1. University of Lübeck

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    1. Mentioned In 152 Articles

    2. Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology

      Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology
      The discrimination of tumor-infiltrated tissue from non-tumorous brain tissue during neurosurgical tumor excision is a major challenge in neurosurgery. It is critical to achieve full tumor removal since it directly correlates with the survival rate of the patient. Optical coherence tomography (OCT) might be an additional imaging method in the field of neurosurgery that enables the classification of different levels of tumor infiltration and non-tumorous tissue. This work investigated two ...
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    3. Towards phase-stabilized Fourier domain mode-locked frequency combs

      Towards phase-stabilized Fourier domain mode-locked frequency combs
      Fourier domain mode-locked (FDML) lasers are some of the fastest wavelength-swept light sources, and used in many applications like optical coherence tomography (OCT), OCT endoscopy, Raman microscopy, light detection and ranging, and two-photon microscopy. For a deeper understanding of the underlying laser physics, it is crucial to investigate the light field evolution of the FDML laser and to clarify whether the FDML laser provides a frequency comb structure. In this ...
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    4. Intravital imaging of mucus transport in asthmatic mice using microscopic optical coherence tomography

      Intravital imaging of mucus transport in asthmatic mice using microscopic optical coherence tomography
      Asthma is one of the most common chronic diseases. Mucus overproduction is consistently linked to asthma morbidity and mortality. Despite the knowledge of the importance of mucus, little data exists on how mucus is transported in asthma and the immediate effects of therapeutic intervention. We therefore used microscopic optical coherence tomography (mOCT) to study spontaneous and induced mucus transport in an interleukin-13 (IL-13) induced asthma mouse model and examined the ...
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    5. Chronological Registration of OCT and Autofluorescence Findings in CSCR: Two Distinct Patterns in Disease Course

      Chronological Registration of OCT and Autofluorescence Findings in CSCR: Two Distinct Patterns in Disease Course
      Optical coherence tomography (OCT) and fundus autofluorescence (FAF) are important imaging modalities for the assessment and prognosis of central serous chorioretinopathy (CSCR). However, setting the findings from both into spatial and temporal contexts as desirable for disease analysis remains a challenge due to both modalities being captured in different perspectives: sparse three-dimensional (3D) cross sections for OCT and two-dimensional (2D) en face images for FAF. To bridge this gap, we ...
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    6. Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma

      Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma
      The purpose of this study was to ascertain whether a correlation exists between glaucoma-associated alteration of ocular vascular haemodynamics and endothelin-1 (ET-1) levels exist. Eyes of patients with cataract (n=30) or glaucoma (n=68) were examined with optical coherence tomography (OCT) and OCT-angiography (OCT-A; AngioVue-RTVue-XR; Optovue, Fremont, California, USA). The peripapillary and the macular vessel density (VD) values were measured. Inferior and superior retinal nerve fibre layer (RNFL) thickness ...
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    7. Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study

      Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study
      Objectives: Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) is a novel OCT technology that was specifically designed for home monitoring of neovascular age-related macular degeneration (AMD). First clinical findings have been reported before. This trial investigates an improved prototype for patients with AMD and focusses on device operability and diagnostic accuracy compared with established spectral-domain OCT (SD-OCT). Design: Prospective single-arm diagnostic accuracy study. Setting: Tertiary care centre (University Eye Clinic ...
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    8. Post Doc / research group leader for intravital imaging in airway at the Institute of Biomedical Optics, University of Lübeck

      Post Doc / research group leader for intravital imaging in airway at the Institute of Biomedical Optics, University of Lübeck
      ...ysiological and pathological processes of cystic fibrosis, asthma, and allergy down to a cellular level. The University of Lübeck is specialized in health sciences and holds vast expertise in medical imaging. In particu...
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    9. Dynamic Contrast Microscopic Optical Coherence Tomography As a Novel Method for Assessing Corneal Epithelium During Exposure to Benzalkonium Chloride

      Dynamic Contrast Microscopic Optical Coherence Tomography As a Novel Method for Assessing Corneal Epithelium During Exposure to Benzalkonium Chloride
      Purpose: Microscopic optical coherence tomography (mOCT) has an imaging resolution of 1 m in all voxel dimensions, but individual epithelial cells are difficult to resolve due to lack of scattering contrast. Adding dynamic contrast processing to mOCT (dmOCT) results in color images that enable visualization of individual cells and possibly give information on cellular function via the calculation of a motility coefficient. We propose this technique as a novel method ...
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    10. Registration of histological brain images onto optical coherence tomography images based on shape information

