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2. Near-infrared and mid-infrared semiconductor broadband light emitters
  
  Explore Nature Publishing Group Apr 27 2018 Broadband Sources
  
  Semiconductor broadband light emitters have emerged as ideal and vital light sources for a range of biomedical sensing/imaging applications, especially for optical coherence tomography systems. Although near-infrared broadband light emitters have found increasingly wide utilization in these imaging applications, the requirement to simultaneously achieve both a high spectral bandwidth and output power is still challenging for such devices. Owing to the relatively weak amplified spontaneous emission, as a consequence ...
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  Mentions: University of Sheffield Chinese Academy of Sciences Richard A. Hogg
3. Sub-clinical assessment of atopic dermatitis severity using angiographic optical coherence tomography
  
  Explore OSA | OSA Publishing Apr 16 2018 Dermatology
  
  Measurement of sub-clinical atopic dermatitis (AD) is important for determining how long therapies should be continued after clinical clearance of visible AD lesions. An important biomarker of subclinical AD is epidermal hypertrophy, the structural measures of which often make optical coherence tomography (OCT) challenging due to the lack of a clearly delineated dermal-epidermal junction in AD patients. Alternatively, angiographic OCT measurements of vascular depth and morphology may represent a robust ...
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  Mentions: University of Sheffield Steven J. Matcher
4. Vascular patterning of subcutaneous mouse fibrosarcomas expressing individual VEGF isoforms can be differentiated using angiographic optical coherence tomography
  
  Explore OSA | OSA Publishing Sep 26 2017
  
  Subcutaneously implanted experimental tumors in mice are commonly used in cancer research. Despite their superficial location, they remain a challenge to image non-invasively at sufficient spatial resolution for microvascular studies. Here we evaluate the capabilities of optical coherence tomography (OCT) angiography for imaging such tumors directly through the murine skin in-vivo. Data sets were collected from mouse tumors derived from fibrosarcoma cells genetically engineered to express only single splice variant ...
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  Mentions: University of Sheffield Steven J. Matcher
5. New Non-invasive Techniques to Quantify Skin Surface Strain and Sub-surface Layer Deformation of Finger-pad during Sliding
  
  Explore ScienceDirect Jul 22 2017 Dermatology , Other Non-Medical
  
  tudies on the variation of skin properties with gender, age and anatomical region, with regards to interaction with different materials have resulted in significant research output. Investigations on skin surface strain and sub-surface layer deformation during sliding, however, have not received as much attention. This novel study uses two non-invasive techniques, optical coherence tomography (OCT) and digital image correlation (DIC), to measure properties of the index finger of a 25 ...
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  Mentions: University of Sheffield Steven J. Matcher
6. Measuring contact area in a sliding human finger-pad contact
  
  Explore Wiley Online Library Jun 2 2017 Dermatology
  
  Background/Purpose The work outlined in this paper was aimed at achieving further understanding of skin frictional behaviour by investigating the contact area between human finger-pads and flat surfaces. Methods Both the static and the dynamic contact areas (in macro- and micro-scales) were measured using various techniques, including ink printing, optical coherence tomography (OCT) and Digital Image Correlation (DIC). Results In the studies of the static measurements using ink printing ...
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  Mentions: University of Sheffield Steven J. Matcher
7. Clinical applications of ultra-high resolution and phase-sensitive optical coherence tomography (Thesis)
  
  Explore Welcome to White Rose eTheses Online Mar 15 2017 Student Theses
  
  The transparency of the human cornea is vital in maintaining vision. The cells on the surface, corneal epithelium cells, are constantly replaced by differentiated limbal stem cells. Damage to the limbus can cause a deficiency in the limbal stem cell population which can cause cornea opacity and vascularisation consequently leading to blindness. Currently limbal stem cell deficiency can be detected clinically and treated surgically by transplanting stem cells onto the ...
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  Mentions: University of Sheffield
8. Investigation into surface interaction between the contact lens, the upper eyelid and cornea using optical coherence tomography
  
  Explore Conference Proceedings Mar 1 2017 Ophthalmology
  
  Background and Aim: Over 50% of the total 125 million contact lens users complain of discomforts due to contact lenses. The aim of the project is to understand the effect of contact lenses on the morphological parameters of cornea and eyelid surfaces. Methods and results: Five volunteers were recruited for this study (3 soft contact lens users and 2 non-users). The volunteers were imaged using a slit lamp and Optical ...
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  Mentions: University of Sheffield Steven J. Matcher
9. Gallium nitride light sources for optical coherence tomography
  
