Tissue properties and biomechanics of the optic nerve head (ONH) are important to the development and progression of glaucoma, but remain mostly unmeasurable in the experiment. We hypothesized that these can be estimated numerically from ocular parameters measurable in-vivo with optical coherence tomography (OCT). Using previously reported parametric models representing human ONHs we simulated acute intraocular pressure (IOP) increases (10 mmHg). Statistical models were fit to predict, from OCT-measurable parameters, 15 outputs of interest including tissue properties, stresses and deformations. The calculations were repeated adding parameters that have recently been proposed as potentially measurable with OCT. We evaluated the sensitivity ...

Glaucoma is the world’s second leading cause of blindness. In recognition of that, the World Glaucoma Association has named March 9-15 World Glaucoma Week. This is a week dedicated to encouraging everyone to find out if they are at risk. Joel S. Schuman, MD, FACS, and his team have been working on a way to diagnose glaucoma earlier. Dr. Schuman’s team has been using Optical Coherence Tomography (OCT) to detect early abnormalities in the optic nerve that occur before the change is detectable in the vision field. This development enables ophthalmologists to diagnose glaucoma earlier than ever before ...