1. University of Houston

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    1. Mentioned In 193 Articles

    2. Effects of Thickness on Corneal Biomechanical Properties Using Optical Coherence Elastography

      Effects of Thickness on Corneal Biomechanical Properties Using Optical Coherence Elastography
      SIGNIFICANCE Measured corneal biomechanical properties are driven by intraocular pressure, tissue thickness, and inherent material properties. We demonstrate tissue thickness as an important factor in the measurement of corneal biomechanics that can confound short-term effects due to UV riboflavin cross-linking (CXL) treatment. PURPOSE We isolate the effects of tissue thickness on the measured corneal biomechanical properties using optical coherence elastography by experimentally altering the tissue hydration state and stiffness. METHODS ...
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    3. Quantifying changes in lens biomechanical properties due to cold cataract with optical coherence elastography

      Quantifying changes in lens biomechanical properties due to cold cataract with optical coherence elastography
      Cataract is the most prevalent cause of visual impairment worldwide. Cataracts can be formed due to trauma, radiation, drug abuse, or low temperatures. Thus, early detection of cataract can be immensely helpful for preserving visual acuity by ensuring that the appropriate therapeutic procedures are performed at earlier stages of disease onset and progression. In this work, we utilized a phase-sensitive optical coherence elastography (OCE) system to quantify changes in biomechanical ...
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    4. Biomechanical assessment of myocardial infarction using optical coherence elastography

      Biomechanical assessment of myocardial infarction using optical coherence elastography
      Myocardial infarction (MI) leads to cardiomyocyte loss, impaired cardiac function, and heart failure. Molecular genetic analyses of myocardium in mouse models of ischemic heart disease have provided great insight into the mechanisms of heart regeneration, which is promising for novel therapies after MI. Although biomechanical factors are considered an important aspect in cardiomyocyte proliferation, there are limited methods for mechanical assessment of the heart in the mouse MI model. This ...
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    5. Evaluating the Effects of Maternal Alcohol Consumption on Murine Fetal Brain Vasculature Using Optical Coherence Tomography

      Evaluating the Effects of Maternal Alcohol Consumption on Murine Fetal Brain Vasculature Using Optical Coherence Tomography
      Prenatal alcohol exposure (PAE) can result in a range of anomalies including brain and behavioral dysfunctions, collectively termed fetal alcohol spectrum disorder (FASD). PAE during the 1 st and 2 nd trimester is common, and research in animal models has documented significant neural developmental deficits associated with PAE during this period. However, little is known about the immediate effects of PAE on fetal brain vasculature. In this study, we used ...
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    6. Common-path phase-sensitive optical coherence tomography provides enhanced phase stability and detection sensitivity for dynamic elastography

      Common-path phase-sensitive optical coherence tomography provides enhanced phase stability and detection sensitivity for dynamic elastography
      Phase-sensitive optical coherence elastography (PhS-OCE) is an emerging optical technique to quantify soft-tissue biomechanical properties. We implemented a common-path OCT design to enhance displacement sensitivity and optical phase stability for dynamic elastography imaging. The background phase stability was greater in common-path PhS-OCE (0.24 0.07nm) than conventional PhS-OCE (1.60 0.11m). The coefficient of variation for surface displacement measurements using conventional PhS-OCE averaged 11% versus 2% for common-path ...
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    7. Use of A-scan Ultrasound and Optical Coherence Tomography to Differentiate Papilledema From Pseudopapilledema

      Use of A-scan Ultrasound and Optical Coherence Tomography to Differentiate Papilledema From Pseudopapilledema
      SIGNIFICANCE Differentiating papilledema from pseudopapilledema reflecting tilted/crowded optic discs or disc drusen is critical but can be challenging. Our study suggests that spectral-domain optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness and retrobulbar optic nerve sheath diameter (ONSD) measured by A-scan ultrasound provide useful information when differentiating the two conditions. PURPOSE To evaluate the use of A-scan ultrasound and spectral-domain OCT retinal nerve fiber layer thickness (RNFLT ...
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    8. Comparison and combination of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study

      Comparison and combination of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study
      Several optical imaging techniques have been applied for high-resolution embryonic imaging using different contrast mechanisms, each with their own benefits and limitations. In this study, we imaged the same E9.5 mouse embryo with rotational imaging optical coherence tomography (RI-OCT) and selective plane illumination microscopy (SPIM). RI-OCT overcomes optical penetration limits of traditional OCT imaging that prohibit full-body imaging of mouse embryos at later stages by imaging the samples from ...
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    9. Evaluating biomechanical properties of murine embryos using Brillouin microscopy and optical coherence tomography

      Evaluating biomechanical properties of murine embryos using Brillouin microscopy and optical coherence tomography
      Embryogenesis is regulated by numerous changes in mechanical properties of the cellular microenvironment. Thus, studying embryonic mechanophysiology can provide a more thorough perspective of embryonic development, potentially improving early detection of congenital abnormalities as well as evaluating and developing therapeutic interventions. A number of methods and techniques have been used to study cellular biomechanical properties during embryogenesis. While some of these techniques are invasive or involve the use of external ...
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    10. Postnatal maturation of the fovea in Macaca mulatta using optical coherence tomography

      Postnatal maturation of the fovea in Macaca mulatta using optical coherence tomography
      Changes in the foveal anatomy during infancy are an important component in early development of spatial vision. The present longitudinal study in rhesus monkeys was undertaken to characterize the postnatal maturation of the fovea. Starting at four weeks after birth, the retinas of the left eyes of sixteen infant monkeys were imaged using spectral domain optical coherence tomography (SD OCT). Retinal scans were repeated every 30 days during the first ...
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    11. Optical coherence elastography to assess biomechanics and detect progression of ocular and other tissues degenerative diseases

      Optical coherence elastography to assess biomechanics and detect progression of ocular and other tissues degenerative diseases
      An excitation force (internal or external) and phase-sensitive optical coherence elastography (OCE) system, used in conjunction with a data analyzing algorithm, is capable of measuring and quantifying biomechanical parameters of tissues in situ and in vivo. The method was approbated and demonstrated on an example of the system that combines a pulsed ultrasound system capable of producing an acoustic radiation force on the crystalline lens surface and a phase-sensitive optical ...
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    12. Persistent Asymmetric Optic Disc Swelling After Long-Duration Space Flight: Implications for Pathogenesis

      Persistent Asymmetric Optic Disc Swelling After Long-Duration Space Flight: Implications for Pathogenesis
      Background: Several ophthalmic findings including optic disc swelling, globe flattening and choroidal folds have been observed in astronauts following long-duration space flight. The authors now report asymmetric choroidal expansion, disc swelling and optic disc morphologic changes in a 45-year-old astronaut which occurred during long-duration space flight and persisted following his space mission. Methods: Case study of ocular findings in an astronaut documented during and after a long-duration space flight of ...
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  2. About University of Houston

    University of Houston

    University of Houston is a public doctoral/research university located in Houston, Texas. It is the flagship institution and the only doctoral degree-granting university in the University of Houston System, which includes three other universities and two multi-institution teaching centers.  Biomedical Optics Laboratory at the University of Houston is located within the Biomedical Engineering and Mechanical Enginnering Department at the University of Houston (UH). The research activities of the laboratory, under the direction of Dr. Kirill Larin, concern the development of new methods for protein biosensing (based on nanooptics) and tissue functional imaging (based on Optical Coherence Tomography).