1. University of North Carolina

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    1. Mentioned In 93 Articles

    2. Comparative analysis of autofluorescence and OCT angiography in Stargardt disease

      Comparative analysis of autofluorescence and OCT angiography in Stargardt disease
      Aims To characterise the vasculature of the retina in patients with Stargardt disease (STGD) using optical coherence tomography angiography (OCTA) and to compare these functional findings with fundus autofluorescence (FAF) imaging. Methods This observational study included consecutive patients with STGD. The choriocapillaris (CC) layer was analysed on OCTA and retinal pigment epithelium (RPE) changes were assessed on FAF. Areas of CC and RPE impairment were quantified and correlated. Results Twenty-two ...
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    3. Intraoperative optical coherence tomography-assisted retrocorneal fibrous membrane biopsy and excision

      Intraoperative optical coherence tomography-assisted retrocorneal fibrous membrane biopsy and excision
      Purpose We report a case of retrocorneal fibrous membrane (RCFM) formation following penetrating keratoplasty (PK) and intraoperative optical coherence tomography (OCT)-guided excision of this membrane. Observations A 68-year-old woman with primary open angle glaucoma and corneal decompensation of the right eye secondary to tube shunt presented for 3-month follow-up of PK. On examination of the right eye, the patient was noted to have a glassy pupillary membrane with traction ...
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    4. Quantification of the Effect of Toxicants on the Intracellular Kinetic Energy and Cross-Sectional Area of Mammary Epithelial Organoids by OCT Fluctuation Spectroscopy

      Quantification of the Effect of Toxicants on the Intracellular Kinetic Energy and Cross-Sectional Area of Mammary Epithelial Organoids by OCT Fluctuation Spectroscopy
      The ability to assess toxicant exposures of 3D in vitro mammary models that recapitulate the tissue microenvironment can aid in our understanding of environmental exposure risk over time. Longitudinal studies of 3D model systems, however, are cumbersome and suffer from a lack of high-throughput toxicological assays. In this study, we establish a noninvasive and label-free optical coherence tomography (OCT)-based imaging platform for tracking exposure-response relationships in 3D human mammary ...
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    5. Diffusion tensor optical coherence tomography

      Diffusion tensor optical coherence tomography
      In situ measurements of diffusive particle transport provide insight into tissue architecture, drug delivery, and cellular function. Analogous to diffusion-tensor magnetic resonance imaging (DT-MRI), where the anisotropic diffusion of water molecules is mapped on the millimeter scale to elucidate the fibrous structure of tissue, here we propose diffusion-tensor optical coherence tomography (DT-OCT) for measuring directional diffusivity and flow of optically scattering particles within tissue. Because DT-OCT is sensitive to the ...
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    6. Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography

      Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography
      We propose a novel suite of algorithms for automatically segmenting the airway lumen and mucus in endobronchial optical coherence tomography (OCT) data sets, as well as a novel approach for quantifying the contents of the mucus. Mucus and lumen were segmented using a robust, multi-stage algorithm that requires only minimal input regarding sheath geometry. The algorithm performance was highly accurate in a wide range of airway and noise conditions. Mucus ...
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    7. Optical coherence tomography angiography characterisation of Best disease and associated choroidal neovascularisation

      Optical coherence tomography angiography characterisation of Best disease and associated choroidal neovascularisation
      Aims To characterise the vasculature of the retina in patients with Best vitelliform dystrophy, including those with choroidal neovascularisation (CNV), using optical coherence tomography angiography (OCTA) and correlate with fluorescein angiography (FA). Methods This prospective observational study included 19 eyes of 10 patients with Best disease. Using OCTA, all layers of retina were qualitatively characterised for each eye. Patients with CNV also underwent FA, and areas of CNV were measured ...
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    8. Feature of the Week 05/14/2017: Real-Time Monitoring of Mucus Thinning Treatments using Diffusion-Sensitive Optical Coherence Tomography

      Feature of the Week 05/14/2017: Real-Time Monitoring of Mucus Thinning Treatments using Diffusion-Sensitive Optical Coherence Tomography
      ...rsonalized treatments in the clinic. For more information see recent Article . Courtesy Richard Blackmon from University of North Carolina . The airway epithelium is coated with a biopolymeric mucus gel which is responsi...
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    9. Direct monitoring of pulmonary disease treatment biomarkers using plasmonic gold nanorods with diffusion-sensitive OCT

