1. University of Milan

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    1. Mentioned In 78 Articles

    2. Does real-time artificial intelligence-based visual pathology enhancement of three-dimensional optical coherence tomography scans optimise treatment decision in patients with nAMD? Rationale and design of the RAZORBILL study

      Does real-time artificial intelligence-based visual pathology enhancement of three-dimensional optical coherence tomography scans optimise treatment decision in patients with nAMD? Rationale and design of the RAZORBILL study
      Background/rationale Artificial intelligence (AI)-based clinical decision support tools, being developed across multiple fields in medicine, need to be evaluated for their impact on the treatment and outcomes of patients as well as optimisation of the clinical workflow. The RAZORBILL study will investigate the impact of advanced AI segmentation algorithms on the disease activity assessment in patients with neovascular age-related macular degeneration (nAMD) by enriching three-dimensional (3D) retinal optical ...
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    3. Optical coherence tomography angiography application to pigmented iris: Could a new index quantify blood flow?

      Optical coherence tomography angiography application to pigmented iris: Could a new index quantify blood flow?
      Purpose: To assess the blood flow and vascular visibility of irises in relation to pigmentation and pupil size, using an anterior segment optical coherence tomography angiography (OCTA). Materials and methods: This is a cross-sectional study. OCTA images were acquired in the nasal and temporal quadrants from a cohort of 30 healthy subjects in photopic (miosis) and scotopic (mydriasis) conditions. Patients were divided according to iris color (less pigmented: group L ...
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    4. An en face swept source optical coherence tomography study of the vitreous in eyes with anterior uveitis

      An en face swept source optical coherence tomography study of the vitreous in eyes with anterior uveitis
      Purpose: To analyse vitreous anatomy patients with anterior uveitis (AU) using swept source optical coherence tomography (SS-OCT). Methods: Patients with newly diagnosed AU and healthy participants were scanned using 16-mm SS-OCT B-scans and 12 12 mm cube centred at the fovea. Linear SS-OCT scans were evaluated to identify the premacular bursa (PB) above the macula and the Cloquet's canal above the optic disc. A dynamic evaluation of the 12 ...
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    5. Optical Coherence Tomography Signs of Early Atrophy in Age-related Macular Degeneration: Inter-Reader Agreement. CAM Report 6

      Optical Coherence Tomography Signs of Early Atrophy in Age-related Macular Degeneration: Inter-Reader Agreement. CAM Report 6
      Objective: To determine the inter-reader agreement for incomplete and complete retinal pigment epithelium and outer retinal atrophy (iRORA and cRORA respectively) and their related features in age-related macular degeneration (AMD). Design: Inter-reader agreement study. Participants: Twelve readers from six reading centers. Methods: Following formal training, readers qualitatively assessed 60 optical coherence tomography (OCT) B-scans from 60 eyes with AMD for nine individual features associated with early atrophy and performed seven ...
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    6. Can deep learning improve the automatic segmentation of deep foveal avascular zone in optical coherence tomography angiography

      Can deep learning improve the automatic segmentation of deep foveal avascular zone in optical coherence tomography angiography
      Optical coherence tomography angiography (OCTA) is extensively used for visualizing retinal vasculature, including the foveal avascular zone (FAZ). Assessment of the FAZ is critical in the diagnosis and management of various retinal diseases. Accurately segmenting the FAZ in the deep retinal layer (dFAZ) is very challenging due to unclear capillary terminals. In this study, a customized encoder-decoder deep learning network was used for dFAZ segmentation. Six-fold cross-validation was performed on ...
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    7. Near-infrared fundus autofluorescence alterations correlate with swept-source optical coherence tomography angiography findings in patients with retinitis pigmentosa

      Near-infrared fundus autofluorescence alterations correlate with swept-source optical coherence tomography angiography findings in patients with retinitis pigmentosa
      Thirty-eight patients from 37 families with retinitis pigmentosa (RP) underwent macular 6 6-mm swept-source optical coherence tomography angiography (SS-OCTA) and 30 near-infrared fundus autofluorescence (NIR-FAF) acquisitions in one eye. Superficial vascular complex (SVC), deep capillary complex (DCC) and choriocapillaris (CC) angiograms were registered with NIR-FAF acquisitions to comparatively assess subjects with and without central area of preserved NIR-FAF (APA). On the subset of patients showing an APA, the vessel densities ...
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    8. Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA)

      Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA)
      The advent of optical coherence tomography (OCT) revolutionized both clinical assessment and research of vitreoretinal conditions. Since then, extraordinary advances have been made in this imaging technology, including the relatively recent development of swept-source OCT (SS-OCT). SS-OCT enables a fast scan rate and utilizes a tunable swept laser at longer wavelengths than conventional spectral-domain devices. These features enable imaging of larger areas with reduced motion artifact, and a better visualization ...
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    9. Optical coherence tomography features of choroidal neovascularization and their correlation with age, gender and underlying disease

