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1. Mentioned In 59 Articles
2. Sorptivity of water in enamel for categorizing caries lesions
  
  Explore ScienceDirect Sep 12 2020 Dentistry
  
  Objective The aim of this research was to determine the association between sorptivity of water and the state of mineralization in carious enamel of different stages of severity. Methods As a preliminary work, water droplets of 1.5 L were placed on the surfaces of hydroxyapatite (HA) discs of different densities. The water droplet profile was dynamically recorded every second over a period of 10 s using a contact angle ...
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  Mentions: University of Minnesota
3. Retinal Nerve Fibre Layer Thickness Increases with Decreasing Spectralis OCT Signal Strength in Normal Eyes
  
  Explore Taylor & Francis Online May 13 2020 Ophthalmology
  
  We sought to determine effect of signal strength on mean retinal nerve fibre layer (RNFL) using Spectralis optical coherence tomography (S-OCT). Thirty normal subjects (18 female, mean 37.9 years, range 24-61) were imaged with S-OCT using variably dense Bangerter foils to alter Q value (1 unit signal strength = 4 units Q). We found a statistically significant (p 0.01) linear relationship (R = 0.8643) between Q and RNFL (1 ...
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  Mentions: Heidelberg Engineering University of Minnesota
4. University of Minnesota Receives NIH Grant for Optical Imaging of Neural Activity Based on Lorentz Effect
  
  Explore Optical Coherence Tomography News Apr 8 2020 Funding
  
  ...the needed stability.
  
  University of Minnesota Receives a 2020 NIH Grant for $275,000 for Optical Imaging of Neural Activity Based on...
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  Mentions: National Institutes of Health University of Minnesota Taner Akkin
5. Glioma cell migration dynamics in brain tissue assessed by multimodal optical imaging
  
  Explore ScienceDirect Aug 20 2019 Neurology
  
  Glioblastoma is a primary malignant brain tumor characterized by highly infiltrative glioma cells. Vasculature and white matter tracts are considered to be the preferred and fastest routes for glioma invasion through brain tissue. In this study, we systematically quantified the routes and motility of the U251 human glioblastoma cell line in mouse brain slices by multimodal imaging. Specifically, we used polarization-sensitive optical coherence tomography to delineate nerve fiber tracts while ...
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  Mentions: University of Minnesota Taner Akkin
6. Contrast-enhanced serial optical coherence scanner with deep learning network reveals vasculature and white matter organization of mouse brain
  
  Explore SPIE Digital Library Jul 27 2019 Neurology
  
  Optical coherence tomography provides volumetric reconstruction of brain structure with micrometer resolution. Gray matter and white matter can be highlighted using conventional and polarization-based contrasts; however, vasculature in ex-vivo fixed brain has not been investigated at large scale due to lack of intrinsic contrast. We present contrast enhancement to visualize the vasculature by perfusing titanium dioxide particles transcardially into the mouse vascular system. The brain, after dissection and fixation, is ...
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  Mentions: University of Minnesota Taner Akkin
7. Ruptures and Thickening : Optical Coherence Tomography as the Arbiter of the Fibrous Cap
  
  Explore ScienceDirect Jun 9 2018 Cardiology
  
  Coronary artery disease remains a leading cause of mortality worldwide, primarily through acute events mediated by progression and disruption of thrombosis-provoking atheroma. The necrotic core of advanced atheroma harbors highly prothrombotic material, including components of tissue factor, von Willebrand factor, and plasminogen activator inhibitor1. Exposure of these contents to flowing blood can spur thrombosis and is a critical feature of many acute coronary syndromes (ACS). It is therefore vital that ...
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  Mentions: Massachusetts General Hospital Harvard University University of Minnesota
8. Polarization-sensitive optical coherence tomography reveals gray matter and white matter atrophy in SCA1 mouse models
  
  Explore ScienceDirect May 19 2018 Neurology
  
  Spinocerebellar ataxia type 1 (SCA1) is a fatal inherited neurodegenerative disease. In this study, we demonstrate the label-free optical imaging methodology that can detect, with a high degree of sensitivity, discrete areas of degeneration in the cerebellum of the SCA1 mouse models. We used ATXN1[82Q] and ATXN1[30Q]-D776 mice in which the transgene is directed only to Purkinje cells. Molecular layer, granular layer, and white matter regions are ...
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  Mentions: University of Minnesota Taner Akkin
9. Fully Automated Segmentation of Fluid/Cyst Regions in Optical Coherence Tomography Images With Diabetic Macular Edema Using Neutrosophic Sets and Graph Algorithms
  
