1. University of Lübeck

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    1. Mentioned In 108 Articles

    2. Reduction of periodic noise in Fourier domain optical coherence tomography images by frequency domain filtering

      Reduction of periodic noise in Fourier domain optical coherence tomography images by frequency domain filtering
      In Fourier domain optical coherence tomography (FDOCT) coherence noise is caused by interference of light waves back-reflected or scattered from different spots within a measuring depth or from optical components within the OCT system such as a bended optical fibre. This coherence noise appears as periodic stripe patterns along the axial direction in resulting images. Background subtraction and physical segmentation are used to degrade the periodic coherence noise in previous ...
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    3. Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations

      Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations
      Computational adaptive optics (CAO) is emerging as a viable alternative to hardware-based adaptive opticsin particular when applied to optical coherence tomography of the retina. For this technique, algorithms are required that detect wavefront errors precisely and quickly. Here we propose an extension of the frequently used subaperture image correlation. By applying this algorithm iteratively and, more importantly, comparing each subaperture not to the central subaperture but to several randomly selected ...
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    4. Motorized capsule for shadow-free OCT imaging and synchronous beam control

      Motorized capsule for shadow-free OCT imaging and synchronous beam control
      We demonstrate a tethered motorized capsule for unobstructed optical coherence tomography (OCT) imaging of the esophagus. By using a distal reflector design, we avoided the common shadow artifact induced by the motor wires. A synchronous driving technique features three types of beam-scanning modes of the capsule, i.e., circumferential beam scanning, localized beam scanning, and accurate beam positioning. We characterized these three modes and carried out ex vivo imaging experiments ...
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    5. Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks

      Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks
      Optical coherence tomography (OCT) enables the non-invasive acquisition of high-resolution three-dimensional cross-sectional images at micrometer scale and is mainly used in the field of ophthalmology for diagnosis as well as monitoring of eye diseases. Also in other areas, such as dermatology, OCT is already well established. Due to its non-invasive nature, OCT is also employed for research studies involving animal models. Manual evaluation of OCT images of animal models is ...
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    6. Evaluating diurnal changes in choroidal sublayer perfusion using optical coherence tomography angiography

      Evaluating diurnal changes in choroidal sublayer perfusion using optical coherence tomography angiography
      Purpose To investigate diurnal changes of choroidal sublayer perfusion in normal eyes and to identify influencing factors using optical coherence tomography angiography (OCTA). Methods A prospective study was conducted on healthy volunteers, each of whom underwent repeated measurements of subfoveal choroidal thickness (SFCT) via enhanced depth imaging (EDI) optical coherence tomography (OCT) as well as perfusion of choroidal vascular sublayers using OCTA at 7 a.m., 12 p.m., 4 ...
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    7. Retinal perfusion 6 months after trabeculectomy as measured by optical coherence tomography angiography

      Retinal perfusion 6 months after trabeculectomy as measured by optical coherence tomography angiography
      Purpose To investigate potential changes of vessel density (VD) at the optic nerve head (ONH) and the macula 6 months after trabeculectomy (TE). Methods In a prospective monocentric study, 19 eyes with open-angle glaucoma were treated with TE+MMC (mitomycin C). At four different time points multiple morphological papillary parameters were measured by OCT, and the ONH VD in the radial peripapillary capillary layer and the superficial and deep plexuses ...
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    8. Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography

      Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography
      Optical coherence tomography angiography (OCTA) provides in-vivo images of microvascular perfusion in high resolution. For its application to basic and clinical research, an automatic and robust quantification of the capillary architecture is mandatory. Only this makes it possible to reliably analyze large amounts of image data, to establish biomarkers, and to monitor disease developments. However, due to its optical properties, OCTA images of skin often suffer from a poor signal-to-noise ...
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    9. Permanent Professor Position available at University of Lubeck

