1. University of Pittsburgh

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    1. Mentioned In 254 Articles

    2. Internal limiting membrane detachment in acute central retinal artery occlusion: a novel prognostic sign seen on OCT

      Internal limiting membrane detachment in acute central retinal artery occlusion: a novel prognostic sign seen on OCT
      ackground: To present a series of acute central retinal artery occlusion (CRAO) cases showing internal limiting membrane detachment (ILMD) on optical coherence tomography (OCT) and to describe the possible etiopathogenesis and outcomes associated with it. Methods: Demographic and OCT features of patients with acute CRAO were analysed retrospectively. OCT parameters noted were posterior vitreous opacities, ILMD, inner retinal layer stratification, hyperreflectivity and thickening, cystoid macular edema, neurosensory detachment. Eyes were ...
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    3. Automated delineation of corneal layers on OCT images using a boundary-guided CNN

      Automated delineation of corneal layers on OCT images using a boundary-guided CNN
      Accurate segmentation of corneal layers depicted on optical coherence tomography (OCT) images is very helpful for quantitatively assessing and diagnosing corneal diseases ( e.g ., keratoconus and dry eye). In this study, we presented a novel boundary-guided convolutional neural network (CNN) architecture (BG-CNN) to simultaneously extract different corneal layers and delineate their boundaries. The developed BG-CNN architecture used three convolutional blocks to construct two network modules on the basis of the ...
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    4. Real-world outcomes of anti-VEGF therapy in treatment-naïve neovascular age-related macular degeneration diagnosed on OCT angiography: the REVEAL study

      Real-world outcomes of anti-VEGF therapy in treatment-naïve neovascular age-related macular degeneration diagnosed on OCT angiography: the REVEAL study
      Purpose: To compare the 12 months visual and anatomical outcomes of treatment-nave neovascular age-related macular degeneration (nAMD) patients diagnosed by optical coherence tomography angiography (OCT-A) compared with fluorescein angiography (FA)/indocyanine green angiography (ICGA), after anti-VEGF treatment in a real-world setting. Methods: Monocentric, observational, parallel-group study of nAMD patients diagnosed with either FA/ICGA or non-invasive OCT-A methods. Patients were treated with a fixed dosing regimen of intravitreal ranibizumab or ...
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    5. A high-accuracy and high-efficiency digital volume correlation method to characterize in-vivo optic nerve head biomechanics from optical coherence tomography

      A high-accuracy and high-efficiency digital volume correlation method to characterize in-vivo optic nerve head biomechanics from optical coherence tomography
      In-vivo optic nerve head (ONH) biomechanics characterization is emerging as a promising way to study eye physiology and pathology. We propose a high-accuracy and high-efficiency digital volume correlation (DVC) method for the purpose of characterizing the in-vivo ONH deformation from volumes acquired by optical coherence tomography (OCT). Using a combination of synthetic tests and analysis of OCTs from monkey ONHs subjected to acute and chronically elevated intraocular pressure, we demonstrate ...
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    6. Intraretinal, sub-retinal, and sub-retinal pigmented epithelium fluid in non-exudative age-related macular degeneration: follow-up with OCT imaging

      Intraretinal, sub-retinal, and sub-retinal pigmented epithelium fluid in non-exudative age-related macular degeneration: follow-up with OCT imaging
      Background/objectives: To evaluate the presence and evolution of fluid in non-exudative age-related macular degeneration (AMD) through serial OCT. Subjects/methods: A retrospective analysis of eyes with non-exudative AMD with a minimum of 4 year follow-up was done. Parameters including intraretinal fluid (IRF), subretinal fluid (SRF), and sub-retinal pigment epithelium (RPE) fluid (SRPEF); subfoveal choroidal thickness (SFCT) and type of drusen were evaluated using optical coherence tomography (OCT) scans at ...
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    7. Non invasive live imaging of a novel RPE stress model with Dynamic Full-Field OCT

      Non invasive live imaging of a novel RPE stress model with Dynamic Full-Field OCT
      Retinal degenerative diseases lead to the blindness of millions of people around the world. In case of age-related macular degeneration (AMD), the atrophy of retinal pigment epithelium (RPE) precedes neural dystrophy. But as crucial as understanding both healthy and pathological RPE cell physiology is for those diseases, no current technique allows subcellular in vivo or in vitro live observation of this critical cell layer. To fill this gap, we propose ...
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    8. En-face analysis of short posterior ciliary arteries crossing the sclera to choroid using wide-field swept-source optical coherence tomography

      En-face analysis of short posterior ciliary arteries crossing the sclera to choroid using wide-field swept-source optical coherence tomography
      To study the topographic distribution of the short posterior ciliary arteries (SPCA) entry sites into the choroid in normal eyes using structural en-face swept source optical coherence tomography (SS-OCT). Retrospective analysis of SS-OCT scans (wide-field structural SS-OCT 12 12 mm) of 13 healthy subjects was performed. Cross-sectional swept-source OCT scans derived from a volume scan were represented as en-face image display following the Choroid-Scleral Interface to obtain en-face OCT. SPCAs ...
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    9. Study of retinal structural–functional relationship in choroideremia using fundus autofluorescence and optical coherence tomography

      Study of retinal structural–functional relationship in choroideremia using fundus autofluorescence and optical coherence tomography
      Objective The objective of this study was to assess the structuralfunctional relationship in choroideremia (CHM) patients using optical coherence tomography (OCT) and autofluorescence (AF) images. Methods In this study, 53 eyes of 28 CHM patients were included. Demographic, ocular and clinical fundus features were recorded. Fundus AF and OCT images were analysed. Patients were classified into two groups based on AF features: group 1, CHM patients where the foveal island ...
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    10. OCT-Angiography as a reliable prognostic tool in laser-treated proliferative diabetic retinopathy: The RENOCTA Study

