Purpose To determine the intra- and inter-visit reproducibility of ganglion cell-inner plexiform layer thickness measures using handheld optical coherence tomography (OCT) in sedated children with optic pathway gliomas and/or Neurofibromatosis type 1 (NF1). Design Prospective longitudinal cohort study Methods Children with sporadic optic pathway gliomas and/or NF1 who had ≥ 2 volumes acquired over the macula using handheld OCT during sedation for a clinically indicated MRI were eligible for the intra-visit cohort. Children with repeat handheld OCT imaging within 6 months were eligible for the inter-visit cohort. Total retinal thickness and ganglion cell-inner plexiform layer thickness were measured using ...

Systems and methods of analyzing an optical coherence tomography image of a retina are discussed. A 2-dimensional slice of the image can be aligned to produce an approximately horizontal image of the retina and an edge map based at least in part on the aligned slice. Also, at least one global representation can be determined based on a (multi-scale) spatial division, such as multi-scale spatial pyramid, on the slice and/or edge map. Creating the local features is based on the specified cell structure of the global representation. The local features can be constructed based on local binary pattern (LBP ...

Tissue properties and biomechanics of the optic nerve head (ONH) are important to the development and progression of glaucoma, but remain mostly unmeasurable in the experiment. We hypothesized that these can be estimated numerically from ocular parameters measurable in-vivo with optical coherence tomography (OCT). Using previously reported parametric models representing human ONHs we simulated acute intraocular pressure (IOP) increases (10 mmHg). Statistical models were fit to predict, from OCT-measurable parameters, 15 outputs of interest including tissue properties, stresses and deformations. The calculations were repeated adding parameters that have recently been proposed as potentially measurable with OCT. We evaluated the sensitivity ...

Glaucoma is the world’s second leading cause of blindness. In recognition of that, the World Glaucoma Association has named March 9-15 World Glaucoma Week. This is a week dedicated to encouraging everyone to find out if they are at risk. Joel S. Schuman, MD, FACS, and his team have been working on a way to diagnose glaucoma earlier. Dr. Schuman’s team has been using Optical Coherence Tomography (OCT) to detect early abnormalities in the optic nerve that occur before the change is detectable in the vision field. This development enables ophthalmologists to diagnose glaucoma earlier than ever before ...