1. University of Michigan

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    1. Mentioned In 55 Articles

    2. High-resolution multimodal photoacoustic microscopy and optical coherence tomography image-guided laser induced branch retinal vein occlusion in living rabbits

      High-resolution multimodal photoacoustic microscopy and optical coherence tomography image-guided laser induced branch retinal vein occlusion in living rabbits
      Joint high-resolution multimodal photoacoustic microscopy (PAM) and optical coherence tomography (OCT) was developed to improve the efficiency for visualizing newly developed retinal neovascularization (RNV) and to monitor the dynamic changes of retinal vein occlusion (RVO) in living rabbits. The RNV and RVO models were created in New Zealand rabbits by Rose Bengal laser-induced RVO. Dual modalities imaging equipment, including color fundus photography, fluorescein angiography (FA), OCT, and PAM, was used ...
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    3. In Vivo 3D Imaging of Retinal Neovascularization Using Multimodal Photoacoustic Microscopy and Optical Coherence Tomography Imaging

      In Vivo 3D Imaging of Retinal Neovascularization Using Multimodal Photoacoustic Microscopy and Optical Coherence Tomography Imaging
      The pathological process of neovascularization of the retina plays a critical role in causing vision loss in several diseases, including diabetes, retinal vein occlusion, and sickle cell disease. Retinal neovascularization can lead to vitreous hemorrhage and retinal detachment, yet the pathological process of neovascularization is a complex phenomenon under active investigation. Understanding and monitoring retinal neovascularization is critically important in clinical ophthalmology. This study describes a novel multimodal ocular imaging ...
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    4. Photoacoustic Ophthalmoscopy: Principle, Application, and Future Directions

      Photoacoustic Ophthalmoscopy: Principle, Application, and Future Directions
      Photoacoustic ophthalmoscopy (PAOM) is a novel, hybrid, non-ionizing, and non-invasive imaging technology that has been used to assess the retina. PAOM can provide both anatomic and functional retinal characterizations with high resolution, high sensitivity, high contrast, and a high depth of penetration. Thus, ocular diseases can be precisely detected and visualized at earlier stages, resulting in an improved understanding of pathophysiology, improved management, and the improved monitoring of retinal treatment ...
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    5. High-resolution, in vivo multimodal photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy imaging of rabbit retinal neovascularization

      High-resolution, in vivo multimodal photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy imaging of rabbit retinal neovascularization
      Photoacoustic microscopy (PAM) is an emerging imaging technology that can non-invasively visualize ocular structures in animal eyes. This report describes an integrated multimodality imaging system that combines PAM, optical coherence tomography (OCT), and fluorescence microscopy (FM) to evaluate angiogenesis in larger animal eyes. High-resolution in vivo imaging was performed in live rabbit eyes with vascular endothelial growth factor (VEGF)-induced retinal neovascularization (RNV). The results demonstrate that our multimodality imaging ...
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    6. Three-dimensional endoscopic OCT using sparse sampling with a miniature magnetic-driven scanning probe

      Three-dimensional endoscopic OCT using sparse sampling with a miniature magnetic-driven scanning probe
      We propose to apply sparse sampling and compressive sensing (CS) reconstruction in three-dimensional (3D) endoscopic optical coherence tomography (OCT) to reduce the amount of data required in the imaging process. We used a homemade miniature side-imaging magnetic-driven scanning probe with an outer diameter of 1.4 mm in a 1310 nm swept-source OCT system to acquire two-dimensional (2D) circumferential cross-sectional images of an ex vivo pigeon trachea sample. 3D imaging ...
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    7. Advances in Retinal Optical Imaging

      Advances in Retinal Optical Imaging
      Retinal imaging has undergone a revolution in the past 50 years to allow for better understanding of the eye in health and disease. Significant improvements have occurred both in hardware such as lasers and optics in addition to software image analysis. Optical imaging modalities include optical coherence tomography (OCT), OCT angiography (OCTA), photoacoustic microscopy (PAM), scanning laser ophthalmoscopy (SLO), adaptive optics (AO), fundus autofluorescence (FAF), and molecular imaging (MI). These ...
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    8. Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes

      Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes
      Photoacoustic ocular imaging is an emerging ophthalmic imaging technology that can noninvasively visualize ocular tissue by converting light energy into sound waves and is currently under intensive investigation. However, most reported work to date is focused on the imaging of the posterior segment of the eyes of small animals, such as rats and mice, which poses challenges for clinical human translation due to small eyeball sizes. This manuscript describes a ...
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    9. Integrated photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy for multimodal chorioretinal imaging

      Integrated photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy for multimodal chorioretinal imaging
      Current clinical available retinal imaging techniques have limitations, including limited depth of penetration or requirement for the invasive injection of exogenous contrast agents. Here, we developed a novel multimodal imaging system for high-speed, high-resolution retinal imaging of larger animals, such as rabbits. The system integrates three state-of-the-art imaging modalities, including photoacoustic microscopy (PAM), optical coherence tomography (OCT), and fluorescence microscopy (FM). In vivo experimental results of rabbit eyes show that ...
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    10. Optical coherence tomography and T cell gene expression analysis in patients with benign multiple sclerosis

      Optical coherence tomography and T cell gene expression analysis in patients with benign multiple sclerosis
      Benign multiple sclerosis is a retrospective diagnosis based primarily on a lack of motor symptom progression. Recent findings that suggest patients with benign multiple sclerosis experience non-motor symptoms highlight the need for a more prospective means to diagnose benign multiple sclerosis early in order to help direct patient care. In this study, we present optical coherence tomography and T cell neurotrophin gene analysis findings in a small number of patients ...
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  2. About University of Michigan

    University of Michigan

    The University of Michigan, Ann Arbor (UM, U of M or U-M) is a coeducational public research university in the state of Michigan, and one of the foremost universities in the United States. The university was founded in 1817 in Detroit, about 20 years before the territory of Michigan officially became a state, and moved to Ann Arbor in 1837. Today, it is the state's oldest university and the flagship campus of the University of Michigan system, which now has two satellite campuses, the University of Michigan, Flint and the University of Michigan, Dearborn.  In its 2007 edition, U.S. News & World Report ranked the university's undergraduate program 2nd in the United States among public universities and 24th among all universities. In its last published survey in 1995 the National Research Council ranked UM 3rd in the United States in a study that spanned 41 graduate disciplines as to aggregate quality of graduate programs. The university has one of the largest research expenditures of any American university and one of the largest number of living alumni at 420,000. UM also owns one of the most well-regarded academic medical centers in the United States, the University of Michigan Health System. The university is also recognized for its history of student activism and its athletic teams, notably in football, men's basketball, and ice hockey.  Despite being a public institution, the University of Michigan is known for its high student fees; tuition for out-of-state students is currently the most expensive in the country. Also, though the university successfully affirmed before the U.S. Supreme Court that consideration of race as a factor in admissions to universities was constitutional in 2003, Michigan voters approved restrictions on affirmative action in public universities and governmental hiring in November 2006. This forced UM to cease using race and gender as criteria for admissions."