1. University of Melbourne

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    1. Mentioned In 90 Articles

    2. Validation of an Automated Quantification of Relative Ellipsoid Zone Reflectivity on Spectral Domain-Optical Coherence Tomography Images

      Validation of an Automated Quantification of Relative Ellipsoid Zone Reflectivity on Spectral Domain-Optical Coherence Tomography Images
      Purpose : Relative ellipsoid zone reflectivity (rEZR) represents a potential biomarker of photoreceptor health on spectral-domain optical coherence tomography (SD-OCT). Because manual quantification of rEZR is laborious and lacks of spatial resolution, automated quantification of the rEZR would be beneficial. The purpose of this study was to evaluate the reliability and reproducibility of an automated rEZR quantification method. Methods : The rEZR was acquired using a manual and an automated approach in ...
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    3. High Spatial Endothelial Shear Stress Gradient Independently Predicts Site of Acute Coronary Plaque Rupture and Erosion

      High Spatial Endothelial Shear Stress Gradient Independently Predicts Site of Acute Coronary Plaque Rupture and Erosion
      Aims To investigate local haemodynamics in the setting of acute coronary plaque rupture and erosion. Methods and Results Intracoronary optical coherence tomography performed in 37 patients with acute coronary syndromes caused by plaque rupture (n=19) or plaque erosion (n=18) was used for 3D reconstruction and computational fluid dynamic simulation. Endothelial shear stress (ESS), spatial ESS gradient (ESSG), and oscillatory shear index (OSI) were compared between plaque rupture and ...
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    4. Predicting Progression of Age-Related Macular Degeneration Using Optical Coherence Tomography and Fundus Photography

      Predicting Progression of Age-Related Macular Degeneration Using Optical Coherence Tomography and Fundus Photography
      Purpose To compare the performance of automatically quantified optical coherence tomography (OCT) imaging biomarkers and conventional risk factors manually graded on color fundus photographs (CFP) for predicting progression to late age-related macular degeneration (AMD). Design Longitudinal observational study. Participants 280 eyes from 140 participants with bilateral large drusen. Methods All participants underwent OCT and CFP imaging at baseline and were then reviewed at six-monthly intervals to determine progression to late ...
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    5. A Topographic Comparison of OCT Minimum rim Width (BMO-MRW) and Circumpapillary Retinal nerve Fiber Layer (cRNFL) Thickness Measures in Eyes with or Suspected Glaucoma

      A Topographic Comparison of OCT Minimum rim Width (BMO-MRW) and Circumpapillary Retinal nerve Fiber Layer (cRNFL) Thickness Measures in Eyes with or Suspected Glaucoma
      Prcis: Bruchs membrane opening-minimum rim width and circumpapillary retinal nerve fiber layer thickness measures may be improved by comparing probability levels and accounting for blood vessel locations. Purpose: To understand the differences between two optical coherence tomography (OCT) measures of glaucomatous damage: the Bruchs membrane opening-minimum rim width ( BMO-MRW ) and circumpapillary retinal nerve fiber layer (cRNFL) thickness. Materialsand Methods: OCT circle scans were obtained for an early glaucoma group (EG ...
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    6. Quantitative Phase Imaging Using Digital Holographic Microscopy Reliably Assesses Morphology and Reflects Elastic Properties of Fibrotic Intestinal Tissue

      Quantitative Phase Imaging Using Digital Holographic Microscopy Reliably Assesses Morphology and Reflects Elastic Properties of Fibrotic Intestinal Tissue
      Intestinal strictures are a frequent complication in patients with Crohns Disease (CD) and the presence of fibrosis within strictures impacts the therapeutic treatment approach. Here, we evaluate quantitative phase imaging (QPI) using digital holographic microscopy (DHM) for the evaluation of fibrosis within CD strictures. 30 full thickness resection specimens were obtained from non-stenotic and stenotic tissue areas of 15 CD patients. Cryostat sections were analyzed by DHM to measure the ...
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    7. Sample Size Requirements of Glaucoma Clinical Trials When Using Combined Optical Coherence Tomography and Visual Field Endpoints

      Sample Size Requirements of Glaucoma Clinical Trials When Using Combined Optical Coherence Tomography and Visual Field Endpoints
      Glaucoma clinical trials using visual field (VF) endpoints currently require large sample sizes because of the slowly-progressive nature of this disease. We sought to examine whether the combined use of VF testing and non-invasive optical coherence tomography (OCT) imaging of the neuroretinal tissue could improve the feasibility of such trials. To examine this, we included 192 eyes of 121 glaucoma participants seen at 5 visits over a 2-year period to ...
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    8. Qualitative evaluation of neuroretinal rim and retinal nerve fibre layer on optical coherence tomography to detect glaucomatous damage

