1. University of Hannover

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    1. Mentioned In 17 Articles

    2. Feature tracking for automated volume of interest stabilization on 4D-OCT images

      Feature tracking for automated volume of interest stabilization on 4D-OCT images
      A common representation of volumetric medical image data is the triplanar view (TV), in which the surgeon manually selects slices showing the anatomical structure of interest. In addition to common medical imaging such as MRI or computed tomography, recent advances in the field of optical coherence tomography (OCT) have enabled live processing and volumetric rendering of four-dimensional images of the human body. Due to the region of interest undergoing motion ...
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    3. Experimental Visualization of Labyrinthine Structure with Optical Coherence Tomography

      Experimental Visualization of Labyrinthine Structure with Optical Coherence Tomography
      Introduction: Visualization of inner ear structures is a valuable strategy for researchers and clinicians working on hearing pathologies. Optical coherence tomography (OCT) is a high-resolution imaging technology which may be used for the visualization of tissues. In this experimental study we aimed to evaluate inner ear anatomy in well-prepared human labyrinthine bones. Materials and Methods: Three fresh human explanted temporal bones were trimmed, chemically decalcified with ethylenediaminetetraacetic acid (EDTA), and ...
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    4. Comparative study of presurgical skin infiltration depth measurements of melanocytic lesions with OCT and high frequency ultrasound

      Comparative study of presurgical skin infiltration depth measurements of melanocytic lesions with OCT and high frequency ultrasound
      A reliable, fast, and non-invasive determination of melanoma thickness in vivo is highly desirable for clinical dermatology as it may facilitate the identification of surgical melanoma margins, determine if a sentinel node biopsy should be performed or not, and reduce the number of surgical interventions for patients. In this work, optical coherence tomography (OCT) and high frequency ultrasound (HFUS) are evaluated for quantitative in vivo preoperative assessment of the skin ...
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    5. Simple model to simulate OCT-depth signal in weakly and strongly scattering homogeneous media

      Simple model to simulate OCT-depth signal in weakly and strongly scattering homogeneous media
      We present a simple and efficient Monte Carlo model to predict the scattering coefficients and the influence of multiple photon scattering with increasing concentration of scattering centers from optical coherence tomography (OCT) data. While the model reliably estimates optical sample parameters for a broad range of concentrations, it does not require inclusion of more complex phenomena such as dependent scattering. Instead, it relies on a particular weighting function which is ...
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    6. Towards multimodal detection of melanoma thickness based on optical coherence tomography and optoacoustics

      Towards multimodal detection of melanoma thickness based on optical coherence tomography and optoacoustics
      Melanoma skin cancer has one of the highest mortality rates of all types of cancer if not detected at an early stage. The survival rate is highly dependent on its penetration depth, which is commonly determined by histopathology. In this work, we aim at combining optical coherence tomography and optoacoustic as a non-invasive all-optical method to measure the penetration depth of melanoma. We present our recent achievements to setup a ...
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    7. Fast and automatic depth control of iterative bone ablation based on optical coherence tomography data

      Fast and automatic depth control of iterative bone ablation based on optical coherence tomography data
      Laser surgery is an established clinical procedure in dental applications, soft tissue ablation, and ophthalmology. The presented experimental set-up for closed-loop control of laser bone ablation addresses a feedback system and enables safe ablation towards anatomical structures that usually would have high risk of damage. This study is based on combined working volumes of optical coherence tomography (OCT) and Er:YAG cutting laser. High level of automation in fast image ...
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    8. Retinal Layer Measurements After Successful Macula-off Retinal Detachment Repair using OCT

      Retinal Layer Measurements After Successful Macula-off Retinal Detachment Repair using OCT
      Purpose: Optical coherence tomography (OCT) was used to analyze the thickness of various retinal layers of patients following successful macula-off retinal detachment (RD) repair. Methods: OCT scans of patients after successful macula-off RD repair were re-analyzed with a sub-segmentation algorithm to measure various retinal layers. Regression analysis was performed to correlate time after surgery with changes in layer thickness. In addition, patients were divided in two groups. Group 1 had ...
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    9. Normal distributions transform in multi-modal image registration of optical coherence tomography and computed tomography datasets

      Normal distributions transform in multi-modal image registration of optical coherence tomography and computed tomography datasets
      In recent years, optical coherence tomography (OCT) has gained increasing attention not only as an imaging device, but also as a navigation system for surgical interventions. This approach demands to register intraoperative OCT to pre-operative computed tomography (CT) data. In this study, we evaluate algorithms for multi-modal image registration of OCT and CT data of a human temporal bone specimen. We focus on similarity measures that are common in this ...
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    10. In situ optical coherence tomography of percutaneous implant-tissue interfaces in a murine model

      In situ optical coherence tomography of percutaneous implant-tissue interfaces in a murine model
      Novel surface coatings of percutaneous implants need to be tested in biocompatibility studies. The use of animal models for testing usually involves numerous lethal biopsies for the analysis of the implant-tissue interface. In this study, optical coherence tomography (OCT) was used to monitor the reaction of the skin to a percutaneous implant in an animal model of hairless but immunocompetent mice. In vivo optical biopsies with OCT were taken at ...
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    11. A one step vs. a multi step geometric calibration of an optical coherence tomography

