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2. Demonstration of Optical Coherence Tomography Guided Big Bubble Technique for Deep Anterior Lamellar Keratoplasty (DALK)
  
  Explore MDPI Open Access Journals Platform Jan 12 2020 Ophthalmology
  
  Deep anterior lamellar keratoplasty (DALK) is a highly challenging procedure for cornea transplant that involves removing the corneal layers above Descemets membrane (DM). This is achieved by a big bubble technique where a needle is inserted into the stroma of the cornea down to DM and the injection of either air or liquid. DALK has important advantages over penetrating keratoplasty (PK) including lower rejection rate, less endothelial cell loss, and ...
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  Mentions: University of Maryland Johns Hopkins University
3. Post-doctoral Adaptive Optics Research Fellow at U.S. Food and Drug Administration
  
  Explore Optical Coherence Tomography News Apr 9 2019 Jobs & Studentships
  
  ...mpact on public health. The candidate will have an opportunity to work with several collaborators at NIH NEI, University of Maryland, and other local clinical and academic sites to develop tools and approaches to acceler...
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  Mentions: University of Maryland Daniel X. Hammer FDA
4. 3-D printed photoreceptor phantoms for evaluating lateral resolution of adaptive optics imaging systems
  
  Explore OSA | OSA Publishing Apr 2 2019
  
  With adaptive optics (AO), optical coherence tomography and scanning laser ophthalmoscopy imaging systems can resolve individual photoreceptor cells in living eyes, due to enhanced lateral spatial resolution. However, no standard test method exists for experimentally quantifying this parameter in ophthalmic AO imagers. Here, we present three-dimensional (3-D) printed phantoms, which enable the measurement of lateral resolution in an anatomically relevant manner. We used two-photon polymerization to fabricate two phantoms, which ...
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  Mentions: University of Maryland National Institutes of Health Daniel X. Hammer
5. AO-OCT Comes into Focus
  
  Explore Photonics.com Feb 25 2019 Ophthalmology
  
  ... Eye Institute of the National Institutes of Health, and Dr. Osamah Saeedi, a clinical ophthalmologist at the University of Maryland 6 . Using a multimodal AO system that combines it with scanning laser ophthalmoscopy an...
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  Mentions: University of Maryland Daniel X. Hammer Wasatch Photonics
6. Watching an embryo's neural tube close
  
  Explore EurekAlert! Sep 4 2018 Developmental Biology
  
  ...ege of Medicine professor Richard H. Finnell and Giuliano Scarcelli, assistant professor of bioengineering at University of Maryland, Larin will create new technology combining Brillouin spectroscopy and optical coherenc...
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  Mentions: University of Maryland National Institutes of Health Baylor College of Medicine
7. Depth-resolved mapping of muscular bundles in myocardium pulmonary junction using optical coherence tomography
  
  Explore SPIE Digital Library Jul 12 2018 Cardiology
  
  Atrial fibrillation (AF) is the most common cardiac arrhythmia and has high patient morbidity. One of the root causes of AF is initiating triggers from atrial myocardium extending into the pulmonary veins. Visualizing the muscular bundles of myocardial extension is essential to guide the catheter radio-frequency ablation and confirm the curative tissue necrosis thereafter. We applied optical coherence tomography (OCT) for direct visualization of cardial muscle extension in myocardium pulmonary ...
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  Mentions: University of Maryland Yu Chen Fujian Normal University
8. Quantitative Optical Coherence Tomography Methods for Functional Microvascular Imaging (Thesis)
  
  Explore Log In Jun 12 2018 Student Theses
  
  In recent years, the importance of blood flow distribution has been highlighted in a wide range of diseases that involve the cerebral microvasculature. Specifically, microvascular heterogeneity, related to the non-uniform distribution of blood flow through the microvasculature, is an important parameter that is critical to the efficacy of oxygen extraction. As increased heterogeneity may lead to oxygen insufficiency, even with blood flow above ischemic levels, heterogeneity may be an important ...
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  Mentions: University of Maryland Vivek J. Srinivasan
9. 3D mesoscopic fluorescence tomography for imaging micro-distribution of antibody-photon absorber conjugates during near infrared photoimmunotherapy in vivo
  
  Explore ScienceDirect Apr 26 2018
  
  As a novel low-side-effect cancer therapy, photo-immunotherapy (PIT) is based on conjugating monoclonal antibody (mAb) with a near-infrared (NIR) phthalocyanine dye IRDye700DX (IR 700). IR700 is not only fluorescent to be used as an imaging agent, but also phototoxic. When illuminating with NIR light, PIT can induce highly-selective cancer cell death while leaving most of tumor blood vessels unharmed, leading to an effect termed super-enhanced permeability and retention (SUPR), which ...
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  Mentions: University of Maryland FDA Yu Chen
10. Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease
  