      OCT-Angiography as a reliable prognostic tool in laser-treated proliferative diabetic retinopathy: The RENOCTA Study
      Purpose: To quantitatively assess retinal neovascularizations (RNVs) in proliferative diabetic retinopathy (PDR) before and after photocoagulative laser treatment (PLT) using Optical Coherence Tomography Angiography (OCT-A). Methods: Consecutive patients with PDR were examined with fluorescein angiography (FA) and OCT-A before and after PLT. Baseline and after-treatment FA images were quantitatively analyzed to assess both the RNVs area and leakage area. On OCT-A RNVs area, vascular perfusion density (VPD), vessel length density ...
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    11. BG-CNN: A Boundary Guided Convolutional Neural Network for Corneal Layer Segmentation from Optical Coherence Tomography

      BG-CNN: A Boundary Guided Convolutional Neural Network for Corneal Layer Segmentation from Optical Coherence Tomography
      Precise segmentation of corneal layers depicted on optical coherence tomography (OCT) images plays an important role in detecting corneal diseases, such as keratoconus and dry eye. In this study, we present a boundary guided convolutional neural network (BG-CNN) to extract different corneal layers. The developed network uses three convolutional blocks to construct two network modules derived from the classical U-Net network. This network was trained based on a dataset consisting ...
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    12. Measuring 3D Optic Nerve Head Deformations using Digital Volume Correlation of in vivo Optical Coherence Tomography Data (Thesis)

      Measuring 3D Optic Nerve Head Deformations using Digital Volume Correlation of in vivo Optical Coherence Tomography Data (Thesis)
      The optic nerve head (ONH), located in the back of the eye, is a critical site in understanding the pathophysiology of glaucoma. However, longitudinal changes of the ONH as disease develops have not been well characterized. Our goal was to develop an improved tool to quantify these changes in an in vivo monkey model of glaucoma. Longitudinal spectral-domain optical coherence tomography (OCT) imaging of the ONH was performed every other ...
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    13. Assessment Of Central Serous Chorioretinopathy Depicted On Color Fundus Photographs Using Deep Learning

      Assessment Of Central Serous Chorioretinopathy Depicted On Color Fundus Photographs Using Deep Learning
      Purpose: To investigate whether and to what extent central serous chorioretinopathy ( CSC ) depicted on color fundus photographs can be assessed using deep learning technology. Methods: We collected a total of 2,504 fundus images acquired on different subjects. We verified the CSC status of these images using their corresponding optical coherence tomography images. A total of 1,329 images depicted CSC . These images were preprocessed and normalized. This resulting data ...
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    14. Curved-field optical coherence tomography: large-field imaging of human corneal cells and nerves

      Curved-field optical coherence tomography: large-field imaging of human corneal cells and nerves
      Cell-resolution optical imaging methods, such as confocal microscopy and full-field optical coherence tomography, capture flat optical sections of the sample. If the sample is curved, the optical field sections through several sample layers, and the view of each layer is reduced. Here we present curved-field optical coherence tomography, capable of capturing optical sections of arbitrary curvature. We test the device on a challenging task of imaging the human cornea in ...
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    15. Optical coherence tomography angiography findings of fellow eye of proliferative macular telangiectasia type 2: Long term study

      Optical coherence tomography angiography findings of fellow eye of proliferative macular telangiectasia type 2: Long term study
      Purpose: To report the characteristics of non-proliferative fellow eyes in patients with unilateral proliferative macular telangiectasia type 2 (MacTel). Methods: This was a multicenter, retrospective study and included fellow eyes of eyes with subretinal neovascular membrane (SRNVM). Multimodal imaging including fundus photography, optical coherence tomography (OCT), and OCT angiography (OCTA) was performed. OCT and OCTA measurements included central macular thickness (CMT), subfoveal choroidal thickness (SFCT), foveal avascular zone (FAZ) area ...
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    16. University of Pittsburg Receives NIH Grant for Three Dimensional nanoscale Nuclear Architecture Mapping based Taxonomy of Precursor Lesions for Predicting Colorectal Cancer Risk

      University of Pittsburg Receives NIH Grant for Three Dimensional nanoscale Nuclear Architecture Mapping based Taxonomy of Precursor Lesions for Predicting Colorectal Cancer Risk
      University of Pittsburg Receives a 2020 NIH Grant for $437,317 for Three Dimensional nanoscale Nuclear Architecture Mapping based Taxonomy of Precursor Lesions for Predicting Colorectal Cancer Risk. The principal investigator is Yang Liu. Below is a summary of the proposed work. The effectiveness of colorectal cancer (CRC) screening, with a concomitant increased emphasis on detection of even the smallest adenomas, has resulted in a new clinical challenge. An increased ...
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    17. 1-15 of 254 1 2 3 4 ... 15 16 17 »
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  2. About University of Pittsburgh

    University of Pittsburgh

    University of Pittsburgh public research university located in Pittsburgh, Pennsylvania. Pitt is a renowned leader in academic fields as diverse as philosophy and medicine.  University of Pittsburgh Medical Center has a team of about 50,000 employees, UPMC serves the health needs of more than 4 million people each year  Department of Ophthalmology UPMC Eye Center’s mission is to improve quality of life through the preservation and restoration of vision.  Swanson School of Engineering is the engineering school of the University of Pittsburgh in Pittsburgh, Pennsylvania.