1. University of Sheffield

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    1. Mentioned In 105 Articles

    2. Attenuation of stripe artifacts in optical coherence tomography images through wavelet-FFT filtering

      Attenuation of stripe artifacts in optical coherence tomography images through wavelet-FFT filtering
      The use of polarization-maintaining (PM) fibers for polarization-sensitive optical coherence tomography (PS-OCT) can result in numerous image artifacts which degrade the reliability of birefringence measurements. Similar artifacts can also arise in conventional OCT, due to stray reflections from optical surfaces, a problem which is increasing in tandem with the steady rise in source coherence lengths. Here, a recently presented wavelet-FFT filter[Opt. Express 17 (10), 8567 (2009). [ PubMed ] ] is combined ...
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    3. Polarization-sensitive optical coherence tomography with a conical beam scan for the investigation of birefringence and collagen alignment in the human cervix

      Polarization-sensitive optical coherence tomography with a conical beam scan for the investigation of birefringence and collagen alignment in the human cervix
      By measuring the phase retardance of a cervical extracellular matrix, our in-house polarization-sensitive optical coherence tomography (PS-OCT) was shown to be capable of (1) mapping the distribution of collagen fibers in the non-gravid cervix, (2) accurately determining birefringence, and (3) measuring the distinctive depolarization of the cervical tissue. A conical beam scan strategy was also employed to explore the 3D orientation of the collagen fibers in the cervix by interrogating ...
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    4. Superparamagnetic graphene quantum dot as a dual‐modality contrast agent for confocal fluorescence microscopy and magnetomotive optical coherence tomography

      Superparamagnetic graphene quantum dot as a dual‐modality contrast agent for confocal fluorescence microscopy and magnetomotive optical coherence tomography
      A magnetic graphene quantum dot (MGQD) nanoparticle, synthesized by hydrothermally reducing and cutting graphene oxide‐iron oxide sheet, was demonstrated to possess the capabilities of simultaneous confocal fluorescence and magnetomotive optical coherence tomography (MMOCT) imaging. This MGQD shows low toxicity, significant tunable blue fluorescence and superparamagnetism, which can thus be used as a dual‐modality contrast agent for confocal fluorescence microscopy (CFM) and MMOCT. The feasibility of applying MGQD as ...
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    5. Near-infrared and mid-infrared semiconductor broadband light emitters

      Near-infrared and mid-infrared semiconductor broadband light emitters
      Semiconductor broadband light emitters have emerged as ideal and vital light sources for a range of biomedical sensing/imaging applications, especially for optical coherence tomography systems. Although near-infrared broadband light emitters have found increasingly wide utilization in these imaging applications, the requirement to simultaneously achieve both a high spectral bandwidth and output power is still challenging for such devices. Owing to the relatively weak amplified spontaneous emission, as a consequence ...
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    6. Sub-clinical assessment of atopic dermatitis severity using angiographic optical coherence tomography

      Sub-clinical assessment of atopic dermatitis severity using angiographic optical coherence tomography
      Measurement of sub-clinical atopic dermatitis (AD) is important for determining how long therapies should be continued after clinical clearance of visible AD lesions. An important biomarker of subclinical AD is epidermal hypertrophy, the structural measures of which often make optical coherence tomography (OCT) challenging due to the lack of a clearly delineated dermal-epidermal junction in AD patients. Alternatively, angiographic OCT measurements of vascular depth and morphology may represent a robust ...
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    7. Vascular patterning of subcutaneous mouse fibrosarcomas expressing individual VEGF isoforms can be differentiated using angiographic optical coherence tomography

      Vascular patterning of subcutaneous mouse fibrosarcomas expressing individual VEGF isoforms can be differentiated using angiographic optical coherence tomography
      Subcutaneously implanted experimental tumors in mice are commonly used in cancer research. Despite their superficial location, they remain a challenge to image non-invasively at sufficient spatial resolution for microvascular studies. Here we evaluate the capabilities of optical coherence tomography (OCT) angiography for imaging such tumors directly through the murine skin in-vivo. Data sets were collected from mouse tumors derived from fibrosarcoma cells genetically engineered to express only single splice variant ...
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    8. New Non-invasive Techniques to Quantify Skin Surface Strain and Sub-surface Layer Deformation of Finger-pad during Sliding

