1. University of Maryland

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    1. Mentioned In 110 Articles

    2. University of Maryland Receives NIH Grant for In Vivo Assessment of Meningeal Inflammation and its Clinical Impact in Multiple Sclerosis by 7 Tesla MRI

      University of Maryland Receives NIH Grant for In Vivo Assessment of Meningeal Inflammation and its Clinical Impact in Multiple Sclerosis by 7 Tesla MRI
      ...in whom such treatments would be justified and to monitor treatment response.

      University of Maryland Receives a 2020 NIH Grant for $609,639 for In Vivo Assessment of Meningeal Inflammation...

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    3. A review of imaging modalities for detecting early keratoconus

      A review of imaging modalities for detecting early keratoconus
      Objectives Early identification of keratoconus is imperative for preventing iatrogenic corneal ectasia and allowing for early corneal collagen cross-linking treatments to potentially halt progression and decrease transplant burden. However, early diagnosis of keratoconus is currently a diagnostic challenge as there is no uniform screening criteria. We performed a review of the current literature to assess imaging modalities that can be used to help identify subclinical keratoconus. Methods A Pubmed database ...
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    4. Association of Intimal Neovessels Noted by Optical Coherence Tomography with Cardiac Allograft ...

      Association of Intimal Neovessels Noted by Optical Coherence Tomography with Cardiac Allograft ...
      Background Cardiac allograft vasculopathy (CAV) is a leading cause of graft failure in cardiac transplant recipients. Progression of intimal thickening noted during routine surveillance intracoronary imaging is associated with the development of CAV. However, mechanisms of CAV development are poorly understood and targets for therapy modification remain elusive. We investigated the association of neovessels (INs) within the intima, noted by optical coherence tomography (OCT) during routine CAV surveillance imaging, with ...
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    5. Multimodal quantitative optical elastography of the crystalline lens with optical coherence elastography and Brillouin microscopy

      Multimodal quantitative optical elastography of the crystalline lens with optical coherence elastography and Brillouin microscopy
      Assessing the biomechanical properties of the crystalline lens can provide crucial information for diagnosing disease and guiding precision therapeutic interventions. Existing noninvasive methods have been limited to global measurements. Here, we demonstrate the quantitative assessment of the elasticity of crystalline lens with a multimodal optical elastography technique, which combines dynamic wave-based optical coherence elastography (OCE) and Brillouin microscopy to overcome the drawbacks of individual modalities. OCE can provide direct measurements ...
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    6. Demonstration of Optical Coherence Tomography Guided Big Bubble Technique for Deep Anterior Lamellar Keratoplasty (DALK)

      Demonstration of Optical Coherence Tomography Guided Big Bubble Technique for Deep Anterior Lamellar Keratoplasty (DALK)
      Deep anterior lamellar keratoplasty (DALK) is a highly challenging procedure for cornea transplant that involves removing the corneal layers above Descemets membrane (DM). This is achieved by a big bubble technique where a needle is inserted into the stroma of the cornea down to DM and the injection of either air or liquid. DALK has important advantages over penetrating keratoplasty (PK) including lower rejection rate, less endothelial cell loss, and ...
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    7. 3-D printed photoreceptor phantoms for evaluating lateral resolution of adaptive optics imaging systems

      3-D printed photoreceptor phantoms for evaluating lateral resolution of adaptive optics imaging systems
      With adaptive optics (AO), optical coherence tomography and scanning laser ophthalmoscopy imaging systems can resolve individual photoreceptor cells in living eyes, due to enhanced lateral spatial resolution. However, no standard test method exists for experimentally quantifying this parameter in ophthalmic AO imagers. Here, we present three-dimensional (3-D) printed phantoms, which enable the measurement of lateral resolution in an anatomically relevant manner. We used two-photon polymerization to fabricate two phantoms, which ...
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    8. Depth-resolved mapping of muscular bundles in myocardium pulmonary junction using optical coherence tomography

