1. University of Pittsburgh

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    1. Mentioned In 192 Articles

    2. Full-field optical coherence tomography (FFOCT) for evaluation of endometrial cancer

      Full-field optical coherence tomography (FFOCT) for evaluation of endometrial cancer

      Full-field optical coherence tomography (FFOCT) quickly produces images that resemble conventional pathology images. We examined endometrium in an intra-operative like fashion (more than forty samples). FFOCT-imaged endometrium was recognizable to pathologists and compared favorably with microscopy of the same samples. Additional image enhancements and acquisition techniques were explored and may improve interpretation accuracy. Wider evaluation of images is ongoing, using more pathologist subjects. FFOCT may revolutionize pathology practice in the future by permitting rapid diagnosis and in vivo diagnosis; this is potentially a disruptive new diagnostic technique in pathology.

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    3. Evaluating glaucoma damage: emerging imaging technologies

      Evaluating glaucoma damage: emerging imaging technologies

      The use of ocular imaging tools to estimate structural and functional damage in glaucoma has become a common clinical practice and a substantial focus of vision research. The evolution of the imaging technologies through increased scanning speed, penetration depth, image registration and development of multimodal devices has the potential to detect the pathology more reliably and in earlier stages. This review is focused on new ocular imaging modalities used for glaucoma diagnosis.

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    4. New developments in optical coherence tomography

      New developments in optical coherence tomography

      Purpose of review: Optical coherence tomography (OCT) has become the cornerstone technology for clinical ocular imaging in the past few years. The technology is still rapidly evolving with newly developed applications. This manuscript reviews recent innovative OCT applications for glaucoma diagnosis and management. Recent findings: The improvements made in the technology have resulted in increased scanning speed, axial and transverse resolution, and more effective use of the OCT technology as a component of multimodal imaging tools. At the same time, the parallel evolution in novel algorithms makes it possible to efficiently analyze the increased volume of acquired data. Summary: The ...

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    5. Advanced Imaging for Glaucoma Study: Design, Baseline Characteristics, and Inter-Site Comparison

      Advanced Imaging for Glaucoma Study: Design, Baseline Characteristics, and Inter-Site Comparison

      Purpose To report the baseline characteristics of the participants in the Advanced Imaging for Glaucoma Study. To compare the participating sites for variations among subjects and the performance of imaging instruments. Design Multi-center longitudinal observational cohort study Methods A total of 788 participants (1,329 eyes) were enrolled from three academic referral centers. There were 145 participants (289 eyes) in the normal group, 394 participants (663 eyes) in the glaucoma suspect/preperimetric glaucoma group, and 249 participants (377 eyes) in the perimetric glaucoma group. Participants underwent a full clinical exam, standard automated perimetry, and imaging with time-domain and Fourier-domain optical ...

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    6. In Vivo Three-Dimensional Characterization of the Healthy Human Lamina Cribrosa with Adaptive Optics Spectral-Domain Optical Coherence Tomography

      In Vivo Three-Dimensional Characterization of the Healthy Human Lamina Cribrosa with Adaptive Optics Spectral-Domain Optical Coherence Tomography
      ...h, PA, 15213, United States 1. ↵* Department of Ophthalmology, University of Pittsburgh School of Medicine, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Pittsburgh, PA, 1521...
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    7. Dual modality optical coherence and whole-body photoacoustic tomography imaging of chick embryos in multiple development stages

      Dual modality optical coherence and whole-body photoacoustic tomography imaging of chick embryos in multiple development stages
      ...ogy, Medical University of Vienna, Währinger Straße 13, Vienna 1090, Austria ^3Department of Ophthalmology, University of Pittsburgh, Eye & Ear Institute, 203 Lothrop Street, Pittsburgh, PA 15213, USA ^4Department of...
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    8. Bivalirudin versus unfractionated heparin for residual thrombus burden: A frequency-domain optical coherence tomography study

      Bivalirudin versus unfractionated heparin for residual thrombus burden: A frequency-domain optical coherence tomography study

      Objectives: This study aimed to compare the effect of bivalirudin and unfractionated heparin (UFH) on residual thrombus burden assessed by frequency-domain optical coherence tomography (FD-OCT), and on angiographic indices of microvascular obstruction (MVO). Background: The efficacy of bivalirudin to inhibit thrombus formation inside the stent during percutaneous coronary interventions (PCI) as compared to UFH is unknown. Methods: Sixty patients with coronary artery disease who underwent post-PCI FD-OCT were studied, including 20 patients treated with bivalirudin and 40 control patients treated with UFH, matched by clinical presentation, stent characteristics, and periprocedural medications. In-stent thrombus volume, thrombus score (number of quadrants with ...

