1. University of Houston

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    1. Mentioned In 173 Articles

    2. A dual-modality optical coherence tomography and selective plane illumination microscopy system for mouse embryonic imaging

      A dual-modality optical coherence tomography and selective plane illumination microscopy system for mouse embryonic imaging
      Both optical coherence tomography (OCT) and selective plane illumination microscopy (SPIM) are frequently used in mouse embryonic research for high-resolution three-dimensional imaging. However, each of these imaging methods provide a unique and independent advantage: SPIM provides morpho-functional information through immunofluorescence and OCT provides a method for whole-embryo 3D imaging. In this study, we have combined rotational imaging OCT and SPIM into a single, dual-modality device to image E9.5 mouse ...
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    3. Live dynamic analysis of the developing cardiovascular system in mice

      Live dynamic analysis of the developing cardiovascular system in mice
      The study of the developing cardiovascular system in mice is important for understanding human cardiogenesis and congenital heart defects. Our research focuses on imaging early development in the mouse embryo to specifically understand cardiovascular development under the regulation of dynamic factors like contractile force and blood flow using optical coherence tomography (OCT). We have previously developed an OCT based approach that combines static embryo culture and advanced image processing with ...
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    4. Optical coherence tomography for image-guided dermal filler injection and biomechanical evaluation

      Optical coherence tomography for image-guided dermal filler injection and biomechanical evaluation
      Dermal fillers are a very popular anti-aging treatment with estimated sales in the billions of dollars and millions of procedures performed. As the aging population continues to grow, these figures are only expected to increase. Dermal fillers have various compositions depending on their intended application. Reactions to dermal fillers can be severe, such as ischemic events and filler migration to the eyes. However, these adverse reactions are rare. Nevertheless, the ...
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    5. Ultra-fast line-field low coherence holographic elastography using spatial phase shifting

      Ultra-fast line-field low coherence holographic elastography using spatial phase shifting
      Optical coherence elastography (OCE) is an emerging technique for quantifying tissue biomechanical properties. Generally, OCE relies on point-by-point scanning. However, long acquisition times make point-by-point scanning unfeasible for clinical use. Here we demonstrate a noncontact single shot line-field low coherence holography system utilizing an automatic Hilbert transform analysis based on a spatial phase shifting technique. Spatio-temporal maps of elastic wave propagation were acquired with only one air-pulse excitation and used ...
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    6. Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

      Optical coherence elastography – OCT at work in tissue biomechanics [Invited]
      Optical coherence elastography (OCE), as the use of OCT to perform elastography has come to be known, began in 1998, around ten years after the rest of the field of elastography the use of imaging to deduce mechanical properties of tissues. After a slow start, the maturation of OCT technology in the early to mid 2000s has underpinned a recent acceleration in the field. With more than 20 papers published ...
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    7. The University of Houston Receives NIH Grant for Optical Coherence Tomography to Study Effect of Poly-Drug Exposure on Fetal Brain Development

      The University of Houston Receives NIH Grant for Optical Coherence Tomography to Study Effect of Poly-Drug Exposure on Fetal Brain Development
      ...icular significant impact for the development of novel and innovative therapies for reversing teratology. The University of Houston Receives a 2017 NIH Grant for $311,241 for Optical Coherence Tomography to Study Effect ...
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    8. Dynamic imaging and quantitative analysis of cranial neural tube closure in the mouse embryo using optical coherence tomography

      Dynamic imaging and quantitative analysis of cranial neural tube closure in the mouse embryo using optical coherence tomography
      Neural tube closure is a critical feature of central nervous system morphogenesis during embryonic development. Failure of this process leads to neural tube defects, one of the most common forms of human congenital defects. Although molecular and genetic studies in model organisms have provided insights into the genes and proteins that are required for normal neural tube development, complications associated with live imaging of neural tube closure in mammals limit ...
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    9. Assessing the effects of riboflavin/UV-A crosslinking on porcine corneal mechanical anisotropy with optical coherence elastography

