1. University of Pittsburgh

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    1. Mentioned In 268 Articles

    2. Influence of protocol scan on choroidal vascularity measurements: a spectralis optical coherence tomography study

      Influence of protocol scan on choroidal vascularity measurements: a spectralis optical coherence tomography study
      Objectives To compare choroidal vascularity index (CVI) measurements using the automated image binarization algorithm in healthy subjects with two Spectralis spectral-domain optical coherence tomography (SD-OCT) protocol scans. Methods Sixty-nine eyes of 69 healthy volunteers were included in this cross-sectional prospective study. Two subsequent horizontal 20line scans passing through the fovea were acquired with enhanced-depth imaging mode with high speed (HS) and high resolution (HR) protocol scans. CVI and its subcomponents ...
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    3. Volumetric quantification of choroid and Haller's sublayer using OCT scans: An accurate and unified approach based on stratified smoothing

      Volumetric quantification of choroid and Haller's sublayer using OCT scans: An accurate and unified approach based on stratified smoothing
      Background and objective: The choroid, a dense vascular structure in the posterior segment of the eye, maintains the health of the retina by supplying oxygen and nutrients, and assumes clinical significance in screening ocular diseases including age-related macular degeneration (AMD) and central serous chorioretinopathy (CSCR). As a technological assist, algorithmic estimation of choroidal biomarkers has been suggested based on sectional (B-scan) optical coherence tomography (OCT) images. However, most such 2D ...
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    4. Dynamic full-field optical coherence tomography allows live imaging of retinal pigment epithelium stress model

      Dynamic full-field optical coherence tomography allows live imaging of retinal pigment epithelium stress model
      Retinal degenerative diseases lead to the blindness of millions of people around the world. In case of age-related macular degeneration (AMD), the atrophy of retinal pigment epithelium (RPE) precedes neural dystrophy. But as crucial as understanding both healthy and pathological RPE cell physiology is for those diseases, no current technique allows subcellular in vivo or in vitro live observation of this critical cell layer. To fill this gap, we propose ...
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    5. Spectral domain OCT features in type 2 macular telangiectasia (type 2 MacTel): its relevance with clinical staging and visual acuity

      Spectral domain OCT features in type 2 macular telangiectasia (type 2 MacTel): its relevance with clinical staging and visual acuity
      Background: To report spectral domain optical coherence tomography (SDOCT) imaging findings in type 2 macular telangiectasia (MacTel) and correlate them with clinical stages and visual acuity. Methods: This retrospective, cross-sectional study included type 2 MacTel cases who underwent SDOCT imaging with Spectralis machine. Macular SDOCT images were analysed. Imaging features were tested for correlation with different clinicals stages and visual acuity. Results: 212 eyes of 108 type 2 MacTel patients ...
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    6. Prediction of Neoplastic Progression in Barrett’s Esophagus Using Nanoscale Nuclear Architecture Mapping: A Pilot Study

      Prediction of Neoplastic Progression in Barrett’s Esophagus Using Nanoscale Nuclear Architecture Mapping: A Pilot Study
      Background and Aims Nanoscale nuclear architecture mapping (nanoNAM), an optical coherence tomography-derived approach, is capable of detecting with nanoscale sensitivity, structural alterations in the chromatin of epithelial cell nuclei at risk for malignant transformation. Since these alterations predate the development of dysplasia, we aimed to utilize nanoNAM to identify patients with Barretts esophagus (BE) who progress to high grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). Methods This is a nested ...
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    7. In-vivo visualization of the photoreceptors using Spectralis High Magnification Module imaging in central serous chorioretinopath

      In-vivo visualization of the photoreceptors using Spectralis High Magnification Module imaging in central serous chorioretinopath
      Purpose To visualize photoreceptors using the Spectralis High Magnification Module (HMM) in a case of central serous chorioretinopathy (CSCR) and to correlate the findings with those of optical coherence tomography (OCT) and optical coherence tomography angiography (OCT-A). Observations A 35-year-old Caucasian male presenting with chronic CSCR in the left eye was examined using HMM, OCT and OCT-A. The photoreceptors mosaic was assessed both in diseased and apparently uninvolved areas. A ...
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    8. En face optical coherence tomography transillumination for evaluation of retinal pigment epithelium alteration in central serous chorioretinopathy: correlation with multimodal imaging

