1. University of Pennsylvania

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    1. Mentioned In 112 Articles

    2. Imaging Retinal Vasculature in Infant Eyes

      Imaging Retinal Vasculature in Infant Eyes
      Retinopathy of prematurity is a leading cause of childhood blindness worldwide. The fovea, a critical location in the retina determining visual acuity and visual function, and the blood vessels around it, are abnormally developed in infants with retinopathy of prematurity. However, how these blood vessels form during development of the human fovea remains unclear. This research will advance our understanding of the fundamental knowledge of how the blood vessels around ...
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    3. Biphasic change in retinal nerve fibre layer thickness from 30 to 60 weeks postmenstrual age in preterm infants

      Biphasic change in retinal nerve fibre layer thickness from 30 to 60 weeks postmenstrual age in preterm infants
      Background/Aims The optic nerve development during the critical postnatal weeks of preterm infants is unclear. We aimed to investigate the change of retinal nerve fibre layer (RNFL) in preterm infants. Methods We used an investigational handheld optical coherence tomography (OCT) system to serially image awake preterm infants between 30 and 60 weeks postmenstrual age (PMA) at the bedside. We assessed RNFL thickness in the papillomacular bundle and nasal macular ...
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    4. Flexible method for generating needle-shaped beams and its application in optical coherence tomography

      Flexible method for generating needle-shaped beams and its application in optical coherence tomography
      Needle-shaped beams (NBs) featuring a long depth-of-focus (DOF) can drastically improve the resolution of microscopy systems. However, thus far, the implementation of a specific NB has been onerous due to the lack of a common, flexible generation method. Here we develop a spatially multiplexed phase pattern that creates many axially closely spaced foci as a universal platform for customizing various NBs, allowing flexible manipulations of beam length and diameter, uniform ...
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    5. Quantitative and qualitative characterization of retinal dystrophies in canine models of inherited retinal diseases using spectral domain optical coherence tomography (SD-OCT)

      Quantitative and qualitative characterization of retinal dystrophies in canine models of inherited retinal diseases using spectral domain optical coherence tomography (SD-OCT)
      The purpose of this study was to establish spectral domain optical coherence tomography (SD-OCT) assessment data in well-established canine models of inherited retinal dystrophies: PDE6B-rod-cone dysplasia 1 (RCD1: early onset retinitis pigmentosa), PRCD-progressive rod-cone degeneration (PRCD: late onset retinitis pigmentosa), CNGB3-achromatopsia, and RPE65-Leber congenital amaurosis (LCA). High resolution SD-OCT images of the retina were acquired from both eyes in 5 planes: temporal; superotemporal; superior; nasal; and inferior in adult dogs ...
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    6. Novel insights into chorioretinal and juxtapapillary colobomas by optical coherence tomography

      Novel insights into chorioretinal and juxtapapillary colobomas by optical coherence tomography
      Purpose: The purpose was to describe the in vivo microanatomy of typical and atypical chorioretinal and juxtapapillary colobomas in the dog. Methods: Three cross-breed dogs were found to be affected with colobomas. Two of the cases were NEHJ1 homozygous and Collie Eye Anomaly (CEA) affected and had the typical optic nerve head colobomas seen with the disease. The third case had an unexpected atypical coloboma. In vivo retinal photography and ...
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    7. Elevated Intracranial Pressure in Patients with Craniosynostosis by Optical Coherence Tomography

      Elevated Intracranial Pressure in Patients with Craniosynostosis by Optical Coherence Tomography
      Background: Craniosynostosis may lead to elevated intracranial pressure, which may be implicated with impaired neurocognitive development. However, accurately measuring intracranial pressure is challenging, and patterns in craniosynostosis patients are poorly characterized. Spectral-domain optical coherence tomography may enable noninvasive assessment of intracranial pressure in pediatric patients with craniosynostosis. Methods: Pediatric patients with craniosynostosis undergoing surgical intervention between 2014 and 2019 prospectively underwent optical coherence tomographic evaluation. Intracranial pressure was directly measured ...
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    8. Characterization of the Canine Retinal Vasculature With Optical Coherence Tomography Angiography: Comparisons With Histology and Fluorescein Angiography

      Characterization of the Canine Retinal Vasculature With Optical Coherence Tomography Angiography: Comparisons With Histology and Fluorescein Angiography
      Purpose: To present a methodology for quantification of the canine retinal vasculature imaged by optical coherence tomography angiography (OCTA) and validate this approach by comparison with fluorescein angiography (FA) and confocal imaging of retinal wholemounts labelled by immunohistochemistry (IHC). Methods: Six normal adult dogs underwent retinal OCTA imaging in both eyes. The images extracted from the different microvascular plexuses at eight retinal locations spanning the central and mid-peripheral fundus were ...
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    9. Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau

      Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau
      Alzheimer's disease (AD) is associated with inner retina (nerve fiber and ganglion cell layers) thinning. In contrast, we have seen outer retina thinning driven by photoreceptor outer nuclear layer (ONL) thinning with antemortem optical coherence tomography (OCT) among patients considered to have a frontotemporal degeneration tauopathy (FTLD-Tau). Our objective was to determine if postmortem retinal tissue from FTLD-Tau patients demonstrates ONL loss observed antemortem on OCT. Two probable FTLD-Tau ...
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    10. Retinal Microanatomy in Retinopathy of Prematurity

      Retinal Microanatomy in Retinopathy of Prematurity
      Retinopathy of prematurity (ROP) is a disorder of development of the neural retina and its vasculature that can impact vision in vulnerable preterm neonates for a lifetime. This study tests high-speed optical coherence tomography (OCT) technology compared to conventional color photographs at the bedside of very preterm infants in the intensive care nursery, to characterize previously unseen abnormalities that can predict a need for referral for ROP treatment, or poor ...
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    11. Evaluation of the Cirrus HD-OCT Normative Database Probability Codes in an African American Population

      Evaluation of the Cirrus HD-OCT Normative Database Probability Codes in an African American Population
      Objective: Race-adjusted interpretation of data from Cirrus high-definition optical coherence tomography (HD-OCT) devices is not standard practice. The aim of this study is to evaluate differences in peripapillary retinal nerve fiber layer (RNFL) thickness between healthy African Americans and the Cirrus HD-OCT normative database. Design: This is a cross-sectional observational study using control patients recruited from the greater Philadelphia, Pennsylvania area. Subjects: A total of 466 eyes were included in ...
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    12. Post-doctoral Associate Positions in Biophotonics at Washington University in St. Louis

      Post-doctoral Associate Positions in Biophotonics at Washington University in St. Louis
      ...">Dr. Chao Zhou obtained his B.S. degree in 2001 from Peking University and his Ph.D. degree in 2007 from the University of Pennsylvania under the guidance of Prof. Arjun G. Yodh.  After graduation, he joined Profes...
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  2. About University of Pennsylvania

    University of Pennsylvania

    University of Pennsylvania (commonly referred to as Penn or UPenn), one of the eight members of the Ivy League, is a private research university located in Philadelphia, Pennsylvania, United States. Penn is the fourth-oldest institution of higher education in the United States, and is considered the first university in the United States, with both undergraduate and graduate studies. Penn is also one of the Colonial Colleges.