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    9. Prevalence and Characteristics of TCFA and Degree of Coronary Artery Stenosis An OCT, IVUS, and Angiographic Study

      Prevalence and Characteristics of TCFA and Degree of Coronary Artery Stenosis An OCT, IVUS, and Angiographic Study

      Background The relationship between features of vulnerable plaque and angiographic coronary stenosis is unknown. Objectives The purpose of this study was to systematically investigate the absolute number, relative prevalence, and characteristics of thin-cap fibroatheroma (TCFA) at different degrees of stenosis using optical coherence tomography (OCT), intravascular ultrasound, and coronary angiography. Methods We identified 643 plaques from 255 subjects who underwent OCT imaging in all 3 coronary arteries. They were divided into 3 groups on the basis of angiographic diameter stenosis: Group A (30% to 49%, n = 325), Group B (50% to 69%, n = 227), and Group C (>70%, n = 91 ...

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    10. Microscopy without Slides: An Introduction to Optical Coherence Tomography (OCT)

      Microscopy without Slides: An Introduction to Optical Coherence Tomography (OCT)

      Optical coherence tomography (OCT) is one of several exciting, advanced imaging techniques that are beginning to appear in pathology. OCT can rapidly generate photomicrograph-like images directly from tissue, without the need for glass slide histology. Because the images resemble low-to-medium magnification microscope images, pathologists should be able to adapt their existing diagnostic expertise to these novel images. Both in-vivo and specimen (ex-vivo) applications are possible; this means that advanced imaging may permit pathologists to make diagnoses directly on patient images. Advanced imaging therefore represents a fabulous opportunity for pathologists in the 21st century. This talk will focus on specimen OCT ...

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    11. Intra- and Inter-visit Reproducibility of Ganglion Cell – Inner Plexiform Layer Measurements Using Handheld Optical Coherence Tomography in Children with Optic Pathway Gliomas

      Intra- and Inter-visit Reproducibility of Ganglion Cell – Inner Plexiform Layer Measurements Using Handheld Optical Coherence Tomography in Children with Optic Pathway Gliomas

      Purpose To determine the intra- and inter-visit reproducibility of ganglion cell-inner plexiform layer thickness measures using handheld optical coherence tomography (OCT) in sedated children with optic pathway gliomas and/or Neurofibromatosis type 1 (NF1). Design Prospective longitudinal cohort study Methods Children with sporadic optic pathway gliomas and/or NF1 who had ≥ 2 volumes acquired over the macula using handheld OCT during sedation for a clinically indicated MRI were eligible for the intra-visit cohort. Children with repeat handheld OCT imaging within 6 months were eligible for the inter-visit cohort. Total retinal thickness and ganglion cell-inner plexiform layer thickness were measured using ...

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    12. Reproducibility of Circumpapillary Retinal Nerve Fiber Layer Measurements Using Handheld Optical Coherence Tomography in Sedated Children

      Reproducibility of Circumpapillary Retinal Nerve Fiber Layer Measurements Using Handheld Optical Coherence Tomography in Sedated Children
      ...Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA * Department of Bioengineering, Swanson School o...
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    13. University of Pittsburgh Receives NIH Grant for Microsurgical In-Situ Image Guidance With Optical Coherence Tomography

      University of Pittsburgh Receives NIH Grant for Microsurgical In-Situ Image Guidance With Optical Coherence Tomography
      ...ents. We expect to write a competitive renewal for such trials during the final year of the current proposal. University of Pittsburgh Receives a 2014 NIH Grant for $542,064 for Microsurgical In-Situ Image Guidance With ...
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  2. About University of Pittsburgh

    University of Pittsburgh

    University of Pittsburgh public research university located in Pittsburgh, Pennsylvania. Pitt is a renowned leader in academic fields as diverse as philosophy and medicine.  University of Pittsburgh Medical Center has a team of about 50,000 employees, UPMC serves the health needs of more than 4 million people each year  Department of Ophthalmology UPMC Eye Center’s mission is to improve quality of life through the preservation and restoration of vision.  Swanson School of Engineering is the engineering school of the University of Pittsburgh in Pittsburgh, Pennsylvania.