1. University of Michigan

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    1. Mentioned In 46 Articles

    2. Advances in Retinal Optical Imaging

      Advances in Retinal Optical Imaging
      Retinal imaging has undergone a revolution in the past 50 years to allow for better understanding of the eye in health and disease. Significant improvements have occurred both in hardware such as lasers and optics in addition to software image analysis. Optical imaging modalities include optical coherence tomography (OCT), OCT angiography (OCTA), photoacoustic microscopy (PAM), scanning laser ophthalmoscopy (SLO), adaptive optics (AO), fundus autofluorescence (FAF), and molecular imaging (MI). These ...
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    3. Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes

      Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes
      Photoacoustic ocular imaging is an emerging ophthalmic imaging technology that can noninvasively visualize ocular tissue by converting light energy into sound waves and is currently under intensive investigation. However, most reported work to date is focused on the imaging of the posterior segment of the eyes of small animals, such as rats and mice, which poses challenges for clinical human translation due to small eyeball sizes. This manuscript describes a ...
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    4. Integrated photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy for multimodal chorioretinal imaging

      Integrated photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy for multimodal chorioretinal imaging
      Current clinical available retinal imaging techniques have limitations, including limited depth of penetration or requirement for the invasive injection of exogenous contrast agents. Here, we developed a novel multimodal imaging system for high-speed, high-resolution retinal imaging of larger animals, such as rabbits. The system integrates three state-of-the-art imaging modalities, including photoacoustic microscopy (PAM), optical coherence tomography (OCT), and fluorescence microscopy (FM). In vivo experimental results of rabbit eyes show that ...
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    5. Optical coherence tomography and T cell gene expression analysis in patients with benign multiple sclerosis

      Optical coherence tomography and T cell gene expression analysis in patients with benign multiple sclerosis
      Benign multiple sclerosis is a retrospective diagnosis based primarily on a lack of motor symptom progression. Recent findings that suggest patients with benign multiple sclerosis experience non-motor symptoms highlight the need for a more prospective means to diagnose benign multiple sclerosis early in order to help direct patient care. In this study, we present optical coherence tomography and T cell neurotrophin gene analysis findings in a small number of patients ...
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    6. Noninvasive chorioretinal imaging in living rabbits using integrated photoacoustic microscopy and optical coherence tomography

      Noninvasive chorioretinal imaging in living rabbits using integrated photoacoustic microscopy and optical coherence tomography
      Most reported photoacoustic ocular imaging work to date uses small animals, such as mice and rats, the eyeball sizes of which are less than one-third of those of humans, posing challenges for clinical translation. Here we developed a novel integrated photoacoustic microscopy (PAM) and optical coherence tomography (OCT) system for dual-modality chorioretinal imaging of larger animals, such as rabbits. The system has quantified lateral resolutions of 4.1 m (PAM ...
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    7. Cystoid macular changes on optical coherence tomography in a patient with maternally inherited diabetes and deafness (MIDD)-associated macular dystrophy

      Cystoid macular changes on optical coherence tomography in a patient with maternally inherited diabetes and deafness (MIDD)-associated macular dystrophy
      The clinical presentation and optical coherence tomography findings in a patient with maternally inherited diabetes and deafness (MIDD) are presented to highlight the presence of macular cystoid spaces in some patients with this disease. Typically, patients with MIDD demonstrate progression of a pigmentary maculopathy into areas of geographic macular atrophy. At the time of initial visit, the 30-year-old patient had large macular cystoid changes in addition to retinal pigmentary changes ...
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    8. Choroidal and Retinal Abnormalities by Optical Coherence Tomography in Endogenous Cushing’s Syndrome

      Choroidal and Retinal Abnormalities by Optical Coherence Tomography in Endogenous Cushing’s Syndrome
      Context: Cortisol has been suggested as a risk factor for choroidal thickening, which may lead to retinal changes. Objective: To compare choroidal thickness measurements using optical coherence tomography (OCT) in patients with endogenous active Cushings syndrome (CS) and to evaluate the occurrence of retinal abnormalities in the same group of patients. Design: Cross-sectional study. Setting: Outpatient clinic. Patients: Eleven female patients with CS in hypercortisolism state as determined by the ...
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    9. Spectral-Domain Optical Coherence Tomography, Wide-Field Photography, and Fundus Autofluorescence Correlation of Posterior Ophthalmomyiasis Interna

