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    1. Mentioned In 91 Articles

    2. Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

      Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography
      Early detection of neoplastic changes remains a critical challenge in clinical cancer diagnosis and treatment. Many cancers arise from epithelial layers such as those of the gastrointestinal (GI) tract. Current standard endoscopic technology is difficult to detect the subsurface lesions. In this research, we investigated the feasibility of a novel multi-modal optical imaging approach including high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence laminar optical tomography (FLOT) for structural and ...
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    3. Histopathological Differential Diagnosis of Optical Coherence Tomographic Image Interpretation After Stenting

      Histopathological Differential Diagnosis of Optical Coherence Tomographic Image Interpretation After Stenting
      Objectives The aim of this study was to identify histological features that correlate with terms commonly used to describe optical coherence tomographic (OCT) and optical frequency-domain imaging (OFDI) images of stented vessels, by means of a histopathological validation study using stented human coronary arteries. Background OCT imaging and OFDI are used to evaluate vascular responses to stent implantation. Descriptive terms such as peristrut low attenuation and heterogeneous have been used ...
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    4. Coherence gated doppler motion sensor and medical applications

      Coherence gated doppler motion sensor and medical applications
      A motion sensor applicable to medical procedures includes a source of light with a wavelength bandwidth and an optical detector. A first optical coupler terminates in a first probe tip and couples the light into the first probe tip. A second optical coupler terminates in a second probe tip and directs onto the detector scattered light returning through the second probe tip. A presentation device outputs a signal that indicates ...
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    5. Imaging Spinal Structures With Polarization-Sensitive Optical Coherence Tomography

      Imaging Spinal Structures With Polarization-Sensitive Optical Coherence Tomography
      Impact Statement: We investigate polarization-sensitive optical coherence tomography (PS-OCT) to obtain both intensity and polarization contrast images of in vivo and ex vivo spinal structures like subcutaneous fat, supraspinous ligament, interspinous ligament, ligamentum flavum, dura, and spinal cord in a piglet model. The PS-OCT can provide enhanced contrast characteristic structures compared to the intensity OCT; therefore it has the potential for guidance in spine interventional procedures. Abstract: We investigate polarization-sensitive ...
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    6. Multi-modality Optical Imaging of Rat Kidney Dysfunction: In Vivo Response to Various Ischemia Times

      Multi-modality Optical Imaging of Rat Kidney Dysfunction: In Vivo Response to Various Ischemia Times
      We observed in vivo kidney dysfunction with various ischemia times at 30, 75, 90, and 120 min using multi-modality optical imaging: optical coherence tomography (OCT), Doppler OCT (DOCT), and two-photon microscopy (TPM). We imaged the renal tubule lumens and glomerulus at several areas of each kidney before, during, and after ischemia of 5-month-old female Munich-Wistar rats. For animals with 30 and 75 min ischemia times, we observed that all areas ...
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    7. Optical Coherence Tomography of the Aging Kidney

      Optical Coherence Tomography of the Aging Kidney
      Objectives: The aging kidney exhibits a progressive decline in renal function with characteristic histopathologic changes and is a risk factor for renal transplant. However, the degree to which the kidney exhibits this decline depends on several factors that vary from one individual to the next. Optical coherence tomography is an evolving noninvasive imaging technology that has recently been used to evaluate acute tubular necrosis of living-human donor kidneys before their ...
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    8. Validation of Human Small Airway Measurements Using Endobronchial Optical Coherence Tomography

      Validation of Human Small Airway Measurements Using Endobronchial Optical Coherence Tomography
      PURPOSE: To evaluate the usefulness of endobronchial optical coherence tomography (EB-OCT) in assessing small airways morphology in vivo. METHODS: Twelve patients with pulmonary nodules scheduled for lung resection underwent spirometry, multidetector computed tomography (MDCT) and EB-OCT. We measured Dmean (mean luminal diameter), Ai (inner luminal area), Aw (airway wall area) and Aw% [Aw/(Ai+Aw) 100%] from the 3rd to 5th generation bronchi of RB9 segment by MDCT. Dmean, Ai ...
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    9. OCT imaging of myocardium extending to pulmonary vein