  Explore SPIE Digital Library Dec 5 2017 Urology
  
  Chronic kidney disease (CKD) is characterized by a progressive loss of renal function over time. Histopathological analysis of the condition of glomeruli and the proximal convolutional tubules over time can provide valuable insights into the progression of CKD. Optical coherence tomography (OCT) is a technology that can analyze the microscopic structures of a kidney in a nondestructive manner. Recently, we have shown that OCT can provide real-time imaging of kidney ...
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  Mentions: University of Maryland Yu Chen
11. Monitoring Kidney Microanatomy Changes During Ischemia-Reperfusion Process Using Texture Analysis of OCT Images
  
  Explore IEEE Xplore Nov 15 2017 Urology
  
  Impact Statement: Tubular diameter has been developed previously as a potential biomarker for the transplant kidney. However, the tubular lumens were segmented out based on an empirically-determined threshold. In our study, a fully automatic texture analysis algorithm has been developed for OCT image analysis of kidney microanatomy during ischemia-reperfusion process. Our method can potentially be applicable in evaluating the status of donor kidneys prior to and after their transplantation. Abstract ...
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  Mentions: University of Maryland Yu Chen
12. Anticipating, measuring, and minimizing MEMS mirror scan error to improve laser scanning microscopy's speed and accuracy
  
  Explore Journals | PLOS Oct 3 2017 Probes
  
  We describe a method to speed up m icro e lectro m echanical s ystem (MEMS) mirror scanning by 20x, while also improving scan accuracy. We use Landweber deconvolution to determine an input voltage which would produce a desired output, based on the measured MEMS impulse response. Since the MEMS is weakly nonlinear, the observed behavior deviates from expectations, and we iteratively improve our input to minimize this deviation. This ...
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  Mentions: University of Maryland National Institutes of Health
13. Evaluating biomechanical properties of murine embryos using Brillouin microscopy and optical coherence tomography
  
  Explore SPIE Digital Library Sep 9 2017 Developmental Biology
  
  Embryogenesis is regulated by numerous changes in mechanical properties of the cellular microenvironment. Thus, studying embryonic mechanophysiology can provide a more thorough perspective of embryonic development, potentially improving early detection of congenital abnormalities as well as evaluating and developing therapeutic interventions. A number of methods and techniques have been used to study cellular biomechanical properties during embryogenesis. While some of these techniques are invasive or involve the use of external ...
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  Mentions: University of Maryland Kirill V. Larin University of Houston
14. Apparatus and methods for non-invasive assessment of transplant kidney viability
  
  Explore uspto.gov Aug 22 2017 Urology , Patents
  
  A kidney viability assessment system (KVAS) is disclosed which provides objective and reliable tests to assess the viability of transplant or donor kidneys in vivo and predict their post-transplant outcomes. KVAS includes an optical device augmented by an intelligent algorithm that can evaluate the viability or quality of the donor kidney in a real-time, non-invasive way. In particular, it includes a handheld optical coherence tomography (OCT) imaging device and at ...
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  Mentions: University of Maryland Yu Chen Georgetown University
15. Postdoctoral Fellow, Bioengineering at University of Maryland - College Park
  
  Explore Optical Coherence Tomography News Aug 16 2017 Jobs & Studentships
  
  We are seeking a postdoctoral fellow to pursue research on developing novel optical imaging devices and applications on cancer diagnosis, functional brain imaging and tissue engineering. Candidates must hold a Ph.D. in engineering, physics, or related fields and have prior experience with Optics, OCT, Microscopy (e.g. fluorescence, confocal, Two-photon), and image analysis software development. Experience with cell culture and/or animals experiments is a plus. Please submit a ...
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  Mentions: University of Maryland Yu Chen
16. Introduction to the feature issue on the 25 year anniversary of optical coherence tomography
  
  Explore OSA | OSA Publishing Jun 20 2017
  
  This feature issue commemorates the approximately 25 year history of Optical Coherence Tomography (OCT), one of the most successful biophotonic technologies. While OCT has technological origins traceable to ultrafast laser development and fiber optic system test instrumentation of the 1980s, innovations in low coherence interferometry for optical ranging and imaging for biomedical applications in the U.S., Europe and Japan by the early 1990s led to coinage of the now ...
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  Mentions: Brett E. Bouma Johannes F. de Boer Joseph A. Izatt
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