1. University of Hannover

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    1. Mentioned In 25 Articles

    2. Open Source Optical Coherence Tomography Software

      Open Source Optical Coherence Tomography Software
      Optical coherence tomography (OCT) is a non-invasive imaging technique that is often described as the optical equivalent to ultrasound imaging. The basic building block of OCT acquisitions is an optical interference pattern that can be processed into a depth profile, which is also called A-scan. Several adjacent A-scans can be merged into a cross-sectional image. Most research that incorporates OCT requires a software solution for processing of the acquired raw ...
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    3. Effect of image artefacts on phase conjugation with spectral domain optical coherence tomography

      Effect of image artefacts on phase conjugation with spectral domain optical coherence tomography
      Recently the acquisition of the time-resolved reflection matrix was demonstrated based on spectral domain optical coherence tomography. In principle, the matrix describes the linear dependence of the OCT signal received from different depths on the field which is incident to the scattering sample. Knowledge of the matrix, hence, enables beam shaping to selectively enhance the received signal, for example to increase the penetration depth when imaging turbid media. We investigate ...
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    4. Double Interferometer Design for Independent Wavefront Manipulation in Spectral Domain Optical Coherence Tomography

      Double Interferometer Design for Independent Wavefront Manipulation in Spectral Domain Optical Coherence Tomography
      Spectral domain optical coherence tomography (SD-OCT) is a highly versatile method which allows for three dimensional optical imaging in scattering media. A number of recent publications demonstrated the technique to benefit from structured illumination and beam shaping approaches, e.g. to enhance the signal-to-noise ratio or the penetration depth with samples such as biological tissue. We present a compact and easy to implement design for independent wavefront manipulation and beam ...
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    5. Semantic denoising autoencoders for retinal optical coherence tomography

      Semantic denoising autoencoders for retinal optical coherence tomography
      Noise in speckle-prone optical coherence tomography tends to obfuscate important details necessary for medical diagnosis. In this paper, a denoising approach that preserves disease characteristics on retinal optical coherence tomography images in ophthalmology is presented. By combining a deep convolutional autoencoder with a priorly trained ResNet image classifier as regularizer, the perceptibility of delicate details is encouraged and only information-less background noise is filtered out. With our approach, higher peak ...
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    6. Iterative wavefront correction for complex spectral domain optical coherence tomography

      Iterative wavefront correction for complex spectral domain optical coherence tomography
      We propose a compact setup for wavefront manipulation in spectral domain optical coherence tomography (OCT). The system can easily be implemented into existing free-space OCT setups through modification of the source path only. We demonstrate complex-valued OCT signal acquisition based on phase shifting combined with iterative optical wavefront shaping, which locally enhances the OCT signal acquired from within a scattering sample. The system lends itself to future imaging studies in ...
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    7. Deep learning based 2.5D flow field estimation for maximum intensity projections of 4D optical coherence tomography

      Deep learning based 2.5D flow field estimation for maximum intensity projections of 4D optical coherence tomography
      In laser microsurgery, image-based control of the ablation laser can lead to higher accuracy and patient safety. However, camera-based image acquisition lacks the subcutaneous tissue perception. Optical coherence tomography (OCT) as high-resolution imaging modality yields transsectional images of tissue and can provide the missing depth information. Therefore, this paper deals with the tracking of distinctive subcutaneous structures on OCTs for automated control of ablation lasers in microsurgery. We present a ...
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    8. Development of a combined OCT-Raman probe for the prospective in vivo clinical melanoma skin cancer screening

      Development of a combined OCT-Raman probe for the prospective in vivo clinical melanoma skin cancer screening
      A combined optical coherence tomography (OCT)-Raman probe was designed and built into a spectral domain OCT head, and its performance was evaluated and compared to the most common Raman probe setups, based on a fiber bundle and confocal free space optics. Due to the use of the full field of view of an OCT scanning lens, the combined probe has a superior performance within maximum permissible exposure limits, compared ...
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    9. Feature tracking for automated volume of interest stabilization on 4D-OCT images

