1. University of Melbourne

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    1. Mentioned In 100 Articles

    2. Optical Coherence Tomography of Coronary Plaque Progression and Destabilization: JACC Focus Seminar Part 3/3

      Optical Coherence Tomography of Coronary Plaque Progression and Destabilization: JACC Focus Seminar Part 3/3
      The development of optical coherence tomography (OCT) has revolutionized our understanding of coronary artery disease. In vivo OCT research has paralleled with advances in computational fluid dynamics, providing additional insights in the various hemodynamic factors influencing plaque growth and stability. Recent OCT studies introduced a new concept of plaque healing in relation to clinical presentation. In addition to known mechanisms of acute coronary syndromes such as plaque rupture and plaque ...
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    3. The eye in migraine: a review of retinal imaging findings in migraine

      The eye in migraine: a review of retinal imaging findings in migraine
      Migraine is a common headache disorder with neurovascular involvement. Because eyecare practitioners are likely to encounter people with migraine in their everyday practice, it is important to understand how migraine might impact on ocular health. In this narrative review, we provide an update on the latest ophthalmic imaging evidence for retinal involvement in migraine, derived from studies of retinal structure and retinal vascular perfusion using spectral domain and swept source ...
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    4. Optical coherence tomography in ablation-related coronary artery injury

      Optical coherence tomography in ablation-related coronary artery injury
      A 43-year-old male with recurrent atrioventricular re-entrant tachycardia refractory to adenosine, amiodarone, and intravenous flecainide underwent a right femoral access radiofrequency ablation (RFA) using four sheaths (6F, 7F, 28F). The procedure was performed using TactiCath DF irrigated contact force ablation catheter and EnSite Precision 3D mapping system (Abbott Laboratories, Chicago, IL, USA). Earliest atrial activation was found at the middle coronary sinus (CS) electrodes. Following trans-septal puncture to access the ...
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    5. A normative database of A-scan data using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography machine

      A normative database of A-scan data using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography machine
      Purpose To develop the first normative database of macular and circumpapillary scans with reference values at the level of the A-scan using the Heidelberg Spectralis Optical Coherence Tomography (OCT) machine. Methods This study is a retrospective cross sectional analysis of macular and circumpapillary OCT scans of healthy individuals. All participants had a full ophthalmic examination, including best corrected visual acuity, intraocular pressure, biomicroscopy, posterior segment examination and OCT scan. The ...
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    6. The APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies

      The APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies
      Objective: To update the consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results, thus revising the previously published Advised Protocol for OCT Study Terminology and Elements (APOSTEL) recommendations. Methods: To identify studies reporting quantitative OCT results, we performed a PubMed search for the terms "quantitative" and "optical coherence tomography" from 2015 to 2017. Corresponding authors of the identified publications were invited to provide feedback on the initial ...
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    7. Optical Coherence Tomography Signs of Early Atrophy in Age-related Macular Degeneration: Inter-Reader Agreement. CAM Report 6

      Optical Coherence Tomography Signs of Early Atrophy in Age-related Macular Degeneration: Inter-Reader Agreement. CAM Report 6
      Objective: To determine the inter-reader agreement for incomplete and complete retinal pigment epithelium and outer retinal atrophy (iRORA and cRORA respectively) and their related features in age-related macular degeneration (AMD). Design: Inter-reader agreement study. Participants: Twelve readers from six reading centers. Methods: Following formal training, readers qualitatively assessed 60 optical coherence tomography (OCT) B-scans from 60 eyes with AMD for nine individual features associated with early atrophy and performed seven ...
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    8. A Normative Database of A-Scan Data Using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography Machine

      A Normative Database of A-Scan Data Using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography Machine
      Purpose Develop the first normative database of macular and circumpapillary scans with reference values at the level of the A-scan using the Heidelberg Spectralis Optical Coherence Tomography (OCT) machine. Methods This study is a retrospective cross sectional analysis of macular and circumpapillary OCT scans of healthy individuals. All participants had a full ophthalmic examination, including best corrected visual acuity, intraocular pressure, biomicroscopy, posterior segment examination and OCT scan. The volume ...
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    9. Objective quantification of lens nuclear opacities using swept-source anterior segment optical coherence tomography

      Objective quantification of lens nuclear opacities using swept-source anterior segment optical coherence tomography
      Background/aims: The primary objective is to quantify the lens nuclear opacity using swept-source anterior segment optical coherence tomography (SS-ASOCT) and to evaluate its correlations with Lens Opacities Classification System III (LOCS-III) system and surgical parameters. The secondary objective is to assess the diagnostic performance for hard nuclear cataract. Methods: This cross-sectional study included 1222 patients eligible for cataract surgery (1222 eyes). The latest SS-ASOCT (CASIA-2) was used to obtain ...
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    10. Early diagnosis of multiple sclerosis by OCT analysis using Cohen's d method and a neural network as classifier

      Early diagnosis of multiple sclerosis by OCT analysis using Cohen's d method and a neural network as classifier
      Background The consequences of inflammation, demyelination, axonal degeneration and neuronal loss in the central nervous system, typical of the development of multiple sclerosis (MS), are manifested in thinning of the retina and optic nerve. The purpose of this work is to diagnose early-stage MS patients based on analysis of retinal layer thickness obtained by swept-source optical coherence tomography (SS-OCT). Method OCT (Triton SS-OCT device -Topcon, Tokyo, Japan-) recordings were obtained ...
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    11. Hyper-reflectivity on optical coherence tomography in macular telangiectasia type 2

