University of Illinois at Urbana-Champaign

Positive Results: A New Era for Medical Diagnostics - News from UIUC

Explore beckman.illinois.edu (May 1 2012)

A revolution in medical diagnostics and treatment has often been proclaimed because of recent advances like genetic screening and “lab-on-a-chip” technology. But this revolution, often referred to as personalized medicine, won’t take place without a new generation of diagnostic devices that fundamentally change the way diseases are detected and treated. And that technology is being developed, put into clinical trials, and in some cases commercialized by Beckman Institute researchers ... (Read Full Article)

Comment Mentions:   Stephen A. Boppart   University of Illinois at Urbana-Champaign   Gabriel Popescu

Real-time three-dimensional optical coherence tomography image-guided core-needle biopsy system

Explore opticsinfobase.org (Apr 30 2012) Probes

Advances in optical imaging modalities, such as optical coherence tomography (OCT), enable us to observe tissue microstructure at high resolution and in real time. Currently, core-needle biopsies are guided by external imaging modalities such as ultrasound imaging and x-ray computed tomography (CT) for breast and lung masses, respectively. These image-guided procedures are frequently limited by spatial resolution when using ultrasound imaging, or by temporal resolution (rapid real-time feedback capabilities) when ... (Read Full Article)

Comment Mentions:   Stephen A. Boppart   University of Illinois at Urbana-Champaign   Wen-Chuan Kuo

Computational adaptive optics for broadband optical interferometric tomography of biological tissue

Explore pnas.org (Apr 26 2012) Microscopy

..., and bDepartments of Electrical and Computer Engineering, cBioengineering, and dInternal Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801 Aberrations in optical microscopy reduce image resolution and contrast, and can l... (Read Full Article)

Comment Mentions:   Stephen A. Boppart   University of Illinois at Urbana-Champaign   Steven G. Adie

Computing the best high-resolution 3-D tissue images - News from Beckman Institute at UIUC

Explore News Bureau (Apr 23 2012)

Real-time, 3-D microscopic tissue imaging could be a revolution for medical fields such as cancer diagnosis, minimally invasive surgery and ophthalmology. University of Illinois researchers have developed a technique to computationally correct for aberrations in optical tomography, bringing the future of medical imaging into focus. The computational technique could provide faster, less expensive and higher resolution tissue imaging to a broader population of users. The group describes its technique this ... (Read Full Article)

Comment Mentions:   Stephen A. Boppart   University of Illinois at Urbana-Champaign   Steven G. Adie

Aberration characterization for the optimal design of high-resolution endoscopic optical coherence tomography catheters

Explore opticsinfobase.org (Mar 12 2012) Cardiology , Gastroenterology

We study the major factors causing degradation in the lateral resolution of gradient-index-lens-based catheters used for high-resolution optical coherence tomography. Chromatic aberration and astigmatism were taken into account in the propagation of broadband single-mode Gaussian beams through the catheter geometry. It was found that, while chromatic aberration did not preclude achieving high resolution, astigmatism posed a major technical difficulty, because its correction requires a very sensitive adjustment of parameters, especially ... (Read Full Article)

Comment Mentions:   Stephen A. Boppart   University of Illinois at Urbana-Champaign

Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin

Explore Wiley Online Library (Feb 27 2012) Dermatology , Microscopy

An integrated multimodal optical microscope is demonstrated for high-resolution, structural and functional imaging of engineered and natural skin. This microscope incorporates multiple imaging modalities including optical coherence (OCM), multi-photon (MPM), and fluorescence lifetime imaging microscopy (FLIM), enabling simultaneous visualization of multiple contrast sources and mechanisms from cells and tissues. Spatially co-registered OCM/MPM/FLIM images of multi-layered skin tissues are obtained, which are formed based on complementary information provided by ... (Read Full Article)

Comment Mentions:   Stephen A. Boppart   University of Illinois at Urbana-Champaign   Eric J. Chaney

Device and method for imaging the ear using optical coherence tomography

Explore uspto.gov (Feb 14 2012) Otolaryngology , Patents

A method of forming an image of tissue. The method includes non-invasively inserting a fiber-based device into a patient's ear canal and acquiring OCT data from ear tissue while the fiber-based device is in the ear canal. The method also includes converting the OCT data into at least one image. (Read Full Article)

Comment Mentions:   Stephen A. Boppart   University of Illinois at Urbana-Champaign