      Permanent Professor Position available at University of Lubeck
      The Institute of Biomedical Optics at the Department of Computer Science/Engineering and Department of Natural Sciences (STEM) at the Universität zu Lübeck invites applications for a permanent University Professorship (W2) in Biomedical Optics and Photonics commencing as soon as possible. Conditions of the appointment are in accordance with the Higher Education Act (Hochschulgesetz) of Schleswig Holstein. Details will be explained on request. The successful candidate will represent ...
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    10. MUcociliary Clearance IN Stroke

      MUcociliary Clearance IN Stroke
      Survival and functional outcome of stroke is strongly depending on the occurence of pneumonia (stroke-associated pneumonia, SAP). Early diagnose and treatment of SAP is paramount in the treatment of stroke patients. While dysphagia strongly contributes to its pathogenesis, recent years have also shown a strong risk-modulation by CNS injury induced immunosuppression, making stroke patients more susceptible to SAP. Additionally, murine models of stroke showed changes in mucociliary clearance as possible ...
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    11. Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion

      Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion
      In optical coherence tomography (OCT), lateral motion is determined either by speckle tracking or by multi-aperture Doppler OCT. Here we show that both methods may provide incorrect results because, outside the focal plane, non-uniform axial motion is misinterpreted as lateral motion. First, we demonstrate the existence of this artifact by means of a simulation for speckle tracking. Then the physical origin of the artifact and its mathematical relation to defocus ...
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    12. OptoRes presents world-record 3 MHz swept laser at SPIE BiOS / Photonics West in San Francisco

      OptoRes presents world-record 3 MHz swept laser at SPIE BiOS / Photonics West in San Francisco
      ...ength for high- quality OCT images. According to Prof. Robert Huber, Optores co-founder and professor at the Universität zu Lübeck, Optores’ core technology Fourier-domain mode-locking (FDML) plays a crucial role: “Opto...
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    13. Optical coherence tomography provides an optical biopsy of burn wounds in children—a pilot study

      Optical coherence tomography provides an optical biopsy of burn wounds in children—a pilot study
      Thermic injuries are among the most severe injuries in childhood. Burn depth is the most relevant prognostic factor, and still its assessment is both difficult and controversial. This diagnostic uncertainty results in repeated wound assessments over a 10-day period and carries a relevant risk for over- and undertreatment. Precise wound assessment would thus be a significant step toward improved care. Optical coherence tomography (OCT) is a noninvasive laser-based technique with ...
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    14. Simple approach for aberration-corrected OCT imaging of the human retina

      Simple approach for aberration-corrected OCT imaging of the human retina
      Aberration-corrected imaging of human photoreceptor cells, whether hardware or software based, presently requires a complex and expensive setup. Here we use a simple and inexpensive off-axis full-field time-domain optical coherence tomography (OCT) approach to acquire volumetric data of an in vivo human retina. Full volumetric data are recorded in 1.3 s. After computationally correcting for aberrations, single photoreceptor cells were visualized. In addition, the numerical correction of ametropia is ...
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    15. High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography

      High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography
      We present a forward-viewing fiber scanning endoscope (FSE) for high-speed volumetric optical coherence tomography (OCT). The reduction in size of the probe was achieved by substituting the focusing optics by an all-fiber-based imaging system which consists of a combination of scanning single-mode fibers, a glass spacer, made from a step-index multi-mode fiber, and a gradient-index fiber. A lateral resolution of 11 m was achieved at a working distance of 1 ...
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  2. About University of Lübeck

    University of Lübeck

    Universität zu Lübeck is recognised as “The Founders’ University” And ranked as one of three best universities under the EXIST sponsorship programme run by the Federal Ministry of Economics & Technology. The Universität zu Lübeck is the Founders’ University. It won this coveted title, as one of the three best universities, for its overall strategy to support start-ups. This was the outcome of the “EXIST Start-Up Culture – The Founders’ University” competition run by the Federal Ministry of Economics & Technology. The Federal Minister, Dr. Philipp Rösler, conferred the accolade at a celebration held on 9 January 2013 in Berlin.