1. University of Minnesota

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    1. Mentioned In 56 Articles

    2. Glioma cell migration dynamics in brain tissue assessed by multimodal optical imaging

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      Glioma cell migration dynamics in brain tissue assessed by multimodal optical imaging
      Glioblastoma is a primary malignant brain tumor characterized by highly infiltrative glioma cells. Vasculature and white matter tracts are considered to be the preferred and fastest routes for glioma invasion through brain tissue. In this study, we systematically quantified the routes and motility of the U251 human glioblastoma cell line in mouse brain slices by multimodal imaging. Specifically, we used polarization-sensitive optical coherence tomography to delineate nerve fiber tracts while ...
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      Mentions: University of Minnesota Taner Akkin

    3. Contrast-enhanced serial optical coherence scanner with deep learning network reveals vasculature and white matter organization of mouse brain

      Explore SPIE Digital Library Neurology
      Contrast-enhanced serial optical coherence scanner with deep learning network reveals vasculature and white matter organization of mouse brain
      Optical coherence tomography provides volumetric reconstruction of brain structure with micrometer resolution. Gray matter and white matter can be highlighted using conventional and polarization-based contrasts; however, vasculature in ex-vivo fixed brain has not been investigated at large scale due to lack of intrinsic contrast. We present contrast enhancement to visualize the vasculature by perfusing titanium dioxide particles transcardially into the mouse vascular system. The brain, after dissection and fixation, is ...
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      Mentions: University of Minnesota Taner Akkin

    4. Ruptures and Thickening : Optical Coherence Tomography as the Arbiter of the Fibrous Cap

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      Ruptures and Thickening : Optical Coherence Tomography as the Arbiter of the Fibrous Cap
      Coronary artery disease remains a leading cause of mortality worldwide, primarily through acute events mediated by progression and disruption of thrombosis-provoking atheroma. The necrotic core of advanced atheroma harbors highly prothrombotic material, including components of tissue factor, von Willebrand factor, and plasminogen activator inhibitor1. Exposure of these contents to flowing blood can spur thrombosis and is a critical feature of many acute coronary syndromes (ACS). It is therefore vital that ...
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      Mentions: Massachusetts General Hospital Harvard University University of Minnesota

    5. Polarization-sensitive optical coherence tomography reveals gray matter and white matter atrophy in SCA1 mouse models

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      Polarization-sensitive optical coherence tomography reveals gray matter and white matter atrophy in SCA1 mouse models
      Spinocerebellar ataxia type 1 (SCA1) is a fatal inherited neurodegenerative disease. In this study, we demonstrate the label-free optical imaging methodology that can detect, with a high degree of sensitivity, discrete areas of degeneration in the cerebellum of the SCA1 mouse models. We used ATXN1[82Q] and ATXN1[30Q]-D776 mice in which the transgene is directed only to Purkinje cells. Molecular layer, granular layer, and white matter regions are ...
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      Mentions: University of Minnesota Taner Akkin

    7. White matter atrophy in spinocerebellar ataxia type 1 mouse models revealed by serial optical coherence scanner

      Explore SPIE Digital Library Neurology
      White matter atrophy in spinocerebellar ataxia type 1 mouse models revealed by serial optical coherence scanner
      Spinocerebellar ataxia type 1 (SCA1) is a fatal inherited neurodegenerative disease. Post-mortem studies showed neurodegeneration involving white matter components in the cerebral lobes, the cerebellar peduncles and the more distal cranial nerves in human patients. However, the progression of SCA1 in the brain remains unclear. We present the study of white matter atrophy of SCA1 mouse models using serial optical coherence scanner (SOCS). SOCS consists of a polarization sensitive optical ...
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      Mentions: University of Minnesota Taner Akkin

    8. Polarization-maintaining fiber-based Optical Coherence Tomography and its applications (Thesis)

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      Polarization-maintaining fiber-based Optical Coherence Tomography and its applications (Thesis)
      Recent advances in Optical Coherence Tomography (OCT) have enabled wide ranges of attractive applications, including characterization of biological tissues, morphological tracking, intravascular imaging, developmental biology and in functional spectroscopic aspects. Neural activity has been studied using optical methods in the past few decades. The use of light to probe neural activity allows outstanding resolution, and the possibility for simultaneous measurement from a range of targeted locations without physical contact with ...
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      Mentions: University of Minnesota

    9. Assessing the dynamic biofilm removal of sulfonated phenolics using CP-OCT

      Explore Conference Proceedings Dentistry
      Assessing the dynamic biofilm removal of sulfonated phenolics using CP-OCT
      Examining the physical mechanisms related to biofilm removal of sulfonated phenolics (SP) is difficult using conventional microscopy techniques. A custom flow cell system integrated with a real time cross polarization optical coherence tomography system investigated the dynamic speed of biofilm removal when oral multi-species biofilms are exposed to SP under sheer stress. The Near infrared 1310-nm CP-OCT system non-destructively imaged fluid immersed oral biofilms at nearly 30 frames/s. This ...
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      Mentions: University of Minnesota Robert S. Jones

