1. University of Houston

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    1. Mentioned In 249 Articles

    2. University of Houston Receives NIH Grant for Multimodal Optical Imaging on the Effect of Maternal Polysubstance Exposure on Fetal Brain Microvessel Function

      University of Houston Receives NIH Grant for Multimodal Optical Imaging on the Effect of Maternal Polysubstance Exposure on Fetal Brain Microvessel Function
      ...rategies targeted to prevent or reverse the effects of PEE and PNE on fetuses

      University of Houston Received a 2022 NIH Grant for $609,697 for Multimodal Optical Imaging on the Effect of M...

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    3. Widefield OCT Imaging for Quantifying Inner Retinal Thickness in the Nonhuman Primate

      Widefield OCT Imaging for Quantifying Inner Retinal Thickness in the Nonhuman Primate
      Purpose: To determine the agreement and repeatability of inner retinal thickness measures from widefield imaging compared to standard scans in healthy nonhuman primates. Methods: Optical coherence tomography (OCT) scans were acquired from 30 healthy rhesus monkeys, with 11 animals scanned at multiple visits. The scan protocol included 20 20 raster scans centered on the macula and optic nerve head (ONH), a 12 diameter circular scan centered on the ONH, and ...
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    4. Introduction to optical coherence elastography: tutorial

      Introduction to optical coherence elastography: tutorial
      Optical coherence elastography (OCE) has seen rapid growth since its introduction in 1998. The past few decades have seen tremendous advancements in the development of OCE technology and a wide range of applications, including the first clinical applications. This tutorial introduces the basics of solid mechanics, which form the foundation of all elastography methods. We then describe how OCE measurements of tissue motion can be used to quantify tissue biomechanical ...
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    5. Longitudinal assessment of the effect of alkali burns on corneal biomechanical properties using optical coherence elastography

      Longitudinal assessment of the effect of alkali burns on corneal biomechanical properties using optical coherence elastography
      Eye injury due to alkali burn is a severe ocular trauma that can profoundly affect corneal structure and function, including its biomechanical properties. Here, we assess the changes in the mechanical behavior of mouse corneas in response to alkali-induced injury by conducting longitudinal measurements using optical coherence elastography (OCE). A non-contact air-coupled ultrasound transducer was used to induce elastic waves in control and alkali-injured mouse corneas in vivo, which were ...
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    6. Spatial Assessment of Heterogeneous Tissue Natural Frequency Using Micro-Force Optical Coherence Elastography

      Spatial Assessment of Heterogeneous Tissue Natural Frequency Using Micro-Force Optical Coherence Elastography
      Analysis of corneal tissue natural frequency was recently proposed as a biomarker for corneal biomechanics and has been performed using high-resolution optical coherence tomography (OCT)-based elastography (OCE). However, it remains unknown whether natural frequency analysis can resolve local variations in tissue structure. We measured heterogeneous samples to evaluate the correspondence between natural frequency distributions and regional structural variations. Sub-micrometer sample oscillations were induced point-wise by microliter air pulses (6085 ...
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    7. Multimodal imaging system combining optical coherence tomography and Brillouin microscopy for neural tube imaging

      Multimodal imaging system combining optical coherence tomography and Brillouin microscopy for neural tube imaging
      To understand the dynamics of tissue stiffness during neural tube formation and closure in a murine model, we have developed a multimodal, coaligned imaging system combining optical coherence tomography (OCT) and Brillouin microscopy. Brillouin microscopy can map the longitudinal modulus of tissue but cannot provide structural images. Thus, it is limited for imaging dynamic processes such as neural tube formation and closure. To overcome this limitation, we have combined Brillouin ...
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    8. Assessing Porcine Iris Elasticity and Mechanical Anisotropy with Optical Coherence Elastography

      Assessing Porcine Iris Elasticity and Mechanical Anisotropy with Optical Coherence Elastography
      The relaxation and contraction of the sphincter and dilator muscles of the iris play a critical role in vision, yet little is known about the biomechanic al properties of these mus cles. This study aimed to determine the elastic properties of the iris as a function of its anatomy and intraocular pressure. A high - resolution phase - sensitive OCE system was employed to detect acoustic radiation force induced propagation of elastic ...
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    9. Ultra-fast dynamic line-field optical coherence elastography

      Ultra-fast dynamic line-field optical coherence elastography
      Abstract In this work, we present an ultra-fast line-field optical coherence elastography system (LF-OCE) with an 11.5 MHz equivalent A-line rate. The system was composed of a line-field spectral domain optical coherence tomography system based on a supercontinuum light source, Michelson-type interferometer, and a high-speed 2D spectrometer. The system performed ultra-fast imaging of elastic waves in tissue-mimicking phantoms of various elasticities.
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    10. Accuracy of Common Motion Estimators in Wave-Based Optical Coherence Elastography

      Accuracy of Common Motion Estimators in Wave-Based  Optical Coherence Elastography
      Abstract. Motion estimators are commonly used in shear wave optical coherence elastography to compute small displacements. This work focuses on comparing three motion estimators: Kasai, Loupas, and the vector method. Our results show that the vector method is superi or in low - SNR, low - amplitude situations for group velocity calculation and profile reconstruction . 202 1 Journal of Biomedical Photonics Engineering.
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    11. Multimodal high-resolution embryonic imaging with light sheet fluorescence microscopy and optical coherence tomography

      Multimodal high-resolution embryonic imaging with light sheet fluorescence microscopy and optical coherence tomography
      A high-resolution imaging system combining optical coherence tomography (OCT) and light sheet fluorescence microscopy (LSFM) was developed. LSFM confined the excitation to only the focal plane, removing the out of plane fluorescence. This enabled imaging a murine embryo with higher speed and specificity than traditional fluorescence microscopy. OCT gives information about the structure of the embryo from the same plane illuminated by LSFM. The co-planar OCT and LSFM instrument was ...
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    12. Deep learning improves image reconstruction in optical coherence tomography using less data

      Deep learning improves image reconstruction in optical coherence tomography using less data
      Optical coherence tomography (OCT) is a non-invasive imaging method that can provide 3D information of biological samples. The first generation of OCT systems were based on time-domain imaging, using a mechanical scanning set-up. However, the relatively slow data acquisition speed of these earlier time-domain OCT systems partially limited their use for imaging live specimen. The introduction of the spectral-domain OCT techniques with higher sensitivity has contributed to a dramatic increase ...
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  2. About University of Houston

    University of Houston

    University of Houston is a public doctoral/research university located in Houston, Texas. It is the flagship institution and the only doctoral degree-granting university in the University of Houston System, which includes three other universities and two multi-institution teaching centers.  Biomedical Optics Laboratory at the University of Houston is located within the Biomedical Engineering and Mechanical Enginnering Department at the University of Houston (UH). The research activities of the laboratory, under the direction of Dr. Kirill Larin, concern the development of new methods for protein biosensing (based on nanooptics) and tissue functional imaging (based on Optical Coherence Tomography).