Articles that mention University of North Carolina -Optical Coherence Tomography News

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2. Tracking the invasion of breast cancer cells in paper-based 3D cultures by OCT motility analysis
  
  Explore OSA | OSA Publishing May 24 2020
  
  3D paper-based cultures (PBCs) are easy-to-use and provide a biologically representative microenvironment. By stacking a sheet of cell-laden paper below sheets containing cell-free hydrogel, we form an assay capable of segmenting cells by the distance they invaded from the original cell-seeded layer. These invasion assays are limited to end-point analyses with fluorescence-based readouts due to the highly scattering nature of the paper scaffolds. Here we demonstrate that optical coherence tomography ...
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  Mentions: Amy L. Oldenburg University of North Carolina
3. a/LCI-OCT Pilot in Esophagus
  
  Explore Home - ClinicalTrials.gov May 18 2020 Gastroenterology , Clinical Trials
  
  This study will test a newly developed dual modality probe, including optical coherence tomography (OCT) and angle-resolved low-coherence interferometry (a/LCI), in the human esophagus to determine 1) whether adequate tissue contact can be attained by the probe to acquire high quality images, and 2) to identify if these images can discern whether the imaged tissue is squamous or Barrett's Esophagus (BE) epithelium. This pilot study will test the ...
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  Mentions: National Cancer Institute Duke University University of North Carolina
4. Characterizing optical coherence tomography speckle fluctuation spectra of mammary organoids during suppression of intracellular motility
  
  Explore Home Sep 24 2019
  
  Background: An understanding of how the mammary gland responds to toxicant and drug exposures can shed light on mechanisms of breast cancer initiation/progression and therapeutic effectiveness, respectively. In this study, we employed noninvasive, label-free and high-throughput optical coherence tomography speckle fluctuation spectroscopy (OCT-SFS) to track exposure-response relationships in three-dimensional (3D) mammary epithelial organoid models. Methods: OCT-SFS is sensitive to relatively high speed (~0.168 m/min) motions of subcellular ...
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  Mentions: Amy L. Oldenburg University of North Carolina
5. First Clinical Application of Low-Cost OCT
  
  Explore TVST Journal Jun 29 2019 Ophthalmology
  
  Purpose : We present the design of a new low-cost optical coherence tomography (OCT) system and compare its retinal imaging capabilities to a standard commercial system through a clinical study. Methods : A spectral-domain OCT system was designed using various cost-reduction techniques to be low-cost, highly portable, and completely stand-alone. Clinical imaging was performed on 120 eyes of 60 patients (60 eyes of normal volunteers and 60 eyes with retinal disease) using ...
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  Mentions: Duke University Adam Wax University of North Carolina
6. Localized compliance measurement of the airway wall using anatomic optical coherence elastography
  
  Explore OSA | OSA Publishing Jun 4 2019 Pulmonology
  
  We describe an elastographic method to circumferentially-resolve airway wall compliance using endoscopic, anatomic optical coherence tomography (aOCT) combined with an intraluminal pressure catheter. The method was first demonstrated on notched silicone phantoms of known elastic modulus under respiratory ventilation, where localized compliance measurements were validated against those predicted by finite element modeling. Then, ex vivo porcine tracheas were scanned, and the pattern of compliance was found to be consistent with ...
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  Mentions: Amy L. Oldenburg University of North Carolina
7. Geometric Validation of Continuous, Finely Sampled 3-D Reconstructions From aOCT and CT in Upper Airway Models
  
  Explore IEEE Xplore Apr 4 2019 Pulmonology
  
  Identification and treatment of obstructive airway disorders (OADs) are greatly aided by imaging of the geometry of the airway lumen. Anatomical optical coherence tomography (aOCT) is a promising high-speed and minimally invasive endoscopic imaging modality for providing micrometer-resolution scans of the upper airway. Resistance to airflow in OADs is directly caused by the reduction in luminal cross-sectional area (CSA). It is hypothesized that aOCT can produce airway CSA measurements as ...
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  Mentions: Amy L. Oldenburg University of North Carolina
8. Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway
  
  Explore SPIE Digital Library Oct 27 2018 Pulmonology
  
  It is hypothesized that the local, viscoelastic (time-dependent) properties of the airway are important to accurately model and ultimately predict dynamic airway collapse in airway obstruction. Toward this end, we present a portable, endoscopic, swept-source anatomical optical coherence tomography (aOCT) system combined with a pressure catheter to capture local airway dynamics in vivo during respiration. aOCT scans were performed in the airways of a mechanically ventilated pig under paralysis with ...
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  Mentions: Thorlabs Amy L. Oldenburg University of North Carolina
9. Geometric Validation of Continuous, Finely-Sampled 3D Reconstructions from aOCT and CT in Upper Airway Models
  
