1. University of Erlangen

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    1. Mentioned In 78 Articles

    2. Maximum A Posteriori Signal Recovery for Optical Coherence Tomography Angiography Image Generation and Denoising

      Maximum A Posteriori Signal Recovery for Optical Coherence Tomography Angiography Image Generation and Denoising
      Optical coherence tomography angiography (OCTA) is a novel and clinically promising imaging modality to image retinal and sub-retinal vasculature. Based on repeated optical coherence tomography (OCT) scans, intensity changes are observed over time and used to compute OCTA image data. OCTA data are prone to noise and artifacts caused by variations in flow speed and patientmovement. We propose a novel iterativemaximuma posteriori signal recovery algorithm in order to generate OCTA ...
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    3. N2NSR‐OCT: Simultaneous denoising and super‐resolution in optical coherence tomography images using semi‐supervised deep learning

      N2NSR‐OCT: Simultaneous denoising and super‐resolution in optical coherence tomography images using semi‐supervised deep learning
      Optical coherence tomography (OCT) imaging shows a significant potential in clinical routines due to its noninvasive property. However, the quality of OCT images is generally limited by inherent speckle noise of OCT imaging and low sampling rate. To obtain high signal‐to‐noise ratio (SNR) and high‐resolution (HR) OCT images within a short scanning time, we presented a learning‐based method to recover high‐quality OCT images from noisy ...
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    4. Retinal choroidal vessel imaging based on multi-wavelength fundus imaging with the guidance of optical coherence tomography

      Retinal choroidal vessel imaging based on multi-wavelength fundus imaging with the guidance of optical coherence tomography
      A multispectral fundus camera (MSFC), as a novel noninvasive technology, uses an extensive range of monochromatic light sources that enable the view of different sectional planes of the retinal and choroidal structures. However, MSFC imaging involves complex processes affected by various factors, and the recognized theory based on light absorption above the choroid is not sufficient. In an attempt to supplement the relevant explanations, in this study, we used optical ...
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    5. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography

      Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
      Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction. To overcome this limitation, we developed split-spectrum amplitude-decorrelation angiography (SSADA) to improve the signal-to-noise ratio (SNR) of flow detection. The full OCT spectrum was split into several narrower ...
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    6. Novel input polarisation independent endoscopic cross polarised optical coherence tomography probe

      Novel input polarisation independent endoscopic cross polarised optical coherence tomography probe
      Lead by the original idea to perform noninvasive optical biopsies of various tissue, optical coherence tomography found numerous medical applications within the last two decades. The interference based imaging technique opens the possibility to visualise subcellular morphology up to an imaging depth of 3mm and up to micron level axial and lateral resolution. The birefringence properties of the tissue are visualised with enhanced contrast using polarisation sensitive or cross polarised ...
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    7. Optical Coherence Tomography with an SU(1,1) interferometer in the high parametric gain regime

      Optical Coherence Tomography with an SU(1,1) interferometer in the high parametric gain regime
      Gerard J. Machado,1, a) Gaetano Frascella,2, 3 Juan P. Torres,1, 4 and Maria V. Chekhova We demonstrate optical coherence tomography based on an SU(1,1) nonlinear interferometer with high-gain parametric down-conversion. For imaging and sensing applications, this scheme promises to outperform previous experiments working at low parametric gain, since higher photon fluxes provide better sensitivity and lower integration times for obtaining high-quality images. Moreover, there is ...
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    8. Correction propagation for user-assisted optical coherence tomography segmentation: general framework and application to Bruch’s membrane segmentation

      Correction propagation for user-assisted optical coherence tomography segmentation: general framework and application to Bruch’s membrane segmentation
      Optical coherence tomography (OCT) is a commonly used ophthalmic imaging modality. While OCT has traditionally been viewed cross-sectionally (i.e., as a sequence of B-scans), higher A-scan rates have increased interest in en face OCT visualization and analysis. The recent clinical introduction of OCT angiography (OCTA) has further spurred this interest, with chorioretinal OCTA being predominantly displayed via en face projections. Although en face visualization and quantitation are natural for ...
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    9. Input polarization-independent polarization-sensitive optical coherence tomography using a depolarizer

      Input polarization-independent polarization-sensitive optical coherence tomography using a depolarizer
      Polarization-sensitive optical coherence tomography is gaining attention because of its ability to diagnose certain pathological conditions at an early stage. The majority of polarization-sensitive optical coherence tomography systems require a polarization controller and a polarizer to obtain the optimal polarization state of the light at the sample. Such systems are prone to misalignment since any movement of the optical fiber normally coupled to the light source will change the polarization ...
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    10. Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography

      Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography
      Spectral-domain optical coherence tomography (SD-OCT) represents a reliable tool for retinal layer volume and thickness measurement. The aim of this study was to evaluate retinal changes indicating neurodegenerative processes in patients with end-stage renal disease (ESRD) compared to healthy controls. This was a cross-sectional, single-center study comprising 32 ESRD patients and 38 controls. Sectoral retinal nerve fiber layer (RNFL) thickness and retinal layer volumes were obtained by SD-OCT. Age- and ...
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    11. Comparative study of deep learning models for optical coherence tomography angiography

      Comparative study of deep learning models for optical coherence tomography angiography
      Optical coherence tomography angiography (OCTA) is a promising imaging modality for microvasculature studies. Meanwhile, deep learning has achieved rapid development in image-to-image translation tasks. Some studies have proposed applying deep learning models to OCTA reconstruction and have obtained preliminary results. However, current studies are mostly limited to a few specific deep neural networks. In this paper, we conducted a comparative study to investigate OCTA reconstruction using deep learning models. Four ...
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    12. Compressed Sensing for Optical Coherence Tomography Angiography Volume Generation

      Compressed Sensing for Optical Coherence Tomography Angiography Volume Generation
      Optical coherence tomography angiography (OCTA) is an increasingly popular modality for imaging of the retinal vasculature. Repeated optical coherence tomography (OCT) scans of the retina allow the computation of motion contrast to display the retinal vasculature. To the best of our knowledge, we present the first application of compressed sensing for the generation of OCTA volumes. Using a probabilistic signal model for the computation of OCTA volumes and a 3D ...
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    13. Swept source cross-polarized optical coherence tomography for any input polarized light

      Swept source cross-polarized optical coherence tomography for any input polarized light
      Cross polarized optical coherence tomography offers enhanced contrast in certain pathological conditions. Traditional cross-polarized optical coherence tomography systems require a defined input polarization and thus require several polarization controlling elements increasing the overall complexity of the system. Our proposed system requires a single quarter wave plate as a polarization controller thus simplifying the system significantly. Majority of Cross-polarized optical coherence tomography systems are spectrometer based which suffers from slow speed ...
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    14. Noise reduction in optical coherence tomography images using a deep neural network with perceptually-sensitive loss function

      Noise reduction in optical coherence tomography images using a deep neural network with perceptually-sensitive loss function
      Optical coherence tomography (OCT) is susceptible to the coherent noise, which is the speckle noise that deteriorates contrast and the detail structural information of OCT images, thus imposing significant limitations on the diagnostic capability of OCT. In this paper, we propose a novel OCT image denoising method by using an end-to-end deep learning network with a perceptually-sensitive loss function. The method has been validated on OCT images acquired from healthy ...
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    15. Deep OCT Angiography Image Generation for Motion Artifact Suppression

      Deep OCT Angiography Image Generation for Motion Artifact Suppression
      Eye movements, blinking and other motion during the acquisition of optical coherence tomography (OCT) can lead to artifacts, when processed to OCT angiography (OCTA) images. Affected scans emerge as high intensity (white) or missing (black) regions, resulting in lost information. The aim of this research is to fill these gaps using a deep generative model for OCT to OCTA image translation relying on a single intact OCT scan. Therefore, a ...
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    16. Application of Corneal Optical Coherence Tomography Angiography for Assessment of Vessel Depth in Corneal Neovascularization

      Application of Corneal Optical Coherence Tomography Angiography for Assessment of Vessel Depth in Corneal Neovascularization
      Purpose: To map and measure the depths of corneal neovascularization (NV) using 3-dimensional optical coherence tomography angiography (OCTA) at 2 different wavelengths. Methods: Corneal NV of varying severity, distribution, and underlying etiology was examined. Average NV depth and vessel density were measured using 840-nm spectral-domain OCTA and 1050-nm swept-source OCTA. The OCTA results were compared with clinical slit-lamp estimation of NV depth. Results: Twelve eyes with corneal NV from 12 ...
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  2. About University of Erlangen

    University of Erlangen

    University of Erlangen: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) is one of the largest universities in Germany. With its five faculties, FAU offers an almost unique scope of subjects ranging from the Humanities to Law and Economics as well as Sciences, Medicine and Engineering. The close collaboration between the single disciplines is reflected by the University’s Mission Statement "Advance through Networks". FAU thus offers perfect conditions for interdisciplinary research and learning to students and scientists alike.