1. University of North Carolina

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    1. Mentioned In 95 Articles

    2. Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway

      Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway
      It is hypothesized that the local, viscoelastic (time-dependent) properties of the airway are important to accurately model and ultimately predict dynamic airway collapse in airway obstruction. Toward this end, we present a portable, endoscopic, swept-source anatomical optical coherence tomography (aOCT) system combined with a pressure catheter to capture local airway dynamics in vivo during respiration. aOCT scans were performed in the airways of a mechanically ventilated pig under paralysis with ...
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    3. Geometric Validation of Continuous, Finely-Sampled 3D Reconstructions from aOCT and CT in Upper Airway Models

      Geometric Validation of Continuous, Finely-Sampled 3D Reconstructions from aOCT and CT in Upper Airway Models
      Identification and treatment of obstructive airway disorders (OADs) is greatly aided by imaging of the geometry of the airway lumen. Anatomical optical coherence tomography (aOCT) is a promising high-speed and minimally-invasive endoscopic imaging modality for providing micrometer-resolution scans of the upper airway. Resistance to airflow in OADs is directly caused by reduction in luminal cross-sectional area (CSA). It is hypothesized that aOCT can produce airway CSA measurements as accurate as ...
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    4. Comparative analysis of autofluorescence and OCT angiography in Stargardt disease

      Comparative analysis of autofluorescence and OCT angiography in Stargardt disease
      Aims To characterise the vasculature of the retina in patients with Stargardt disease (STGD) using optical coherence tomography angiography (OCTA) and to compare these functional findings with fundus autofluorescence (FAF) imaging. Methods This observational study included consecutive patients with STGD. The choriocapillaris (CC) layer was analysed on OCTA and retinal pigment epithelium (RPE) changes were assessed on FAF. Areas of CC and RPE impairment were quantified and correlated. Results Twenty-two ...
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    5. Intraoperative optical coherence tomography-assisted retrocorneal fibrous membrane biopsy and excision

      Intraoperative optical coherence tomography-assisted retrocorneal fibrous membrane biopsy and excision
      Purpose We report a case of retrocorneal fibrous membrane (RCFM) formation following penetrating keratoplasty (PK) and intraoperative optical coherence tomography (OCT)-guided excision of this membrane. Observations A 68-year-old woman with primary open angle glaucoma and corneal decompensation of the right eye secondary to tube shunt presented for 3-month follow-up of PK. On examination of the right eye, the patient was noted to have a glassy pupillary membrane with traction ...
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    6. Quantification of the Effect of Toxicants on the Intracellular Kinetic Energy and Cross-Sectional Area of Mammary Epithelial Organoids by OCT Fluctuation Spectroscopy

      Quantification of the Effect of Toxicants on the Intracellular Kinetic Energy and Cross-Sectional Area of Mammary Epithelial Organoids by OCT Fluctuation Spectroscopy
      The ability to assess toxicant exposures of 3D in vitro mammary models that recapitulate the tissue microenvironment can aid in our understanding of environmental exposure risk over time. Longitudinal studies of 3D model systems, however, are cumbersome and suffer from a lack of high-throughput toxicological assays. In this study, we establish a noninvasive and label-free optical coherence tomography (OCT)-based imaging platform for tracking exposure-response relationships in 3D human mammary ...
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    7. Diffusion tensor optical coherence tomography

      Diffusion tensor optical coherence tomography
      In situ measurements of diffusive particle transport provide insight into tissue architecture, drug delivery, and cellular function. Analogous to diffusion-tensor magnetic resonance imaging (DT-MRI), where the anisotropic diffusion of water molecules is mapped on the millimeter scale to elucidate the fibrous structure of tissue, here we propose diffusion-tensor optical coherence tomography (DT-OCT) for measuring directional diffusivity and flow of optically scattering particles within tissue. Because DT-OCT is sensitive to the ...
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    8. Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography

      Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography
      We propose a novel suite of algorithms for automatically segmenting the airway lumen and mucus in endobronchial optical coherence tomography (OCT) data sets, as well as a novel approach for quantifying the contents of the mucus. Mucus and lumen were segmented using a robust, multi-stage algorithm that requires only minimal input regarding sheath geometry. The algorithm performance was highly accurate in a wide range of airway and noise conditions. Mucus ...
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    9. Optical coherence tomography angiography characterisation of Best disease and associated choroidal neovascularisation

