1. University of Lübeck

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    1. Mentioned In 129 Articles

    2. Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases

      Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases
      Purpose The treatment guidelines for many macular diseases rely on frequent monitoring with optical coherence tomography (OCT). However, the burden of frequent disease control leads to low therapy adherence in real life. OCT home monitoring would address this issue but requires an inexpensive and self-operable device. With self-examination low-cost full-field OCT (SELFF-OCT), our group has introduced a novel technology that may fulfill both requirements. In this pilot study, we report ...
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    3. Evaluating Retinal and Choroidal Perfusion Changes After Ocular Massage of Healthy Eyes Using Optical Coherence Tomography Angiography

      Evaluating Retinal and Choroidal Perfusion Changes After Ocular Massage of Healthy Eyes Using Optical Coherence Tomography Angiography
      Background and objectives: Ocular massage (OM) is used as a treatment option for acute retinal artery occlusion, under the assumption that it induces vessel dilatation and enhances perfusion. Since evidence of ocular perfusion alteration due to OM is lacking, we investigate the impact of OM on the hemodynamics of the posterior pole in healthy eyes in a noninvasive fashion by using optical coherence tomography angiography (OCTA). Materials and Methods: A ...
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    4. PhD Position Available in Lübeck: Development of an Ultra-Wideband FDML-Laser

      PhD Position Available in Lübeck: Development of an Ultra-Wideband FDML-Laser
      We offer a three year PhD student position for an Early Stage Researcher (ESR) on laser development in biomedical optics. The position is part of a Marie Skłodowska-Curie Innovative Training Network (ITN) within the EU Horizon 2020 Framework Programme. It will be within the project NETLAS (https://cordis.europa.eu/project/id/860807), which focuses on innovative solutions for fast, narrow linewidth, phase stable and wide tuning bandwidth swept sources ...
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    5. Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging

      Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging
      In order to realize adjustable A-scan rates of fast optical coherence tomography (OCT) systems, we investigate averaging of OCT image data acquired with a MHz-OCT system based on a Fourier Domain Mode Locked (FDML) laser. Increased system sensitivity and image quality can be achieved with the same system at the cost of lower imaging speed. Effectively, the A-scan rate can be reduced in software by a freely selectable factor. We ...
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    6. An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations

      An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations
      Caries, the worlds most common chronic disease, remains a major cause of invasive restorative dental treatment. To take advantage of the diagnostic potential of optical coherence tomography (OCT) in contemporary dental prevention and treatment, an intraorally applicable spectral-domain OCT probe has been developed based on an OCT hand-held scanner equipped with a rigid 90-optics endoscope. The probe was verified in vitro. In vivo, all tooth surfaces could be imaged with ...
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    7. Quantitative Comparison of the Vascular Structure of Macular Neovascularizations Between Swept-Source and Spectral-Domain Optical Coherence Tomography Angiography

      Quantitative Comparison of the Vascular Structure of Macular Neovascularizations Between Swept-Source and Spectral-Domain Optical Coherence Tomography Angiography
      ...h1,3,4 1Department of Ophthalmology, St. Franziskus Hospital, Münster, Germany; 2Department of Ophthalmology, University of Lübeck, Lübeck, Germany; 3Department of Ophthalmology, University of Essen–Duisburg, Essen, Germ...
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    8. Micro-optical coherence tomography for high-resolution morphologic imaging of cellular and nerval corneal micro-structures

      Micro-optical coherence tomography for high-resolution morphologic imaging of cellular and nerval corneal micro-structures
      We demonstrate the highest resolution (1.51.51 m) micrometer optical coherence tomography (OCT) imaging of the morphologic micro-structure of excised swine and non-human primate corneas. Besides epithelial, stromal, and endothelial cell morphology, this report focuses on investigating the most peripheral corneal nerve fibers, the nerve fibers of the subbasal plexus (SBP). Alterations of SBP nerve density and composition are reportedly linked to major neurologic disorders, such as diabetic neuropathy ...
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    9. Optical coherence tomography for fast bedside imaging, assessment and monitoring of autoimmune inflammatory skin diseases?

