1. University of Iowa

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    1. Mentioned In 143 Articles

    2. Optical coherence tomography in multiple sclerosis: A 3-year prospective multicenter study

      Optical coherence tomography in multiple sclerosis: A 3-year prospective multicenter study
      Objective: To evaluate changes over 3 years in the thickness of inner retinal layers including the peripapillary retinal nerve fiber layer (pRNFL), and combined macular ganglion cell and inner plexiform layers (mGCIPL), in individuals with relapsing-remitting multiple sclerosis (RRMS) versus healthy controls; to determine whether optical coherence tomography (OCT) is sufficiently sensitive and reproducible to detect small degrees of neuroaxonal loss over time that correlate with changes in brain volume ...
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    3. Optical coherence tomography in multiple sclerosis: A 3-year prospective multicenter study

      Optical coherence tomography in multiple sclerosis: A 3-year prospective multicenter study
      Objective: To evaluate changes over 3 years in the thickness of inner retinal layers including the peripapillary retinal nerve fiber layer (pRNFL), and combined macular ganglion cell and inner plexiform layers (mGCIPL), in individuals with relapsing-remitting multiple sclerosis (RRMS) versus healthy controls; to determine whether optical coherence tomography (OCT) is sufficiently sensitive and reproducible to detect small degrees of neuroaxonal loss over time that correlate with changes in brain volume ...
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    4. Paracentral acute middle maculopathy in non-ischaemic central retinal vein occlusion: the role of en face optical coherence tomography

      Paracentral acute middle maculopathy in non-ischaemic central retinal vein occlusion: the role of en face optical coherence tomography
      A 64-year-old man presented with an acute-onset central visual deficit in the left eye. He described a specific pattern of paracentral scotoma consisting of grey spots arranged in a honeycomb pattern. He was a 10 pack-year smoker and his medications included low-dose aspirin, which was prescribed, 2years prior, following an episode of amaurosis fugax in the same eye. Investigations at that time had not revealed significant carotid stenosis. He was ...
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    5. Toward a New Staging System for Diabetic Retinopathy Using Wide Field Swept-Source Optical Coherence Tomography Angiography

      Toward a New Staging System for Diabetic Retinopathy Using Wide Field Swept-Source Optical Coherence Tomography Angiography
      Purpose of review: For over 50 years, diabetic retinopathy (DR) has been classified by pathologic features seen on clinical examination and conventional retinal photographs. However, newer technology such as optical coherence tomography angiography (OCTA) now enables rapid acquisition of retinal structural and vascular information in a reliable, non-invasive, high-resolution fashion. Here, we highlight recent studies that have explored wide field swept-source OCTA (WF SS-OCTA) for the diagnosis and management of ...
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    6. Utility of Spectral-Domain Optical Coherence Tomography in Differentiating Papilledema From Pseudopapilledema: A Prospective Longitudinal Study

      Utility of Spectral-Domain Optical Coherence Tomography in Differentiating Papilledema From Pseudopapilledema: A Prospective Longitudinal Study
      Background: Prospective and longitudinal studies assessing the utility of spectral-domain optical coherence tomography (SD-OCT) to differentiate papilledema from pseudopapilledema are lacking. We studied the sensitivity and specificity of baseline and longitudinal changes in SD-OCT parameters with 3D segmentation software to distinguish between papilledema and pseudopapilledema in a cohort of patients referred for evaluation of undiagnosed optic disc elevation. Methods: Fifty-two adult patients with optic disc elevation were enrolled in a ...
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    7. Diagnosis and Grading Of Papilledema Using Optical Coherence Tomography Compared To Clinical Staging By Frise´n Scale

      Diagnosis and Grading Of Papilledema Using Optical Coherence Tomography Compared To Clinical Staging By Frise´n Scale
      Objectives To compare and contrast 2 methods of quantitating papilledema, namely, optical coherence tomography (OCT) and Modified Frisn Scale (MFS). Methods Digital optic disc photographs and OCT fast retinal nerve fiber layer (RNFL) thickness, fast RNFL map, total retinal thickness, and fast disc images were obtained in 36 patients with papilledema. Digital optic disc photographs were randomized and graded by 4 masked expert reviewers using the MFS. We performed Spearman ...
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    8. A Deep-Learning Approach for Automated OCT En-Face Retinal Vessel Segmentation in Cases of Optic Disc Swelling Using Multiple En-Face Images as Input

      A Deep-Learning Approach for Automated OCT En-Face Retinal Vessel Segmentation in Cases of Optic Disc Swelling Using Multiple En-Face Images as Input
      Purpose : In cases of optic disc swelling, segmentation of projected retinal blood vessels from optical coherence tomography (OCT) volumes is challenging due to swelling-based shadowing artifacts. Based on our hypothesis that simultaneously considering vessel information from multiple projected retinal layers can substantially increase vessel visibility, in this work, we propose a deep-learning-based approach to segment vessels involving the simultaneous use of three OCT en-face images as input. Methods : A human ...
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    9. Optical Coherence Tomography Findings in the Junctional Scotoma of Traquair

