1. University of Lübeck

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    1. Mentioned In 116 Articles

    2. Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice

      Explore American Physiological Society Journal Pulmonology
      Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice
      Airway mucus obstruction is a hallmark of chronic lung diseases such as cystic fibrosis, asthma and COPD, and the development of more effective mucus mobilizing therapies remains an important unmet need for patients with these muco-obstructive lung diseases. However, methods for sensitive visualization and quantitative assessment of immediate effects of therapeutic interventions on mucus clearance in vivo are lacking. In this study, we determined if newly developed high-speed microscopic optical ...
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      Mentions: Gereon Hüttmann University of Lübeck

    3. Segmentation of Retinal Low-Cost Optical Coherence Tomography Images using Deep Learning

      Explore arxiv.org Ophthalmology
      Segmentation of Retinal Low-Cost Optical Coherence Tomography Images using Deep Learning
      The treatment of age-related macular degeneration (AMD) requires continuous eye exams using optical coherence tomography (OCT). The need for treatment is determined by the presence or change of disease-specific OCTbased biomarkers. Therefore, the monitoring frequency has a significant influence on the success of AMD therapy. However, the monitoring frequency of current treatment schemes is not individually adapted to the patient and therefore often insufficient. While a higher monitoring frequency would ...
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      Mentions: Gereon Hüttmann University of Lübeck

    5. Capillary Refill—The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography

      Explore Wiley Online Library Dermatology
      Capillary Refill—The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography
      Background/Objectives: Standard optical coherence tomography angiography (OCTA) has been limited to imaging blood vessels actively undergoing perfusion, providing a temporary picture of surface microvasculature. Capillary perfusion in the skin is dynamic and changes in response to the surrounding tissue's respiratory, nutritional, and thermoregulatory needs. Hence, OCTA often represents a given perfusion state without depicting the actual extent of the vascular network. Here we present a method for obtaining ...
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      Mentions: Massachusetts General Hospital Gereon Hüttmann Reginald Birngruber

    6. Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT

      Explore Infinite Science Publishing NDE/NDT
      Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT
      Optical coherence tomography is a non-invasive and label-free imaging modality based on the detection of backscattered light in samples. As microscopic OCT (mOCT) combines high axial and lateral resolution, an investigation of biological and printed samples at subcellular level is feasible. The additional excellent depth resolution enables mOCT to be a suitable quality control of 3D printed samples. The use of speckle variance adds information about cell viability. Here we ...
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      Mentions: Gereon Hüttmann University of Lübeck

    7. Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography

      Explore IEEE Xplore Cardiology
      Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography
      We demonstrate three-dimensional intravascular flow imaging compatible with routine clinical image acquisition workflow by means of megahertz (MHz) intravascular Doppler Optical Coherence Tomography (OCT). The OCT system relies on a 1.1 mm diameter motorized imaging catheter and a 1.5 MHz Fourier Domain Mode Locked (FDML) laser. Using a post processing method to compensate the drift of the FDML laser output, we can resolve the Doppler phase shift between ...
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      Mentions: Robert A. Huber Gijs van Soest Anton F. W. van der Steen

    9. Reduction of periodic noise in Fourier domain optical coherence tomography images by frequency domain filtering

      Explore Home
      Reduction of periodic noise in Fourier domain optical coherence tomography images by frequency domain filtering
      In Fourier domain optical coherence tomography (FDOCT) coherence noise is caused by interference of light waves back-reflected or scattered from different spots within a measuring depth or from optical components within the OCT system such as a bended optical fibre. This coherence noise appears as periodic stripe patterns along the axial direction in resulting images. Background subtraction and physical segmentation are used to degrade the periodic coherence noise in previous ...
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      Mentions: University of Freiburg University of Lübeck

    11. Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations

      Explore OSA | OSA Publishing
      Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations
      Computational adaptive optics (CAO) is emerging as a viable alternative to hardware-based adaptive opticsin particular when applied to optical coherence tomography of the retina. For this technique, algorithms are required that detect wavefront errors precisely and quickly. Here we propose an extension of the frequently used subaperture image correlation. By applying this algorithm iteratively and, more importantly, comparing each subaperture not to the central subaperture but to several randomly selected ...
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      Mentions: Gereon Hüttmann University of Lübeck Hendrik Spahr