      Registration of histological brain images onto optical coherence tomography images based on shape information
      Identifying tumour infiltration zones during tumour resection in order to excise as much tumour tissue as possible without damaging healthy brain tissue is still a major challenge in neurosurgery. The detection of tumour infiltrated regions so far requires histological analysis of biopsies taken from at expected tumour boundaries. The gold standard for histological analysis is the staining of thin cut specimen and the evaluation by a neuropathologist. This work presents ...
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    11. Outcome of a polymer-free drug-coated coronary stent in bifurcation lesions—Pilot registry with serial OCT imaging

      Outcome of a polymer-free drug-coated coronary stent in bifurcation lesions—Pilot registry with serial OCT imaging
      Background: Polymer-free and carrier-free drug-coated stents (DCS) represent a novel therapeutic option for the treatment of coronary artery disease. The objective of this pilot registry is to evaluate the safety and efficacy of DCS implantation in bifurcation lesions. Methods: Overall, 23 consecutive patients with 24 lesions received a Biolimus A9-coated DCS for coronary bifurcation lesions. Patients were examined with quantitative coronary angiography (QCA) and optical coherence tomography (OCT) at 3-6 ...
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    12. Retinal blood flow imaging with combined full-field swept-source optical coherence tomography and laser Doppler holography

      Retinal blood flow imaging with combined full-field swept-source optical coherence tomography and laser Doppler holography
      Full-field swept-source optical coherence tomography (FF-SS-OCT) and laser Doppler holography (LDH) are two holographic imaging techniques presenting unique capabilities for ophthalmology. We report on interlaced FF-SS-OCT and LDH imaging with a single instrument. Effectively, retinal blood flow and pulsation could be quasi-simultaneously monitored. This instrument holds potential for a wide scope of ophthalmic applications.
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    13. OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives

      OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives
      Optical coherence tomography (OCT) has been recently suggested as a promising method to obtain in vivo and real-time high-resolution images of tissue structure in brain tumor surgery. This review focuses on the basics of OCT imaging, types of OCT images and currently suggested OCT scanner devices and the results of their application in neurosurgery. OCT can assist in achieving intraoperative precision identification of tumor infiltration within surrounding brain parenchyma by ...
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    14. Spectroscopic thermo-elastic optical coherence tomography for tissue characterization

      Spectroscopic thermo-elastic optical coherence tomography for tissue characterization
      Optical imaging techniques that provide free space, label free imaging are powerful tools in obtaining structural and biochemical information in biological samples. To date, most of the optical imaging technologies create images with a specific contrast and require multimodality integration to add additional contrast. In this study, we demonstrate spectroscopic Thermo-elastic Optical Coherence Tomography (TE-OCT) as a potential tool in tissue identification. TE-OCT creates images based on two different forms ...
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    15. Dynamic microscopic optical coherence tomography to visualize morphological and functional micro-anatomy of the airways

      Dynamic microscopic optical coherence tomography to visualize morphological and functional micro-anatomy of the airways
      Microscopic evaluation of airway tissue is a long established method in diagnostic and research. Especially the assessment of surgical biopsies is a cornerstone in the diagnostic of airway diseases, but the invasiveness of the preceding excision poses a significant hurdle for a wide application. Furthermore, fixation, dehydration, and staining terminate any biochemical processes and only a static image is created. Therefore, biopsies can not investigate dynamic processes. Airway function, however ...
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  2. About University of Lübeck

    University of Lübeck

    Universität zu Lübeck is recognised as “The Founders’ University” And ranked as one of three best universities under the EXIST sponsorship programme run by the Federal Ministry of Economics & Technology. The Universität zu Lübeck is the Founders’ University. It won this coveted title, as one of the three best universities, for its overall strategy to support start-ups. This was the outcome of the “EXIST Start-Up Culture – The Founders’ University” competition run by the Federal Ministry of Economics & Technology. The Federal Minister, Dr. Philipp Rösler, conferred the accolade at a celebration held on 9 January 2013 in Berlin.