      Assessing the effects of riboflavin/UV-A crosslinking on porcine corneal mechanical anisotropy with optical coherence elastography
      In this work we utilize optical coherence elastography (OCE) to assess the effects of UV-A/riboflavin corneal collagen crosslinking (CXL) on the mechanical anisotropy of in situ porcine corneas at various intraocular pressures (IOP). There was a distinct meridian of increased Youngs modulus in all samples, and the mechanical anisotropy increased as a function of IOP and also after CXL. The presented noncontact OCE technique was able to quantify the ...
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    10. OCT Expanded Clinical Data Analysis (OCT Aboard Space Station)

      OCT Expanded Clinical Data Analysis (OCT Aboard Space Station)
      Vision changes identified in long duration space fliers has led to a more comprehensive clinical monitoring protocol. Optical Coherence Tomography (OCT) was recently implemented on board the International Space Station in 2013. NASA is collaborating with Heidelberg Engineering to expand our current OCT data analysis capability by implementing a volumetric approach. Volumetric maps will be created by combining the circle scan, the disc block scan, and the radial scan. This ...
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    11. Optical Modalities for Embryonic Imaging

      Optical Modalities for Embryonic Imaging
      tudies of disease etiology often rely on the murine (mouse) model, which provides valuable genotypic information. Yet associated phenotypic information from murine embryos is often lacking. Of the various techniques that have been proposed for imaging such embryos, optical modalities may provide the best compromise among speed, penetration depth and resolution. This year, we developed approaches to improve embryonic imaging with optical coherence tomography (OCT), 1 and also provided a ...
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    12. Optical coherence elastography assessment of corneal viscoelasticity with a modified Rayleigh-Lamb wave model

      Optical coherence elastography assessment of corneal viscoelasticity with a modified Rayleigh-Lamb wave model
      The biomechanical properties of the cornea play a critical role in forming vision. Diseases such as keratoconus can structurally degenerate the cornea causing a pathological loss in visual acuity. UV-A/riboflavin corneal collagen crosslinking (CXL) is a clinically available treatment to stiffen the cornea and restore its healthy shape and function. However, current CXL techniques do not account for pre-existing biomechanical properties of the cornea nor the effects of the ...
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    13. Quantifying tissue viscoelasticity using optical coherence elastography and the Rayleigh wave model

      Quantifying tissue viscoelasticity using optical coherence elastography and the Rayleigh wave model
      This study demonstrates the feasibility of using the Rayleigh wave model (RWM) in combination with optical coherence elastography (OCE) technique to assess the viscoelasticity of soft tissues. Dispersion curves calculated from the spectral decomposition of OCE-measured air-pulse induced elastic waves were used to quantify the viscoelasticity of samples using the RWM. Validation studies were first conducted on 10% gelatin phantoms with different concentrations of oil. The results showed that the ...
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    14. Investigating Elastic Anisotropy of the Porcine Cornea as a Function of Intraocular Pressure With Optical Coherence Elastography

      Investigating Elastic Anisotropy of the Porcine Cornea as a Function of Intraocular Pressure With Optical Coherence Elastography
      PURPOSE: To evaluate the elastic anisotropy of porcine corneas at different intraocular pressures (IOPs) using a noncontact optical coherence elastography (OCE) technique. METHODS: A focused air-pulse induced low amplitude ( 10 m) elastic waves in fresh porcine corneas (n = 7) in situ in the whole eye globe configuration. A home-built phase-stabilized swept source optical coherence elastography (PhS-SSOCE) system imaged the elastic wave propagation at different stepped radial directions. A closed-loop feedback ...
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    15. 1-15 of 173 1 2 3 4 ... 10 11 12 »
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  2. About University of Houston

    University of Houston

    University of Houston is a public doctoral/research university located in Houston, Texas. It is the flagship institution and the only doctoral degree-granting university in the University of Houston System, which includes three other universities and two multi-institution teaching centers.  Biomedical Optics Laboratory at the University of Houston is located within the Biomedical Engineering and Mechanical Enginnering Department at the University of Houston (UH). The research activities of the laboratory, under the direction of Dr. Kirill Larin, concern the development of new methods for protein biosensing (based on nanooptics) and tissue functional imaging (based on Optical Coherence Tomography).