1. University of Maryland

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    1. Mentioned In 117 Articles

    2. Intravascular imaging and histological correlates of medial and intimal calcification in peripheral artery disease

      Intravascular imaging and histological correlates of medial and intimal calcification in peripheral artery disease
      Background: In peripheral artery disease, two different types of calcification are frequently observed, i.e., medial and intimal calcification. Aims: The aim of this study was to determine the ability of intravascular ultrasound (IVUS) imaging and optical frequency domain imaging (OFDI) to detect medial and intimal calcification in human peripheral arteries. Methods: We performed ex vivo intravascular imaging of cadaveric human peripheral arteries with calcifications. IVUS and OFDI images were ...
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    3. Indoor localization of hand-held OCT probe using visual odometry and real-time segmentation using deep learning

      Indoor localization of hand-held OCT probe using visual odometry and real-time segmentation using deep learning
      Objective: Optical coherence tomography (OCT) is an established medical imaging modality that has found widespread use due to its ability to visualize tissue structures at a high resolution. Currently, OCT hand-held imaging probes lack positional information, making it difficult or even impossible to link a specific image to the location it was originally obtained. In this study, we propose a camera-based localization method to track and record the scanner position ...
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    4. Inter-rater Reliability and Repeatability of Manual Anterior Segment Optical Coherence Tomography Image Grading in Keratoconus

      Inter-rater Reliability and Repeatability of Manual Anterior Segment Optical Coherence Tomography Image Grading in Keratoconus
      Objectives: To determine the repeatability of corneal measurements from anterior segment optical coherence tomography (AS-OCT) images using ImageJ software in healthy eyes compared with eyes with keratoconus. Methods: Anterior segment OCT images of 25 eyes from 14 healthy subjects and 25 eyes from 15 subjects with keratoconus between the ages of 20 and 80 years were evaluated. Two trained observers used ImageJ to measure the central corneal cross-sectional area and ...
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    5. Quantitative analysis of vascular changes during photoimmunotherapy using speckle variance optical coherence tomography (SV-OCT)

      Quantitative analysis of vascular changes during photoimmunotherapy using speckle variance optical coherence tomography (SV-OCT)
      Near-infrared (NIR) photoimmunotherapy (NIR-PIT) is an emerging cancer therapy based on a monoclonal antibody and phthalocyanine dye conjugate. Direct tumor necrosis and immunogenic cell death occur during NIR irradiation. However, the alteration of tumor blood vessels and blood volume inside the blood vessels induced by the NIR-PIT process is still unknown. In our study, a speckle variance (SV) algorithm combined with optical coherence tomography (OCT) technology was applied to monitor ...
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    6. Past, present and future role of retinal imaging in neurodegenerative disease

      Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts of information about the structure, function and molecular composition of retinal tissue in humans in vivo . Most importantly, this information can be obtained rapidly, non-invasively and in many cases using Food and Drug Administration-approved devices that are commercially available. Technologies such as optical coherence tomography have dramatically changed our understanding of retinal disease and in many cases have significantly ...
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    7. Direct laser writing of a titanium dioxide-laden retinal cone phantom for adaptive optics-optical coherence tomography

      Direct laser writing of a titanium dioxide-laden retinal cone phantom for adaptive optics-optical coherence tomography
      The spatial resolution of adaptive optics-optical coherence tomography (AO-OCT) enables visualization of retinal components ( e.g ., photoreceptors), which can advance clinical diagnosis of ocular diseases. Currently, however, variability in AO-OCT system performance suggests a need for standardized physical models, or phantoms, that replicate the opto-structural properties of retinal components. Here we employ direct laser writing a two-photon polymerization-based additive manufacturing technology using a light scattering titanium (IV) dioxide nanoparticle-laden photomaterial ...
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    8. University of Maryland Receives NIH Grant for In Vivo Assessment of Meningeal Inflammation and its Clinical Impact in Multiple Sclerosis by 7 Tesla MRI

      University of Maryland Receives NIH Grant for In Vivo Assessment of Meningeal Inflammation and its Clinical Impact in Multiple Sclerosis by 7 Tesla MRI
      ...in whom such treatments would be justified and to monitor treatment response.

