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1. Mentioned In 262 Articles
2. Prediction of Neoplastic Progression in Barrett’s Esophagus Using Nanoscale Nuclear Architecture Mapping: A Pilot Study
  
  Explore Gastrointestinal Endoscopy Jan 20 2022 Gastroenterology , Oncology
  
  Background and Aims Nanoscale nuclear architecture mapping (nanoNAM), an optical coherence tomography-derived approach, is capable of detecting with nanoscale sensitivity, structural alterations in the chromatin of epithelial cell nuclei at risk for malignant transformation. Since these alterations predate the development of dysplasia, we aimed to utilize nanoNAM to identify patients with Barretts esophagus (BE) who progress to high grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). Methods This is a nested ...
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  Mentions: University of Pittsburgh Cleveland Clinic
3. In-vivo visualization of the photoreceptors using Spectralis High Magnification Module imaging in central serous chorioretinopath
  
  Explore ScienceDirect Jan 15 2022 Ophthalmology
  
  Purpose To visualize photoreceptors using the Spectralis High Magnification Module (HMM) in a case of central serous chorioretinopathy (CSCR) and to correlate the findings with those of optical coherence tomography (OCT) and optical coherence tomography angiography (OCT-A). Observations A 35-year-old Caucasian male presenting with chronic CSCR in the left eye was examined using HMM, OCT and OCT-A. The photoreceptors mosaic was assessed both in diseased and apparently uninvolved areas. A ...
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  Mentions: University of Pittsburgh University of Perugia
4. En face optical coherence tomography transillumination for evaluation of retinal pigment epithelium alteration in central serous chorioretinopathy: correlation with multimodal imaging
  
  Explore Home - Springer Jan 6 2022 Ophthalmology
  
  Purpose: To study optical coherence tomography (OCT) en face imaging approach to evaluate retinal pigment epithelium (RPE) alteration in central serous chorioretinopathy (CSC). Methods: Forty eyes with CSC were imaged with structural en face OCT, fluorescein angiography (FA), and fundus autofluorescence (FAF). Structural en face OCT projections were generated using a 200-m slab with the inner limit at the outer choroid to register choroidal hypertransmission signal in transillumination manner. Two ...
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  Mentions: University of Pittsburgh
5. Evaluation of Choroidal Thickness Using Optical Coherent Tomography: A Review
  
  Explore Frontiers Dec 29 2021 Ophthalmology
  
  The choroid is the main source of blood and nourishment supply to the eye. The dysfunction of the choroid has been implicated in various retinal and choroidal diseases. The identification and in-depth understanding of pachychoroid spectrum disorders are based on the tremendous progress of optical coherence tomography (OCT) technology in recent years, although visibility of choroid is challenging in the era of the time or spectral domain OCT. The recent ...
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  Mentions: University of Pittsburgh Capital Medical University
6. Integrated Intraoperative Optical Coherence Tomography during Scleral Pass in Strabismus Surgery
  
  Explore Taylor & Francis Online Dec 12 2021 Ophthalmology
  
  We describe a novel application of integrated intraoperative OCT (iiOCT) to strabismus surgery during the scleral pass and demonstrate it to be a useful tool. A number of complications can arise from inappropriate scleral pass depth during strabismus surgery, leading to an increased risk of unwanted complications including endophthalmitis, retinal detachment, and a lost or slipped muscle. Our study demonstrated that the use of iiOCT provides easy to interpret, real-time ...
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  Mentions: University of Pittsburgh
7. Circular functional analysis of OCT data for precise identification of structural phenotypes in the eye
  
  Explore Nature Publishing Group Dec 4 2021 Ophthalmology
  
  Progressive optic neuropathies such as glaucoma are major causes of blindness globally. Multiple sources of subjectivity and analytical challenges are often encountered by clinicians in the process of early diagnosis and clinical management of these diseases. In glaucoma, the structural damage is often characterized by neuroretinal rim (NRR) thinning of the optic nerve head, and other clinical parameters. Baseline structural heterogeneity in the eyes can play a key role in ...
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  Mentions: University of Pittsburgh L V Prasad Eye Institute Academic Hospital Maastricht
8. EE-Net: An edge-enhanced deep learning network for jointly identifying corneal micro-layers from optical coherence tomography
  
  Explore ScienceDirect Oct 24 2021 Ophthalmology
  
  Accurate delineation of the corneal micro-layers depicted on optical coherence tomography (OCT) plays an important role in computerized detection and diagnosis of various corneal diseases ( e.g. , keratoconus and dry eye). In this study, we present a novel edge-enhanced convolutional neural network termed EE-Net to automatically delineate three corneal micro-layers from OCT images at the same time, including the epithelium layer, Bowmans layer, and stroma layer. We innovatively introduced a ...
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  Mentions: University of Pittsburgh Wenzhou Medical College
9. Optical coherence tomography predictors of progression of non-exudative age-related macular degeneration to advanced atrophic and exudative disease
  
  Explore Home - Springer Oct 5 2021 Ophthalmology
  
  Purpose: To study the natural history of optical coherence tomography (OCT) imaging-based findings seen in non-exudative age-related macular degeneration (neAMD) and model their relative likelihood in predicting development of incomplete retinal pigment epithelium and outer retinal atrophy (iRORA), complete retinal pigment epithelium and outer retinal atrophy (cRORA), and neovascular AMD (nAMD). Methods: Retrospective chart review was performed at two academic practices. Patients diagnosed with neAMD for whom yearly OCT scans ...
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  Mentions: University of Pittsburgh
10. Internal limiting membrane detachment in acute central retinal artery occlusion: a novel prognostic sign seen on OCT
  
