. Despite their superficial location, they remain a challenge to image non-invasively at sufficient spatial resolution for microvascular studies. Here we evaluate the capabilities of optical coherence tomography (OCT) angiography for imaging such tumors directly through the murine skin in-vivo. Data sets were collected from mouse tumors derived from fibrosarcoma cells genetically engineered to express only single splice variant ...
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      Mentions: University of Sheffield Steven J. Matcher

    8. New Non-invasive Techniques to Quantify Skin Surface Strain and Sub-surface Layer Deformation of Finger-pad during Sliding

      Explore ScienceDirect Dermatology , Other Non-Medical
      New Non-invasive Techniques to Quantify Skin Surface Strain and Sub-surface Layer Deformation of Finger-pad during Sliding
      tudies on the variation of skin properties with gender, age and anatomical region, with regards to interaction with different materials have resulted in significant research output. Investigations on skin surface strain and sub-surface layer deformation during sliding, however, have not received as much attention. This novel study uses two non-invasive techniques, optical coherence tomography (OCT) and digital image correlation (DIC), to measure properties of the index finger of a 25 ...
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      Mentions: University of Sheffield Steven J. Matcher

    9. Measuring contact area in a sliding human finger-pad contact

      Explore Wiley Online Library Dermatology
      Measuring contact area in a sliding human finger-pad contact
      Background/Purpose The work outlined in this paper was aimed at achieving further understanding of skin frictional behaviour by investigating the contact area between human finger-pads and flat surfaces. Methods Both the static and the dynamic contact areas (in macro- and micro-scales) were measured using various techniques, including ink printing, optical coherence tomography (OCT) and Digital Image Correlation (DIC). Results In the studies of the static measurements using ink printing ...
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      Mentions: University of Sheffield Steven J. Matcher

    10. Clinical applications of ultra-high resolution and phase-sensitive optical coherence tomography (Thesis)

      Explore Welcome to White Rose eTheses Online Student Theses
      Clinical applications of ultra-high resolution and phase-sensitive optical coherence tomography (Thesis)
      The transparency of the human cornea is vital in maintaining vision. The cells on the surface, corneal epithelium cells, are constantly replaced by differentiated limbal stem cells. Damage to the limbus can cause a deficiency in the limbal stem cell population which can cause cornea opacity and vascularisation consequently leading to blindness. Currently limbal stem cell deficiency can be detected clinically and treated surgically by transplanting stem cells onto the ...
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      Mentions: University of Sheffield

    11. Investigation into surface interaction between the contact lens, the upper eyelid and cornea using optical coherence tomography

      Explore Conference Proceedings Ophthalmology
      Investigation into surface interaction between the contact lens, the upper eyelid and cornea using optical coherence tomography
      Background and Aim: Over 50% of the total 125 million contact lens users complain of discomforts due to contact lenses. The aim of the project is to understand the effect of contact lenses on the morphological parameters of cornea and eyelid surfaces. Methods and results: Five volunteers were recruited for this study (3 soft contact lens users and 2 non-users). The volunteers were imaged using a slit lamp and Optical ...
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      Mentions: University of Sheffield Steven J. Matcher

    12. Gallium nitride light sources for optical coherence tomography

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      Gallium nitride light sources for optical coherence tomography
      The advent of optical coherence tomography (OCT) has permitted high-resolution, non-invasive, in vivo imaging of the eye, skin and other biological tissue. The axial resolution is limited by source bandwidth and central wavelength. With the growing demand for short wavelength imaging, super-continuum sources and non-linear fibre-based light sources have been demonstrated in tissue imaging applications exploiting the near-UV and visible spectrum. Whilst the potential has been identified of using gallium ...
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      Mentions: University of Sheffield Wakayama Medical University Richard A. Hogg

    13. Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography

      Explore Conference Proceedings Dermatology
      Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography
      Background and Aim: With inflammatory skin conditions such as atopic dermatitis (AD), epidermal thickness is mediated by both pathological hyperplasia and atrophy such as that resulting from corticosteroid treatment. Such changes are likely to influence the depth and shape of the underlying microcirculation. Optical coherence tomography (OCT) provides a non-invasive view into the tissue, however structural measures of epidermal thickness are made challenging due to the lack of a delineated ...
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      Mentions: University of Sheffield Steven J. Matcher

    14. Quantum Well and Quantum Dot broadband Optical Devices for Optical Coherence Tomography Applications (Thesis)

      Explore Welcome to White Rose eTheses Online Broadband Sources , Student Theses
      Quantum Well and Quantum Dot broadband Optical Devices for Optical Coherence Tomography Applications (Thesis)
      In this thesis quantum well (QW) and quantum dot (QD) based devices are investigated with the aim of obtaining broad bandwidth light sources for optical coherence tomography (OCT) applications. QD based structures have many possible advantages for broadband applications due to their inhomogeneous broadening. However, more investigation is required in order to fulfill this potential. Firstly, in chapter one, an introduction to the fundamental principles of semiconductor heterostructures is provided ...
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      Mentions: University of Sheffield

    16. In vivo measurement of skin surface strain and sub-surface layer deformation induced by natural tissue stretching

      Explore ScienceDirect Dermatology
      In vivo measurement of skin surface strain and sub-surface layer deformation induced by natural tissue stretching
      Stratum corneum and epidermal layers change in terms of thickness and roughness with gender, age and anatomical site. Knowledge of the mechanical and tribological properties of skin associated with these structural changes are needed to aid in the design of exoskeletons, prostheses, orthotics, body mounted sensors used for kinematics measurements and in optimum use of wearable on-body devices. In this case study, optical coherence tomography (OCT) and digital image correlation ...
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      Mentions: Michelson Diagnostics University of Sheffield Steven J. Matcher
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  4. About University of Sheffield

    University of Sheffield

    The University of Sheffield in England is one of the UK's leading universities.   We have nearly 24,000 students from 124 countries, and almost 6000 staff.  Engineering Materials Department at The University of Sheffield, England has interest is in the development and application of novel biophotonic tools to aid the characterisation of biological tissues. Photonics offers many unique advantages over other imaging techniques for studying biological systems, including structural and functional contrast, cellular level resolution, speed, non-destructiveness and cost.

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