      University of Maryland Receives a 2020 NIH Grant for $609,639 for In Vivo Assessment of Meningeal Inflammation...

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    9. A review of imaging modalities for detecting early keratoconus

      A review of imaging modalities for detecting early keratoconus
      Objectives Early identification of keratoconus is imperative for preventing iatrogenic corneal ectasia and allowing for early corneal collagen cross-linking treatments to potentially halt progression and decrease transplant burden. However, early diagnosis of keratoconus is currently a diagnostic challenge as there is no uniform screening criteria. We performed a review of the current literature to assess imaging modalities that can be used to help identify subclinical keratoconus. Methods A Pubmed database ...
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    10. Association of Intimal Neovessels Noted by Optical Coherence Tomography with Cardiac Allograft ...

      Association of Intimal Neovessels Noted by Optical Coherence Tomography with Cardiac Allograft ...
      Background Cardiac allograft vasculopathy (CAV) is a leading cause of graft failure in cardiac transplant recipients. Progression of intimal thickening noted during routine surveillance intracoronary imaging is associated with the development of CAV. However, mechanisms of CAV development are poorly understood and targets for therapy modification remain elusive. We investigated the association of neovessels (INs) within the intima, noted by optical coherence tomography (OCT) during routine CAV surveillance imaging, with ...
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    11. Multimodal quantitative optical elastography of the crystalline lens with optical coherence elastography and Brillouin microscopy

      Multimodal quantitative optical elastography of the crystalline lens with optical coherence elastography and Brillouin microscopy
      Assessing the biomechanical properties of the crystalline lens can provide crucial information for diagnosing disease and guiding precision therapeutic interventions. Existing noninvasive methods have been limited to global measurements. Here, we demonstrate the quantitative assessment of the elasticity of crystalline lens with a multimodal optical elastography technique, which combines dynamic wave-based optical coherence elastography (OCE) and Brillouin microscopy to overcome the drawbacks of individual modalities. OCE can provide direct measurements ...
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    12. Demonstration of Optical Coherence Tomography Guided Big Bubble Technique for Deep Anterior Lamellar Keratoplasty (DALK)

      Demonstration of Optical Coherence Tomography Guided Big Bubble Technique for Deep Anterior Lamellar Keratoplasty (DALK)
      Deep anterior lamellar keratoplasty (DALK) is a highly challenging procedure for cornea transplant that involves removing the corneal layers above Descemets membrane (DM). This is achieved by a big bubble technique where a needle is inserted into the stroma of the cornea down to DM and the injection of either air or liquid. DALK has important advantages over penetrating keratoplasty (PK) including lower rejection rate, less endothelial cell loss, and ...
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    13. 3-D printed photoreceptor phantoms for evaluating lateral resolution of adaptive optics imaging systems

      3-D printed photoreceptor phantoms for evaluating lateral resolution of adaptive optics imaging systems
      With adaptive optics (AO), optical coherence tomography and scanning laser ophthalmoscopy imaging systems can resolve individual photoreceptor cells in living eyes, due to enhanced lateral spatial resolution. However, no standard test method exists for experimentally quantifying this parameter in ophthalmic AO imagers. Here, we present three-dimensional (3-D) printed phantoms, which enable the measurement of lateral resolution in an anatomically relevant manner. We used two-photon polymerization to fabricate two phantoms, which ...
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  2. About University of Maryland

    University of Maryland

    The University System of Maryland is a public corporation and charter school system comprising 13 Maryland institutions of higher education. It is the 12th-largest university system in the USA with over 100,000 undergraduate, 30,000 graduate and 8,700 faculty.   Some of the major campuses

    University of Maryland, College Park and University of Maryland, Baltimore.