1. University of Rochester

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    1. Mentioned In 129 Articles

    2. Verification of cascade optical coherence tomography for freeform optics form metrology

      Verification of cascade optical coherence tomography for freeform optics form metrology
      Freeform optical components enable dramatic advances for optical systems in both performance and packaging. Surface form metrology of manufactured freeform optics remains a challenge and an active area of research. Towards addressing this challenge, we previously reported on a novel architecture, cascade optical coherence tomography (C-OCT), which was validated for its ability of high-precision sag measurement at a given point. Here, we demonstrate freeform surface measurements, enabled by the development ...
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    3. Speckle Statistics of Biological Tissues in Optical Coherence Tomography

      Speckle Statistics of Biological Tissues in Optical Coherence Tomography
      The speckle statistics of optical coherence tomography images of biological tissue have been studied using several historical probability density functions. A recent hypothesis implies that underlying power-law distributions in the medium structure, such as the fractal branching vasculature, will contribute to power-law probability distributions of speckle statistics. Specifically, these are the Burr type XII distribution for speckle amplitude, the Lomax distribution for intensity, and the generalized logistic distribution for log ...
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    4. Line-field confocal optical coherence tomography for three-dimensional skin imaging

      Line-field confocal optical coherence tomography for three-dimensional skin imaging
      This paper reports on the latest advances in line-field confocal optical coherence tomography (LC-OCT), a recently invented imaging technology that now allows the generation of either horizontal ( x y ) section images at an adjustable depth or vertical ( x z ) section images at an adjustable lateral position, as well as three-dimensional images. For both two-dimensional imaging modes, images are acquired in real-time, with real-time control of the depth and lateral positions ...
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    5. Anterior Segment Optical Coherence Tomography in Ocular Argyrosis

      Anterior Segment Optical Coherence Tomography in Ocular Argyrosis
      Purpose: To highlight the novel application of anterior segment optical coherence tomography (AS-OCT) to detect corneal silver deposition in a case of ocular argyrosis. Methods: This is a case report and review of the literature. Results: A 67-year-old man with a 30-year history of chronic occupational exposure to silver-halides secondary to photographic film manufacturing presented with significant ocular argyrosis.
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    6. Repeatability of binarization thresholding methods for optical coherence tomography angiography image quantification

      Repeatability of binarization thresholding methods for optical coherence tomography angiography image quantification
      Binarization is a critical step in analysis of retinal optical coherence tomography angiography (OCTA) images, but the repeatability of metrics produced from various binarization methods has not been fully assessed. This study set out to examine the repeatability of OCTA quantification metrics produced using different binarization thresholding methods, all of which have been applied in previous studies, across multiple devices and plexuses. Successive 33 mm foveal OCTA images of 13 ...
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    7. Using the Pathophysiology of Dry AMD to Guide Binarization of the Choriocapillaris on OCTA: A Model

      Using the Pathophysiology of Dry AMD to Guide Binarization of the Choriocapillaris on OCTA: A Model
      Especially since the incorporation of swept laser sources, optical coherence tomography angiography (OCTA) has enabled quantification of choriocapillaris perfusion. A critical step in this process is binarization, which makes angiographic images quantifiable in terms of perfusion metrics. It remains challenging to have confidence that choriocapillaris perfusion metrics reflect the reality of pathophysiologic flow, largely because choice of binarization method can result in significantly different perfusion metric outcomes. This commentary discusses ...
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    8. Cascade optical coherence tomography (C-OCT)

      Cascade optical coherence tomography (C-OCT)
      Significant advances for optical systems in terms of both performance and packaging are enabled by freeform optical components. Yet, surface form metrology for freeform optics remains a challenge. We developed and investigated a point-cloud cascade optical coherence tomography (C-OCT) technique to address this metrology challenge. The mathematical framework for the working principle of C-OCT is presented. A novel detection scheme is developed to enable high-speed measurements. Experimental results validate the ...
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    9. Anterior Segment Optical Coherence Tomography in Ocular Argyrosis

      Anterior Segment Optical Coherence Tomography in Ocular Argyrosis
      Purpose The current study investigated differences in the peripapillary and macular choroidal areas between patients with primary open-angle glaucoma (POAG) and healthy controls because the choroid may potentially play a role in glaucoma pathophysiology. Methods We assessed 57 healthy controls and 42 POAG patients in a cross-sectional comparative study. We used enhanced depth imaging optical coherence tomography (EDI-OCT) and then converted the luminal and interstitial areas to binary images using ...
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    10. Dynamic optical coherence elastography (Thesis)

      Dynamic optical coherence elastography (Thesis)
      Dynamic optical coherence elastography (OCE) is a functional imaging modality which leverages the propagation of mechanical waves in order to estimate the mechanical properties of tissues. It is very useful since it does not require (i) a priori knowledge of force/stress, (ii) mandatory direct contact between the mechanical loading source and the tissue under study, and (iii) large deformation of tissues. Therefore, dynamic OCE shows promise for non-contact, in ...
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    11. In vivo imaging of corneal nerves and cellular structures in mice with Gabor-domain optical coherence microscopy

      In vivo imaging of corneal nerves and cellular structures in mice with Gabor-domain optical coherence microscopy
      Gabor-domain optical coherence microscopy (GDOCM) demonstrated in vivo corneal imaging with cellular resolution and differentiation in mice over a field of view of 1 mm 2 . Contact and non-contact imaging was conducted on six healthy and six hyperglycemic C57BL/6J mice. Cellular resolution in the 3D GDOCM images was achieved after motion correction. Corneal nerve fibers were traced and their lengths and branches calculated. Noncontact, label-free imaging of corneal nerves ...
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  2. About University of Rochester

    University of Rochester

    University of Rochester, founded in 1850, is one of the nation's leading private universities. With just over 4,500 undergraduates, Rochester is one of the smallest and most collegiate in character among the top research universities

    Founded in 1850, UR offers degree programs at the bachelor's, master's, and doctoral levels, as well as in several professional disciplines. Its undergraduate and graduate degree programs in political science, business administration and music are among the best in the nation. The Institute of Optics at the university is also the oldest optics program in the U.S., having granted about half of the optics degrees in the nation.

    UR is a highly research oriented institution, hosting numerous centers of research, including the Laboratory for Laser Energetics, which boasts the most powerful ultraviolet laser in the world, and the University of Rochester Medical Center, featuring numerous biomedical and healthcare research facilities. Since 2005, UR with its affiliated Strong Health System, has been the largest employer in the Greater Rochester area.