1. University of Houston

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    1. Mentioned In 241 Articles

    2. Assessing Porcine Iris Elasticity and Mechanical Anisotropy with Optical Coherence Elastography

      Assessing Porcine Iris Elasticity and Mechanical Anisotropy with Optical Coherence Elastography
      The relaxation and contraction of the sphincter and dilator muscles of the iris play a critical role in vision, yet little is known about the biomechanic al properties of these mus cles. This study aimed to determine the elastic properties of the iris as a function of its anatomy and intraocular pressure. A high - resolution phase - sensitive OCE system was employed to detect acoustic radiation force induced propagation of elastic ...
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    3. Ultra-fast dynamic line-field optical coherence elastography

      Ultra-fast dynamic line-field optical coherence elastography
      Abstract In this work, we present an ultra-fast line-field optical coherence elastography system (LF-OCE) with an 11.5 MHz equivalent A-line rate. The system was composed of a line-field spectral domain optical coherence tomography system based on a supercontinuum light source, Michelson-type interferometer, and a high-speed 2D spectrometer. The system performed ultra-fast imaging of elastic waves in tissue-mimicking phantoms of various elasticities.
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    4. Accuracy of Common Motion Estimators in Wave-Based Optical Coherence Elastography

      Accuracy of Common Motion Estimators in Wave-Based  Optical Coherence Elastography
      Abstract. Motion estimators are commonly used in shear wave optical coherence elastography to compute small displacements. This work focuses on comparing three motion estimators: Kasai, Loupas, and the vector method. Our results show that the vector method is superi or in low - SNR, low - amplitude situations for group velocity calculation and profile reconstruction . 202 1 Journal of Biomedical Photonics Engineering.
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    5. Multimodal high-resolution embryonic imaging with light sheet fluorescence microscopy and optical coherence tomography

      Multimodal high-resolution embryonic imaging with light sheet fluorescence microscopy and optical coherence tomography
      A high-resolution imaging system combining optical coherence tomography (OCT) and light sheet fluorescence microscopy (LSFM) was developed. LSFM confined the excitation to only the focal plane, removing the out of plane fluorescence. This enabled imaging a murine embryo with higher speed and specificity than traditional fluorescence microscopy. OCT gives information about the structure of the embryo from the same plane illuminated by LSFM. The co-planar OCT and LSFM instrument was ...
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    6. Deep learning improves image reconstruction in optical coherence tomography using less data

      Deep learning improves image reconstruction in optical coherence tomography using less data
      Optical coherence tomography (OCT) is a non-invasive imaging method that can provide 3D information of biological samples. The first generation of OCT systems were based on time-domain imaging, using a mechanical scanning set-up. However, the relatively slow data acquisition speed of these earlier time-domain OCT systems partially limited their use for imaging live specimen. The introduction of the spectral-domain OCT techniques with higher sensitivity has contributed to a dramatic increase ...
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    7. In vivo human corneal natural frequency quantification using dynamic optical coherence elastography: repeatability and reproducibility

      In vivo human corneal natural frequency quantification using dynamic optical coherence elastography: repeatability and reproducibility
      Reliable and quantitative assessment of corneal biomechanics is important for the detection and treatment of corneal disease. The present study evaluates the repeatability and reproducibility of a novel optical coherence tomography (OCT)-based elastography (OCE) method for in vivo quantification of corneal natural frequency in 20 normal human eyes. Sub-micron corneal oscillations were induced by repeated low-force (13 Pa) microliter air pulses at the corneal apex and were observed by ...
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    8. Neural network-based image reconstruction in swept-source optical coherence tomography using undersampled spectral data

      Neural network-based image reconstruction in swept-source optical coherence tomography using undersampled spectral data
      Optical Coherence Tomography (OCT) is a widely used non-invasive biomedical imaging modality that can rapidly provide volumetric images of samples. Here, we present a deep learning-based image reconstruction framework that can generate swept-source OCT (SS-OCT) images using undersampled spectral data, without any spatial aliasing artifacts. This neural network-based image reconstruction does not require any hardware changes to the optical set- up and can be easily integrated with existing swept-source or ...
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    9. Heartbeat optical coherence elastography: corneal biomechanics in vivo

      Heartbeat optical coherence elastography: corneal biomechanics in vivo
      Significance: Mechanical assessment of the cornea can provide important structural and functional information regarding its health. Current clinically available tools are limited in their efficacy at measuring corneal mechanical properties. Elastography allows for the direct estimation of mechanical properties of tissues in vivo but is generally performed using external excitation force. Aim: To show that heartbeat optical coherence elastography (Hb-OCE) can be used to assess the mechanical properties of the ...
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    10. In Vivo Human Corneal Shear-wave Optical Coherence Elastography

      In Vivo Human Corneal Shear-wave Optical Coherence Elastography
      SIGNIFICANCE A novel imaging technology, dynamic optical coherence elastography (OCE), was adapted for clinical noninvasive measurements of corneal biomechanics. PURPOSE Determining corneal biomechanical properties is a long-standing challenge. Elasticity imaging methods have recently been developed and applied for clinical evaluation of soft tissues in cancer detection, atherosclerotic plaque evaluation, surgical guidance, and more. Here, we describe the use of dynamic OCE to characterize mechanical wave propagation in the human cornea ...
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    11. Confocal air-coupled ultrasonic optical coherence elastography probe for quantitative biomechanics

      Confocal air-coupled ultrasonic optical coherence elastography probe for quantitative biomechanics
      We present an air-coupled ultrasonic radiation force probe co-focused with a phase-sensitive optical coherence tomography (OCT) system for quantitative wave-based elastography. A custom-made 1 MHz spherically focused piezoelectric transducer with a concentric 10 mm wide circular opening allowed for confocal micro-excitation of waves and phase-sensitive OCT imaging.
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    12. Dynamic Optical Coherence Elastography of the Anterior Eye: Understanding the Biomechanics of the Limbus

      Dynamic Optical Coherence Elastography of the Anterior Eye: Understanding the Biomechanics of the Limbus
      Purpose : Currently, the biomechanical properties of the corneo-scleral limbus when the eye-globe deforms are largely unknown. The purpose of this study is to evaluate changes in elasticity of the cornea, sclera, and limbus when subjected to different intraocular pressures (IOP) using wave-based optical coherence elastography (OCE). Special attention was given to the elasticity changes of the limbal region with respect to the elasticity variations in the neighboring corneal and scleral ...
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    13. 1-15 of 241 1 2 3 4 ... 14 15 16 »
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  2. About University of Houston

    University of Houston

    University of Houston is a public doctoral/research university located in Houston, Texas. It is the flagship institution and the only doctoral degree-granting university in the University of Houston System, which includes three other universities and two multi-institution teaching centers.  Biomedical Optics Laboratory at the University of Houston is located within the Biomedical Engineering and Mechanical Enginnering Department at the University of Houston (UH). The research activities of the laboratory, under the direction of Dr. Kirill Larin, concern the development of new methods for protein biosensing (based on nanooptics) and tissue functional imaging (based on Optical Coherence Tomography).