      Depth-resolved mapping of muscular bundles in myocardium pulmonary junction using optical coherence tomography
      Atrial fibrillation (AF) is the most common cardiac arrhythmia and has high patient morbidity. One of the root causes of AF is initiating triggers from atrial myocardium extending into the pulmonary veins. Visualizing the muscular bundles of myocardial extension is essential to guide the catheter radio-frequency ablation and confirm the curative tissue necrosis thereafter. We applied optical coherence tomography (OCT) for direct visualization of cardial muscle extension in myocardium pulmonary ...
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    9. Quantitative Optical Coherence Tomography Methods for Functional Microvascular Imaging (Thesis)

      Quantitative Optical Coherence Tomography Methods for Functional Microvascular Imaging (Thesis)
      In recent years, the importance of blood flow distribution has been highlighted in a wide range of diseases that involve the cerebral microvasculature. Specifically, microvascular heterogeneity, related to the non-uniform distribution of blood flow through the microvasculature, is an important parameter that is critical to the efficacy of oxygen extraction. As increased heterogeneity may lead to oxygen insufficiency, even with blood flow above ischemic levels, heterogeneity may be an important ...
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    10. 3D mesoscopic fluorescence tomography for imaging micro-distribution of antibody-photon absorber conjugates during near infrared photoimmunotherapy in vivo

      3D mesoscopic fluorescence tomography for imaging micro-distribution of antibody-photon absorber conjugates during near infrared photoimmunotherapy in vivo
      As a novel low-side-effect cancer therapy, photo-immunotherapy (PIT) is based on conjugating monoclonal antibody (mAb) with a near-infrared (NIR) phthalocyanine dye IRDye700DX (IR 700). IR700 is not only fluorescent to be used as an imaging agent, but also phototoxic. When illuminating with NIR light, PIT can induce highly-selective cancer cell death while leaving most of tumor blood vessels unharmed, leading to an effect termed super-enhanced permeability and retention (SUPR), which ...
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    11. Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease

      Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease
      Chronic kidney disease (CKD) is characterized by a progressive loss of renal function over time. Histopathological analysis of the condition of glomeruli and the proximal convolutional tubules over time can provide valuable insights into the progression of CKD. Optical coherence tomography (OCT) is a technology that can analyze the microscopic structures of a kidney in a nondestructive manner. Recently, we have shown that OCT can provide real-time imaging of kidney ...
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    12. Monitoring Kidney Microanatomy Changes During Ischemia-Reperfusion Process Using Texture Analysis of OCT Images

      Monitoring Kidney Microanatomy Changes During Ischemia-Reperfusion Process Using Texture Analysis of OCT Images
      Impact Statement: Tubular diameter has been developed previously as a potential biomarker for the transplant kidney. However, the tubular lumens were segmented out based on an empirically-determined threshold. In our study, a fully automatic texture analysis algorithm has been developed for OCT image analysis of kidney microanatomy during ischemia-reperfusion process. Our method can potentially be applicable in evaluating the status of donor kidneys prior to and after their transplantation. Abstract ...
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    13. Anticipating, measuring, and minimizing MEMS mirror scan error to improve laser scanning microscopy's speed and accuracy

      Anticipating, measuring, and minimizing MEMS mirror scan error to improve laser scanning microscopy's speed and accuracy
      We describe a method to speed up m icro e lectro m echanical s ystem (MEMS) mirror scanning by 20x, while also improving scan accuracy. We use Landweber deconvolution to determine an input voltage which would produce a desired output, based on the measured MEMS impulse response. Since the MEMS is weakly nonlinear, the observed behavior deviates from expectations, and we iteratively improve our input to minimize this deviation. This ...
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  2. About University of Maryland

    University of Maryland

    The University System of Maryland is a public corporation and charter school system comprising 13 Maryland institutions of higher education. It is the 12th-largest university system in the USA with over 100,000 undergraduate, 30,000 graduate and 8,700 faculty.   Some of the major campuses

    University of Maryland, College Park and University of Maryland, Baltimore.