      Hyper-reflectivity on optical coherence tomography in macular telangiectasia type 2
      Purpose: To define, characterize and classify hyper-reflectivity on optical coherence tomography (OCT) and report its prevalence in macular telangiectasia type 2 (MacTel). Methods: In a primary cross-sectional analysis, multimodal imaging data were retrospectively analyzed. The definition of hyper-reflectivity and neovascularization on OCT followed OCT-angiography-based criteria. Eyes were graded for the presence of hyper-reflectivity and neovascularization and further categorized into three classes based on position and extent of hyper-reflectivity. In a ...
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    12. Validation of an Automated Quantification of Relative Ellipsoid Zone Reflectivity on Spectral Domain-Optical Coherence Tomography Images

      Validation of an Automated Quantification of Relative Ellipsoid Zone Reflectivity on Spectral Domain-Optical Coherence Tomography Images
      Purpose : Relative ellipsoid zone reflectivity (rEZR) represents a potential biomarker of photoreceptor health on spectral-domain optical coherence tomography (SD-OCT). Because manual quantification of rEZR is laborious and lacks of spatial resolution, automated quantification of the rEZR would be beneficial. The purpose of this study was to evaluate the reliability and reproducibility of an automated rEZR quantification method. Methods : The rEZR was acquired using a manual and an automated approach in ...
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    13. High Spatial Endothelial Shear Stress Gradient Independently Predicts Site of Acute Coronary Plaque Rupture and Erosion

      High Spatial Endothelial Shear Stress Gradient Independently Predicts Site of Acute Coronary Plaque Rupture and Erosion
      Aims To investigate local haemodynamics in the setting of acute coronary plaque rupture and erosion. Methods and Results Intracoronary optical coherence tomography performed in 37 patients with acute coronary syndromes caused by plaque rupture (n=19) or plaque erosion (n=18) was used for 3D reconstruction and computational fluid dynamic simulation. Endothelial shear stress (ESS), spatial ESS gradient (ESSG), and oscillatory shear index (OSI) were compared between plaque rupture and ...
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    14. Predicting Progression of Age-Related Macular Degeneration Using Optical Coherence Tomography and Fundus Photography

      Predicting Progression of Age-Related Macular Degeneration Using Optical Coherence Tomography and Fundus Photography
      Purpose To compare the performance of automatically quantified optical coherence tomography (OCT) imaging biomarkers and conventional risk factors manually graded on color fundus photographs (CFP) for predicting progression to late age-related macular degeneration (AMD). Design Longitudinal observational study. Participants 280 eyes from 140 participants with bilateral large drusen. Methods All participants underwent OCT and CFP imaging at baseline and were then reviewed at six-monthly intervals to determine progression to late ...
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    15. A Topographic Comparison of OCT Minimum rim Width (BMO-MRW) and Circumpapillary Retinal nerve Fiber Layer (cRNFL) Thickness Measures in Eyes with or Suspected Glaucoma

      A Topographic Comparison of OCT Minimum rim Width (BMO-MRW) and Circumpapillary Retinal nerve Fiber Layer (cRNFL) Thickness Measures in Eyes with or Suspected Glaucoma
      Prcis: Bruchs membrane opening-minimum rim width and circumpapillary retinal nerve fiber layer thickness measures may be improved by comparing probability levels and accounting for blood vessel locations. Purpose: To understand the differences between two optical coherence tomography (OCT) measures of glaucomatous damage: the Bruchs membrane opening-minimum rim width ( BMO-MRW ) and circumpapillary retinal nerve fiber layer (cRNFL) thickness. Materialsand Methods: OCT circle scans were obtained for an early glaucoma group (EG ...
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    16. Quantitative Phase Imaging Using Digital Holographic Microscopy Reliably Assesses Morphology and Reflects Elastic Properties of Fibrotic Intestinal Tissue

      Quantitative Phase Imaging Using Digital Holographic Microscopy Reliably Assesses Morphology and Reflects Elastic Properties of Fibrotic Intestinal Tissue
      Intestinal strictures are a frequent complication in patients with Crohns Disease (CD) and the presence of fibrosis within strictures impacts the therapeutic treatment approach. Here, we evaluate quantitative phase imaging (QPI) using digital holographic microscopy (DHM) for the evaluation of fibrosis within CD strictures. 30 full thickness resection specimens were obtained from non-stenotic and stenotic tissue areas of 15 CD patients. Cryostat sections were analyzed by DHM to measure the ...
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  2. About University of Melbourne

    University of Melbourne

    University of Melbourne, is a public university located in Melbourne, Victoria. The second oldest university in Australia, and the oldest in Victoria, its main campus is in Parkville, an inner suburb just north of the Melbourne CBD. Other campuses across Melbourne and rural Victoria have been acquired through amalgamation with smaller colleges of advanced education. It is a member of Australia's "Group of Eight" lobby group, and the Sandstone universities. Melbourne University is ranked amongst the top universities both in Australia and the world. The University is highly regarded in the fields of the arts, humanities, and biomedicine. The University has almost 40,000 students, who are supported by nearly 6,000 staff members (full or part-time).