1. University of Sheffield

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    1. Mentioned In 98 Articles

    2. Vascular patterning of subcutaneous mouse fibrosarcomas expressing individual VEGF isoforms can be differentiated using angiographic optical coherence tomography

      Vascular patterning of subcutaneous mouse fibrosarcomas expressing individual VEGF isoforms can be differentiated using angiographic optical coherence tomography
      Subcutaneously implanted experimental tumors in mice are commonly used in cancer research. Despite their superficial location, they remain a challenge to image non-invasively at sufficient spatial resolution for microvascular studies. Here we evaluate the capabilities of optical coherence tomography (OCT) angiography for imaging such tumors directly through the murine skin in-vivo. Data sets were collected from mouse tumors derived from fibrosarcoma cells genetically engineered to express only single splice variant ...
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    3. New Non-invasive Techniques to Quantify Skin Surface Strain and Sub-surface Layer Deformation of Finger-pad during Sliding

      New Non-invasive Techniques to Quantify Skin Surface Strain and Sub-surface Layer Deformation of Finger-pad during Sliding
      tudies on the variation of skin properties with gender, age and anatomical region, with regards to interaction with different materials have resulted in significant research output. Investigations on skin surface strain and sub-surface layer deformation during sliding, however, have not received as much attention. This novel study uses two non-invasive techniques, optical coherence tomography (OCT) and digital image correlation (DIC), to measure properties of the index finger of a 25 ...
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    4. Measuring contact area in a sliding human finger-pad contact

      Measuring contact area in a sliding human finger-pad contact
      Background/Purpose The work outlined in this paper was aimed at achieving further understanding of skin frictional behaviour by investigating the contact area between human finger-pads and flat surfaces. Methods Both the static and the dynamic contact areas (in macro- and micro-scales) were measured using various techniques, including ink printing, optical coherence tomography (OCT) and Digital Image Correlation (DIC). Results In the studies of the static measurements using ink printing ...
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    5. Clinical applications of ultra-high resolution and phase-sensitive optical coherence tomography (Thesis)

      Clinical applications of ultra-high resolution and phase-sensitive optical coherence tomography (Thesis)
      The transparency of the human cornea is vital in maintaining vision. The cells on the surface, corneal epithelium cells, are constantly replaced by differentiated limbal stem cells. Damage to the limbus can cause a deficiency in the limbal stem cell population which can cause cornea opacity and vascularisation consequently leading to blindness. Currently limbal stem cell deficiency can be detected clinically and treated surgically by transplanting stem cells onto the ...
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    6. Investigation into surface interaction between the contact lens, the upper eyelid and cornea using optical coherence tomography

      Investigation into surface interaction between the contact lens, the upper eyelid and cornea using optical coherence tomography
      Background and Aim: Over 50% of the total 125 million contact lens users complain of discomforts due to contact lenses. The aim of the project is to understand the effect of contact lenses on the morphological parameters of cornea and eyelid surfaces. Methods and results: Five volunteers were recruited for this study (3 soft contact lens users and 2 non-users). The volunteers were imaged using a slit lamp and Optical ...
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    7. Gallium nitride light sources for optical coherence tomography

      Gallium nitride light sources for optical coherence tomography
      The advent of optical coherence tomography (OCT) has permitted high-resolution, non-invasive, in vivo imaging of the eye, skin and other biological tissue. The axial resolution is limited by source bandwidth and central wavelength. With the growing demand for short wavelength imaging, super-continuum sources and non-linear fibre-based light sources have been demonstrated in tissue imaging applications exploiting the near-UV and visible spectrum. Whilst the potential has been identified of using gallium ...
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    8. Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography

      Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography
      Background and Aim: With inflammatory skin conditions such as atopic dermatitis (AD), epidermal thickness is mediated by both pathological hyperplasia and atrophy such as that resulting from corticosteroid treatment. Such changes are likely to influence the depth and shape of the underlying microcirculation. Optical coherence tomography (OCT) provides a non-invasive view into the tissue, however structural measures of epidermal thickness are made challenging due to the lack of a delineated ...
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    9. Quantum Well and Quantum Dot broadband Optical Devices for Optical Coherence Tomography Applications (Thesis)

