1. University of Rochester

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    1. Mentioned In 116 Articles

    2. In vivo imaging of corneal nerves and cellular structures in mice with Gabor-domain optical coherence microscopy

      In vivo imaging of corneal nerves and cellular structures in mice with Gabor-domain optical coherence microscopy
      Gabor-domain optical coherence microscopy (GDOCM) demonstrated in vivo corneal imaging with cellular resolution and differentiation in mice over a field of view of 1 mm 2 . Contact and non-contact imaging was conducted on six healthy and six hyperglycemic C57BL/6J mice. Cellular resolution in the 3D GDOCM images was achieved after motion correction. Corneal nerve fibers were traced and their lengths and branches calculated. Noncontact, label-free imaging of corneal nerves ...
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    3. Preoperative biometric measurements with anterior segment optical coherence tomography and prediction of postoperative intraocular lens position

      Preoperative biometric measurements with anterior segment optical coherence tomography and prediction of postoperative intraocular lens position
      The purpose of this study is to evaluate the biometric parameters of crystalline lens components and to find effective factors for predicting postoperative intraocular lens (IOL) position. This retrospective study included 97 eyes from 97 patients with a mean age of 63.00 12.38 (SD) years. The biometric measurements were performed by means of a 3-dimensional optical coherence tomography (3D-OCT) device. Specifically, anterior chamber depth (ACD), aqueous depth (AD ...
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    4. Imaging Techniques for the Visualization and Evaluation of Tear Film Dynamics (Book Chapter)

      Imaging Techniques for the Visualization and Evaluation of Tear Film Dynamics (Book Chapter)
      Significant efforts have been made with the development of various imaging techniques to visualize and understand the tear film dynamics. This chapter reviews three imaging techniques with established impact on imaging the tear film dynamics: fluorescent imaging, interferometry, and optical coherence tomography.
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    5. Absolute linear-in-k spectrometer designs enabled by freeform optics

      Absolute linear-in-k spectrometer designs enabled by freeform optics
      Linear-in-wavenumber, k , spectrometers have the merits of saving signal processing time and improving the sensitivity of spectral-domain optical coherence tomography (SD-OCT) by avoiding post- k -interpolation. We report on an approach leveraging freeform optics to linearize spectrometers in k to achieve an extremely low residual k -nonlinearity in design. A freeform lens reduced the k -nonlinearity from 2.47% for a benchmark spectrometer to 2.79 10 5 % and 3 ...
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    6. Reverberant 3D optical coherence elastography maps the elasticity of individual corneal layers

      Reverberant 3D optical coherence elastography maps the elasticity of individual corneal layers
      The elasticity mapping of individual layers in the cornea using non-destructive elastography techniques advances diagnosis and monitoring of ocular diseases and treatments in ophthalmology. However, transient Lamb waves, currently used in most dynamic optical coherence and ultrasound elastography techniques, diminish the translation of wave speed into shear/Youngs modulus. Here, we present reverberant 3D optical coherence elastography (Rev3D-OCE), a novel approach leveraging the physical properties of diffuse fields in detecting ...
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    7. Quantitative assessment of human donor corneal endothelium with Gabor domain optical coherence microscopy

      Quantitative assessment of human donor corneal endothelium with Gabor domain optical coherence microscopy
      We report on a pathway for Gabor domain optical coherence microscopy (GD-OCM)-based metrology to assess the donors corneal endothelial layers ex vivo . Six corneas from the Lions Eye Bank at Albany and Rochester were imaged with GD-OCM. The raw 3-D images of the curved corneas were flattened using custom software to enhance the 2-D visualization of endothelial cells (ECs); then the ECs within a circle of 500-m-diameter were analyzed ...
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    8. Capabilities of Gabor-domain optical coherence microscopy for the assessment of corneal disease

