1. University of Pennsylvania

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    1. Mentioned In 90 Articles

    2. Steps Forward in Analyzing Optical Coherence Tomography in Age-Related Macular Degeneration—Capitalizing on the Power of Artificial Intelligence

      Steps Forward in Analyzing Optical Coherence Tomography in Age-Related Macular Degeneration—Capitalizing on the Power of Artificial Intelligence
      Imaging of the retina, originally by stereoscopic fundus photography and later by optical coherence tomography (OCT), has been essential to the diagnosis and monitoring of progression of age-related macular degeneration. Manual grading of color photographs acquired during the Age-Related Eye Disease Study to detect and quantify drusen and pigmentary changes led to a detailed severity scale that stratified 5-year risk of late AMD into 9 categories, with risk estimates ranging ...
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    3. Optic Neuropathy in Charcot–Marie–Tooth Disease

      Optic Neuropathy in Charcot–Marie–Tooth Disease
      Background: CharcotMarieTooth disease Type 2A (CMT2A) presents with optic atrophy in a subset of patients, but the prevalence and severity of optic nerve involvement in relation to other CMT subtypes has not been explored. Methods: Patients with genetically confirmed CMT2A (n = 5), CMT1A (n = 9) and CMTX1 (n = 10) underwent high- and low-contrast acuity testing using Sloan letter charts, and circumpapillary retinal nerve fiber layer (RNFL) and macular total retinal ...
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    4. Post-doctoral Associate Positions in Biophotonics / Biomedical Optical Imaging at Washington University in St. Louis

      Post-doctoral Associate Positions in Biophotonics / Biomedical Optical Imaging at Washington University in St. Louis
      ... Dr. Chao Zhou obtained his B.S. degree in 2001 from Peking University and his Ph.D. degree in 2007 from the University of Pennsylvania under the guidance of Prof. Arjun G. Yodh.  After graduation, he joined Professor J...
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    5. Comparison of the Iowa Reference Algorithm to the Heidelberg Spectralis optical coherence tomography segmentation algorithm

      Comparison of the Iowa Reference Algorithm to the Heidelberg Spectralis optical coherence tomography segmentation algorithm
      For spectral‐domain optical coherence tomography (SD‐OCT) studies of neurodegeneration, it is important to understand how segmentation algorithms differ in retinal layer thickness measurements, segmentation error locations and the impact of manual correction. Using macular SD‐OCT images of frontotemporal degeneration patients and controls, we compare the individual and aggregate retinal layer thickness measurements provided by two commonly used algorithms, the Iowa Reference Algorithm and Heidelberg Spectralis, with manual ...
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    6. Intracranial pressure patterns in children with craniosynostosis utilizing optical coherence tomography

      Intracranial pressure patterns in children with craniosynostosis utilizing optical coherence tomography
      Background Better understanding the incidence and patterns of elevated intracranial pressure (ICP) in patients with craniosynostosis may facilitate more timely intervention to alter neurocognitive outcomes. Spectral-domain optical coherence tomography (OCT) of the retina can non-invasively diagnose elevated ICP, and has demonstrated high sensitivity and specificity among patients with craniosynostosis. This study sought to characterize patterns of elevated ICP among patients with craniosynostosis. Methods Quantitative retinal parameters were prospectively assessed in ...
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    7. Near‐infrared imaging and optical coherence tomography for intraoperative visualization of tumors

      Near‐infrared imaging and optical coherence tomography for intraoperative visualization of tumors
      Surgical excision is the foundation of treatment for early‐stage solid tumors in man and companion animals. Complete excision with appropriate margins of surrounding tumor‐free tissue is crucial to survival. Intraoperative imaging allows real‐time visualization of tumors, assessment of surgical margins, and, potentially, lymph nodes and satellite metastatic lesions, allowing surgeons to perform complete tumor resections while sparing surrounding vital anatomic structures. This Review will focus on the ...
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    8. Baseline Spectral Domain Optical Coherence Tomography Characteristics of Age-Related Macular Degeneration