      OCT imaging of myocardium extending to pulmonary vein
      In this study, we propose to use optical coherence tomography to enable a direct visualization of myocardium extending into the pulmonary vein (PV). The results showed that there are obvious differences in the morphology of myocardium and fibrous tissue in the transition region of myocardial sleeve, which is in agreement with the histological analysis. In addition, the myocardial area in transition point has three layers in the depth of 1 ...
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    10. Optical Coherence Tomographic Elastography Reveals Mesoscale Shear Strain Inhomogeneities in the Annulus Fibrosus

      Optical Coherence Tomographic Elastography Reveals Mesoscale Shear Strain Inhomogeneities in the Annulus Fibrosus
      Study Design. Basic science study using in vitro tissue testing and imaging to characterize local strains in annulus fibrosus (AF) tissue. Objective. To characterize mesoscale strain inhomogeneities between lamellar and inter-/translamellar (ITL) matrix compartments during tissue shear loading. Summary of Background Data. The intervertebral disc (IVD) is characterized by significant heterogeneities in tissue structure and plays a critical role in load distribution and force transmission in the spine. In ...
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    11. Optimal operational conditions for supercontinuum-based ultrahigh-resolution endoscopic OCT imaging

      Optimal operational conditions for supercontinuum-based ultrahigh-resolution endoscopic OCT imaging
      We investigated the optimal operational conditions for utilizing a broadband supercontinuum (SC) source in a portable 800 nm spectral-domain (SD) endoscopic OCT system to enable high resolution, high-sensitivity, and high-speed imaging in vivo . A SC source with a 3-dB bandwidth of 246 nm was employed to obtain an axial resolution of 2.7 m (in air) and an optimal detection sensitivity of 107 dB with an imaging speed up to ...
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    12. Validation of human small airway measurements using endobronchial optical coherence tomography

      Validation of human small airway measurements using endobronchial optical coherence tomography
      Background Small airway remodeling is the cardinal feature underlying chronic airway diseases. There is no modality which identifies small airway pathological changes, which is crucial for early diagnosis, efficacy and prognostic assessment. Objective To evaluate the usefulness of endobronchial optical coherence tomography (EB-OCT) in assessing small airways morphology in vivo . Methods Twelve patients with pulmonary nodules scheduled for lung resection underwent spirometry, multi-detector computed tomography (MDCT) and EB-OCT. We measured ...
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    13. Observation of sound-induced corneal vibrational modes by optical coherence tomography

      Observation of sound-induced corneal vibrational modes by optical coherence tomography
      The mechanical stability of the cornea is critical for maintaining its normal shape and refractive function. Here, we report an observation of the mechanical resonance modes of the cornea excited by sound waves and detected by using phase-sensitive optical coherence tomography. The cornea in bovine eye globes exhibited three resonance modes in a frequency range of 50-400 Hz. The vibration amplitude of the fundamental mode at 80-120 Hz was ~8 ...
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    14. Apparatus And Methods For NON-INVASIVE Assessment Of Transplant Kidney Viability

      Apparatus And Methods For NON-INVASIVE Assessment Of Transplant Kidney Viability
      A kidney viability assessment system (KVAS) is disclosed which provides objective and reliable tests to assess the viability of transplant or donor kidneys in vivo and predict their post-transplant outcomes. KVAS includes an optical device augmented by an intelligent algorithm that can evaluate the viability or quality of the donor kidney in a real-time, non-invasive way. In particular, it includes a handheld optical coherence tomography (OCT) imaging device and at ...
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    15. 1-15 of 91 1 2 3 4 5 6 »
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  2. About University of Maryland

    University of Maryland

    The University System of Maryland is a public corporation and charter school system comprising 13 Maryland institutions of higher education. It is the 12th-largest university system in the USA with over 100,000 undergraduate, 30,000 graduate and 8,700 faculty.   Some of the major campuses

    University of Maryland, College Park and University of Maryland, Baltimore.