    12. Motorized capsule for shadow-free OCT imaging and synchronous beam control

      Explore OSA | OSA Publishing Gastroenterology , Probes
      Motorized capsule for shadow-free OCT imaging and synchronous beam control
      We demonstrate a tethered motorized capsule for unobstructed optical coherence tomography (OCT) imaging of the esophagus. By using a distal reflector design, we avoided the common shadow artifact induced by the motor wires. A synchronous driving technique features three types of beam-scanning modes of the capsule, i.e., circumferential beam scanning, localized beam scanning, and accurate beam positioning. We characterized these three modes and carried out ex vivo imaging experiments ...
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      Mentions: Brett E. Bouma Massachusetts General Hospital Harvard University

    13. Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks

      Explore OSA | OSA Publishing Dermatology
      Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks
      Optical coherence tomography (OCT) enables the non-invasive acquisition of high-resolution three-dimensional cross-sectional images at micrometer scale and is mainly used in the field of ophthalmology for diagnosis as well as monitoring of eye diseases. Also in other areas, such as dermatology, OCT is already well established. Due to its non-invasive nature, OCT is also employed for research studies involving animal models. Manual evaluation of OCT images of animal models is ...
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      Mentions: Massachusetts General Hospital Gereon Hüttmann University of Lübeck

    14. Evaluating diurnal changes in choroidal sublayer perfusion using optical coherence tomography angiography

      Explore Wiley Online Library Ophthalmology
      Evaluating diurnal changes in choroidal sublayer perfusion using optical coherence tomography angiography
      Purpose To investigate diurnal changes of choroidal sublayer perfusion in normal eyes and to identify influencing factors using optical coherence tomography angiography (OCTA). Methods A prospective study was conducted on healthy volunteers, each of whom underwent repeated measurements of subfoveal choroidal thickness (SFCT) via enhanced depth imaging (EDI) optical coherence tomography (OCT) as well as perfusion of choroidal vascular sublayers using OCTA at 7 a.m., 12 p.m., 4 ...
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      Mentions: University of Lübeck

    15. Retinal perfusion 6 months after trabeculectomy as measured by optical coherence tomography angiography

      Explore Home - Springer Ophthalmology
      Retinal perfusion 6 months after trabeculectomy as measured by optical coherence tomography angiography
      Purpose To investigate potential changes of vessel density (VD) at the optic nerve head (ONH) and the macula 6 months after trabeculectomy (TE). Methods In a prospective monocentric study, 19 eyes with open-angle glaucoma were treated with TE+MMC (mitomycin C). At four different time points multiple morphological papillary parameters were measured by OCT, and the ONH VD in the radial peripapillary capillary layer and the superficial and deep plexuses ...
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      Mentions: Optovue University of Lübeck

    16. Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography

      Explore SPIE Digital Library Dermatology
      Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography
      Optical coherence tomography angiography (OCTA) provides in-vivo images of microvascular perfusion in high resolution. For its application to basic and clinical research, an automatic and robust quantification of the capillary architecture is mandatory. Only this makes it possible to reliably analyze large amounts of image data, to establish biomarkers, and to monitor disease developments. However, due to its optical properties, OCTA images of skin often suffer from a poor signal-to-noise ...
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      Mentions: Massachusetts General Hospital Harvard University Gereon Hüttmann
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  4. About University of Lübeck

    University of Lübeck

    Universität zu Lübeck is recognised as “The Founders’ University” And ranked as one of three best universities under the EXIST sponsorship programme run by the Federal Ministry of Economics & Technology. The Universität zu Lübeck is the Founders’ University. It won this coveted title, as one of the three best universities, for its overall strategy to support start-ups. This was the outcome of the “EXIST Start-Up Culture – The Founders’ University” competition run by the Federal Ministry of Economics & Technology. The Federal Minister, Dr. Philipp Rösler, conferred the accolade at a celebration held on 9 January 2013 in Berlin.

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