      Feature tracking for automated volume of interest stabilization on 4D-OCT images
      A common representation of volumetric medical image data is the triplanar view (TV), in which the surgeon manually selects slices showing the anatomical structure of interest. In addition to common medical imaging such as MRI or computed tomography, recent advances in the field of optical coherence tomography (OCT) have enabled live processing and volumetric rendering of four-dimensional images of the human body. Due to the region of interest undergoing motion ...
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    10. Experimental Visualization of Labyrinthine Structure with Optical Coherence Tomography

      Experimental Visualization of Labyrinthine Structure with Optical Coherence Tomography
      Introduction: Visualization of inner ear structures is a valuable strategy for researchers and clinicians working on hearing pathologies. Optical coherence tomography (OCT) is a high-resolution imaging technology which may be used for the visualization of tissues. In this experimental study we aimed to evaluate inner ear anatomy in well-prepared human labyrinthine bones. Materials and Methods: Three fresh human explanted temporal bones were trimmed, chemically decalcified with ethylenediaminetetraacetic acid (EDTA), and ...
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    11. Comparative study of presurgical skin infiltration depth measurements of melanocytic lesions with OCT and high frequency ultrasound

      Comparative study of presurgical skin infiltration depth measurements of melanocytic lesions with OCT and high frequency ultrasound
      A reliable, fast, and non-invasive determination of melanoma thickness in vivo is highly desirable for clinical dermatology as it may facilitate the identification of surgical melanoma margins, determine if a sentinel node biopsy should be performed or not, and reduce the number of surgical interventions for patients. In this work, optical coherence tomography (OCT) and high frequency ultrasound (HFUS) are evaluated for quantitative in vivo preoperative assessment of the skin ...
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    12. Simple model to simulate OCT-depth signal in weakly and strongly scattering homogeneous media

      Simple model to simulate OCT-depth signal in weakly and strongly scattering homogeneous media
      We present a simple and efficient Monte Carlo model to predict the scattering coefficients and the influence of multiple photon scattering with increasing concentration of scattering centers from optical coherence tomography (OCT) data. While the model reliably estimates optical sample parameters for a broad range of concentrations, it does not require inclusion of more complex phenomena such as dependent scattering. Instead, it relies on a particular weighting function which is ...
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    13. Towards multimodal detection of melanoma thickness based on optical coherence tomography and optoacoustics

      Towards multimodal detection of melanoma thickness based on optical coherence tomography and optoacoustics
      Melanoma skin cancer has one of the highest mortality rates of all types of cancer if not detected at an early stage. The survival rate is highly dependent on its penetration depth, which is commonly determined by histopathology. In this work, we aim at combining optical coherence tomography and optoacoustic as a non-invasive all-optical method to measure the penetration depth of melanoma. We present our recent achievements to setup a ...
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    14. Fast and automatic depth control of iterative bone ablation based on optical coherence tomography data

      Fast and automatic depth control of iterative bone ablation based on optical coherence tomography data
      Laser surgery is an established clinical procedure in dental applications, soft tissue ablation, and ophthalmology. The presented experimental set-up for closed-loop control of laser bone ablation addresses a feedback system and enables safe ablation towards anatomical structures that usually would have high risk of damage. This study is based on combined working volumes of optical coherence tomography (OCT) and Er:YAG cutting laser. High level of automation in fast image ...
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    15. Retinal Layer Measurements After Successful Macula-off Retinal Detachment Repair using OCT

      Retinal Layer Measurements After Successful Macula-off Retinal Detachment Repair using OCT
      Purpose: Optical coherence tomography (OCT) was used to analyze the thickness of various retinal layers of patients following successful macula-off retinal detachment (RD) repair. Methods: OCT scans of patients after successful macula-off RD repair were re-analyzed with a sub-segmentation algorithm to measure various retinal layers. Regression analysis was performed to correlate time after surgery with changes in layer thickness. In addition, patients were divided in two groups. Group 1 had ...
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  2. About University of Hannover

    University of Hannover

    University of Hanover, officially the Gottfried Wilhelm Leibniz Universität Hannover, is a university located in Hanover, Germany. It was founded in 1831 and is organized in nine faculties. The university's profile, from its beginning, centered on science and technology. In the course of the 20th century faculties for arts and humanities were added, and the formerly independent Teachers Training College was made an integral part of the university.