1. University of Pittsburgh

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    1. Mentioned In 231 Articles

    3. Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT

      Explore OSA | OSA Publishing Ophthalmology
      Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT
      We describe recent technological progress in multimodal en face full-field optical coherence tomography that has allowed detection of slow and fast dynamic processes in the eye. We show that by combining static, dynamic and fluorescence contrasts we can achieve label-free high-resolution imaging of the retina and anterior eye with temporal resolution from milliseconds to several hours, allowing us to probe biological activity at subcellular scales inside 3D bulk tissue. Our ...
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      Mentions: University of Pittsburgh Claude Boccara Sun Yat-Sen University

    4. Cellular-scale evaluation of induced photoreceptor degeneration in the living primate eye

      Explore OSA | OSA Publishing Ophthalmology
      Cellular-scale evaluation of induced photoreceptor degeneration in the living primate eye
      Progress is needed in developing animal models of photoreceptor degeneration and evaluating such models with longitudinal, noninvasive techniques. We employ confocal scanning laser ophthalmoscopy, optical coherence tomography (OCT) and high-resolution retinal imaging to noninvasively observe the retina of non-human primates with induced photoreceptor degeneration. Photoreceptors were imaged at the single-cell scale in three modalities of adaptive optics scanning light ophthalmoscopy: traditional confocal reflectance, indicative of waveguiding; a non-confocal offset aperture ...
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      Mentions: University of Pittsburgh University of Rochester University of Tübingen

    5. LEARNING TO SEGMENT CORNEAL TISSUE INTERFACES IN OCT IMAGES

      Explore arxiv.org Ophthalmology
      LEARNING TO SEGMENT CORNEAL TISSUE INTERFACES IN OCT IMAGES
      Accurate and repeatable delineation of corneal tissue interfaces is necessary for surgical planning during anterior segment interventions, such as Keratoplasty. Designing an approach to identify interfaces, which generalizes to datasets acquired from different Optical Coherence Tomographic (OCT) scanners, is paramount. In this paper, we present a Convolutional Neural Network (CNN) based framework called CorNet that can accurately segment three corneal interfaces across datasets obtained with different scan settings from different ...
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      Mentions: University of Pittsburgh

    6. Optical coherence tomography as a rapid, accurate, non-contact method of visualizing the palisades of Vogt

      Explore uspto.gov Ophthalmology , Patents
      Optical coherence tomography as a rapid, accurate, non-contact method of visualizing the palisades of Vogt
      The innovation provides for a system and method available to image and visualize the palisades of Vogt via a non-contact process, analyze the image volumes acquired, evaluate the status of the palisades of Vogt from the data represented therein, and display the data in real-time or as a part of a medical record for ongoing consideration and evaluation.
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      Mentions: University of Pittsburgh Joel S. Schuman

    7. Depth-resolved spatial-domain low-coherence quantitative phase microscopy for unstained tissue and cells

      Explore uspto.gov Patents
      Depth-resolved spatial-domain low-coherence quantitative phase microscopy for unstained tissue and cells
      Provided are systems, methods, and other embodiments associated with depth-resolved spatial-domain low-coherence quantitative phase microscopy for high-throughput analysis of 3D nanoscale architectural alterations in unstained tissue and cells. A spatial-domain low-coherence quantitative phase microscopy apparatus includes a drOPD mapping module, a transmission phase imaging module, and a bright-field and transmission phase imaging module. The drOPD mapping module includes a reflection-mode low-coherence spectral interferometry for drOPD mapping of unstained tissue. The ...
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      Mentions: University of Pittsburgh

    8. In vivo high resolution human corneal imaging using full-field optical coherence tomography

      Explore OSA | OSA Publishing Ophthalmology
      In vivo high resolution human corneal imaging using full-field optical coherence tomography
      We present the first full-field optical coherence tomography (FFOCT) device capable of in vivo imaging of the human cornea. We obtained images of the epithelial structures, Bowmans layer, sub-basal nerve plexus (SNP), anterior and posterior stromal keratocytes, stromal nerves, Descemets membrane and endothelial cells with visible nuclei. Images were acquired with a high lateral resolution of 1.7 m and relatively large field-of-view of 1.26 mm x 1.26 ...
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      Mentions: University of Pittsburgh Johns Hopkins University Claude Boccara

    9. Signal normalization among multiple optical coherence tomography devices

      Explore uspto.gov Patents
      Signal normalization among multiple optical coherence tomography devices
      The present disclosure is directed to systems and methods for normalizing an image of an eye among multiple optical coherence tomography (OCT) devices. The system can receive an OCT image and generate a normalized OCT image. The system is configured to normalize a sample density of the received image, normalize an amount of noise using a suitable noise reduction technique, normalize a distribution of signal amplitudes of the image, and ...
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      Mentions: University of Pittsburgh Joel S. Schuman Gadi Wollstein

    10. Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study

      Explore ScienceDirect Cardiology
      Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study
      Background Lipid-rich plaque (LRP) is thought to be a precursor to cardiac events. However, its clinical significance in coronary arteries has never been systematically investigated. Objectives This study investigated the prevalence and clinical significance of LRP in the nonculprit region of the target vessel in patients undergoing percutaneous coronary intervention (PCI). Methods The study included 1,474 patients from 20 sites across 6 countries undergoing PCI, who had optical coherence ...
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      Mentions: University of Pittsburgh Massachusetts Institute of Technology James G. Fujimoto