      Capabilities of Gabor-domain optical coherence microscopy for the assessment of corneal disease
      To identify the microstructural modification of the corneal layers during the course of the disease, optical technologies have been pushing the boundary of innovation to achieve cellular resolution of deep layers of the cornea. Gabor-domain optical coherence microscopy (GD-OCM), an optical coherence tomography-based technique that can achieve an isotropic of 2-m resolution over a volume of 1mm1mm1.2mm, was developed to investigate the microstructural modifications of corneal layers in four ...
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    9. Telecentric broadband objective lenses for optical coherence tomography (OCT) in the context of low uncertainty metrology of freeform optical components: from design to testing for wavefront and telecentricity

      Telecentric broadband objective lenses for optical coherence tomography (OCT) in the context of low uncertainty metrology of freeform optical components: from design to testing for wavefront and telecentricity
      Freeform optical components enable significant advances for optical systems. A major challenge for freeform optics is the current lack of metrology methods with measurement uncertainty on the order of tens of nanometers or less. Towards addressing this challenge, optical coherence tomography (OCT) is a viable technique. In the context of low uncertainty metrology, the design requirements pertaining to the sample arm of an OCT metrology system are explicitly addressed in ...
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    10. Cellular-scale evaluation of induced photoreceptor degeneration in the living primate eye

      Cellular-scale evaluation of induced photoreceptor degeneration in the living primate eye
      Progress is needed in developing animal models of photoreceptor degeneration and evaluating such models with longitudinal, noninvasive techniques. We employ confocal scanning laser ophthalmoscopy, optical coherence tomography (OCT) and high-resolution retinal imaging to noninvasively observe the retina of non-human primates with induced photoreceptor degeneration. Photoreceptors were imaged at the single-cell scale in three modalities of adaptive optics scanning light ophthalmoscopy: traditional confocal reflectance, indicative of waveguiding; a non-confocal offset aperture ...
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    11. Reflectance and thickness analysis of retinal layers in patients with epiretinal membranes using spectral-domain optical coherence tomography before and after vitrectomy with membrane peeling

      Reflectance and thickness analysis of retinal layers in patients with epiretinal membranes using spectral-domain optical coherence tomography before and after vitrectomy with membrane peeling
      Objective To compare thickness and reflectance of retinal layer findings in patients with idiopathic epiretinal membranes (ERMs), before and after surgery, to normal controls. Design A retrospective study Subjects Patients with ERMs before and after surgery and normal controls. Methods Spectral domain optical coherence tomography (SD-OCT) of eyes with ERMs, before and after surgery, and normal eyes were analyzed for morphologic appearance and using a customized algorithm to measure retinal ...
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    12. Optical Coherence Tomography for Barrett Esophagus

      Optical Coherence Tomography for Barrett Esophagus
      GH Can you provide a brief overview of optical coherence tomography? VK Optical coherence tomography (OCT) is an advanced imaging technology that was developed in the 1990s. Its application in the endoscopic realm began in the late 1990s. Approximately 5 years ago, a second-generation, advanced OCT technology known as volumetric laser endomicroscopy (VLE; NvisionVLE Imaging System, NinePoint Medical) became available in the US market. Since then, VLE has been the ...
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  2. About University of Rochester

    University of Rochester

    University of Rochester, founded in 1850, is one of the nation's leading private universities. With just over 4,500 undergraduates, Rochester is one of the smallest and most collegiate in character among the top research universities

    Founded in 1850, UR offers degree programs at the bachelor's, master's, and doctoral levels, as well as in several professional disciplines. Its undergraduate and graduate degree programs in political science, business administration and music are among the best in the nation. The Institute of Optics at the university is also the oldest optics program in the U.S., having granted about half of the optics degrees in the nation.

    UR is a highly research oriented institution, hosting numerous centers of research, including the Laboratory for Laser Energetics, which boasts the most powerful ultraviolet laser in the world, and the University of Rochester Medical Center, featuring numerous biomedical and healthcare research facilities. Since 2005, UR with its affiliated Strong Health System, has been the largest employer in the Greater Rochester area.