  Explore Conference Proceedings Mar 1 2017 Broadband Sources
  
  The advent of optical coherence tomography (OCT) has permitted high-resolution, non-invasive, in vivo imaging of the eye, skin and other biological tissue. The axial resolution is limited by source bandwidth and central wavelength. With the growing demand for short wavelength imaging, super-continuum sources and non-linear fibre-based light sources have been demonstrated in tissue imaging applications exploiting the near-UV and visible spectrum. Whilst the potential has been identified of using gallium ...
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  Mentions: University of Sheffield Wakayama Medical University Richard A. Hogg
10. Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography
  
  Explore Conference Proceedings Feb 11 2017 Dermatology
  
  Background and Aim: With inflammatory skin conditions such as atopic dermatitis (AD), epidermal thickness is mediated by both pathological hyperplasia and atrophy such as that resulting from corticosteroid treatment. Such changes are likely to influence the depth and shape of the underlying microcirculation. Optical coherence tomography (OCT) provides a non-invasive view into the tissue, however structural measures of epidermal thickness are made challenging due to the lack of a delineated ...
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  Mentions: University of Sheffield Steven J. Matcher
11. Quantum Well and Quantum Dot broadband Optical Devices for Optical Coherence Tomography Applications (Thesis)
  
  Explore Welcome to White Rose eTheses Online Jan 6 2017 Broadband Sources , Student Theses
  
  In this thesis quantum well (QW) and quantum dot (QD) based devices are investigated with the aim of obtaining broad bandwidth light sources for optical coherence tomography (OCT) applications. QD based structures have many possible advantages for broadband applications due to their inhomogeneous broadening. However, more investigation is required in order to fulfill this potential. Firstly, in chapter one, an introduction to the fundamental principles of semiconductor heterostructures is provided ...
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  Mentions: University of Sheffield
12. Imaging Microscopic Features of Keratoconic Corneal Morphology
  
  Explore LWW Online Nov 26 2016 Microscopy , Ophthalmology
  
  ...nt, keratocyte nuclei were manually counted by 2 operators using the Fiji “cell counter” plugin (Kurt De Vos, University of Sheffield) to assess repeatability. Only bright and clear oval features were considered to be nu...
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  Mentions: National Institutes of Health Optovue University of Sheffield
13. In vivo measurement of skin surface strain and sub-surface layer deformation induced by natural tissue stretching
  
  Explore ScienceDirect Jun 19 2016 Dermatology
  
  Stratum corneum and epidermal layers change in terms of thickness and roughness with gender, age and anatomical site. Knowledge of the mechanical and tribological properties of skin associated with these structural changes are needed to aid in the design of exoskeletons, prostheses, orthotics, body mounted sensors used for kinematics measurements and in optimum use of wearable on-body devices. In this case study, optical coherence tomography (OCT) and digital image correlation ...
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  Mentions: Michelson Diagnostics University of Sheffield Steven J. Matcher
14. Microrheology of complex fluids
  
  Explore IOPscience Jun 2 2016 Other Non-Medical
  
  The field of microrheology is concerned with how materials store and dissipate mechanical energy as a function of length scale. Recent developments in the theory and instrumentation of the microrheology of complex fluids are reviewed. Equal emphasis is given to the physical phenomena probed, advances in instrumentation, and specific experimental systems in which this field has already had an impact. The inversion of the compliance data, measurement of sample heterogeneity ...
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  Mentions: University of Sheffield
15. Towards in-situ process monitoring in selective laser sintering using optical coherence tomography
  
  Explore Conference Proceedings Apr 21 2016 NDE/NDT
  
  Selective laser sintering (SLS) enables fast, flexible and cost-efficient production of parts directly from 3D CAD data. However, compared with more established machine tools, there is a marked lack of process monitoring and feedback control of key process variables to optimize production parameters in-situ. We apply optical coherence tomography (OCT) to evaluate components produced by SLS and suggest a route for its application in in-situ process monitoring within the SLS ...
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  Mentions: University of Sheffield Steven J. Matcher David T. D. Childs
16. Electrophysiological and Anatomical Correlates of Spinal Cord Optical Coherence Tomography
  
  Explore Journals | PLOS Apr 6 2016
  
  ...versity of St Andrews, UK, and significant sections of OCT software were written while NK was employed by the University of Sheffield. PON01_01297 and from the Ministero dell'Istruzione Universita' e Ricerca (MIUR). Comp...
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  Mentions: Thorlabs Superlum University of Sheffield
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