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2. Quantitative Optical Coherence Tomography Methods for Functional Microvascular Imaging (Thesis)
  
  Explore Log In Jun 12 2018 Student Theses
  
  In recent years, the importance of blood flow distribution has been highlighted in a wide range of diseases that involve the cerebral microvasculature. Specifically, microvascular heterogeneity, related to the non-uniform distribution of blood flow through the microvasculature, is an important parameter that is critical to the efficacy of oxygen extraction. As increased heterogeneity may lead to oxygen insufficiency, even with blood flow above ischemic levels, heterogeneity may be an important ...
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  Mentions: University of Maryland Vivek J. Srinivasan
3. 3D mesoscopic fluorescence tomography for imaging micro-distribution of antibody-photon absorber conjugates during near infrared photoimmunotherapy in vivo
  
  Explore ScienceDirect Apr 26 2018
  
  As a novel low-side-effect cancer therapy, photo-immunotherapy (PIT) is based on conjugating monoclonal antibody (mAb) with a near-infrared (NIR) phthalocyanine dye IRDye700DX (IR 700). IR700 is not only fluorescent to be used as an imaging agent, but also phototoxic. When illuminating with NIR light, PIT can induce highly-selective cancer cell death while leaving most of tumor blood vessels unharmed, leading to an effect termed super-enhanced permeability and retention (SUPR), which ...
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  Mentions: University of Maryland FDA Yu Chen
4. Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease
  
  Explore SPIE Digital Library Dec 5 2017 Urology
  
  Chronic kidney disease (CKD) is characterized by a progressive loss of renal function over time. Histopathological analysis of the condition of glomeruli and the proximal convolutional tubules over time can provide valuable insights into the progression of CKD. Optical coherence tomography (OCT) is a technology that can analyze the microscopic structures of a kidney in a nondestructive manner. Recently, we have shown that OCT can provide real-time imaging of kidney ...
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  Mentions: University of Maryland Yu Chen
5. Monitoring Kidney Microanatomy Changes During Ischemia-Reperfusion Process Using Texture Analysis of OCT Images
  
  Explore IEEE Xplore Nov 15 2017 Urology
  
  Impact Statement: Tubular diameter has been developed previously as a potential biomarker for the transplant kidney. However, the tubular lumens were segmented out based on an empirically-determined threshold. In our study, a fully automatic texture analysis algorithm has been developed for OCT image analysis of kidney microanatomy during ischemia-reperfusion process. Our method can potentially be applicable in evaluating the status of donor kidneys prior to and after their transplantation. Abstract ...
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  Mentions: University of Maryland Yu Chen
6. Anticipating, measuring, and minimizing MEMS mirror scan error to improve laser scanning microscopy's speed and accuracy
  
  Explore Journals | PLOS Oct 3 2017 Probes
  
  We describe a method to speed up m icro e lectro m echanical s ystem (MEMS) mirror scanning by 20x, while also improving scan accuracy. We use Landweber deconvolution to determine an input voltage which would produce a desired output, based on the measured MEMS impulse response. Since the MEMS is weakly nonlinear, the observed behavior deviates from expectations, and we iteratively improve our input to minimize this deviation. This ...
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  Mentions: University of Maryland National Institutes of Health
7. Evaluating biomechanical properties of murine embryos using Brillouin microscopy and optical coherence tomography
  
  Explore SPIE Digital Library Sep 9 2017 Developmental Biology
  
  Embryogenesis is regulated by numerous changes in mechanical properties of the cellular microenvironment. Thus, studying embryonic mechanophysiology can provide a more thorough perspective of embryonic development, potentially improving early detection of congenital abnormalities as well as evaluating and developing therapeutic interventions. A number of methods and techniques have been used to study cellular biomechanical properties during embryogenesis. While some of these techniques are invasive or involve the use of external ...
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  Mentions: University of Maryland Kirill V. Larin University of Houston
8. Apparatus and methods for non-invasive assessment of transplant kidney viability
  
  Explore uspto.gov Aug 22 2017 Urology , Patents
  
  A kidney viability assessment system (KVAS) is disclosed which provides objective and reliable tests to assess the viability of transplant or donor kidneys in vivo and predict their post-transplant outcomes. KVAS includes an optical device augmented by an intelligent algorithm that can evaluate the viability or quality of the donor kidney in a real-time, non-invasive way. In particular, it includes a handheld optical coherence tomography (OCT) imaging device and at ...
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  Mentions: University of Maryland Yu Chen Georgetown University
9. Postdoctoral Fellow, Bioengineering at University of Maryland - College Park
  
