1. University of North Carolina

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    1. Mentioned In 99 Articles

    2. Characterizing optical coherence tomography speckle fluctuation spectra of mammary organoids during suppression of intracellular motility

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      Characterizing optical coherence tomography speckle fluctuation spectra of mammary organoids during suppression of intracellular motility
      Background: An understanding of how the mammary gland responds to toxicant and drug exposures can shed light on mechanisms of breast cancer initiation/progression and therapeutic effectiveness, respectively. In this study, we employed noninvasive, label-free and high-throughput optical coherence tomography speckle fluctuation spectroscopy (OCT-SFS) to track exposure-response relationships in three-dimensional (3D) mammary epithelial organoid models. Methods: OCT-SFS is sensitive to relatively high speed (~0.168 m/min) motions of subcellular ...
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      Mentions: Amy L. Oldenburg University of North Carolina

    3. First Clinical Application of Low-Cost OCT

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      First Clinical Application of Low-Cost OCT
      Purpose : We present the design of a new low-cost optical coherence tomography (OCT) system and compare its retinal imaging capabilities to a standard commercial system through a clinical study. Methods : A spectral-domain OCT system was designed using various cost-reduction techniques to be low-cost, highly portable, and completely stand-alone. Clinical imaging was performed on 120 eyes of 60 patients (60 eyes of normal volunteers and 60 eyes with retinal disease) using ...
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      Mentions: Duke University Adam Wax University of North Carolina

    4. Localized compliance measurement of the airway wall using anatomic optical coherence elastography

      Explore OSA | OSA Publishing Pulmonology
      Localized compliance measurement of the airway wall using anatomic optical coherence elastography
      We describe an elastographic method to circumferentially-resolve airway wall compliance using endoscopic, anatomic optical coherence tomography (aOCT) combined with an intraluminal pressure catheter. The method was first demonstrated on notched silicone phantoms of known elastic modulus under respiratory ventilation, where localized compliance measurements were validated against those predicted by finite element modeling. Then, ex vivo porcine tracheas were scanned, and the pattern of compliance was found to be consistent with ...
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      Mentions: Amy L. Oldenburg University of North Carolina

    5. Geometric Validation of Continuous, Finely Sampled 3-D Reconstructions From aOCT and CT in Upper Airway Models

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      Geometric Validation of Continuous, Finely Sampled 3-D Reconstructions From aOCT and CT in Upper Airway Models
      Identification and treatment of obstructive airway disorders (OADs) are greatly aided by imaging of the geometry of the airway lumen. Anatomical optical coherence tomography (aOCT) is a promising high-speed and minimally invasive endoscopic imaging modality for providing micrometer-resolution scans of the upper airway. Resistance to airflow in OADs is directly caused by the reduction in luminal cross-sectional area (CSA). It is hypothesized that aOCT can produce airway CSA measurements as ...
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      Mentions: Amy L. Oldenburg University of North Carolina

    6. Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway

      Explore SPIE Digital Library Pulmonology
      Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway
      It is hypothesized that the local, viscoelastic (time-dependent) properties of the airway are important to accurately model and ultimately predict dynamic airway collapse in airway obstruction. Toward this end, we present a portable, endoscopic, swept-source anatomical optical coherence tomography (aOCT) system combined with a pressure catheter to capture local airway dynamics in vivo during respiration. aOCT scans were performed in the airways of a mechanically ventilated pig under paralysis with ...
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      Mentions: Thorlabs Amy L. Oldenburg University of North Carolina

    7. Geometric Validation of Continuous, Finely-Sampled 3D Reconstructions from aOCT and CT in Upper Airway Models

      Explore IEEE Xplore Pulmonology
      Geometric Validation of Continuous, Finely-Sampled 3D Reconstructions from aOCT and CT in Upper Airway Models
      Identification and treatment of obstructive airway disorders (OADs) is greatly aided by imaging of the geometry of the airway lumen. Anatomical optical coherence tomography (aOCT) is a promising high-speed and minimally-invasive endoscopic imaging modality for providing micrometer-resolution scans of the upper airway. Resistance to airflow in OADs is directly caused by reduction in luminal cross-sectional area (CSA). It is hypothesized that aOCT can produce airway CSA measurements as accurate as ...
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      Mentions: Amy L. Oldenburg University of North Carolina

    8. Comparative analysis of autofluorescence and OCT angiography in Stargardt disease

      Explore BJO Online Ophthalmology
      Comparative analysis of autofluorescence and OCT angiography in Stargardt disease
      Aims To characterise the vasculature of the retina in patients with Stargardt disease (STGD) using optical coherence tomography angiography (OCTA) and to compare these functional findings with fundus autofluorescence (FAF) imaging. Methods This observational study included consecutive patients with STGD. The choriocapillaris (CC) layer was analysed on OCTA and retinal pigment epithelium (RPE) changes were assessed on FAF. Areas of CC and RPE impairment were quantified and correlated. Results Twenty-two ...
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      Mentions: L V Prasad Eye Institute University of North Carolina University of Perugia