      Quantum Well and Quantum Dot broadband Optical Devices for Optical Coherence Tomography Applications (Thesis)
      In this thesis quantum well (QW) and quantum dot (QD) based devices are investigated with the aim of obtaining broad bandwidth light sources for optical coherence tomography (OCT) applications. QD based structures have many possible advantages for broadband applications due to their inhomogeneous broadening. However, more investigation is required in order to fulfill this potential. Firstly, in chapter one, an introduction to the fundamental principles of semiconductor heterostructures is provided ...
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    10. In vivo measurement of skin surface strain and sub-surface layer deformation induced by natural tissue stretching

      In vivo measurement of skin surface strain and sub-surface layer deformation induced by natural tissue stretching
      Stratum corneum and epidermal layers change in terms of thickness and roughness with gender, age and anatomical site. Knowledge of the mechanical and tribological properties of skin associated with these structural changes are needed to aid in the design of exoskeletons, prostheses, orthotics, body mounted sensors used for kinematics measurements and in optimum use of wearable on-body devices. In this case study, optical coherence tomography (OCT) and digital image correlation ...
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    11. Microrheology of complex fluids

      Microrheology of complex fluids
      The field of microrheology is concerned with how materials store and dissipate mechanical energy as a function of length scale. Recent developments in the theory and instrumentation of the microrheology of complex fluids are reviewed. Equal emphasis is given to the physical phenomena probed, advances in instrumentation, and specific experimental systems in which this field has already had an impact. The inversion of the compliance data, measurement of sample heterogeneity ...
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    12. Towards in-situ process monitoring in selective laser sintering using optical coherence tomography

      Towards in-situ process monitoring in selective laser sintering using optical coherence tomography
      Selective laser sintering (SLS) enables fast, flexible and cost-efficient production of parts directly from 3D CAD data. However, compared with more established machine tools, there is a marked lack of process monitoring and feedback control of key process variables to optimize production parameters in-situ. We apply optical coherence tomography (OCT) to evaluate components produced by SLS and suggest a route for its application in in-situ process monitoring within the SLS ...
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    13. Skin surface and sub-surface strain and deformation imaging using optical coherence tomography and digital image correlation

      Skin surface and sub-surface strain and deformation imaging using optical coherence tomography and digital image correlation
      Bio-mechanical properties of the human skin deformed by external forces at difference skin/material interfaces attract much attention in medical research. For instance, such properties are important design factors when one designs a healthcare device, i.e., the device might be applied directly at skin/device interfaces. In this paper, we investigated the bio-mechanical properties, i.e., surface strain, morphological changes of the skin layers, etc., of the human finger-pad ...
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    14. Simulation of broad spectral bandwidth emitters at 1060 nm for retinal optical coherence tomography

      Simulation of broad spectral bandwidth emitters at 1060 nm for retinal optical coherence tomography
      The simulation of broad spectral bandwidth light sources (semiconductor optical amplifiers (SOA) and superluminescent diodes (SLD)) for application in ophthalmic optical coherence tomography is reported. The device requirements and origin of key device parameters are outlined, and a range of single and double InGaAs/GaAs quantum well (QW) active elements are simulated with a view to application in different OCT embodiments. We confirm that utilising higher order optical transitions is ...
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    15. 1-15 of 98 1 2 3 4 5 6 7 »
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  2. About University of Sheffield

    University of Sheffield

    The University of Sheffield in England is one of the UK's leading universities.   We have nearly 24,000 students from 124 countries, and almost 6000 staff.  Engineering Materials Department at The University of Sheffield, England has interest is in the development and application of novel biophotonic tools to aid the characterisation of biological tissues. Photonics offers many unique advantages over other imaging techniques for studying biological systems, including structural and functional contrast, cellular level resolution, speed, non-destructiveness and cost.