      Optical coherence tomography angiography characterisation of Best disease and associated choroidal neovascularisation
      Aims To characterise the vasculature of the retina in patients with Best vitelliform dystrophy, including those with choroidal neovascularisation (CNV), using optical coherence tomography angiography (OCTA) and correlate with fluorescein angiography (FA). Methods This prospective observational study included 19 eyes of 10 patients with Best disease. Using OCTA, all layers of retina were qualitatively characterised for each eye. Patients with CNV also underwent FA, and areas of CNV were measured ...
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    10. Feature of the Week 05/14/2017: Real-Time Monitoring of Mucus Thinning Treatments using Diffusion-Sensitive Optical Coherence Tomography

      Feature of the Week 05/14/2017: Real-Time Monitoring of Mucus Thinning Treatments using Diffusion-Sensitive Optical Coherence Tomography
      ...rsonalized treatments in the clinic. For more information see recent Article . Courtesy Richard Blackmon from University of North Carolina . The airway epithelium is coated with a biopolymeric mucus gel which is responsi...
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    11. Direct monitoring of pulmonary disease treatment biomarkers using plasmonic gold nanorods with diffusion-sensitive OCT

      Direct monitoring of pulmonary disease treatment biomarkers using plasmonic gold nanorods with diffusion-sensitive OCT
      The solid concentration of pulmonary mucus (wt%) is critical to respiratory health. In patients with respiratory disease, such as Cystic Fibrosis (CF) and Chronic Obstructive Pulmonary Disorder (COPD), mucus hydration is impaired, resulting in high wt%. Mucus with high wt% is a hallmark of pulmonary disease that leads to obstructed airways, inflammation, and infection. Methods to measure mucus hydration in situ and in real-time are needed for drug development and ...
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    12. Airway compliance measured by anatomic optical coherence tomography

      Airway compliance measured by anatomic optical coherence tomography
      Quantification of airway compliance can aid in the diagnosis and treatment of obstructive airway disorders by detecting regions vulnerable to collapse. Here we evaluate the ability of a swept-source anatomic optical coherence tomography (SSaOCT) system to quantify airway cross-sectional compliance (CC) by measuring changes in the luminal cross-sectional area (CSA) under physiologically relevant pressures of 1040 cmH 2 O. The accuracy and precision of CC measurements are determined using simulations ...
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    13. Multi-modal anatomical optical coherence tomography and CT for in vivo dynamic upper airway imaging

      Multi-modal anatomical optical coherence tomography and CT for in vivo dynamic upper airway imaging
      We describe a novel, multi-modal imaging protocol for validating quantitative dynamic airway imaging performed using anatomical Optical Coherence Tomography (aOCT). The aOCT system consists of a catheter-based aOCT probe that is deployed via a bronchoscope, while a programmable ventilator is used to control airway pressure. This setup is employed on the bed of a Siemens Biograph CT system capable of performing respiratory-gated acquisitions. In this arrangement the position of the ...
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    14. Choroid Segmentation from Optical Coherence Tomography with Graph-Edge Weights Learned from Deep Convolutional Neural Networks

      Choroid Segmentation from Optical Coherence Tomography with Graph-Edge Weights Learned from Deep Convolutional Neural Networks
      Examining choroid in Optical Coherence Tomography (OCT) plays a vital role in pathophysiologic factors of many ocular conditions. Among the existing approaches to detecting choroidal boundaries, graph-searching based techniques belong to the state-of-the-art. However, most of these techniques rely on hand-crafted models on the graph-edge weight and their performances are limited mainly due to the weak choroidal boundaries, textural structure of the choroid, inhomogeneity of the textural structure of the ...
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    15. High-speed and high-sensitivity parallel spectral-domain optical coherence tomography using a supercontinuum light source

      High-speed and high-sensitivity parallel spectral-domain optical coherence tomography using a supercontinuum light source
      The three most important metrics in optical coherence tomography (OCT) are resolution, speed, and sensitivity. Because there is a complex interplay between these metrics, no previous work has obtained the best performance in all three metrics simultaneously. We demonstrate that a high-power supercontinuum source, in combination with parallel spectral-domain OCT, achieves an unparalleled combination of resolution, speed, and sensitivity. This system captures cross-sectional images spanning 4 mm 0.5 mm ...
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  2. About University of North Carolina

    University of North Carolina

    University of North Carolina was chartered in 1789, and was the first public university in the United States and the only one to graduate students in the eighteenth century. Today, UNC is a multi-campus university composed of all 16 of North Carolina's public institutions that grant baccalaureate degrees, as well as the NC School of Science and Mathematics, the nation's first public residential high school for gifted students.