      Optical coherence tomography for fast bedside imaging, assessment and monitoring of autoimmune inflammatory skin diseases?
      Optical coherence tomography (OCT) is a non‐invasive, high‐resolution imaging technique with a growing impact in dermatology. The principle of OCT is comparable to that of sonography, except that it uses infrared laser light instead of ultrasound waves. It has been clinically demonstrated that OCT is suitable for discriminating between different types of non‐melanoma skin cancer at an early stage of disease. Optical coherence tomography generates two‐ or ...
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    10. Dynamic contrast in scanning microscopic OCT

      Dynamic contrast in scanning microscopic OCT
      While optical coherence tomography (OCT) provides a resolution down to 1 m, it has difficulties in visualizing cellular structures due to a lack of scattering contrast. By evaluating signal fluctuations, a significant contrast enhancement was demonstrated using time-domain full-field OCT (FF-OCT), which makes cellular and subcellular structures visible. The putative cause of the dynamic OCT signal is the site-dependent active motion of cellular structures in a sub-micrometer range, which provides ...
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    11. Frequency-doubled FDML-MOPA laser in the visible

      Frequency-doubled FDML-MOPA laser in the visible
      Wavelength-swept lasers enable high-speed measurements in absorption spectroscopy, Raman spectroscopy, nonlinear Raman hyperspectral microscopy, rapid confocal microscopy, short impulse generation, and most importantly for high-speed optical coherence tomography, with speeds up to video-rate volumetric imaging. Recently, we introduced a pulsed wavelength-swept laser based on the Fourier domain mode-locked (FDML) laser principle combined with a master-oscillator power amplifier (MOPA) architecture. The high peak powers reached with this laser enabled rapid two-photon ...
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    12. Evaluating diurnal variations in retinal perfusion using optical coherence tomography angiography

      Evaluating diurnal variations in retinal perfusion using optical coherence tomography angiography
      Background Optical coherence tomography angiography (OCTA) is a non-invasive tool for imaging and quantifying the retinal and choroidal vasculature as well as perfusion state in healthy eyes. Choroidal perfusion is subject to diurnal variation, showing lowest perfusion in the morning and highest in the afternoon. In this index study, OCTA was used to investigate diurnal changes of the retinal perfusion in healthy adult eyes and to identify impacting factors since ...
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    13. Stromal Nerve Imaging and Tracking Using Micro-Optical Coherence Tomography

      Stromal Nerve Imaging and Tracking Using Micro-Optical Coherence Tomography
      urpose : To image, track and map the nerve fiber distribution in excised rabbit corneas over the entire stromal thickness using micro-optical coherence tomography (OCT) to develop a screening tool for early peripheral neuropathy. Methods : Excised rabbit corneas were consecutively imaged by a custom-designed OCT prototype and a commercial laser scanning fluorescence confocal microscope. The OCT images with a field of view of approximately 1 1 mm were recorded with axial ...
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    14. Dynamic contrast in scanning microscopic OCT

      Dynamic contrast in scanning microscopic OCT
      While optical coherence tomography (OCT) provides a resolution down to 1 micrometer it has difficulties to visualize cellular structures due to a lack of scattering contrast. By evaluating signal fluctuations, a significant contrast enhancement was demonstrated using time-domain full-field OCT (FF-OCT), which makes cellular and subcellular structures visible. The putative cause of the dynamic OCT signal is ATP-dependent motion of cellular structures in a sub-micrometer range, which provides histology-like contrast ...
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    15. Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice

      Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice
      Airway mucus obstruction is a hallmark of chronic lung diseases such as cystic fibrosis, asthma and COPD, and the development of more effective mucus mobilizing therapies remains an important unmet need for patients with these muco-obstructive lung diseases. However, methods for sensitive visualization and quantitative assessment of immediate effects of therapeutic interventions on mucus clearance in vivo are lacking. In this study, we determined if newly developed high-speed microscopic optical ...
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    16. Segmentation of Retinal Low-Cost Optical Coherence Tomography Images using Deep Learning

      Segmentation of Retinal Low-Cost Optical Coherence Tomography Images using Deep Learning
      The treatment of age-related macular degeneration (AMD) requires continuous eye exams using optical coherence tomography (OCT). The need for treatment is determined by the presence or change of disease-specific OCTbased biomarkers. Therefore, the monitoring frequency has a significant influence on the success of AMD therapy. However, the monitoring frequency of current treatment schemes is not individually adapted to the patient and therefore often insufficient. While a higher monitoring frequency would ...
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  2. About University of Lübeck

    University of Lübeck

    Universität zu Lübeck is recognised as “The Founders’ University” And ranked as one of three best universities under the EXIST sponsorship programme run by the Federal Ministry of Economics & Technology. The Universität zu Lübeck is the Founders’ University. It won this coveted title, as one of the three best universities, for its overall strategy to support start-ups. This was the outcome of the “EXIST Start-Up Culture – The Founders’ University” competition run by the Federal Ministry of Economics & Technology. The Federal Minister, Dr. Philipp Rösler, conferred the accolade at a celebration held on 9 January 2013 in Berlin.