1. University of North Carolina

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    1. Mentioned In 105 Articles

    2. Innovative method offers a new way of studying developmental cardiac biomechanics, live in 4-D

      Innovative method offers a new way of studying developmental cardiac biomechanics, live in 4-D
      ...fast dynamics of the beating heart. Amy L. Oldenburg, director of the Optical Coherence Imaging Laboratory at University of North Carolina at Chapel Hill, remarked, "The innovative method offers a new way of studying dev...
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    3. Atlas of Optical Coherence Tomography for Glaucoma (Textbook)

      Atlas of Optical Coherence Tomography for Glaucoma (Textbook)
      Atlas of Optical Coherence Tomography for Glaucoma is a case-based atlas intended to teach the reader how to interpret the results of OCT in glaucoma patients and glaucoma suspects. After a brief description of how OCT is used in particular situations, chapters depict actual case presentations from authors practices with legends that describe the case and how OCT is used to make the diagnosis of glaucoma or glaucoma progression. Emphasis ...
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    4. DEVELOPMENT OF A LINE-FIELD MAGNETO-MOTIVE OPTICAL COHERENCE TOMOGRAPHY SYSTEM (Thesis)

      DEVELOPMENT OF A LINE-FIELD MAGNETO-MOTIVE OPTICAL COHERENCE TOMOGRAPHY SYSTEM (Thesis)
      The mechanism by which certain species of animals are able to detect the Earths magnetic field has remained a mystery for as long as we have known that they exhibit geomagnetic navigation. Certain species of bacteria are known to contain single chains of magnetite crystals, each with a diameter of ~50 nm, that are used to orient the bacteria. Searching for similar magnetoreceptors in larger animals requires a high-speed, high-resolution ...
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    5. Tracking the invasion of breast cancer cells in paper-based 3D cultures by OCT motility analysis

      Tracking the invasion of breast cancer cells in paper-based 3D cultures by OCT motility analysis
      3D paper-based cultures (PBCs) are easy-to-use and provide a biologically representative microenvironment. By stacking a sheet of cell-laden paper below sheets containing cell-free hydrogel, we form an assay capable of segmenting cells by the distance they invaded from the original cell-seeded layer. These invasion assays are limited to end-point analyses with fluorescence-based readouts due to the highly scattering nature of the paper scaffolds. Here we demonstrate that optical coherence tomography ...
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    6. a/LCI-OCT Pilot in Esophagus

      a/LCI-OCT Pilot in Esophagus
      This study will test a newly developed dual modality probe, including optical coherence tomography (OCT) and angle-resolved low-coherence interferometry (a/LCI), in the human esophagus to determine 1) whether adequate tissue contact can be attained by the probe to acquire high quality images, and 2) to identify if these images can discern whether the imaged tissue is squamous or Barrett's Esophagus (BE) epithelium. This pilot study will test the ...
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    7. Characterizing optical coherence tomography speckle fluctuation spectra of mammary organoids during suppression of intracellular motility

      Characterizing optical coherence tomography speckle fluctuation spectra of mammary organoids during suppression of intracellular motility
      Background: An understanding of how the mammary gland responds to toxicant and drug exposures can shed light on mechanisms of breast cancer initiation/progression and therapeutic effectiveness, respectively. In this study, we employed noninvasive, label-free and high-throughput optical coherence tomography speckle fluctuation spectroscopy (OCT-SFS) to track exposure-response relationships in three-dimensional (3D) mammary epithelial organoid models. Methods: OCT-SFS is sensitive to relatively high speed (~0.168 m/min) motions of subcellular ...
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    8. First Clinical Application of Low-Cost OCT

      First Clinical Application of Low-Cost OCT
      Purpose : We present the design of a new low-cost optical coherence tomography (OCT) system and compare its retinal imaging capabilities to a standard commercial system through a clinical study. Methods : A spectral-domain OCT system was designed using various cost-reduction techniques to be low-cost, highly portable, and completely stand-alone. Clinical imaging was performed on 120 eyes of 60 patients (60 eyes of normal volunteers and 60 eyes with retinal disease) using ...
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    9. Localized compliance measurement of the airway wall using anatomic optical coherence elastography