      New Non-invasive Techniques to Quantify Skin Surface Strain and Sub-surface Layer Deformation of Finger-pad during Sliding
      tudies on the variation of skin properties with gender, age and anatomical region, with regards to interaction with different materials have resulted in significant research output. Investigations on skin surface strain and sub-surface layer deformation during sliding, however, have not received as much attention. This novel study uses two non-invasive techniques, optical coherence tomography (OCT) and digital image correlation (DIC), to measure properties of the index finger of a 25 ...
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    9. Measuring contact area in a sliding human finger-pad contact

      Measuring contact area in a sliding human finger-pad contact
      Background/Purpose The work outlined in this paper was aimed at achieving further understanding of skin frictional behaviour by investigating the contact area between human finger-pads and flat surfaces. Methods Both the static and the dynamic contact areas (in macro- and micro-scales) were measured using various techniques, including ink printing, optical coherence tomography (OCT) and Digital Image Correlation (DIC). Results In the studies of the static measurements using ink printing ...
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    10. Clinical applications of ultra-high resolution and phase-sensitive optical coherence tomography (Thesis)

      Clinical applications of ultra-high resolution and phase-sensitive optical coherence tomography (Thesis)
      The transparency of the human cornea is vital in maintaining vision. The cells on the surface, corneal epithelium cells, are constantly replaced by differentiated limbal stem cells. Damage to the limbus can cause a deficiency in the limbal stem cell population which can cause cornea opacity and vascularisation consequently leading to blindness. Currently limbal stem cell deficiency can be detected clinically and treated surgically by transplanting stem cells onto the ...
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    11. Investigation into surface interaction between the contact lens, the upper eyelid and cornea using optical coherence tomography

      Investigation into surface interaction between the contact lens, the upper eyelid and cornea using optical coherence tomography
      Background and Aim: Over 50% of the total 125 million contact lens users complain of discomforts due to contact lenses. The aim of the project is to understand the effect of contact lenses on the morphological parameters of cornea and eyelid surfaces. Methods and results: Five volunteers were recruited for this study (3 soft contact lens users and 2 non-users). The volunteers were imaged using a slit lamp and Optical ...
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    12. Gallium nitride light sources for optical coherence tomography

      Gallium nitride light sources for optical coherence tomography
      The advent of optical coherence tomography (OCT) has permitted high-resolution, non-invasive, in vivo imaging of the eye, skin and other biological tissue. The axial resolution is limited by source bandwidth and central wavelength. With the growing demand for short wavelength imaging, super-continuum sources and non-linear fibre-based light sources have been demonstrated in tissue imaging applications exploiting the near-UV and visible spectrum. Whilst the potential has been identified of using gallium ...
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    13. Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography

      Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography
      Background and Aim: With inflammatory skin conditions such as atopic dermatitis (AD), epidermal thickness is mediated by both pathological hyperplasia and atrophy such as that resulting from corticosteroid treatment. Such changes are likely to influence the depth and shape of the underlying microcirculation. Optical coherence tomography (OCT) provides a non-invasive view into the tissue, however structural measures of epidermal thickness are made challenging due to the lack of a delineated ...
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    14. Quantum Well and Quantum Dot broadband Optical Devices for Optical Coherence Tomography Applications (Thesis)

      Quantum Well and Quantum Dot broadband Optical Devices for Optical Coherence Tomography Applications (Thesis)
      In this thesis quantum well (QW) and quantum dot (QD) based devices are investigated with the aim of obtaining broad bandwidth light sources for optical coherence tomography (OCT) applications. QD based structures have many possible advantages for broadband applications due to their inhomogeneous broadening. However, more investigation is required in order to fulfill this potential. Firstly, in chapter one, an introduction to the fundamental principles of semiconductor heterostructures is provided ...
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  2. About University of Sheffield

    University of Sheffield

    The University of Sheffield in England is one of the UK's leading universities.   We have nearly 24,000 students from 124 countries, and almost 6000 staff.  Engineering Materials Department at The University of Sheffield, England has interest is in the development and application of novel biophotonic tools to aid the characterisation of biological tissues. Photonics offers many unique advantages over other imaging techniques for studying biological systems, including structural and functional contrast, cellular level resolution, speed, non-destructiveness and cost.