    9. Intraoperative optical coherence tomography-assisted retrocorneal fibrous membrane biopsy and excision

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      Intraoperative optical coherence tomography-assisted retrocorneal fibrous membrane biopsy and excision
      Purpose We report a case of retrocorneal fibrous membrane (RCFM) formation following penetrating keratoplasty (PK) and intraoperative optical coherence tomography (OCT)-guided excision of this membrane. Observations A 68-year-old woman with primary open angle glaucoma and corneal decompensation of the right eye secondary to tube shunt presented for 3-month follow-up of PK. On examination of the right eye, the patient was noted to have a glassy pupillary membrane with traction ...
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      Mentions: University of North Carolina

    11. Quantification of the Effect of Toxicants on the Intracellular Kinetic Energy and Cross-Sectional Area of Mammary Epithelial Organoids by OCT Fluctuation Spectroscopy

      Explore Journals Developmental Biology
      Quantification of the Effect of Toxicants on the Intracellular Kinetic Energy and Cross-Sectional Area of Mammary Epithelial Organoids by OCT Fluctuation Spectroscopy
      The ability to assess toxicant exposures of 3D in vitro mammary models that recapitulate the tissue microenvironment can aid in our understanding of environmental exposure risk over time. Longitudinal studies of 3D model systems, however, are cumbersome and suffer from a lack of high-throughput toxicological assays. In this study, we establish a noninvasive and label-free optical coherence tomography (OCT)-based imaging platform for tracking exposure-response relationships in 3D human mammary ...
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      Mentions: Amy L. Oldenburg University of North Carolina Richard L. Blackmon

    12. Diffusion tensor optical coherence tomography

      Explore IOPscience
      Diffusion tensor optical coherence tomography
      In situ measurements of diffusive particle transport provide insight into tissue architecture, drug delivery, and cellular function. Analogous to diffusion-tensor magnetic resonance imaging (DT-MRI), where the anisotropic diffusion of water molecules is mapped on the millimeter scale to elucidate the fibrous structure of tissue, here we propose diffusion-tensor optical coherence tomography (DT-OCT) for measuring directional diffusivity and flow of optically scattering particles within tissue. Because DT-OCT is sensitive to the ...
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      Mentions: Duke University Amy L. Oldenburg University of North Carolina

    13. Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography

      Explore OSA | OSA Publishing Pulmonology
      Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography
      We propose a novel suite of algorithms for automatically segmenting the airway lumen and mucus in endobronchial optical coherence tomography (OCT) data sets, as well as a novel approach for quantifying the contents of the mucus. Mucus and lumen were segmented using a robust, multi-stage algorithm that requires only minimal input regarding sheath geometry. The algorithm performance was highly accurate in a wide range of airway and noise conditions. Mucus ...
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      Mentions: Massachusetts General Hospital Harvard University University of North Carolina

    14. Optical coherence tomography angiography characterisation of Best disease and associated choroidal neovascularisation

      Explore BJO Online Ophthalmology
      Optical coherence tomography angiography characterisation of Best disease and associated choroidal neovascularisation
      Aims To characterise the vasculature of the retina in patients with Best vitelliform dystrophy, including those with choroidal neovascularisation (CNV), using optical coherence tomography angiography (OCTA) and correlate with fluorescein angiography (FA). Methods This prospective observational study included 19 eyes of 10 patients with Best disease. Using OCTA, all layers of retina were qualitatively characterised for each eye. Patients with CNV also underwent FA, and areas of CNV were measured ...
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      Mentions: L V Prasad Eye Institute University of North Carolina

    15. Feature of the Week 05/14/2017: Real-Time Monitoring of Mucus Thinning Treatments using Diffusion-Sensitive Optical Coherence Tomography

      Explore Optical Coherence Tomography News
      Feature of the Week 05/14/2017: Real-Time Monitoring of Mucus Thinning Treatments using Diffusion-Sensitive Optical Coherence Tomography
      ...rsonalized treatments in the clinic. For more information see recent Article . Courtesy Richard Blackmon from University of North Carolina . The airway epithelium is coated with a biopolymeric mucus gel which is responsi...
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      Mentions: Amy L. Oldenburg University of North Carolina Richard L. Blackmon

    16. Direct monitoring of pulmonary disease treatment biomarkers using plasmonic gold nanorods with diffusion-sensitive OCT

      Explore RSC Publishing Home
      Direct monitoring of pulmonary disease treatment biomarkers using plasmonic gold nanorods with diffusion-sensitive OCT
      The solid concentration of pulmonary mucus (wt%) is critical to respiratory health. In patients with respiratory disease, such as Cystic Fibrosis (CF) and Chronic Obstructive Pulmonary Disorder (COPD), mucus hydration is impaired, resulting in high wt%. Mucus with high wt% is a hallmark of pulmonary disease that leads to obstructed airways, inflammation, and infection. Methods to measure mucus hydration in situ and in real-time are needed for drug development and ...
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      Mentions: Amy L. Oldenburg University of North Carolina Richard L. Blackmon
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  4. About University of North Carolina

    University of North Carolina

    University of North Carolina was chartered in 1789, and was the first public university in the United States and the only one to graduate students in the eighteenth century. Today, UNC is a multi-campus university composed of all 16 of North Carolina's public institutions that grant baccalaureate degrees, as well as the NC School of Science and Mathematics, the nation's first public residential high school for gifted students.

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