1. University of Lübeck

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    1. Mentioned In 120 Articles

    2. Frequency-doubled FDML-MOPA laser in the visible

      Frequency-doubled FDML-MOPA laser in the visible
      Wavelength-swept lasers enable high-speed measurements in absorption spectroscopy, Raman spectroscopy, nonlinear Raman hyperspectral microscopy, rapid confocal microscopy, short impulse generation, and most importantly for high-speed optical coherence tomography, with speeds up to video-rate volumetric imaging. Recently, we introduced a pulsed wavelength-swept laser based on the Fourier domain mode-locked (FDML) laser principle combined with a master-oscillator power amplifier (MOPA) architecture. The high peak powers reached with this laser enabled rapid two-photon ...
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    3. Evaluating diurnal variations in retinal perfusion using optical coherence tomography angiography

      Evaluating diurnal variations in retinal perfusion using optical coherence tomography angiography
      Background Optical coherence tomography angiography (OCTA) is a non-invasive tool for imaging and quantifying the retinal and choroidal vasculature as well as perfusion state in healthy eyes. Choroidal perfusion is subject to diurnal variation, showing lowest perfusion in the morning and highest in the afternoon. In this index study, OCTA was used to investigate diurnal changes of the retinal perfusion in healthy adult eyes and to identify impacting factors since ...
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    4. Stromal Nerve Imaging and Tracking Using Micro-Optical Coherence Tomography

      Stromal Nerve Imaging and Tracking Using Micro-Optical Coherence Tomography
      urpose : To image, track and map the nerve fiber distribution in excised rabbit corneas over the entire stromal thickness using micro-optical coherence tomography (OCT) to develop a screening tool for early peripheral neuropathy. Methods : Excised rabbit corneas were consecutively imaged by a custom-designed OCT prototype and a commercial laser scanning fluorescence confocal microscope. The OCT images with a field of view of approximately 1 1 mm were recorded with axial ...
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    5. Dynamic contrast in scanning microscopic OCT

      Dynamic contrast in scanning microscopic OCT
      While optical coherence tomography (OCT) provides a resolution down to 1 micrometer it has difficulties to visualize cellular structures due to a lack of scattering contrast. By evaluating signal fluctuations, a significant contrast enhancement was demonstrated using time-domain full-field OCT (FF-OCT), which makes cellular and subcellular structures visible. The putative cause of the dynamic OCT signal is ATP-dependent motion of cellular structures in a sub-micrometer range, which provides histology-like contrast ...
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    6. Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice

      Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice
      Airway mucus obstruction is a hallmark of chronic lung diseases such as cystic fibrosis, asthma and COPD, and the development of more effective mucus mobilizing therapies remains an important unmet need for patients with these muco-obstructive lung diseases. However, methods for sensitive visualization and quantitative assessment of immediate effects of therapeutic interventions on mucus clearance in vivo are lacking. In this study, we determined if newly developed high-speed microscopic optical ...
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    7. Segmentation of Retinal Low-Cost Optical Coherence Tomography Images using Deep Learning

      Segmentation of Retinal Low-Cost Optical Coherence Tomography Images using Deep Learning
      The treatment of age-related macular degeneration (AMD) requires continuous eye exams using optical coherence tomography (OCT). The need for treatment is determined by the presence or change of disease-specific OCTbased biomarkers. Therefore, the monitoring frequency has a significant influence on the success of AMD therapy. However, the monitoring frequency of current treatment schemes is not individually adapted to the patient and therefore often insufficient. While a higher monitoring frequency would ...
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    8. Capillary Refill—The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography

      Capillary Refill—The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography
      Background/Objectives: Standard optical coherence tomography angiography (OCTA) has been limited to imaging blood vessels actively undergoing perfusion, providing a temporary picture of surface microvasculature. Capillary perfusion in the skin is dynamic and changes in response to the surrounding tissue's respiratory, nutritional, and thermoregulatory needs. Hence, OCTA often represents a given perfusion state without depicting the actual extent of the vascular network. Here we present a method for obtaining ...
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    9. Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT

      Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT
      Optical coherence tomography is a non-invasive and label-free imaging modality based on the detection of backscattered light in samples. As microscopic OCT (mOCT) combines high axial and lateral resolution, an investigation of biological and printed samples at subcellular level is feasible. The additional excellent depth resolution enables mOCT to be a suitable quality control of 3D printed samples. The use of speckle variance adds information about cell viability. Here we ...
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    10. Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography

      Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography
      We demonstrate three-dimensional intravascular flow imaging compatible with routine clinical image acquisition workflow by means of megahertz (MHz) intravascular Doppler Optical Coherence Tomography (OCT). The OCT system relies on a 1.1 mm diameter motorized imaging catheter and a 1.5 MHz Fourier Domain Mode Locked (FDML) laser. Using a post processing method to compensate the drift of the FDML laser output, we can resolve the Doppler phase shift between ...
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    11. Reduction of periodic noise in Fourier domain optical coherence tomography images by frequency domain filtering

      Reduction of periodic noise in Fourier domain optical coherence tomography images by frequency domain filtering
      In Fourier domain optical coherence tomography (FDOCT) coherence noise is caused by interference of light waves back-reflected or scattered from different spots within a measuring depth or from optical components within the OCT system such as a bended optical fibre. This coherence noise appears as periodic stripe patterns along the axial direction in resulting images. Background subtraction and physical segmentation are used to degrade the periodic coherence noise in previous ...
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    12. Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations

      Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations
      Computational adaptive optics (CAO) is emerging as a viable alternative to hardware-based adaptive opticsin particular when applied to optical coherence tomography of the retina. For this technique, algorithms are required that detect wavefront errors precisely and quickly. Here we propose an extension of the frequently used subaperture image correlation. By applying this algorithm iteratively and, more importantly, comparing each subaperture not to the central subaperture but to several randomly selected ...
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    13. Motorized capsule for shadow-free OCT imaging and synchronous beam control

      Motorized capsule for shadow-free OCT imaging and synchronous beam control
      We demonstrate a tethered motorized capsule for unobstructed optical coherence tomography (OCT) imaging of the esophagus. By using a distal reflector design, we avoided the common shadow artifact induced by the motor wires. A synchronous driving technique features three types of beam-scanning modes of the capsule, i.e., circumferential beam scanning, localized beam scanning, and accurate beam positioning. We characterized these three modes and carried out ex vivo imaging experiments ...
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  2. About University of Lübeck

    University of Lübeck

    Universität zu Lübeck is recognised as “The Founders’ University” And ranked as one of three best universities under the EXIST sponsorship programme run by the Federal Ministry of Economics & Technology. The Universität zu Lübeck is the Founders’ University. It won this coveted title, as one of the three best universities, for its overall strategy to support start-ups. This was the outcome of the “EXIST Start-Up Culture – The Founders’ University” competition run by the Federal Ministry of Economics & Technology. The Federal Minister, Dr. Philipp Rösler, conferred the accolade at a celebration held on 9 January 2013 in Berlin.