      Optical Coherence Tomography Findings in the Junctional Scotoma of Traquair
      A 43-year-old woman presented with a right-sided visual field defect in the right eye. The visual acuity was normal and there was a right relative afferent pupillary defect. Formal visual field testing revealed a junctional scotoma of Traquair. The fundus examination showed optic atrophy in the right eye and optical coherence tomography demonstrated unilateral band atrophy. Neuroimaging revealed a sellar and suprasellar cystic pituitary adenoma for which she underwent a ...
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    10. Bilateral Enlargement of the Foveal Avascular Zone on Optical Coherence Tomography Angiography Associated With Cocaine Use

      Bilateral Enlargement of the Foveal Avascular Zone on Optical Coherence Tomography Angiography Associated With Cocaine Use
      Cocaine is a well-known cause of vascular injury and secondary end-organ damage. The presented case demonstrates retinal vascular abnormalities associated with a history of cocaine use in the absence of other retinal disease. A 61-year-old Latino man was referred for evaluation of gradual worsening near visual acuity and an inability to find a satisfactory refraction. His best-corrected visual acuity was 20/30 in each eye. Optical coherence tomography demonstrated bilateral ...
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    11. Estimation of volumetric optical coherence tomography measurements from 2D color fundus photographs using machine learning

      Estimation of volumetric optical coherence tomography measurements from 2D color fundus photographs using machine learning
      The optic nerve head is the location in the rear of the eye where the nerves exit the eye towards the brain. Swelling of the optic nerve head (ONH) is most accurately quantitatively assessed via volumetric measures using 3D spectral-domain optical coherence tomography (SD-OCT). However, SD-OCT is not always available as its use is primarily limited to specialized eye clinics rather than in primary care or telemedical settings. Thus, there ...
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    12. Region-Based Segmentation of Capillary Density in Optical Coherence Tomography Angiography

      Region-Based Segmentation of Capillary Density in Optical Coherence Tomography Angiography
      Microvascular changes are one of the early symptoms of retinal diseases. Recently developed optical coherence tomography angiography (OCTA) technology allows visualization and analysis of the retinal microvascular network in a non-invasive way. However, automated analysis of microvascular changes in OCTA is not a trivial task. Current approaches often attempt to directly segment the microvasculature. These approaches generally have problems in cases of poor image quality and limited visibility of the ...
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    13. Iowa City Medical Center Receives NIH Grant for Automated Assessment of Optic Nerve Edema with Low-Cost Imaging.

      Iowa City Medical Center Receives NIH Grant for Automated Assessment of Optic Nerve Edema with Low-Cost Imaging.
      Iowa City Medical Center Receives a 2019 NIH Grant for Automated Assessment of Optic Nerve Edema with Low-Cost Imaging. The principal investigator is Mona Garvin. The program began in 2016 and ends in 2020. Below is a summary of the proposed work. Papilledema - a specific type of optic nerve edema associated with elevated intracranial pressure - occurs in veterans due to intracranial masses or hemorrhage, obstructive hydrocephalus, following traumatic brain injury ...
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    14. Subretinal pseudocyst: A novel optical coherence tomography finding in age-related macular degeneration

      Subretinal pseudocyst: A novel optical coherence tomography finding in age-related macular degeneration
      Purpose: To report the presence of a new structural optical coherence tomography finding, namely, subretinal pseudocysts, in a patient affected by age-related macular degeneration. Methods: Case report including multimodal imaging discussion. Case Report: We report a case of a 77-year-old woman affected by age-related macular degeneration from 7years. Best corrected visual acuity was counting fingers and 20/40 in the right and left eye, respectively. The left eye was affected ...
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    15. Effect of Heart Rate on Early Progression of Cardiac Allograft Vasculopathy: A Prospective Study Using Highly Automated 3-D Optical Coherence Tomography Analysis

      Effect of Heart Rate on Early Progression of Cardiac Allograft Vasculopathy: A Prospective Study Using Highly Automated 3-D Optical Coherence Tomography Analysis
      Purpose Despite the controversial effect of elevated heart rate on progression of cardiac allograft vasculopathy (CAV), heart-rate-slowing agents are frequently prescribed with the assumption that higher heart rate predicts worse outcomes in cardiovascular disease. Methods This prospective 2-center trial investigated progression of CAV in 116 heart transplant (HTx) patients. Both baseline (1 month after HTx) and follow-up (12 months after HTx) examinations by coronary optical coherence tomography (OCT) were analyzed ...
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  2. About University of Iowa

    University of Iowa

    University of Iowa, also commonly called Iowa or UI, is a major research university located on a 1700 acres campus in Iowa City, Iowa, US, on the banks of the Iowa River. The university is organized into eleven colleges granting undergraduate, graduate, and professional degrees. The University is a member of the Big Ten Conference, the Committee on Institutional Cooperation, and is considered a "Public Ivy."