  Explore IEEE Xplore Apr 19 2018 Ophthalmology
  
  ...y, the proposed algorithm also achieves sensitivity of 67.3%, 88.8%, and 76.7%, for the Duke, Optima, and the university of minnesota (UMN) datasets, respectively. ...
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  Mentions: University of Minnesota
10. White matter atrophy in spinocerebellar ataxia type 1 mouse models revealed by serial optical coherence scanner
  
  Explore SPIE Digital Library Mar 20 2018 Neurology
  
  Spinocerebellar ataxia type 1 (SCA1) is a fatal inherited neurodegenerative disease. Post-mortem studies showed neurodegeneration involving white matter components in the cerebral lobes, the cerebellar peduncles and the more distal cranial nerves in human patients. However, the progression of SCA1 in the brain remains unclear. We present the study of white matter atrophy of SCA1 mouse models using serial optical coherence scanner (SOCS). SOCS consists of a polarization sensitive optical ...
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  Mentions: University of Minnesota Taner Akkin
11. Polarization-maintaining fiber-based Optical Coherence Tomography and its applications (Thesis)
  
  Explore Log In Jan 25 2018 Student Theses
  
  Recent advances in Optical Coherence Tomography (OCT) have enabled wide ranges of attractive applications, including characterization of biological tissues, morphological tracking, intravascular imaging, developmental biology and in functional spectroscopic aspects. Neural activity has been studied using optical methods in the past few decades. The use of light to probe neural activity allows outstanding resolution, and the possibility for simultaneous measurement from a range of targeted locations without physical contact with ...
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  Mentions: University of Minnesota
12. Assessing the dynamic biofilm removal of sulfonated phenolics using CP-OCT
  
  Explore Conference Proceedings Feb 16 2017 Dentistry
  
  Examining the physical mechanisms related to biofilm removal of sulfonated phenolics (SP) is difficult using conventional microscopy techniques. A custom flow cell system integrated with a real time cross polarization optical coherence tomography system investigated the dynamic speed of biofilm removal when oral multi-species biofilms are exposed to SP under sheer stress. The Near infrared 1310-nm CP-OCT system non-destructively imaged fluid immersed oral biofilms at nearly 30 frames/s. This ...
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  Mentions: University of Minnesota Robert S. Jones
13. Polarization-Maintaining Fiber-Based Optical Coherence Tomography on Functional Imaging in Dense Nerve (Student Thesis)
  
  Explore University Digital Conservancy Home Dec 23 2016 Neurology , Student Theses
  
  The technology and applications of optical coherence tomography (OCT) have been developed rapidly for structural and functional investigations of biological tissues. The use of light yields outstanding resolution and simultaneous measurements from a range of targeted locations without physical contact with tissue. The objective of this thesis was to investigate the feasibility of utilizing polarization-maintaining-fiber (PMF) based OCT to image the microstructure and functional (neural activity) of pike olfactory nerve ...
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  Mentions: University of Minnesota
14. Visualizing and mapping the cerebellum with serial optical coherence scanner
  
  Explore SPIE | Journal Oct 4 2016 Neurology
  
  We present the visualization of the mouse cerebellum and adjacent brainstem using a serial optical coherence scanner, which integrates a vibratome slicer and polarization-sensitive optical coherence tomography for ex vivo imaging. The scanner provides intrinsic optical contrasts to distinguish the cerebellar cortical layers and white matter. Images from serial scans reveal the large-scale anatomy in detail and map the nerve fiber pathways in the cerebellum and brainstem. By incorporating a ...
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  Mentions: University of Minnesota Taner Akkin
15. Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography
  
  Explore IOPscience Sep 13 2016 Oncology
  
  In cancer biology, there has been a recent effort to understand tumor formation in the context of the tissue microenvironment. In particular, recent progress has explored the mechanisms behind how changes in the cell-extracellular matrix ensemble influence progression of the disease. The extensive use of in vitro tissue culture models in simulant matrix has proven effective at studying such interactions, but modalities for non-invasively quantifying aspects of these systems are ...
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  Mentions: Northwestern University Vadim Backman University of Minnesota
16. Quantifying three-dimensional optic axis using polarization-sensitive optical coherence tomography
  
  Explore SPIE | Journal Jul 9 2016
  
  The optic axis of birefringent samples indicates the direction of optical anisotropy, which should be described in three-dimensional (3-D) space. We present a method to quantify the complete 3-D optic axis orientation calculated from in-plane optic axis measurements from a polarization-sensitive optical coherence tomography system. The in-plane axis orientations with different illumination angles allow the calculation of the necessary polar angle. The method then provides the information to produce the ...
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  Mentions: University of Minnesota Taner Akkin Hui Wang
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