  Explore IEEE Xplore Oct 25 2018 Pulmonology
  
  Identification and treatment of obstructive airway disorders (OADs) is greatly aided by imaging of the geometry of the airway lumen. Anatomical optical coherence tomography (aOCT) is a promising high-speed and minimally-invasive endoscopic imaging modality for providing micrometer-resolution scans of the upper airway. Resistance to airflow in OADs is directly caused by reduction in luminal cross-sectional area (CSA). It is hypothesized that aOCT can produce airway CSA measurements as accurate as ...
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  Mentions: Amy L. Oldenburg University of North Carolina
10. Comparative analysis of autofluorescence and OCT angiography in Stargardt disease
  
  Explore BJO Online Sep 1 2018 Ophthalmology
  
  Aims To characterise the vasculature of the retina in patients with Stargardt disease (STGD) using optical coherence tomography angiography (OCTA) and to compare these functional findings with fundus autofluorescence (FAF) imaging. Methods This observational study included consecutive patients with STGD. The choriocapillaris (CC) layer was analysed on OCTA and retinal pigment epithelium (RPE) changes were assessed on FAF. Areas of CC and RPE impairment were quantified and correlated. Results Twenty-two ...
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  Mentions: L V Prasad Eye Institute University of North Carolina University of Perugia
11. Intraoperative optical coherence tomography-assisted retrocorneal fibrous membrane biopsy and excision
  
  Explore ScienceDirect Jun 26 2018 Ophthalmology
  
  Purpose We report a case of retrocorneal fibrous membrane (RCFM) formation following penetrating keratoplasty (PK) and intraoperative optical coherence tomography (OCT)-guided excision of this membrane. Observations A 68-year-old woman with primary open angle glaucoma and corneal decompensation of the right eye secondary to tube shunt presented for 3-month follow-up of PK. On examination of the right eye, the patient was noted to have a glassy pupillary membrane with traction ...
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  Mentions: University of North Carolina
12. Validation of the UNC OCT Index for the Diagnosis of Early Glaucoma
  
  Explore TVST Journal Apr 16 2018 Ophthalmology
  
  ...Purpose : To independently validate the performance of the University of North Carolina Optical Coherence Tomography (UNC OCT) Index in diagnosing and predicting early glaucoma. Methods : Data of 118 normal sub...
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  Mentions: Carl Zeiss Meditec University of North Carolina Donald L. Budenz
13. Quantification of the Effect of Toxicants on the Intracellular Kinetic Energy and Cross-Sectional Area of Mammary Epithelial Organoids by OCT Fluctuation Spectroscopy
  
  Explore Journals Feb 27 2018 Developmental Biology
  
  The ability to assess toxicant exposures of 3D in vitro mammary models that recapitulate the tissue microenvironment can aid in our understanding of environmental exposure risk over time. Longitudinal studies of 3D model systems, however, are cumbersome and suffer from a lack of high-throughput toxicological assays. In this study, we establish a noninvasive and label-free optical coherence tomography (OCT)-based imaging platform for tracking exposure-response relationships in 3D human mammary ...
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  Mentions: Amy L. Oldenburg University of North Carolina Richard L. Blackmon
14. Diffusion tensor optical coherence tomography
  
  Explore IOPscience Dec 2 2017
  
  In situ measurements of diffusive particle transport provide insight into tissue architecture, drug delivery, and cellular function. Analogous to diffusion-tensor magnetic resonance imaging (DT-MRI), where the anisotropic diffusion of water molecules is mapped on the millimeter scale to elucidate the fibrous structure of tissue, here we propose diffusion-tensor optical coherence tomography (DT-OCT) for measuring directional diffusivity and flow of optically scattering particles within tissue. Because DT-OCT is sensitive to the ...
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  Mentions: Duke University Amy L. Oldenburg University of North Carolina
15. Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography
  
  Explore OSA | OSA Publishing Sep 30 2017 Pulmonology
  
  We propose a novel suite of algorithms for automatically segmenting the airway lumen and mucus in endobronchial optical coherence tomography (OCT) data sets, as well as a novel approach for quantifying the contents of the mucus. Mucus and lumen were segmented using a robust, multi-stage algorithm that requires only minimal input regarding sheath geometry. The algorithm performance was highly accurate in a wide range of airway and noise conditions. Mucus ...
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  Mentions: Massachusetts General Hospital Harvard University University of North Carolina
16. Optical coherence tomography angiography characterisation of Best disease and associated choroidal neovascularisation
  
  Explore BJO Online Jul 31 2017 Ophthalmology
  
  Aims To characterise the vasculature of the retina in patients with Best vitelliform dystrophy, including those with choroidal neovascularisation (CNV), using optical coherence tomography angiography (OCTA) and correlate with fluorescein angiography (FA). Methods This prospective observational study included 19 eyes of 10 patients with Best disease. Using OCTA, all layers of retina were qualitatively characterised for each eye. Patients with CNV also underwent FA, and areas of CNV were measured ...
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  Mentions: L V Prasad Eye Institute University of North Carolina
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