      Localized compliance measurement of the airway wall using anatomic optical coherence elastography
      We describe an elastographic method to circumferentially-resolve airway wall compliance using endoscopic, anatomic optical coherence tomography (aOCT) combined with an intraluminal pressure catheter. The method was first demonstrated on notched silicone phantoms of known elastic modulus under respiratory ventilation, where localized compliance measurements were validated against those predicted by finite element modeling. Then, ex vivo porcine tracheas were scanned, and the pattern of compliance was found to be consistent with ...
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    10. Geometric Validation of Continuous, Finely Sampled 3-D Reconstructions From aOCT and CT in Upper Airway Models

      Geometric Validation of Continuous, Finely Sampled 3-D Reconstructions From aOCT and CT in Upper Airway Models
      Identification and treatment of obstructive airway disorders (OADs) are greatly aided by imaging of the geometry of the airway lumen. Anatomical optical coherence tomography (aOCT) is a promising high-speed and minimally invasive endoscopic imaging modality for providing micrometer-resolution scans of the upper airway. Resistance to airflow in OADs is directly caused by the reduction in luminal cross-sectional area (CSA). It is hypothesized that aOCT can produce airway CSA measurements as ...
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    11. Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway

      Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway
      It is hypothesized that the local, viscoelastic (time-dependent) properties of the airway are important to accurately model and ultimately predict dynamic airway collapse in airway obstruction. Toward this end, we present a portable, endoscopic, swept-source anatomical optical coherence tomography (aOCT) system combined with a pressure catheter to capture local airway dynamics in vivo during respiration. aOCT scans were performed in the airways of a mechanically ventilated pig under paralysis with ...
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    12. Geometric Validation of Continuous, Finely-Sampled 3D Reconstructions from aOCT and CT in Upper Airway Models

      Geometric Validation of Continuous, Finely-Sampled 3D Reconstructions from aOCT and CT in Upper Airway Models
      Identification and treatment of obstructive airway disorders (OADs) is greatly aided by imaging of the geometry of the airway lumen. Anatomical optical coherence tomography (aOCT) is a promising high-speed and minimally-invasive endoscopic imaging modality for providing micrometer-resolution scans of the upper airway. Resistance to airflow in OADs is directly caused by reduction in luminal cross-sectional area (CSA). It is hypothesized that aOCT can produce airway CSA measurements as accurate as ...
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    13. Comparative analysis of autofluorescence and OCT angiography in Stargardt disease

      Comparative analysis of autofluorescence and OCT angiography in Stargardt disease
      Aims To characterise the vasculature of the retina in patients with Stargardt disease (STGD) using optical coherence tomography angiography (OCTA) and to compare these functional findings with fundus autofluorescence (FAF) imaging. Methods This observational study included consecutive patients with STGD. The choriocapillaris (CC) layer was analysed on OCTA and retinal pigment epithelium (RPE) changes were assessed on FAF. Areas of CC and RPE impairment were quantified and correlated. Results Twenty-two ...
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    14. Intraoperative optical coherence tomography-assisted retrocorneal fibrous membrane biopsy and excision

      Intraoperative optical coherence tomography-assisted retrocorneal fibrous membrane biopsy and excision
      Purpose We report a case of retrocorneal fibrous membrane (RCFM) formation following penetrating keratoplasty (PK) and intraoperative optical coherence tomography (OCT)-guided excision of this membrane. Observations A 68-year-old woman with primary open angle glaucoma and corneal decompensation of the right eye secondary to tube shunt presented for 3-month follow-up of PK. On examination of the right eye, the patient was noted to have a glassy pupillary membrane with traction ...
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    15. 1-15 of 105 1 2 3 4 5 6 7 »
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  2. About University of North Carolina

    University of North Carolina

    University of North Carolina was chartered in 1789, and was the first public university in the United States and the only one to graduate students in the eighteenth century. Today, UNC is a multi-campus university composed of all 16 of North Carolina's public institutions that grant baccalaureate degrees, as well as the NC School of Science and Mathematics, the nation's first public residential high school for gifted students.