      Qualitative evaluation of neuroretinal rim and retinal nerve fibre layer on optical coherence tomography to detect glaucomatous damage
      Purpose To understand the added value of Bruchs membrane opening-minimum rim width (BMO-MRW) measurements to conventional circumpapillary retinal nerve fibre layer (cpRNFL) thickness measurements on optical coherence tomography (OCT) imaging for discriminating between perimetric glaucoma and healthy eyes, evaluated through a qualitative evaluation. Methods 384 healthy eyes and 188 glaucoma eyes were evaluated, and glaucoma eyes were categorised as perimetric (n=107) based on a history of 3 consecutive abnormal ...
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    9. Anterior segment optical coherence tomography angiography

      Anterior segment optical coherence tomography angiography
      We present a novel method to image the vasculature of the anterior segment of the eye using a non-invasive optical coherence tomography angiography (OCTA) system with a modified lens system. This system utilises the Heidelberg Spectralis OCTA and a 3D printed lens mount holding a simple biconvex lens in place to allow capture of images in the anterior segment.
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    10. Optical coherence tomography: seeing the unseen

      Optical coherence tomography: seeing the unseen
      ptical coherence tomography (OCT) is an imaging technology that has revolutionised the way we detect and manage ocular disease. Quite simply, it allows the clinician to visualise ocular pathology previously not detectable or only evident in advanced disease. OCT has its roots in ultrafast laser‐activated shutters to photograph light echoes, which allowed the depth of objects to be captured. Duguay and Mattick 1 at ATT Bell Laboratories in 1971 ...
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    11. Clozapine-Induced Myocarditis or Acute Coronary Syndrome? Optical Coherence Tomography to the Rescue

      Clozapine-Induced Myocarditis or Acute Coronary Syndrome? Optical Coherence Tomography to the Rescue
      Chest pain and troponin elevation may be due to an acute coronary syndrome, myocarditis, acute cardiomyopathy, or other less common conditions. Management differs depending on the aetiology, and the pathophysiologic diagnosis has direct implications on treatment and patient outcomes. History and clinical examination is supplemented by selected investigations including the electrocardiogram, chest X-ray, echocardiography, coronary angiography, and even myocardial perfusion scintigraphy or cardiac magnetic resonance imaging. Intravascular imaging can provide ...
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    12. An Automated Method for Choroidal Thickness Measurement from Enhanced Depth Imaging Optical Coherence Tomography Images

      An Automated Method for Choroidal Thickness Measurement from Enhanced Depth Imaging Optical Coherence Tomography Images
      The choroid is vascular tissue located underneath the retina and supplies oxygen to the outer retina; any damage to this tissue can be a precursor to retinal diseases. This paper presents an automated method of choroidal segmentation from enhanced depth imaging optical coherence tomography (EDI-OCT) images. The Dijkstra shortest path algorithm is used to segment the choroid-sclera interface (CSI), the outermost border of the choroid. A novel intensity-normalisation technique that ...
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    13. Qualitative and quantitative assessment of posterior segment optical coherence tomography images using standard photos: the Liwan Eye Study

      Qualitative and quantitative assessment of posterior segment optical coherence tomography images using standard photos: the Liwan Eye Study
      Background/aims To develop a standardised grading scheme, using standard photos, for spectral-domain ocular coherence tomography (SD-OCT) images of the posterior eye and evaluate the interobserver agreement among trained ophthalmologists in identifying pathological changes. Methods Subjects were recruited from Liwan District, Guangzhou, with SD-OCT data collection from June 2013 to November 2013 as part of 10-year follow-up visits from the Liwan Eye Study. All subjects underwent SD-OCT imaging of the ...
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    14. Automatic optical coherence tomography imaging analysis for retinal disease screening (Thesis)

      Automatic optical coherence tomography imaging analysis for retinal disease screening (Thesis)
      The retina and the choroid are two important structures of the eye and on which the quality of eye sight depends. They have many tissue layers which are very important for monitoring the health and the progression of the eye disease from an early stage. These layers can be visualised using Optical Coherence Tomography (OCT) imaging. The abnormalities in these layers are indications of several eye diseases that can lead ...
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  2. About University of Melbourne

    University of Melbourne

    University of Melbourne, is a public university located in Melbourne, Victoria. The second oldest university in Australia, and the oldest in Victoria, its main campus is in Parkville, an inner suburb just north of the Melbourne CBD. Other campuses across Melbourne and rural Victoria have been acquired through amalgamation with smaller colleges of advanced education. It is a member of Australia's "Group of Eight" lobby group, and the Sandstone universities. Melbourne University is ranked amongst the top universities both in Australia and the world. The University is highly regarded in the fields of the arts, humanities, and biomedicine. The University has almost 40,000 students, who are supported by nearly 6,000 staff members (full or part-time).