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2. Introduction to the feature issue on the 25 year anniversary of optical coherence tomography
  
  Explore OSA | OSA Publishing Jun 20 2017
  
  This feature issue commemorates the approximately 25 year history of Optical Coherence Tomography (OCT), one of the most successful biophotonic technologies. While OCT has technological origins traceable to ultrafast laser development and fiber optic system test instrumentation of the 1980s, innovations in low coherence interferometry for optical ranging and imaging for biomedical applications in the U.S., Europe and Japan by the early 1990s led to coinage of the now ...
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  Mentions: Brett E. Bouma Johannes F. de Boer Joseph A. Izatt
3. Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography
  
  Explore OSA | OSA Publishing Dec 27 2016 Gastroenterology
  
  Early detection of neoplastic changes remains a critical challenge in clinical cancer diagnosis and treatment. Many cancers arise from epithelial layers such as those of the gastrointestinal (GI) tract. Current standard endoscopic technology is difficult to detect the subsurface lesions. In this research, we investigated the feasibility of a novel multi-modal optical imaging approach including high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence laminar optical tomography (FLOT) for structural and ...
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  Mentions: University of Maryland University of Rochester Harvard University
4. Histopathological Differential Diagnosis of Optical Coherence Tomographic Image Interpretation After Stenting
  
  Explore interventions.onlinejacc.org Nov 29 2016 Cardiology
  
  Objectives The aim of this study was to identify histological features that correlate with terms commonly used to describe optical coherence tomographic (OCT) and optical frequency-domain imaging (OFDI) images of stented vessels, by means of a histopathological validation study using stented human coronary arteries. Background OCT imaging and OFDI are used to evaluate vascular responses to stent implantation. Descriptive terms such as peristrut low attenuation and heterogeneous have been used ...
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  Mentions: University of Maryland Mount Sinai School of Medicine Renu Virmani
5. Coherence gated doppler motion sensor and medical applications
  
  Explore uspto.gov Nov 8 2016 Patents
  
  A motion sensor applicable to medical procedures includes a source of light with a wavelength bandwidth and an optical detector. A first optical coupler terminates in a first probe tip and couples the light into the first probe tip. A second optical coupler terminates in a second probe tip and directs onto the detector scattered light returning through the second probe tip. A presentation device outputs a signal that indicates ...
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  Mentions: University of Maryland Joseph M. Schmitt Yu Chen
6. Imaging Spinal Structures With Polarization-Sensitive Optical Coherence Tomography
  
  Explore IEEE Xplore Sep 27 2016 Neurology
  
  Impact Statement: We investigate polarization-sensitive optical coherence tomography (PS-OCT) to obtain both intensity and polarization contrast images of in vivo and ex vivo spinal structures like subcutaneous fat, supraspinous ligament, interspinous ligament, ligamentum flavum, dura, and spinal cord in a piglet model. The PS-OCT can provide enhanced contrast characteristic structures compared to the intensity OCT; therefore it has the potential for guidance in spine interventional procedures. Abstract: We investigate polarization-sensitive ...
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  Mentions: University of Maryland Yu Chen Fujian Normal University
7. Multi-modality Optical Imaging of Rat Kidney Dysfunction: In Vivo Response to Various Ischemia Times
  
  Explore Home - Springer Aug 16 2016 Developmental Biology , Urology
  
  We observed in vivo kidney dysfunction with various ischemia times at 30, 75, 90, and 120 min using multi-modality optical imaging: optical coherence tomography (OCT), Doppler OCT (DOCT), and two-photon microscopy (TPM). We imaged the renal tubule lumens and glomerulus at several areas of each kidney before, during, and after ischemia of 5-month-old female Munich-Wistar rats. For animals with 30 and 75 min ischemia times, we observed that all areas ...
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  Mentions: University of Maryland Yu Chen Tianjin University
8. Research Associate Position in OCT at the University of Maryland
  
  Explore Optical Coherence Tomography News Jun 13 2016 Jobs & Studentships
  
  ...Position description:
  
  A Postdoctoral Research Associate position is available at the University of Maryland, College Park. Research projects include intraoperative imaging of transplant kidney vi...
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  Mentions: University of Maryland Yu Chen Georgetown University
9. Optical Coherence Tomography of the Aging Kidney
  
  Explore ectrx.org May 5 2016 Urology
  
  Objectives: The aging kidney exhibits a progressive decline in renal function with characteristic histopathologic changes and is a risk factor for renal transplant. However, the degree to which the kidney exhibits this decline depends on several factors that vary from one individual to the next. Optical coherence tomography is an evolving noninvasive imaging technology that has recently been used to evaluate acute tubular necrosis of living-human donor kidneys before their ...
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  Mentions: University of Maryland Yu Chen
10. Validation of Human Small Airway Measurements Using Endobronchial Optical Coherence Tomography
  