      Spectral-Domain Optical Coherence Tomography, Wide-Field Photography, and Fundus Autofluorescence Correlation of Posterior Ophthalmomyiasis Interna
      Posterior ophthalmomyiasis interna is a rare, potentially devastating infestation of the posterior segment by fly larvae. The authors report the first demonstration of spectral-domain optical coherence tomography (SD-OCT) (Spectralis; Heidelberg Engineering, Heidelberg, Germany), wide-field angiography (Optos, Dunfermline, Scotland) and photography, and fundus autofluorescence with temporal progression during a period of 6 months. A 12-year-old white female presented with acute, painless vision loss with hand motions visual acuity. No larva was ...
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    10. An implant to catch metastatic cancer cells before they grow into tumors

      An implant to catch metastatic cancer cells before they grow into tumors
      There could be a way around this, though: a special imaging method under development at Northwestern University called Inverse Spectroscopic Optical Coherence Tomography (ISOCT). ISOCT detects molecular-level differences in the way cells in the body scatter light. And when we scan our implant with ISOCT, the light scatter pattern looks different when it's full of normal cells than when cancer cells are present. In fact, the difference is apparent ...
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    11. Comparison of Peripapillary Choroidal Thickness Measurements via Spectral Domain Optical Coherence Tomography with and without Enhanced Depth Imaging

      Comparison of Peripapillary Choroidal Thickness Measurements via Spectral Domain Optical Coherence Tomography with and without Enhanced Depth Imaging
      Objectives : To compare peripapillary choroidal thickness (PP-CT) measurements using a spectral domain optical coherence tomography (SD-OCT) device with and without enhanced depth imaging (EDI). Methods : Sixty healthy subjects aged from 18 to 40 years were included in this study. PP-CTs were measured in the right eyes by manual segmentation via SD-OCT both with and without EDI. The intraclass correlation coefficient (ICC) for each technique and comparison of PP-CT measurements between ...
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    12. Advances in noninvasive imaging of melanoma

      Advances in noninvasive imaging of melanoma
      Melanoma is the most dangerous type of skin cancer and its incidence has risen sharply in recent decades. Early detection of disease is critical for improving patient outcomes. Any pigmented lesion that is clinically concerning must be removed by biopsy for morphologic investigation on histology. However, biopsies are invasive and can cause significant morbidity, and their accuracy in detecting melanoma may be limited by sampling error. The advent of noninvasive ...
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    13. Development of a phase-sensitive Fourier domain optical coherence tomography system to measure mouse organ of Corti vibrations in two cochlear turns

      Development of a phase-sensitive Fourier domain optical coherence tomography system to measure mouse organ of Corti vibrations in two cochlear turns
      In this study, we have developed a phase-sensitive Fourier-domain optical coherence tomography system to simultaneously measure the in vivo inner ear vibrations in the hook area and second turn of the mouse cochlea. This technical development will enable measurement of intra-cochlear distortion products at ideal locations such as the distortion product generation site and reflection site. This information is necessary to un-mix the complex mixture of intra-cochlear waves comprising the ...
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    14. 1-15 of 46 1 2 3 »
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  2. About University of Michigan

    University of Michigan

    The University of Michigan, Ann Arbor (UM, U of M or U-M) is a coeducational public research university in the state of Michigan, and one of the foremost universities in the United States. The university was founded in 1817 in Detroit, about 20 years before the territory of Michigan officially became a state, and moved to Ann Arbor in 1837. Today, it is the state's oldest university and the flagship campus of the University of Michigan system, which now has two satellite campuses, the University of Michigan, Flint and the University of Michigan, Dearborn.  In its 2007 edition, U.S. News & World Report ranked the university's undergraduate program 2nd in the United States among public universities and 24th among all universities. In its last published survey in 1995 the National Research Council ranked UM 3rd in the United States in a study that spanned 41 graduate disciplines as to aggregate quality of graduate programs. The university has one of the largest research expenditures of any American university and one of the largest number of living alumni at 420,000. UM also owns one of the most well-regarded academic medical centers in the United States, the University of Michigan Health System. The university is also recognized for its history of student activism and its athletic teams, notably in football, men's basketball, and ice hockey.  Despite being a public institution, the University of Michigan is known for its high student fees; tuition for out-of-state students is currently the most expensive in the country. Also, though the university successfully affirmed before the U.S. Supreme Court that consideration of race as a factor in admissions to universities was constitutional in 2003, Michigan voters approved restrictions on affirmative action in public universities and governmental hiring in November 2006. This forced UM to cease using race and gender as criteria for admissions."