      A one step vs. a multi step geometric calibration of an optical coherence tomography
      This contribution compares two approaches for the geometric calibration of an optical coherence tomography (OCT) which forms part of a medical navigation system. For this purpose, a one step and a multi step calibration is performed with a self-produced 3D reference structure and a high-accurate 6 degrees of freedom (DoF) parallel robot, respectively. These 3D landmark-based geometric calibrations are based on the identification of a parameterized grey-box OCT model. We ...
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    12. Towards a one step geometric calibration of an optical coherence tomography

      Towards a one step geometric calibration of an optical coherence tomography
      This article presents a one step geometric calibration for an optical coherence tomography (OCT) which forms part of a medical navigation system. The 3D landmark-based geometric calibration with a self-produced 3D reference structure is based on the identification of a parameterized grey-box OCT model. We show in experimental results by comparing common measurement errors in the field of medical surgery before and after calibration, that the proposed methodology reduces systematic ...
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    13. Compensating Motion Artifacts of 3D in vivo SD-OCT Scans

      Compensating Motion Artifacts of 3D in vivo SD-OCT Scans
      We propose a probabilistic approach for compensating motion artifacts in 3D in vivo SD-OCT (spectral-domain optical coherence tomography) tomographs. Subject movement causing axial image shifting is a major problem for in vivo imaging. Our technique is applied to analyze the tissue at percutaneous implants recorded with SD-OCT in 3D. The key challenge is to distinguish between motion and the natural 3D spatial structure of the scanned subject. To achieve this ...
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    14. An elegant technique for ex vivo imaging in experimental research - optical coherence tomography (OCT)

      An elegant technique for ex vivo imaging in experimental research - optical coherence tomography (OCT)
      Optical coherence tomography (OCT) is an elegant technology for imaging of tissues and organs and has been established for clinical use for around a decade. Thus, it is used in vivo but can also serve as a valuable ex vivo imaging tool in experimental research. Here, a brief overview is given with a focus on an ex vivo application of OCT. Image and video examples of freshly obtained murine lungs ...
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    15. Feature Of The Week 12/4/11: Researchers in Hannover Germany Utilize OCT to Measure Skin Swelling Along Percutaneous Implants

      Feature Of The Week 12/4/11: Researchers in Hannover Germany Utilize OCT to Measure Skin Swelling Along Percutaneous Implants
      ...raphy of percutaneous implants in hairless mice", Proc. SPIE 7554, 75540S (2010) Researchers from the Leibniz University of Hannover (LUH), Laser Zentrum Hannover (LZH), and the Hannover Medical School (MHH) used OCT to ...
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    16. Model Based 3D Segmentation and OCT Image Undistortion of Percutaneous Implants

      Model Based 3D Segmentation and OCT Image Undistortion of Percutaneous Implants
      Optical Coherence Tomography (OCT) is a noninvasive im-aging technique which is used here for in vivo biocompatibility studies of percutaneous implants. A prerequisite for a morphometric analysis of the OCT images is the correction of optical distortions caused by the index of refraction in the tissue. We propose a fully automatic approach for 3D segmentation of percutaneous implants using Markov random fields. Refraction correction is done by using the subcutaneous ...
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    17. Rotationally acquired four-dimensional optical coherence tomography of embryonic chick hearts using retrospective gating on the common central A-scan

      Rotationally acquired four-dimensional optical coherence tomography of embryonic chick hearts using retrospective gating on the common central A-scan
      , , and et al. We introduce a new method of rotational image acquisition for four-dimensional (4D) optical coherence tomography (OCT) of beating embryonic chick hearts. The rotational axis and the central A-scan of the OCT are identical. An out-of-phase image sequence covering multiple heartbeats is acquired at ev ... [J. Biomed. Opt. 16, 096007 (2011)] published Fri Sep 02, 2011.
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    18. Integration of an Optical Coherence Tomography (OCT) System into an Examination Incubator to facilitate in vivo Imaging of Cardiovascular Development in higher vertebrate Embryos under stable physiological Conditions

      Integration of an Optical Coherence Tomography (OCT) System into an Examination Incubator to facilitate in vivo Imaging of Cardiovascular Development in higher vertebrate Embryos under stable physiological Conditions
      ... University of Denmark, Frederiksborgvej 399, 4000 Roskilde, Denmark ^c Institute of Mechatronic Systems, Leibniz Universität Hannover, Appelstraße 11a, 30167 Hannover, Germany ^d Department of Anatomy and Embryol...
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  2. About University of Hannover

    University of Hannover

    University of Hanover, officially the Gottfried Wilhelm Leibniz Universität Hannover, is a university located in Hanover, Germany. It was founded in 1831 and is organized in nine faculties. The university's profile, from its beginning, centered on science and technology. In the course of the 20th century faculties for arts and humanities were added, and the formerly independent Teachers Training College was made an integral part of the university.