    11. Intraoperative Optical Coherence Tomography-Assisted Descemet Stripping Automated Endothelial Keratoplasty for Anterior Chamber Fibrous Ingrowth

      Explore insights.ovid.com Ophthalmology
      Intraoperative Optical Coherence Tomography-Assisted Descemet Stripping Automated Endothelial Keratoplasty for Anterior Chamber Fibrous Ingrowth
      Purpose: Here, we present the first reported case of intraoperative optical coherence tomography (OCT)-assisted Descemet membrane stripping automated endothelial keratoplasty (DSAEK) in a patient with anterior segment fibrous ingrowth. Methods: A 61-year-old woman with corneal edema and chronic angle-closure glaucoma secondary to fibrous ingrowth after 2 glaucoma shunt device implantations underwent dissection and removal of anterior chamber fibrous ingrowth and DSAEK. The surgical techniques using intraoperative OCT and outcome ...
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      Mentions: University of Pittsburgh

    12. MIT Receives a 2017 NIH Grant for Novel Diagnostics with Optical Coherence Tomography

      Explore Optical Coherence Tomography News Funding
      MIT Receives a 2017 NIH Grant for Novel Diagnostics with Optical Coherence Tomography
      ...borative program among investigators at the Massachusetts Institute of Technology, New England Eye Center and University of Pittsburgh Medical Center Eye Center. This is a multidisciplinary program which integrates imagi...
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      Mentions: University of Pittsburgh Massachusetts Institute of Technology National Institutes of Health

    13. Signal Normalization Reduces Image Appearance Disparity Among Multiple Optical Coherence Tomography Devices

      Explore TVST Journal Ophthalmology
      Signal Normalization Reduces Image Appearance Disparity Among Multiple Optical Coherence Tomography Devices
      Purpose : To assess the effect of the previously reported optical coherence tomography (OCT) signal normalization method on reducing the discrepancies in image appearance among spectral-domain OCT (SD-OCT) devices. Methods : Healthy eyes and eyes with various retinal pathologies were scanned at the macular region using similar volumetric scan patterns with at least two out of three SD-OCT devices at the same visit (Cirrus HD-OCT, Zeiss, Dublin, CA; RTVue, Optovue, Fremont, CA ...
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      Mentions: University of Pittsburgh Optovue Heidelberg Engineering

    14. Mapping in-vivo optic nerve head strains caused by intraocular and intracranial pressures

      Explore Conference Proceedings Neurology , Ophthalmology
      Mapping in-vivo optic nerve head strains caused by intraocular and intracranial pressures
      Although it is well documented that abnormal levels of either intraocular (IOP) or intracranial pressure (ICP) can lead to potentially blinding conditions, such as glaucoma and papilledema, little is known about how the pressures actually affect the eye. Even less is known about potential interplay between their effects, namely how the level of one pressure might alter the effects of the other. Our goal was to measure in-vivo the pressure-induced ...
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      Mentions: University of Pittsburgh Joel S. Schuman Gadi Wollstein

    15. Adaptive optics optical coherence tomography in glaucoma

      Explore ScienceDirect Ophthalmology
      Adaptive optics optical coherence tomography in glaucoma
      Since the introduction of commercial optical coherence tomography (OCT) systems, the ophthalmic imaging modality has rapidly expanded and it has since changed the paradigm of visualization of the retina and revolutionized the management and diagnosis of neuro-retinal diseases, including glaucoma. OCT remains a dynamic and evolving imaging modality, growing from time-domain OCT to the improved spectral-domain OCT, adapting novel image analysis and processing methods, and onto the newer swept-source OCT ...
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      Mentions: University of Pittsburgh Joel S. Schuman Gadi Wollstein

    16. Establishing compatibility between two- and three-dimensional optical coherence tomography scans

      Explore uspto.gov Ophthalmology , Patents
      Establishing compatibility between two- and three-dimensional optical coherence tomography scans
      Advances in optical coherence tomography (OCT) have prompted a transition from time domain OCT, providing 2D OCT images, to spectral domain OCT, which has a 3D imaging capability. Yet conventional technology offers little toward the goal of inter-device compatibility between extant 2D OCT images and newer 3D OCT images for the same or comparable subjects, as in the context of ongoing monitoring the quantitative status of a patient's eyes ...
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      Mentions: University of Pittsburgh Joel S. Schuman Gadi Wollstein
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  4. About University of Pittsburgh

    University of Pittsburgh

    University of Pittsburgh public research university located in Pittsburgh, Pennsylvania. Pitt is a renowned leader in academic fields as diverse as philosophy and medicine.  University of Pittsburgh Medical Center has a team of about 50,000 employees, UPMC serves the health needs of more than 4 million people each year  Department of Ophthalmology UPMC Eye Center’s mission is to improve quality of life through the preservation and restoration of vision.  Swanson School of Engineering is the engineering school of the University of Pittsburgh in Pittsburgh, Pennsylvania.

  5. Related Topics

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