  Explore journalretinavitreous.biomedcentral.com Sep 5 2021 Ophthalmology
  
  ackground: To present a series of acute central retinal artery occlusion (CRAO) cases showing internal limiting membrane detachment (ILMD) on optical coherence tomography (OCT) and to describe the possible etiopathogenesis and outcomes associated with it. Methods: Demographic and OCT features of patients with acute CRAO were analysed retrospectively. OCT parameters noted were posterior vitreous opacities, ILMD, inner retinal layer stratification, hyperreflectivity and thickening, cystoid macular edema, neurosensory detachment. Eyes were ...
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  Mentions: University of Pittsburgh
11. Automated delineation of corneal layers on OCT images using a boundary-guided CNN
  
  Explore ScienceDirect Aug 26 2021 Ophthalmology
  
  Accurate segmentation of corneal layers depicted on optical coherence tomography (OCT) images is very helpful for quantitatively assessing and diagnosing corneal diseases ( e.g ., keratoconus and dry eye). In this study, we presented a novel boundary-guided convolutional neural network (CNN) architecture (BG-CNN) to simultaneously extract different corneal layers and delineate their boundaries. The developed BG-CNN architecture used three convolutional blocks to construct two network modules on the basis of the ...
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  Mentions: University of Pittsburgh Wenzhou Medical College
12. Real-world outcomes of anti-VEGF therapy in treatment-naïve neovascular age-related macular degeneration diagnosed on OCT angiography: the REVEAL study
  
  Explore Wiley Online Library Aug 19 2021 Ophthalmology
  
  Purpose: To compare the 12 months visual and anatomical outcomes of treatment-nave neovascular age-related macular degeneration (nAMD) patients diagnosed by optical coherence tomography angiography (OCT-A) compared with fluorescein angiography (FA)/indocyanine green angiography (ICGA), after anti-VEGF treatment in a real-world setting. Methods: Monocentric, observational, parallel-group study of nAMD patients diagnosed with either FA/ICGA or non-invasive OCT-A methods. Patients were treated with a fixed dosing regimen of intravitreal ranibizumab or ...
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  Mentions: University of Pittsburgh
13. A high-accuracy and high-efficiency digital volume correlation method to characterize in-vivo optic nerve head biomechanics from optical coherence tomography
  
  Explore bioRxiv.org Aug 8 2021 Ophthalmology
  
  In-vivo optic nerve head (ONH) biomechanics characterization is emerging as a promising way to study eye physiology and pathology. We propose a high-accuracy and high-efficiency digital volume correlation (DVC) method for the purpose of characterizing the in-vivo ONH deformation from volumes acquired by optical coherence tomography (OCT). Using a combination of synthetic tests and analysis of OCTs from monkey ONHs subjected to acute and chronically elevated intraocular pressure, we demonstrate ...
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  Mentions: University of Pittsburgh Devers Eye Institute
14. Intraretinal, sub-retinal, and sub-retinal pigmented epithelium fluid in non-exudative age-related macular degeneration: follow-up with OCT imaging
  
  Explore SAGE Journals Aug 4 2021 Ophthalmology
  
  Background/objectives: To evaluate the presence and evolution of fluid in non-exudative age-related macular degeneration (AMD) through serial OCT. Subjects/methods: A retrospective analysis of eyes with non-exudative AMD with a minimum of 4 year follow-up was done. Parameters including intraretinal fluid (IRF), subretinal fluid (SRF), and sub-retinal pigment epithelium (RPE) fluid (SRPEF); subfoveal choroidal thickness (SFCT) and type of drusen were evaluated using optical coherence tomography (OCT) scans at ...
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  Mentions: University of Pittsburgh University of Perugia
15. Non invasive live imaging of a novel RPE stress model with Dynamic Full-Field OCT
  
  Explore arxiv.org Jul 1 2021 Ophthalmology
  
  Retinal degenerative diseases lead to the blindness of millions of people around the world. In case of age-related macular degeneration (AMD), the atrophy of retinal pigment epithelium (RPE) precedes neural dystrophy. But as crucial as understanding both healthy and pathological RPE cell physiology is for those diseases, no current technique allows subcellular in vivo or in vitro live observation of this critical cell layer. To fill this gap, we propose ...
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  Mentions: University of Pittsburgh ESPCI ParisTech
16. En-face analysis of short posterior ciliary arteries crossing the sclera to choroid using wide-field swept-source optical coherence tomography
  
  Explore Nature Publishing Group Apr 23 2021 Ophthalmology
  
  To study the topographic distribution of the short posterior ciliary arteries (SPCA) entry sites into the choroid in normal eyes using structural en-face swept source optical coherence tomography (SS-OCT). Retrospective analysis of SS-OCT scans (wide-field structural SS-OCT 12 12 mm) of 13 healthy subjects was performed. Cross-sectional swept-source OCT scans derived from a volume scan were represented as en-face image display following the Choroid-Scleral Interface to obtain en-face OCT. SPCAs ...
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  Mentions: University of Pittsburgh
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