      En face optical coherence tomography transillumination for evaluation of retinal pigment epithelium alteration in central serous chorioretinopathy: correlation with multimodal imaging
      Purpose: To study optical coherence tomography (OCT) en face imaging approach to evaluate retinal pigment epithelium (RPE) alteration in central serous chorioretinopathy (CSC). Methods: Forty eyes with CSC were imaged with structural en face OCT, fluorescein angiography (FA), and fundus autofluorescence (FAF). Structural en face OCT projections were generated using a 200-m slab with the inner limit at the outer choroid to register choroidal hypertransmission signal in transillumination manner. Two ...
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    9. Evaluation of Choroidal Thickness Using Optical Coherent Tomography: A Review

      Evaluation of Choroidal Thickness Using Optical Coherent Tomography: A Review
      The choroid is the main source of blood and nourishment supply to the eye. The dysfunction of the choroid has been implicated in various retinal and choroidal diseases. The identification and in-depth understanding of pachychoroid spectrum disorders are based on the tremendous progress of optical coherence tomography (OCT) technology in recent years, although visibility of choroid is challenging in the era of the time or spectral domain OCT. The recent ...
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    10. Integrated Intraoperative Optical Coherence Tomography during Scleral Pass in Strabismus Surgery

      Integrated Intraoperative Optical Coherence Tomography during Scleral Pass in Strabismus Surgery
      We describe a novel application of integrated intraoperative OCT (iiOCT) to strabismus surgery during the scleral pass and demonstrate it to be a useful tool. A number of complications can arise from inappropriate scleral pass depth during strabismus surgery, leading to an increased risk of unwanted complications including endophthalmitis, retinal detachment, and a lost or slipped muscle. Our study demonstrated that the use of iiOCT provides easy to interpret, real-time ...
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    11. Circular functional analysis of OCT data for precise identification of structural phenotypes in the eye

      Circular functional analysis of OCT data for precise identification of structural phenotypes in the eye
      Progressive optic neuropathies such as glaucoma are major causes of blindness globally. Multiple sources of subjectivity and analytical challenges are often encountered by clinicians in the process of early diagnosis and clinical management of these diseases. In glaucoma, the structural damage is often characterized by neuroretinal rim (NRR) thinning of the optic nerve head, and other clinical parameters. Baseline structural heterogeneity in the eyes can play a key role in ...
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    12. EE-Net: An edge-enhanced deep learning network for jointly identifying corneal micro-layers from optical coherence tomography

      EE-Net: An edge-enhanced deep learning network for jointly identifying corneal micro-layers from optical coherence tomography
      Accurate delineation of the corneal micro-layers depicted on optical coherence tomography (OCT) plays an important role in computerized detection and diagnosis of various corneal diseases ( e.g. , keratoconus and dry eye). In this study, we present a novel edge-enhanced convolutional neural network termed EE-Net to automatically delineate three corneal micro-layers from OCT images at the same time, including the epithelium layer, Bowmans layer, and stroma layer. We innovatively introduced a ...
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    13. Optical coherence tomography predictors of progression of non-exudative age-related macular degeneration to advanced atrophic and exudative disease

      Optical coherence tomography predictors of progression of non-exudative age-related macular degeneration to advanced atrophic and exudative disease
      Purpose: To study the natural history of optical coherence tomography (OCT) imaging-based findings seen in non-exudative age-related macular degeneration (neAMD) and model their relative likelihood in predicting development of incomplete retinal pigment epithelium and outer retinal atrophy (iRORA), complete retinal pigment epithelium and outer retinal atrophy (cRORA), and neovascular AMD (nAMD). Methods: Retrospective chart review was performed at two academic practices. Patients diagnosed with neAMD for whom yearly OCT scans ...
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    14. Internal limiting membrane detachment in acute central retinal artery occlusion: a novel prognostic sign seen on OCT

      Internal limiting membrane detachment in acute central retinal artery occlusion: a novel prognostic sign seen on OCT
      ackground: To present a series of acute central retinal artery occlusion (CRAO) cases showing internal limiting membrane detachment (ILMD) on optical coherence tomography (OCT) and to describe the possible etiopathogenesis and outcomes associated with it. Methods: Demographic and OCT features of patients with acute CRAO were analysed retrospectively. OCT parameters noted were posterior vitreous opacities, ILMD, inner retinal layer stratification, hyperreflectivity and thickening, cystoid macular edema, neurosensory detachment. Eyes were ...
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  2. About University of Pittsburgh

    University of Pittsburgh

    University of Pittsburgh public research university located in Pittsburgh, Pennsylvania. Pitt is a renowned leader in academic fields as diverse as philosophy and medicine.  University of Pittsburgh Medical Center has a team of about 50,000 employees, UPMC serves the health needs of more than 4 million people each year  Department of Ophthalmology UPMC Eye Center’s mission is to improve quality of life through the preservation and restoration of vision.  Swanson School of Engineering is the engineering school of the University of Pittsburgh in Pittsburgh, Pennsylvania.