1. University of Michigan

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    1. Mentioned In 61 Articles

    2. Density-based classification in diabetic retinopathy through thickness of retinal layers from optical coherence tomography

      Density-based classification in diabetic retinopathy through thickness of retinal layers from optical coherence tomography
      Diabetic retinopathy (DR) is a severe retinal disorder that can lead to vision loss, however, its underlying mechanism has not been fully understood. Previous studies have taken advantage of Optical Coherence Tomography (OCT) and shown that the thickness of individual retinal layers are affected in patients with DR. However, most studies analyzed the thickness by calculating summary statistics from retinal thickness maps of the macula region. This study aims to ...
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    3. High Resolution Multimodal Photoacoustic Microscopy and Optical Coherence Tomography Visualization of Choroidal Vascular Occlusion

      High Resolution Multimodal Photoacoustic Microscopy and Optical Coherence Tomography Visualization of Choroidal Vascular Occlusion
      Photoacoustic microscopy is a novel, non-ionizing, non-invasive imaging technology that evaluates tissue absorption of short-pulsed light through the sound waves emitted by the tissue and has numerous biomedical applications. In this study, a custom-built multimodal imaging system, including photoacoustic microscopy (PAM) and optical coherence tomography (OCT), has been developed to evaluate choroidal vascular occlusion (CVO). CVO was performed on three living rabbits using laser photocoagulation. Longitudinal imaging of CVO was ...
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    4. Optical coherence tomography and fluorescence microscopy dual-modality imaging for in vivo single-cell tracking with nanowire lasers

      Optical coherence tomography and fluorescence microscopy dual-modality imaging for in vivo single-cell tracking with nanowire lasers
      Emerging cell-based therapies such as stem cell therapy and immunotherapy have attracted broad attention in both biological research and clinical practice. However, a long-standing technical gap of cell-based therapies is the difficulty of directly assessing treatment efficacy via tracking therapeutically administered cells. Therefore, imaging techniques to follow the in vivo distribution and migration of cells are greatly needed. Optical coherence tomography (OCT) is a clinically available imaging technology with ultrahigh-resolution ...
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    5. Simultaneous photoacoustic microscopy, spectral-domain optical coherence tomography, and fluorescein microscopy multi-modality retinal imaging

      Simultaneous photoacoustic microscopy, spectral-domain optical coherence tomography, and fluorescein microscopy multi-modality retinal imaging
      The goal of this study is to further develop a multi-modality eye imaging system and evaluate its feasibility of acquiring images of different modalities simultaneously. An integrated multimodality imaging system combining spectral-domain optical coherence tomography (SD-OCT), photoacoustic microscopy (PAM), and fluorescence microscopy (FM) was developed, and its performance for eye imaging was validated on multiple clinically-relevant retinal disease models in vivo in rabbits. OCT imaging allows for visualization of the ...
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    6. OCTA: A Practical Method of Image Averaging Using Adobe Photoshop Software

      OCTA: A Practical Method of Image Averaging Using Adobe Photoshop Software
      BACKGROUND AND OBJECTIVE: To describe a method for averaging ocular coherence tomography angiography (OCTA) images using a commercially available photo editing software: Adobe Photoshop CC 2017. PATIENTS AND METHODS: This single-center study assessed the feasibility of using Adobe Photoshop as an OCTA image averaging tool. Three 3.0 mm 3.0 mm OCTA images from each eye were obtained using commercially available OCTA devices. Captured OCTA images were exported in ...
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    7. Cerebral edema detection in vivo after middle cerebral artery occlusion using swept-source optical coherence tomography

      Cerebral edema detection in vivo after middle cerebral artery occlusion using swept-source optical coherence tomography
      Cerebral edema is a severe complication of ischemic cerebrovascular disease, which can lead to microcirculation compression resulting in additional ischemic damage. Real-time and continuous in vivo imaging techniques for edema detection are of great significance to basic research on cerebral edema. We attempted to monitor the cerebral edema status in rats with middle cerebral artery occlusion (MCAO) over time, using a wide field-of-view swept-source optical coherence tomography (SS-OCT) system. Optical ...
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    8. High-resolution multimodal photoacoustic microscopy and optical coherence tomography image-guided laser induced branch retinal vein occlusion in living rabbits