    10. Polarization-Maintaining Fiber-Based Optical Coherence Tomography on Functional Imaging in Dense Nerve (Student Thesis)

      Explore University Digital Conservancy Home Neurology , Student Theses
      Polarization-Maintaining Fiber-Based Optical Coherence Tomography on Functional Imaging in Dense Nerve (Student Thesis)
      The technology and applications of optical coherence tomography (OCT) have been developed rapidly for structural and functional investigations of biological tissues. The use of light yields outstanding resolution and simultaneous measurements from a range of targeted locations without physical contact with tissue. The objective of this thesis was to investigate the feasibility of utilizing polarization-maintaining-fiber (PMF) based OCT to image the microstructure and functional (neural activity) of pike olfactory nerve ...
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      Mentions: University of Minnesota

    11. Visualizing and mapping the cerebellum with serial optical coherence scanner

      Explore SPIE | Journal Neurology
      Visualizing and mapping the cerebellum with serial optical coherence scanner
      We present the visualization of the mouse cerebellum and adjacent brainstem using a serial optical coherence scanner, which integrates a vibratome slicer and polarization-sensitive optical coherence tomography for ex vivo imaging. The scanner provides intrinsic optical contrasts to distinguish the cerebellar cortical layers and white matter. Images from serial scans reveal the large-scale anatomy in detail and map the nerve fiber pathways in the cerebellum and brainstem. By incorporating a ...
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      Mentions: University of Minnesota Taner Akkin

    12. Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography

      Explore IOPscience Oncology
      Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography
      In cancer biology, there has been a recent effort to understand tumor formation in the context of the tissue microenvironment. In particular, recent progress has explored the mechanisms behind how changes in the cell-extracellular matrix ensemble influence progression of the disease. The extensive use of in vitro tissue culture models in simulant matrix has proven effective at studying such interactions, but modalities for non-invasively quantifying aspects of these systems are ...
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      Mentions: Northwestern University Vadim Backman University of Minnesota

    13. Quantifying three-dimensional optic axis using polarization-sensitive optical coherence tomography

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      Quantifying three-dimensional optic axis using polarization-sensitive optical coherence tomography
      The optic axis of birefringent samples indicates the direction of optical anisotropy, which should be described in three-dimensional (3-D) space. We present a method to quantify the complete 3-D optic axis orientation calculated from in-plane optic axis measurements from a polarization-sensitive optical coherence tomography system. The in-plane axis orientations with different illumination angles allow the calculation of the necessary polar angle. The method then provides the information to produce the ...
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      Mentions: University of Minnesota Taner Akkin Hui Wang

    15. Optical coherence tomography findings after chronic Total occlusion interventions: Insights from the “AngiographiC evaluation of the everolimus-eluting stent in chronic Total occlusions” (ACE-CTO) study (NCT01012869)

      Explore ScienceDirect Cardiology
      Optical coherence tomography findings after chronic Total occlusion interventions: Insights from the “AngiographiC evaluation of the everolimus-eluting stent in chronic Total occlusions” (ACE-CTO) study (NCT01012869)
      Background There is limited information on optical coherence tomography (OCT) findings after percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs). OCT allows high resolution imaging that can enhance understanding of the vascular response after stenting of chronically occluded vessels. Methods The Angiographic Evaluation of the Everolimus-Eluting Stent in Chronic Total Occlusions (ACE-CTO) study collected angiographic and clinical outcomes from 100 patients undergoing CTO PCI with the everolimus-eluting stent (EES ...
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      Mentions: University of Minnesota UT Southwestern Medical Center

    16. Diagnostics techniques in nonmuscle invasive bladder cancer

      Explore Indian Journal of Urology (IJU) Urology
      Diagnostics techniques in nonmuscle invasive bladder cancer
      Introduction: Nonmuscle invasive bladder cancer (NMIBC) is the most common presentation of bladder cancer and is often treatable with endoscopic resection and intravesical therapies. Cystoscopy and urine cytology are the gold standard in diagnosis and surveillance but are limited by their sensitivity in some situations. We seek to provide an overview of recent additions to the diagnostic armamentarium for urologists treating this disease. Methods: Articles were identified through a literature ...
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      Mentions: University of Minnesota
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  4. About University of Minnesota

    University of Minnesota

    The University of Minnesota is one of the most comprehensive public universities in the United States and ranks among the most prestigious. It is both the state land-grant university, with a strong tradition of education and public service, and the state's primary research university, with faculty of national and international reputation.

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