1. University of Limerick

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    1. Mentioned In 19 Articles

    2. The design, development and application of a dual-beam spectral-domain optical coherence tomography system for the non-invasive assessment of vascular dynamics by statistical means (Thesis)

      The design, development and application of a dual-beam spectral-domain optical coherence tomography system for the non-invasive assessment of vascular dynamics by statistical means (Thesis)
      This assertion underscores the importance of haematological dynamic assessment, which can benefit greatly from non-invasive high-resolution imaging of blood flow especially at the microvascular level. This importance is further highlighted in oncological applications with recent emphasis on tumour vasculature, angiogenic processes and developments of anti-angiogenic therapies. Optical coherence tomography (OCT) has established itself a firm foothold in the realm of non-invasive optical medical diagnostic imaging, enabling in vivo cross-sectional tomographic ...
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    3. Optimization and extraction of functional information from in vitro flow models using dual-beam spectral-domain optical coherence tomography cross-correlation analysis

      Optimization and extraction of functional information from in vitro flow models using dual-beam spectral-domain optical coherence tomography cross-correlation analysis
      ...greement with that of the applied flow rate. University of Limerick, Department of Physics & Energy, Ireland University of Limerick, Materials and Surface Science Institute, Ireland National University of Ireland, Scho...
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    4. Feasibility of capillary velocity assessment by statistical means using dual-beam spectral-domain Optical Coherence Tomography: a preliminary study

      Feasibility of capillary velocity assessment by statistical means using dual-beam spectral-domain Optical Coherence Tomography: a preliminary study
      The assessment of vascular dynamics has been shown to yield both qualitative and quantitative metrics and thus play a pivotal role in the diagnosis and prognosis of various diseases, which may manifest as microcirculatory irregularities. Optical Coherence Tomography (OCT) is an established imaging modality which utilises the principle of optical interferometry to distinguish between spatial changes in refractive index and thus formulate a multi-dimensional representation of a specimen in vivo ...
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    5. Anti-stokes effect CCD camera and SLD based optical coherence tomography for full-field imaging in the 1550nm region

      Anti-stokes effect CCD camera and SLD based optical coherence tomography for full-field imaging in the 1550nm region
      Full-field Optical coherence tomography is an en-face interferometric imaging technology capable of carrying out high resolution cross-sectional imaging of the internal microstructure of an examined specimen in a non-invasive manner. The presented system is based on competitively priced optical components available at the main optical communications band located in the 1550 nm region. It consists of a superluminescent diode and an anti-stokes imaging device. The single mode fibre coupled SLD ...
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    6. Compact Imaging Reaches Agreement On Research Collaboration with Irish Universities

      Compact Imaging Reaches Agreement On Research Collaboration with Irish Universities
      ...r more information visit www.nuigalway.ie or view all NUI Galway news here . About University of Limerick The University of Limerick is an independent, internationally focussed University with over 11,600 students and 1,...
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    7. Dual-beam optical coherence tomography system for quantification of flow velocity in capillary phantoms

      Dual-beam optical coherence tomography system for quantification of flow velocity in capillary phantoms
      The quantification of (blood) flow velocity within the vasculature has potent diagnostic and prognostic potential. Assessment of flow irregularities in the form of increased permeability (micro haemorrhaging), the presence of avascular areas, or conversely the presence of vessels with enlarged or increased tortuosity in the acral regions of the body may provide a means of non-invasive in vivo assessment. If assessment of dermal flow dynamics were performed in a routine ...
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    8. 1550 nm superluminescent diode and anti-Stokes effect CCD camera based optical coherence tomography for full-field optical metrology

      1550 nm superluminescent diode and anti-Stokes effect CCD camera based optical coherence tomography for full-field optical metrology
      Optical Coherence Tomography (OCT) is a promising non-invasive imaging technology capable of carrying out 3D high-resolution cross-sectional images of the internal microstructure of examined material. However, almost all of these systems are expensive, requiring the use of complex optical setups, expensive light sources and complicated scanning of the sample under test. In addition most of these systems have not taken advantage of the competitively priced optical components available at wavelength ...
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    9. Design and development of a galvanometer inspired dual beam optical coherence tomography system for flow velocity quantification of the microvasculature