      High-resolution multimodal photoacoustic microscopy and optical coherence tomography image-guided laser induced branch retinal vein occlusion in living rabbits
      Joint high-resolution multimodal photoacoustic microscopy (PAM) and optical coherence tomography (OCT) was developed to improve the efficiency for visualizing newly developed retinal neovascularization (RNV) and to monitor the dynamic changes of retinal vein occlusion (RVO) in living rabbits. The RNV and RVO models were created in New Zealand rabbits by Rose Bengal laser-induced RVO. Dual modalities imaging equipment, including color fundus photography, fluorescein angiography (FA), OCT, and PAM, was used ...
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    9. In Vivo 3D Imaging of Retinal Neovascularization Using Multimodal Photoacoustic Microscopy and Optical Coherence Tomography Imaging

      In Vivo 3D Imaging of Retinal Neovascularization Using Multimodal Photoacoustic Microscopy and Optical Coherence Tomography Imaging
      The pathological process of neovascularization of the retina plays a critical role in causing vision loss in several diseases, including diabetes, retinal vein occlusion, and sickle cell disease. Retinal neovascularization can lead to vitreous hemorrhage and retinal detachment, yet the pathological process of neovascularization is a complex phenomenon under active investigation. Understanding and monitoring retinal neovascularization is critically important in clinical ophthalmology. This study describes a novel multimodal ocular imaging ...
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    10. Photoacoustic Ophthalmoscopy: Principle, Application, and Future Directions

      Photoacoustic Ophthalmoscopy: Principle, Application, and Future Directions
      Photoacoustic ophthalmoscopy (PAOM) is a novel, hybrid, non-ionizing, and non-invasive imaging technology that has been used to assess the retina. PAOM can provide both anatomic and functional retinal characterizations with high resolution, high sensitivity, high contrast, and a high depth of penetration. Thus, ocular diseases can be precisely detected and visualized at earlier stages, resulting in an improved understanding of pathophysiology, improved management, and the improved monitoring of retinal treatment ...
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    11. High-resolution, in vivo multimodal photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy imaging of rabbit retinal neovascularization

      High-resolution, in vivo multimodal photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy imaging of rabbit retinal neovascularization
      Photoacoustic microscopy (PAM) is an emerging imaging technology that can non-invasively visualize ocular structures in animal eyes. This report describes an integrated multimodality imaging system that combines PAM, optical coherence tomography (OCT), and fluorescence microscopy (FM) to evaluate angiogenesis in larger animal eyes. High-resolution in vivo imaging was performed in live rabbit eyes with vascular endothelial growth factor (VEGF)-induced retinal neovascularization (RNV). The results demonstrate that our multimodality imaging ...
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    12. Three-dimensional endoscopic OCT using sparse sampling with a miniature magnetic-driven scanning probe

      Three-dimensional endoscopic OCT using sparse sampling with a miniature magnetic-driven scanning probe
      We propose to apply sparse sampling and compressive sensing (CS) reconstruction in three-dimensional (3D) endoscopic optical coherence tomography (OCT) to reduce the amount of data required in the imaging process. We used a homemade miniature side-imaging magnetic-driven scanning probe with an outer diameter of 1.4 mm in a 1310 nm swept-source OCT system to acquire two-dimensional (2D) circumferential cross-sectional images of an ex vivo pigeon trachea sample. 3D imaging ...
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  2. About University of Michigan

    University of Michigan

    The University of Michigan, Ann Arbor (UM, U of M or U-M) is a coeducational public research university in the state of Michigan, and one of the foremost universities in the United States. The university was founded in 1817 in Detroit, about 20 years before the territory of Michigan officially became a state, and moved to Ann Arbor in 1837. Today, it is the state's oldest university and the flagship campus of the University of Michigan system, which now has two satellite campuses, the University of Michigan, Flint and the University of Michigan, Dearborn.  In its 2007 edition, U.S. News & World Report ranked the university's undergraduate program 2nd in the United States among public universities and 24th among all universities. In its last published survey in 1995 the National Research Council ranked UM 3rd in the United States in a study that spanned 41 graduate disciplines as to aggregate quality of graduate programs. The university has one of the largest research expenditures of any American university and one of the largest number of living alumni at 420,000. UM also owns one of the most well-regarded academic medical centers in the United States, the University of Michigan Health System. The university is also recognized for its history of student activism and its athletic teams, notably in football, men's basketball, and ice hockey.  Despite being a public institution, the University of Michigan is known for its high student fees; tuition for out-of-state students is currently the most expensive in the country. Also, though the university successfully affirmed before the U.S. Supreme Court that consideration of race as a factor in admissions to universities was constitutional in 2003, Michigan voters approved restrictions on affirmative action in public universities and governmental hiring in November 2006. This forced UM to cease using race and gender as criteria for admissions."