      Optical coherence tomography features of choroidal neovascularization and their correlation with age, gender and underlying disease
      Purpose: To investigate the influence of age , gender and underlying disease on the optical coherence tomography (OCT) features of choroidal neovascularization (CNV) secondary to Inflammation ( iCNV ), myopia (mCNV) and age -related macular degeneration (AMD-CNV). Methods: Demographic and clinical data of eyes with treatment nave iCNV , mCNV and type 2 AMD-CNV were collected. OCT images were reviewed to determine the presence of pitchfork sign (PFS), pigment epithelial detachment (PED), subretinal fluid ...
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    10. Evaluation of the inner choroid using OCT angiography

      Evaluation of the inner choroid using OCT angiography
      The advent of optical coherence tomography angiography (OCTA) has allowed a qualitative and quantitative analysis of the retinal vasculature and the choriocapillaris. With the use of OCTA, several studies evaluated the changes in the choriocapillaris showing how this vascular structure plays a significant role in the pathogenesis of different conditions. This article reviews the current methods of analysis of the choriocapillaris and the relevant findings in different chorioretinal diseases.
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    11. Microaneurysms visualisation using five different optical coherence tomography angiography devices compared to fluorescein angiography

      Microaneurysms visualisation using five different optical coherence tomography angiography devices compared to fluorescein angiography
      Background To compare fluorescein angiography (FA) and five different optical coherence tomography angiography (OCTA) devices and to test their reproducibility in the evaluation of retinal microaneurysms (MAs) secondary to diabetic retinopathy (DR). Methods On the same day, patients with DR were imaged with FA and five OCTA devices: prototype Spectralis OCTA, prototype PlexElite, RTVue XR Avanti, AngioPlex and DRI OCT Triton. For all OCTA devices, a 33 volume scan pattern ...
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    12. Cyst Detection and Motion Artifact Elimination in Enface Optical Coherence Tomography Angiograms

      Cyst Detection and Motion Artifact Elimination in Enface Optical Coherence Tomography Angiograms
      The correct detection of cysts in Optical Coherence Tomography Angiography images is of crucial importance for allowing reliable quantitative evaluation in patients with macular edema. However, this is a challenging task, since the commercially available software only allows manual cysts delineation. Moreover, even small eye movements can cause motion artifacts that are not always compensated by the commercial software. In this paper, we propose a novel algorithm based on the ...
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    13. CHOROIDAL GRANULOMAS VISUALIZED BY SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      CHOROIDAL GRANULOMAS VISUALIZED BY SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
      Purpose: To assess the visualization of choroidal granulomas with swept-source optical coherence tomography angiography (OCTA). Methods: Consecutive patients with granulomatous choroiditis due to tuberculosis, sarcoidosis, or VogtKoyanagiHarada disease underwent baseline OCTA images using a 12 12-mm field of view, and the choroidal slabs were analyzed by two independent examiners who counted the oval areas of flow void. Simultaneously, indocyanine green angiography (ICGA) and enhanced-depth imaging OCT were performed to mark ...
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    14. Thresholding strategies to measure vessel density by optical coherence tomography angiography

      Thresholding strategies to measure vessel density by optical coherence tomography angiography
      Objective A variety of binarization strategies have been used to measure vessel density by optical coherence tomography angiography (OCT-A), but it is uncertain if they produce similar results. The purpose of the study was to evaluate the impact of different thresholding methods and contrast and brightness adjustment on OCT-A vessel density metrics. Design Observational, cross-sectional case series. Participants Consecutive healthy volunteers. Methods Healthy volunteers underwent fovea-centred 3 mm 3 mm ...
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    15. EXTENDED FIELD IMAGING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FOR THE STUDY OF RETINAL AND CHOROIDAL CHANGES AFTER RADIATION THERAPY FOR CHOROIDAL MELANOMA: Comparison With Wide-Field Angiography

      EXTENDED FIELD IMAGING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FOR THE STUDY OF RETINAL AND CHOROIDAL CHANGES AFTER RADIATION THERAPY FOR CHOROIDAL MELANOMA: Comparison With Wide-Field Angiography
      Purpose: Radiation retinopathy is a common side effect of ocular radiotherapy with no long-term effective therapy. Optical coherence tomography angiography ( OCTA ) and wide-field fluorescein angiography (FA) are widely used for the study of radiation maculopathy and peripheral nonperfusion, respectively. We investigated the role of extended field imaging ( EFI-OCTA ) for the study of retinal and choroidal alterations after radiotherapy for choroidal melanoma . Methods: Cross-sectional observational study of 20 eyes of 20 ...
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    16. Optical coherence tomography angiography for the measurement of optic disc: Macular relationship

      Optical coherence tomography angiography for the measurement of optic disc: Macular relationship
      Introduction: Fundus photography is the gold standard for assessing ocular torsion over the last 30years. However, it is not a precise and reproducible tool during clinical practice. Optical coherence tomography angiography is characterized by precise identification of the macula and the optic disc, and it could be an effective method to easily calculate the angle of ocular torsion, compared to fundus photography. The aim of this study was to show ...
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  2. About University of Milan

    University of Milan

    University of Milan is a public, multidisciplinary teaching and research institution, where different opinions, beliefs and values can circulate freely. The University offers 9 Faculties, 134 study courses (divided between 1st and 2nd level degree programmes), 19 Doctoral Schools and 92 Specialisation Schools.