  Explore Optical Coherence Tomography News Aug 16 2017 Jobs & Studentships
  
  We are seeking a postdoctoral fellow to pursue research on developing novel optical imaging devices and applications on cancer diagnosis, functional brain imaging and tissue engineering. Candidates must hold a Ph.D. in engineering, physics, or related fields and have prior experience with Optics, OCT, Microscopy (e.g. fluorescence, confocal, Two-photon), and image analysis software development. Experience with cell culture and/or animals experiments is a plus. Please submit a ...
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  Mentions: University of Maryland Yu Chen
10. Introduction to the feature issue on the 25 year anniversary of optical coherence tomography
  
  Explore OSA | OSA Publishing Jun 20 2017
  
  This feature issue commemorates the approximately 25 year history of Optical Coherence Tomography (OCT), one of the most successful biophotonic technologies. While OCT has technological origins traceable to ultrafast laser development and fiber optic system test instrumentation of the 1980s, innovations in low coherence interferometry for optical ranging and imaging for biomedical applications in the U.S., Europe and Japan by the early 1990s led to coinage of the now ...
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  Mentions: Brett E. Bouma Johannes F. de Boer Joseph A. Izatt
11. Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography
  
  Explore OSA | OSA Publishing Dec 27 2016 Gastroenterology
  
  Early detection of neoplastic changes remains a critical challenge in clinical cancer diagnosis and treatment. Many cancers arise from epithelial layers such as those of the gastrointestinal (GI) tract. Current standard endoscopic technology is difficult to detect the subsurface lesions. In this research, we investigated the feasibility of a novel multi-modal optical imaging approach including high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence laminar optical tomography (FLOT) for structural and ...
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  Mentions: University of Maryland University of Rochester Harvard University
12. Histopathological Differential Diagnosis of Optical Coherence Tomographic Image Interpretation After Stenting
  
  Explore interventions.onlinejacc.org Nov 29 2016 Cardiology
  
  Objectives The aim of this study was to identify histological features that correlate with terms commonly used to describe optical coherence tomographic (OCT) and optical frequency-domain imaging (OFDI) images of stented vessels, by means of a histopathological validation study using stented human coronary arteries. Background OCT imaging and OFDI are used to evaluate vascular responses to stent implantation. Descriptive terms such as peristrut low attenuation and heterogeneous have been used ...
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  Mentions: University of Maryland Mount Sinai School of Medicine Renu Virmani
13. Coherence gated doppler motion sensor and medical applications
  
  Explore uspto.gov Nov 8 2016 Patents
  
  A motion sensor applicable to medical procedures includes a source of light with a wavelength bandwidth and an optical detector. A first optical coupler terminates in a first probe tip and couples the light into the first probe tip. A second optical coupler terminates in a second probe tip and directs onto the detector scattered light returning through the second probe tip. A presentation device outputs a signal that indicates ...
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  Mentions: University of Maryland Joseph M. Schmitt Yu Chen
14. Imaging Spinal Structures With Polarization-Sensitive Optical Coherence Tomography
  
  Explore IEEE Xplore Sep 27 2016 Neurology
  
  Impact Statement: We investigate polarization-sensitive optical coherence tomography (PS-OCT) to obtain both intensity and polarization contrast images of in vivo and ex vivo spinal structures like subcutaneous fat, supraspinous ligament, interspinous ligament, ligamentum flavum, dura, and spinal cord in a piglet model. The PS-OCT can provide enhanced contrast characteristic structures compared to the intensity OCT; therefore it has the potential for guidance in spine interventional procedures. Abstract: We investigate polarization-sensitive ...
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  Mentions: University of Maryland Yu Chen Fujian Normal University
15. Multi-modality Optical Imaging of Rat Kidney Dysfunction: In Vivo Response to Various Ischemia Times
  
  Explore Home - Springer Aug 16 2016 Developmental Biology , Urology
  
  We observed in vivo kidney dysfunction with various ischemia times at 30, 75, 90, and 120 min using multi-modality optical imaging: optical coherence tomography (OCT), Doppler OCT (DOCT), and two-photon microscopy (TPM). We imaged the renal tubule lumens and glomerulus at several areas of each kidney before, during, and after ischemia of 5-month-old female Munich-Wistar rats. For animals with 30 and 75 min ischemia times, we observed that all areas ...
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  Mentions: University of Maryland Yu Chen Tianjin University
16. Research Associate Position in OCT at the University of Maryland
  
  Explore Optical Coherence Tomography News Jun 13 2016 Jobs & Studentships
  
  ...Position description:
  
  A Postdoctoral Research Associate position is available at the University of Maryland, College Park. Research projects include intraoperative imaging of transplant kidney vi...
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  Mentions: University of Maryland Yu Chen Georgetown University
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