      Design and development of a galvanometer inspired dual beam optical coherence tomography system for flow velocity quantification of the microvasculature
      This paper reports initial experimentation of a dual beam flow velocity estimation setup based on optical coherence tomography (OCT) for biomedical applications. The proposed work incorporates a low cost switching mechanism (rotating galvanometer mirror) for optical signal discrimination between adjacent fiber channels enabling quasisimultaneous multiple specimen scanning. A cascaded interferometric design is used with two sample output arms orientated in parallel to eachother. A cross-correlation computation between these two parallel ...
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    10. In vivo imaging of the microcirculation of the volar forearm using correlation mapping optical coherence tomography (cmOCT)

      In vivo imaging of the microcirculation of the volar forearm using correlation mapping optical coherence tomography (cmOCT)
      Correlation mapping optical coherence tomography (cmOCT) is a recently proposed technique that extends the capabilities of OCT to enable mapping of vasculature networks. The technique is achieved as a processing step on OCT intensity images that does not require any modification to existing OCT hardware. In this paper we apply the cmOCT processing technique to in vivo human imaging of the volar forearm. We illustrate that cmOCT can produce maps ...
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    11. In-vivo assessment of cleavage line orientation in human skin using optical coherence tomography

      In-vivo assessment of cleavage line orientation in human skin using optical coherence tomography
      Collagen and elastin fibers are generally arranged in parallel bundles within the dermis. These bundles are oriented such that they can most efficiently resist the stress and strain that normally occurs on the skin during movement. The pattern of these fiber bundles establishes the lines of cleavage of the skin. Knowledge of the orientation of these is of key importance for surgical procedures. When incisions are cut parallel to the ...
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    12. Correlation mapping method for generating microcirculation morphology from optical coherence tomography (OCT) intensity images

      Correlation mapping method for generating microcirculation morphology from optical coherence tomography (OCT) intensity images
      Standard optical coherence tomography (OCT) in combination with software tools can be harnessed to generate vascular maps in vivo. In this study we have successfully combined a software algorithm based on correlation statistic to reveal microcirculation morphology on OCT intensity images of a mouse brain in vivo captured trans-cranially and through a cranial window. We were able to estimate vessel geometry at bifurcation as well as along vessel segments down-to ...
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    13. In-vivo dynamic characterization of microneedle skin penetration using optical coherence tomography

      In-vivo dynamic characterization of microneedle skin penetration using optical coherence tomography
      The use of microneedles as a method of circumventing the barrier properties of the stratum corneum is receiving much attention. Although skin disruption technologies and subsequent transdermal diffusion rates are being extensively studied, no accurate data on depth and closure kinetics of microneedle-induced skin pores are available, primarily due to the cumbersome techniques currently required for skin analysis. We report on the first use of optical coherence tomography technology to ...
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    14. A new device for assessing changes in skin viscoelasticity using indentation and optical measurement

      A new device for assessing changes in skin viscoelasticity using indentation and optical measurement
      Skin is a viscoelastic material, comprised of fluidic and fibrous components. Changes in viscoelasticity can arise due to a number of conditions including dehydration, swelling (associated with injury or disease), impaired heart function, rehydration therapy, ageing, scarring, sun exposure and genetic conditions affecting connective tissue. Quantification of changes in skin viscoelasticity due to these processes is of great clinical interest in the fields of therapy monitoring, wound healing and disease ...
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  2. About University of Limerick

    University of Limerick

    University of Limerick was established in 1972 as the National Institute for Higher Education.Tvhe university was the first university established since the foundation of the State in 1922, followed later in the same day by the establishment of Dublin City University. The university has currently in excess of 11,000 full-time undergraduate students and 1,500 part-time students. There are also over 800 research postgraduates and 1,300 taught postgraduate students at the university. The Co-Operative Education (commonly called "Co-Op") programme allocates all students with an 8-month work placement as part of their degree. This is one of the first such programmes in the State.