4th Biophotonics Summer School at University of Illinois at Urbana-Champaign May 21st - June 1st, 2012

Explore Optical Coherence Tomography News (Feb 13 2012)

...onal Science Foundation), and the University of Illinois Imaging Initiative, will take place at the University of Illinois at Urbana-Champaign, May 21- June 1, 2012. This is a two-week event aimed at training graduate students and post-doctor... (Read Full Article)

Comment Mentions:   Stephen A. Boppart   University of Illinois at Urbana-Champaign

Real Time Optical Coherence Tomography (OCT) of Human Tissue

Explore ClinicalTrials.gov (Jan 6 2012) Oncology , Clinical Trials

This is a single-arm, prospective, study of an optical imaging device on approximately twenty (20) subjects undergoing lumpectomies at one study site. In vivo and ex vivo imaging will be performed on study subjects with results being compared to final pathology. This study is a single-center, prospective, two-part open label study of an optical imaging device on approximately twenty (20) subjects at one (1) study site. Patients scheduled to undergo ... (Read Full Article)

Comment Mentions:   Stephen A. Boppart   University of Illinois at Urbana-Champaign   Diagnostic Photonics

Spectral near-field optical tomography

Explore uspto.gov (Jan 3 2012) Patents

A method and computer program product for imaging an object are disclosed. The object is illuminated with an electromagnetic wave, characterized by a spectrum of illuminating wavevectors. Electromagnetic waves scattered by the object are detected, and are characterized by a spectrum of detected wavevectors. An aperture equal to or smaller than an instantaneous characterizing wavelength of the illuminating electromagnetic wave is disposed between the source and the detector. At least ... (Read Full Article)

Comment Mentions:   University of Illinois at Urbana-Champaign   P. Scott Carney

Multimodal in vivo skin imaging with integrated optical coherence and multiphoton microscopy

Explore IEEE Xplore (Dec 9 2011) Dermatology , Microscopy

In this paper we demonstrate high resolution, multimodal in vivo imaging of human skin using optical coherence (OCM) and multiphoton microscopy (MPM). These two modalities are integrated into a single instrument to enable simultaneous acquisition and co-registration. The system design and the OCM image processing architecture enable sufficient performance of both modalities for in vivo imaging of human skin. Examples of multimodal in vivo imaging are presented as well as ... (Read Full Article)

Comment Mentions:   Stephen A. Boppart   University of Illinois at Urbana-Champaign

Optical coherence tomography for rapid tissue screening and directed histological sectioning

Explore IOS Press (Dec 3 2011)

In pathology, histological examination of the tissue is the “gold standard” to diagnose various diseases. It has contributed significantly toward identifying the abnormalities in tissues and cells, but has inherent drawbacks when used for fast and accurate diagnosis. These limitations include the lack of in vivo observation in real time and sampling errors due to limited number and area coverage of tissue sections. Its diagnostic yield also varies depending on ... (Read Full Article)

Comment Mentions:   Stephen A. Boppart   University of Illinois at Urbana-Champaign

Boppart Presents at Congressional Briefing

Explore interact.stltoday.com (Nov 15 2011)

University of Illinois at Urbana-Champaign Professor Stephen Boppart will take part in a congressional briefing convened by the Optical Societ... (Read Full Article)

Comment Mentions:   Joseph M. Schmitt   Duke University   Stephen A. Boppart

OSA to Host Congressional Briefing on Optics in Medical Imaging

Explore Optical Coherence Tomography News (Nov 15 2011)

...   Bliss Professor of Engineering, Beckman Institute for Advanced Science and Technology   University of Illinois at Urbana-Champaign   Topic: The Future of Healthcare with Optical Biomedical Imaging       Joseph Schmi... (Read Full Article)

Comment Mentions:   Joseph A. Izatt   Joseph M. Schmitt   Duke University

Robust determination of the anisotropic polarizability of nanoparticles using coherent confocal microscopy

Explore uspto.gov (Oct 25 2011) Microscopy , Patents

A coherent confocal microscope for fully characterizing the elastic scattering properties of a nanoparticle as a function of wavelength. Using a high numerical aperture lens, two-dimensional scanning and a simple vector beam shaper, the rank-2 polarizability tensor is estimated from a single confocal image. A computationally efficient data processing method is described and numerical simulations show that this algorithm is robust to noise and uncertainty in the focal plane position ... (Read Full Article)

Comment Mentions:   University of Illinois at Urbana-Champaign   P. Scott Carney