      Baseline Spectral Domain Optical Coherence Tomography Characteristics of Age-Related Macular Degeneration
      Purpose: To describe spectral domain optical coherence tomography (SD-OCT) findings in an Amish cohort to assess SD-OCT markers for early age-related macular degeneration (AMD). Methods: The authors performed a family-based prospective cohort study of 1,146 elderly Amish subjects (age range 5099 years) (2,292 eyes) who had a family history of at least 1 individual with AMD. All subjects underwent complete ophthalmic examinations, SD-OCT using both Cirrus and Spectralis ...
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    9. Post-doctoral Associate Positions in Biophotonics / Biomedical Optical Imaging at Washington University in St. Louis

      Post-doctoral Associate Positions in Biophotonics / Biomedical Optical Imaging at Washington University in St. Louis
      ... Dr. Chao Zhou obtained his B.S. degree in 2001 from Peking University and his Ph.D. degree in 2007 from the University of Pennsylvania under the guidance of Prof. Arjun G. Yodh.  After graduation, he joined Professor J...
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    10. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University
      ....lehigh.edu/.   About Dr. Chao Zhou: Dr. Chao Zhou obtained his Ph.D. degree in physics in 2007 from the University of Pennsylvania, where he worked with Professor Arjun G. Yodh on the development of diffuse optical...
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    11. Optical coherence tomography identifies outer retina thinning in frontotemporal degeneration

      Optical coherence tomography identifies outer retina thinning in frontotemporal degeneration
      Objective: Whereas Alzheimer disease (AD) is associated with inner retina thinning visualized by spectral-domain optical coherence tomography (SD-OCT), we sought to determine if the retina has a distinguishing biomarker for frontotemporal degeneration (FTD). Methods: Using a cross-sectional design, we examined retinal structure in 38 consecutively enrolled patients with FTD and 44 controls using a standard SD-OCT protocol. Retinal layers were segmented with the Iowa Reference Algorithm. Subgroups of highly predictive ...
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    12. Optical coherence tomography and visual evoked potentials in pediatric MS

      Optical coherence tomography and visual evoked potentials in pediatric MS
      Objective: To determine the relative ability of optical coherence tomography (OCT) and pattern-reversal visual evoked potentials (pVEPs) to detect visual pathway involvement in pediatric-onset MS. Methods: Pediatric-onset MS participants (onset 18 years) and healthy controls (HCs) underwent OCT (Cirrus HD-OCT) and pVEPs. Retinal nerve fiber layer (RNFL), ganglion cell layer to inner plexiform layer (GCL-IPL), and P100 pVEP latency were measured. Generalized estimating equation models were used to compare the ...
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    13. Optical Coherence Tomography Angiography of a Central Retinal Artery Occlusion Before and After Anterior Chamber Paracentesis

      Optical Coherence Tomography Angiography of a Central Retinal Artery Occlusion Before and After Anterior Chamber Paracentesis
      A 74-year-old man presented 6 hours after sudden painless vision loss in the left eye. He had finger counting vision, normal intraocular pressure, and an afferent pupillary defect. Diagnosis of central retinal artery occlusion was made. Optical coherence tomography angiography performed before (Fig 1 A , C ) and immediately after (Fig 1 B , D ) anterior chamber paracentesis showed dramatic improvement in macular perfusion. Vision was 20/70 at the 1-month visit ...
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  2. About University of Pennsylvania

    University of Pennsylvania

    University of Pennsylvania (commonly referred to as Penn or UPenn), one of the eight members of the Ivy League, is a private research university located in Philadelphia, Pennsylvania, United States. Penn is the fourth-oldest institution of higher education in the United States, and is considered the first university in the United States, with both undergraduate and graduate studies. Penn is also one of the Colonial Colleges.