      Direct monitoring of pulmonary disease treatment biomarkers using plasmonic gold nanorods with diffusion-sensitive OCT
      The solid concentration of pulmonary mucus (wt%) is critical to respiratory health. In patients with respiratory disease, such as Cystic Fibrosis (CF) and Chronic Obstructive Pulmonary Disorder (COPD), mucus hydration is impaired, resulting in high wt%. Mucus with high wt% is a hallmark of pulmonary disease that leads to obstructed airways, inflammation, and infection. Methods to measure mucus hydration in situ and in real-time are needed for drug development and ...
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    10. Airway compliance measured by anatomic optical coherence tomography

      Airway compliance measured by anatomic optical coherence tomography
      Quantification of airway compliance can aid in the diagnosis and treatment of obstructive airway disorders by detecting regions vulnerable to collapse. Here we evaluate the ability of a swept-source anatomic optical coherence tomography (SSaOCT) system to quantify airway cross-sectional compliance (CC) by measuring changes in the luminal cross-sectional area (CSA) under physiologically relevant pressures of 1040 cmH 2 O. The accuracy and precision of CC measurements are determined using simulations ...
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    11. Multi-modal anatomical optical coherence tomography and CT for in vivo dynamic upper airway imaging

      Multi-modal anatomical optical coherence tomography and CT for in vivo dynamic upper airway imaging
      We describe a novel, multi-modal imaging protocol for validating quantitative dynamic airway imaging performed using anatomical Optical Coherence Tomography (aOCT). The aOCT system consists of a catheter-based aOCT probe that is deployed via a bronchoscope, while a programmable ventilator is used to control airway pressure. This setup is employed on the bed of a Siemens Biograph CT system capable of performing respiratory-gated acquisitions. In this arrangement the position of the ...
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    12. Choroid Segmentation from Optical Coherence Tomography with Graph-Edge Weights Learned from Deep Convolutional Neural Networks

      Choroid Segmentation from Optical Coherence Tomography with Graph-Edge Weights Learned from Deep Convolutional Neural Networks
      Examining choroid in Optical Coherence Tomography (OCT) plays a vital role in pathophysiologic factors of many ocular conditions. Among the existing approaches to detecting choroidal boundaries, graph-searching based techniques belong to the state-of-the-art. However, most of these techniques rely on hand-crafted models on the graph-edge weight and their performances are limited mainly due to the weak choroidal boundaries, textural structure of the choroid, inhomogeneity of the textural structure of the ...
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    13. High-speed and high-sensitivity parallel spectral-domain optical coherence tomography using a supercontinuum light source

      High-speed and high-sensitivity parallel spectral-domain optical coherence tomography using a supercontinuum light source
      The three most important metrics in optical coherence tomography (OCT) are resolution, speed, and sensitivity. Because there is a complex interplay between these metrics, no previous work has obtained the best performance in all three metrics simultaneously. We demonstrate that a high-power supercontinuum source, in combination with parallel spectral-domain OCT, achieves an unparalleled combination of resolution, speed, and sensitivity. This system captures cross-sectional images spanning 4 mm 0.5 mm ...
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    14. Mass. General studies identify differences underlying the airway responses of patients with asthma

      Mass. General studies identify differences underlying the airway responses of patients with asthma
      ... receptors for type 2 innate immune signals. A collaborator with Luster’s team, Mehmet Kesimer, PhD, from the University of North Carolina at Chapel Hill, analyzed both the amount and the consistency of mucus secreted in...
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    15. University of North Carolina Receives NIH Grant for Imaging Nanophysical Properties of Actively Transporting Bronchial Mucus

      University of North Carolina Receives NIH Grant for Imaging Nanophysical Properties of Actively Transporting Bronchial Mucus
      ...portant link to in vivo-like conditions, providing previously inaccessible insight on MCT and drug therapies. University of North Carolina at Chapel Hill Receives a 2016 NIH Grant for $234,624 for Imaging Nanophysical Pr...
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    16. 1-15 of 93 1 2 3 4 5 6 7 »
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  2. About University of North Carolina

    University of North Carolina

    University of North Carolina was chartered in 1789, and was the first public university in the United States and the only one to graduate students in the eighteenth century. Today, UNC is a multi-campus university composed of all 16 of North Carolina's public institutions that grant baccalaureate degrees, as well as the NC School of Science and Mathematics, the nation's first public residential high school for gifted students.