1. University of Lübeck

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    1. Mentioned In 135 Articles

    2. Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast

      Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast
      Volumetric imaging of dynamic processes with microscopic resolution holds a huge potential in biomedical research and clinical diagnosis. Using supercontinuum light sources and high numerical aperture (NA) objectives, optical coherence tomography (OCT) achieves microscopic resolution and is well suited for imaging cellular and subcellular structures of biological tissues. Currently, the imaging speed of microscopic OCT (mOCT) is limited by the line-scan rate of the spectrometer camera and ranges from 30 ...
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    3. Imaging Inflammation – From Whole Body Imaging to Cellular Resolution

      Imaging Inflammation – From Whole Body Imaging to Cellular Resolution
      Imaging techniques have evolved impressively lately, allowing whole new concepts like multimodal imaging, personal medicine, theranostic therapies, and molecular imaging to increase general awareness of possiblities of imaging to medicine field. Here, we have collected the selected (3D) imaging modalities and evaluated the recent findings on preclinical and clinical inflammation imaging. The focus has been on the feasibility of imaging to aid in inflammation precision medicine, and the key challenges ...
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    4. Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision

      Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision
      In highly dispersion compensated Fourier domain mode locked (FDML) lasers, an ultra-low noise operation can only be achieved by extremely precise and stable matching of the filter tuning period and light circulation time in the cavity. We present a robust and high precision closed-loop control algorithm and an actively cavity length controlled FDML laser. The cavity length control achieves a stability of 0.18 mHz at a sweep repetition rate ...
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    5. Influence of retinal microsecond pulse laser treatment in central serous chorioretinopathy: a short-term optical coherence tomography angiography study

      Influence of retinal microsecond pulse laser treatment in central serous chorioretinopathy: a short-term optical coherence tomography angiography study
      Background: Central serous chorioretinopathy (CSC) is a common macular condition characterized by detachment of the neuroretina and is a frequent cause of central vision loss in adults. Among the various therapeutic strategies, subthreshold microsecond pulsed laser (SML) treatment has become a useful option. Despite the suggested involvement of choroidal circulatory disturbances in CSC, effects of this treatment on macular microperfusion have not been fully evaluated yet. Herein, we report the ...
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    6. Evaluating Retinal and Choroidal Perfusion Changes after Isometric and Dynamic Activity Using Optical Coherence Tomography Angiography

      Evaluating Retinal and Choroidal Perfusion Changes after Isometric and Dynamic Activity Using Optical Coherence Tomography Angiography
      Optical coherence tomography angiography (OCTA) is a non-invasive tool for imaging and quantifying the retinal and choroidal perfusion state in vivo. This study aimed to evaluate the acute effects of isometric and dynamic exercise on retinal and choroidal sublayer perfusion using OCTA. A pilot study was conducted on young, healthy participants, each of whom performed a specific isometric exercise on the first day and a dynamic exercise the day after ...
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    7. Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases

      Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases
      Purpose The treatment guidelines for many macular diseases rely on frequent monitoring with optical coherence tomography (OCT). However, the burden of frequent disease control leads to low therapy adherence in real life. OCT home monitoring would address this issue but requires an inexpensive and self-operable device. With self-examination low-cost full-field OCT (SELFF-OCT), our group has introduced a novel technology that may fulfill both requirements. In this pilot study, we report ...
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    8. Evaluating Retinal and Choroidal Perfusion Changes After Ocular Massage of Healthy Eyes Using Optical Coherence Tomography Angiography

      Evaluating Retinal and Choroidal Perfusion Changes After Ocular Massage of Healthy Eyes Using Optical Coherence Tomography Angiography
      Background and objectives: Ocular massage (OM) is used as a treatment option for acute retinal artery occlusion, under the assumption that it induces vessel dilatation and enhances perfusion. Since evidence of ocular perfusion alteration due to OM is lacking, we investigate the impact of OM on the hemodynamics of the posterior pole in healthy eyes in a noninvasive fashion by using optical coherence tomography angiography (OCTA). Materials and Methods: A ...
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    9. PhD Position Available in Lübeck: Development of an Ultra-Wideband FDML-Laser

      PhD Position Available in Lübeck: Development of an Ultra-Wideband FDML-Laser
      We offer a three year PhD student position for an Early Stage Researcher (ESR) on laser development in biomedical optics. The position is part of a Marie Skłodowska-Curie Innovative Training Network (ITN) within the EU Horizon 2020 Framework Programme. It will be within the project NETLAS (https://cordis.europa.eu/project/id/860807), which focuses on innovative solutions for fast, narrow linewidth, phase stable and wide tuning bandwidth swept sources ...
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    10. Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging

      Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging
      In order to realize adjustable A-scan rates of fast optical coherence tomography (OCT) systems, we investigate averaging of OCT image data acquired with a MHz-OCT system based on a Fourier Domain Mode Locked (FDML) laser. Increased system sensitivity and image quality can be achieved with the same system at the cost of lower imaging speed. Effectively, the A-scan rate can be reduced in software by a freely selectable factor. We ...
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    11. An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations

      An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations
      Caries, the worlds most common chronic disease, remains a major cause of invasive restorative dental treatment. To take advantage of the diagnostic potential of optical coherence tomography (OCT) in contemporary dental prevention and treatment, an intraorally applicable spectral-domain OCT probe has been developed based on an OCT hand-held scanner equipped with a rigid 90-optics endoscope. The probe was verified in vitro. In vivo, all tooth surfaces could be imaged with ...
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    12. Quantitative Comparison of the Vascular Structure of Macular Neovascularizations Between Swept-Source and Spectral-Domain Optical Coherence Tomography Angiography

      Quantitative Comparison of the Vascular Structure of Macular Neovascularizations Between Swept-Source and Spectral-Domain Optical Coherence Tomography Angiography
      ...h1,3,4 1Department of Ophthalmology, St. Franziskus Hospital, Münster, Germany; 2Department of Ophthalmology, University of Lübeck, Lübeck, Germany; 3Department of Ophthalmology, University of Essen–Duisburg, Essen, Germ...
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    13. Micro-optical coherence tomography for high-resolution morphologic imaging of cellular and nerval corneal micro-structures

      Micro-optical coherence tomography for high-resolution morphologic imaging of cellular and nerval corneal micro-structures
      We demonstrate the highest resolution (1.51.51 m) micrometer optical coherence tomography (OCT) imaging of the morphologic micro-structure of excised swine and non-human primate corneas. Besides epithelial, stromal, and endothelial cell morphology, this report focuses on investigating the most peripheral corneal nerve fibers, the nerve fibers of the subbasal plexus (SBP). Alterations of SBP nerve density and composition are reportedly linked to major neurologic disorders, such as diabetic neuropathy ...
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    14. Optical coherence tomography for fast bedside imaging, assessment and monitoring of autoimmune inflammatory skin diseases?

      Optical coherence tomography for fast bedside imaging, assessment and monitoring of autoimmune inflammatory skin diseases?
      Optical coherence tomography (OCT) is a non‐invasive, high‐resolution imaging technique with a growing impact in dermatology. The principle of OCT is comparable to that of sonography, except that it uses infrared laser light instead of ultrasound waves. It has been clinically demonstrated that OCT is suitable for discriminating between different types of non‐melanoma skin cancer at an early stage of disease. Optical coherence tomography generates two‐ or ...
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    15. Dynamic contrast in scanning microscopic OCT

      Dynamic contrast in scanning microscopic OCT
      While optical coherence tomography (OCT) provides a resolution down to 1 m, it has difficulties in visualizing cellular structures due to a lack of scattering contrast. By evaluating signal fluctuations, a significant contrast enhancement was demonstrated using time-domain full-field OCT (FF-OCT), which makes cellular and subcellular structures visible. The putative cause of the dynamic OCT signal is the site-dependent active motion of cellular structures in a sub-micrometer range, which provides ...
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    16. Frequency-doubled FDML-MOPA laser in the visible

      Frequency-doubled FDML-MOPA laser in the visible
      Wavelength-swept lasers enable high-speed measurements in absorption spectroscopy, Raman spectroscopy, nonlinear Raman hyperspectral microscopy, rapid confocal microscopy, short impulse generation, and most importantly for high-speed optical coherence tomography, with speeds up to video-rate volumetric imaging. Recently, we introduced a pulsed wavelength-swept laser based on the Fourier domain mode-locked (FDML) laser principle combined with a master-oscillator power amplifier (MOPA) architecture. The high peak powers reached with this laser enabled rapid two-photon ...
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    17. 1-15 of 135 1 2 3 4 5 6 7 8 9 »
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  2. About University of Lübeck

    University of Lübeck

    Universität zu Lübeck is recognised as “The Founders’ University” And ranked as one of three best universities under the EXIST sponsorship programme run by the Federal Ministry of Economics & Technology. The Universität zu Lübeck is the Founders’ University. It won this coveted title, as one of the three best universities, for its overall strategy to support start-ups. This was the outcome of the “EXIST Start-Up Culture – The Founders’ University” competition run by the Federal Ministry of Economics & Technology. The Federal Minister, Dr. Philipp Rösler, conferred the accolade at a celebration held on 9 January 2013 in Berlin.