  Explore CHEST Journal Apr 21 2016 Pulmonology
  
  PURPOSE: To evaluate the usefulness of endobronchial optical coherence tomography (EB-OCT) in assessing small airways morphology in vivo. METHODS: Twelve patients with pulmonary nodules scheduled for lung resection underwent spirometry, multidetector computed tomography (MDCT) and EB-OCT. We measured Dmean (mean luminal diameter), Ai (inner luminal area), Aw (airway wall area) and Aw% [Aw/(Ai+Aw) 100%] from the 3rd to 5th generation bronchi of RB9 segment by MDCT. Dmean, Ai ...
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  Mentions: University of Maryland
11. OCT imaging of myocardium extending to pulmonary vein
  
  Explore Conference Proceedings Apr 1 2016
  
  In this study, we propose to use optical coherence tomography to enable a direct visualization of myocardium extending into the pulmonary vein (PV). The results showed that there are obvious differences in the morphology of myocardium and fibrous tissue in the transition region of myocardial sleeve, which is in agreement with the histological analysis. In addition, the myocardial area in transition point has three layers in the depth of 1 ...
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  Mentions: University of Maryland Yu Chen Fujian Normal University
12. Optical Coherence Tomographic Elastography Reveals Mesoscale Shear Strain Inhomogeneities in the Annulus Fibrosus
  
  Explore LWW Online Feb 7 2016
  
  Study Design. Basic science study using in vitro tissue testing and imaging to characterize local strains in annulus fibrosus (AF) tissue. Objective. To characterize mesoscale strain inhomogeneities between lamellar and inter-/translamellar (ITL) matrix compartments during tissue shear loading. Summary of Background Data. The intervertebral disc (IVD) is characterized by significant heterogeneities in tissue structure and plays a critical role in load distribution and force transmission in the spine. In ...
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  Mentions: University of Maryland Yu Chen Chao-Wei Chen
13. Optimal operational conditions for supercontinuum-based ultrahigh-resolution endoscopic OCT imaging
  
  Explore OSA | OSA Publishing Jan 9 2016 Gastroenterology , Broadband Sources
  
  We investigated the optimal operational conditions for utilizing a broadband supercontinuum (SC) source in a portable 800 nm spectral-domain (SD) endoscopic OCT system to enable high resolution, high-sensitivity, and high-speed imaging in vivo . A SC source with a 3-dB bandwidth of 246 nm was employed to obtain an axial resolution of 2.7 m (in air) and an optimal detection sensitivity of 107 dB with an imaging speed up to ...
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  Mentions: University of Maryland Xingde Li Jiefeng Xi
14. Validation of human small airway measurements using endobronchial optical coherence tomography
  
  Explore Respiratory Medicine Sep 30 2015 Pulmonology
  
  Background Small airway remodeling is the cardinal feature underlying chronic airway diseases. There is no modality which identifies small airway pathological changes, which is crucial for early diagnosis, efficacy and prognostic assessment. Objective To evaluate the usefulness of endobronchial optical coherence tomography (EB-OCT) in assessing small airways morphology in vivo . Methods Twelve patients with pulmonary nodules scheduled for lung resection underwent spirometry, multi-detector computed tomography (MDCT) and EB-OCT. We measured ...
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  Mentions: University of Maryland Yu Chen Wei Wang
15. The University of Maryland Receives NIH Grant For Monitoring Photo-Immunotherapy Using Multi-Modal Imaging Needles
  
  Explore Optical Coherence Tomography News Sep 8 2015 Funding
  
  ...nment, and will likely be applicable to a wide range of cancer therapies.
  The University of Maryland Receives a 2015 NIH Grant for $76,000 For Monitoring Photo-Immunotherapy Using Multi-Mo...
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  Mentions: University of Maryland National Institutes of Health Yu Chen
16. Observation of sound-induced corneal vibrational modes by optical coherence tomography
  
  Explore OSA | OSA Publishing Aug 11 2015 Ophthalmology
  
  The mechanical stability of the cornea is critical for maintaining its normal shape and refractive function. Here, we report an observation of the mechanical resonance modes of the cornea excited by sound waves and detected by using phase-sensitive optical coherence tomography. The cornea in bovine eye globes exhibited three resonance modes in a frequency range of 50-400 Hz. The vibration amplitude of the fundamental mode at 80-120 Hz was ~8 ...
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  Mentions: Seok-Hyun Yun University of Maryland Massachusetts General Hospital
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