Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University
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Dr. Chao Zhou obtained his Ph.D. degree in physics in 2007 from the University of Pennsylvania, where he worked with Professor Arjun G. Yodh on the development of diffuse optical...
Optometrists investigate changes in eye structure in astronauts
...y glaucoma will more than double between 2010 and 2050, from 2.7 million to 6.3 million. Researchers from the University of Pennsylvania have developed a gene therapy that successfully treats a form of macular degenerati...
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Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University
....lehigh.edu/.
About Dr. Chao Zhou:
Dr. Chao Zhou obtained his Ph.D. degree in physics in 2007 from the University of Pennsylvania, where he worked with Professor Arjun G. Yodh on the development of diffuse optical...
Read Full Article
Optical coherence tomography identifies outer retina thinning in frontotemporal degeneration
Objective: Whereas Alzheimer disease (AD) is associated with inner retina thinning visualized by spectral-domain optical coherence tomography (SD-OCT), we sought to determine if the retina has a distinguishing biomarker for frontotemporal degeneration (FTD). Methods: Using a cross-sectional design, we examined retinal structure in 38 consecutively enrolled patients with FTD and 44 controls using a standard SD-OCT protocol. Retinal layers were segmented with the Iowa Reference Algorithm. Subgroups of highly predictive ...
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Optical coherence tomography and visual evoked potentials in pediatric MS
Objective: To determine the relative ability of optical coherence tomography (OCT) and pattern-reversal visual evoked potentials (pVEPs) to detect visual pathway involvement in pediatric-onset MS. Methods: Pediatric-onset MS participants (onset 18 years) and healthy controls (HCs) underwent OCT (Cirrus HD-OCT) and pVEPs. Retinal nerve fiber layer (RNFL), ganglion cell layer to inner plexiform layer (GCL-IPL), and P100 pVEP latency were measured. Generalized estimating equation models were used to compare the ...
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University of Pennsylvania
Optical Coherence Tomography Angiography of a Central Retinal Artery Occlusion Before and After Anterior Chamber Paracentesis
A 74-year-old man presented 6 hours after sudden painless vision loss in the left eye. He had finger counting vision, normal intraocular pressure, and an afferent pupillary defect. Diagnosis of central retinal artery occlusion was made. Optical coherence tomography angiography performed before (Fig 1 A , C ) and immediately after (Fig 1 B , D ) anterior chamber paracentesis showed dramatic improvement in macular perfusion. Vision was 20/70 at the 1-month visit ...
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University of Pennsylvania
Evaluation of Optical Coherence Tomography to Detect Elevated Intracranial Pressure in Children
Importance Detecting elevated intracranial pressure in children with subacute conditions, such as craniosynostosis or tumor, may enable timely intervention and prevent neurocognitive impairment, but conventional techniques are invasive and often equivocal. Elevated intracranial pressure leads to structural changes in the peripapillary retina. Spectral-domain (SD) optical coherence tomography (OCT) can noninvasively quantify retinal layers to a micron-level resolution. Objective To evaluate whether retinal measurements from OCT can serve as an effective ...
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University of Pennsylvania
Evaluation of Optical Coherence Tomography to Detect Elevated Intracranial Pressure in Children
...oundation, Mackall Trust Funds, the Foundation Fighting Blindness, and the Center for Human Appearance at the University of Pennsylvania for research assistance and biostatistical support. Funding from each of these sour...
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Imaging the adult zebrafish cone mosaic using optical coherence tomography
Zebrafish ( Danio rerio ) provide many advantages as a model organism for studying ocular disease and development, and there is great interest in the ability to non-invasively assess their photoreceptor mosaic. Despite recent applications of scanning light ophthalmoscopy, fundus photography, and gonioscopy to in vivo imaging of the adult zebrafish eye, current techniques either lack accurate scaling information (limiting quantitative analyses) or require euthanizing the fish (precluding longitudinal analyses). Here we ...
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YOUR eyes and ears could help diagnose early signs of dementia and THIS is how
...brain area that is important for memory. Researchers at Columbia University Medical Centre in the US used the University of Pennsylvania Smell Identification Test (UPSIT) to analyse sense of smell in 397 older people wit...
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Outer Retinal Changes Including the Ellipsoid Zone Band in Usher Syndrome 1B due to MYO7A Mutations
Purpose : To study transition zones from normal to abnormal retina in Usher syndrome IB (USH1B) caused by myosin 7A ( MYO7A ) mutations. Methods : Optical coherence tomography (OCT) scattering layers in outer retina were segmented in patients ( n = 16, ages 242; eight patients had serial data, average interval 4.5 years) to quantify outer nuclear layer (ONL) and outer segments (OS) as well as the locus of EZ (ellipsoid zone) edge and ...
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University of Pennsylvania
The fundus photo has met its match: optical coherence tomography and adaptive optics ophthalmoscopy are here to stay
Purpose Over the past 25 years, optical coherence tomography (OCT) and adaptive optics (AO) ophthalmoscopy have revolutionised our ability to non-invasively observe the living retina. The purpose of this review is to highlight the techniques and human clinical applications of recent advances in OCT and adaptive optics scanning laser/light ophthalmoscopy (AOSLO) ophthalmic imaging. Recent findings Optical coherence tomography retinal and optic nerve head (ONH) imaging technology allows high resolution ...
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Mentions:
University of Pennsylvania
Post-doctoral Associate Position in Biophotonics/Biomedical Optical Imaging at Lehigh University
...www.lehigh.edu/.
About Dr. Chao Zhou:
Dr. Chao Zhou obtained his Ph.D. degree in physics in 2007 from the University of Pennsylvania, where he worked with Professor Arjun G. Yodh on the development of diffuse optical...
Read Full Article
Voxel based morphometry in optical coherence tomography: validation and core findings
Optical coherence tomography (OCT) of the human retina is now becoming established as an important modality for the detection and tracking of various ocular diseases. Voxel based morphometry (VBM) is a long standing neuroimaging analysis technique that allows for the exploration of the regional differences in the brain. There has been limited work done in developing registration based methods for OCT, which has hampered the advancement of VBM analyses in ...
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Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study
Background Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available. Methods In this multicentre, cohort study ...
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About University of Pennsylvania
University of Pennsylvania (commonly referred to as Penn or UPenn), one of the eight members of the Ivy League, is a private research university located in Philadelphia, Pennsylvania, United States. Penn is the fourth-oldest institution of higher education in the United States, and is considered the first university in the United States, with both undergraduate and graduate studies. Penn is also one of the Colonial Colleges.