1. University of Lübeck

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    1. Mentioned In 144 Articles

    2. Registration of histological brain images onto optical coherence tomography images based on shape information

      Registration of histological brain images onto optical coherence tomography images based on shape information
      Identifying tumour infiltration zones during tumour resection in order to excise as much tumour tissue as possible without damaging healthy brain tissue is still a major challenge in neurosurgery. The detection of tumour infiltrated regions so far requires histological analysis of biopsies taken from at expected tumour boundaries. The gold standard for histological analysis is the staining of thin cut specimen and the evaluation by a neuropathologist. This work presents ...
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    3. Outcome of a polymer-free drug-coated coronary stent in bifurcation lesions—Pilot registry with serial OCT imaging

      Outcome of a polymer-free drug-coated coronary stent in bifurcation lesions—Pilot registry with serial OCT imaging
      Background: Polymer-free and carrier-free drug-coated stents (DCS) represent a novel therapeutic option for the treatment of coronary artery disease. The objective of this pilot registry is to evaluate the safety and efficacy of DCS implantation in bifurcation lesions. Methods: Overall, 23 consecutive patients with 24 lesions received a Biolimus A9-coated DCS for coronary bifurcation lesions. Patients were examined with quantitative coronary angiography (QCA) and optical coherence tomography (OCT) at 3-6 ...
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    4. Retinal blood flow imaging with combined full-field swept-source optical coherence tomography and laser Doppler holography

      Retinal blood flow imaging with combined full-field swept-source optical coherence tomography and laser Doppler holography
      Full-field swept-source optical coherence tomography (FF-SS-OCT) and laser Doppler holography (LDH) are two holographic imaging techniques presenting unique capabilities for ophthalmology. We report on interlaced FF-SS-OCT and LDH imaging with a single instrument. Effectively, retinal blood flow and pulsation could be quasi-simultaneously monitored. This instrument holds potential for a wide scope of ophthalmic applications.
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    5. OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives

      OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives
      Optical coherence tomography (OCT) has been recently suggested as a promising method to obtain in vivo and real-time high-resolution images of tissue structure in brain tumor surgery. This review focuses on the basics of OCT imaging, types of OCT images and currently suggested OCT scanner devices and the results of their application in neurosurgery. OCT can assist in achieving intraoperative precision identification of tumor infiltration within surrounding brain parenchyma by ...
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    6. Spectroscopic thermo-elastic optical coherence tomography for tissue characterization

      Spectroscopic thermo-elastic optical coherence tomography for tissue characterization
      Optical imaging techniques that provide free space, label free imaging are powerful tools in obtaining structural and biochemical information in biological samples. To date, most of the optical imaging technologies create images with a specific contrast and require multimodality integration to add additional contrast. In this study, we demonstrate spectroscopic Thermo-elastic Optical Coherence Tomography (TE-OCT) as a potential tool in tissue identification. TE-OCT creates images based on two different forms ...
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    7. Dynamic microscopic optical coherence tomography to visualize morphological and functional micro-anatomy of the airways

      Dynamic microscopic optical coherence tomography to visualize morphological and functional micro-anatomy of the airways
      Microscopic evaluation of airway tissue is a long established method in diagnostic and research. Especially the assessment of surgical biopsies is a cornerstone in the diagnostic of airway diseases, but the invasiveness of the preceding excision poses a significant hurdle for a wide application. Furthermore, fixation, dehydration, and staining terminate any biochemical processes and only a static image is created. Therefore, biopsies can not investigate dynamic processes. Airway function, however ...
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    8. Continuous spectral zooming for in vivo live 4D-OCT with MHz A-scan rates and long coherence

      Continuous spectral zooming for in vivo live 4D-OCT with MHz A-scan rates and long coherence
      We present continuous three-dimensional spectral zooming in live 4D-OCT using a home-built FDML based OCT system with 3.28 MHz A-scan rate. Improved coherence characteristics of the FDML laser allow for imaging ranges up to 10 cm. For the axial spectral zoom feature, we switch between high resolution and long imaging range by adjusting the sweep range of our laser. We present a new imaging setup allowing for synchronized adjustments ...
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    9. Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography

      Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography
      Purpose: To investigate the most peripheral corneal nerve plexus using high-resolution micro-optical coherence tomography (OCT) imaging and to assess OCT's clinical potential as a screening tool for corneal and systemic diseases. Methods: An experimental high-resolution (1.5 1.5 1 m) OCT setup was applied for three-dimensional imaging of the subbasal nerve plexus in nonhuman primates (NHPs) and swine within 3 hours postmortem. Morphologic features of subbasal nerves in ...
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    10. Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast

      Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast
      Volumetric imaging of dynamic processes with microscopic resolution holds a huge potential in biomedical research and clinical diagnosis. Using supercontinuum light sources and high numerical aperture (NA) objectives, optical coherence tomography (OCT) achieves microscopic resolution and is well suited for imaging cellular and subcellular structures of biological tissues. Currently, the imaging speed of microscopic OCT (mOCT) is limited by the line-scan rate of the spectrometer camera and ranges from 30 ...
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    11. Imaging Inflammation – From Whole Body Imaging to Cellular Resolution

      Imaging Inflammation – From Whole Body Imaging to Cellular Resolution
      Imaging techniques have evolved impressively lately, allowing whole new concepts like multimodal imaging, personal medicine, theranostic therapies, and molecular imaging to increase general awareness of possiblities of imaging to medicine field. Here, we have collected the selected (3D) imaging modalities and evaluated the recent findings on preclinical and clinical inflammation imaging. The focus has been on the feasibility of imaging to aid in inflammation precision medicine, and the key challenges ...
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    12. Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision

      Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision
      In highly dispersion compensated Fourier domain mode locked (FDML) lasers, an ultra-low noise operation can only be achieved by extremely precise and stable matching of the filter tuning period and light circulation time in the cavity. We present a robust and high precision closed-loop control algorithm and an actively cavity length controlled FDML laser. The cavity length control achieves a stability of 0.18 mHz at a sweep repetition rate ...
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    13. Influence of retinal microsecond pulse laser treatment in central serous chorioretinopathy: a short-term optical coherence tomography angiography study

      Influence of retinal microsecond pulse laser treatment in central serous chorioretinopathy: a short-term optical coherence tomography angiography study
      Background: Central serous chorioretinopathy (CSC) is a common macular condition characterized by detachment of the neuroretina and is a frequent cause of central vision loss in adults. Among the various therapeutic strategies, subthreshold microsecond pulsed laser (SML) treatment has become a useful option. Despite the suggested involvement of choroidal circulatory disturbances in CSC, effects of this treatment on macular microperfusion have not been fully evaluated yet. Herein, we report the ...
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    14. Evaluating Retinal and Choroidal Perfusion Changes after Isometric and Dynamic Activity Using Optical Coherence Tomography Angiography

      Evaluating Retinal and Choroidal Perfusion Changes after Isometric and Dynamic Activity Using Optical Coherence Tomography Angiography
      Optical coherence tomography angiography (OCTA) is a non-invasive tool for imaging and quantifying the retinal and choroidal perfusion state in vivo. This study aimed to evaluate the acute effects of isometric and dynamic exercise on retinal and choroidal sublayer perfusion using OCTA. A pilot study was conducted on young, healthy participants, each of whom performed a specific isometric exercise on the first day and a dynamic exercise the day after ...
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    15. Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases

      Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases
      Purpose The treatment guidelines for many macular diseases rely on frequent monitoring with optical coherence tomography (OCT). However, the burden of frequent disease control leads to low therapy adherence in real life. OCT home monitoring would address this issue but requires an inexpensive and self-operable device. With self-examination low-cost full-field OCT (SELFF-OCT), our group has introduced a novel technology that may fulfill both requirements. In this pilot study, we report ...
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  2. About University of Lübeck

    University of Lübeck

    Universität zu Lübeck is recognised as “The Founders’ University” And ranked as one of three best universities under the EXIST sponsorship programme run by the Federal Ministry of Economics & Technology. The Universität zu Lübeck is the Founders’ University. It won this coveted title, as one of the three best universities, for its overall strategy to support start-ups. This was the outcome of the “EXIST Start-Up Culture – The Founders’ University” competition run by the Federal Ministry of Economics & Technology. The Federal Minister, Dr. Philipp Rösler, conferred the accolade at a celebration held on 9 January 2013 in Berlin.