1. University of Erlangen

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    1. Mentioned In 70 Articles

    2. Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography

      Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography
      Spectral-domain optical coherence tomography (SD-OCT) represents a reliable tool for retinal layer volume and thickness measurement. The aim of this study was to evaluate retinal changes indicating neurodegenerative processes in patients with end-stage renal disease (ESRD) compared to healthy controls. This was a cross-sectional, single-center study comprising 32 ESRD patients and 38 controls. Sectoral retinal nerve fiber layer (RNFL) thickness and retinal layer volumes were obtained by SD-OCT. Age- and ...
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    3. Comparative study of deep learning models for optical coherence tomography angiography

      Comparative study of deep learning models for optical coherence tomography angiography
      Optical coherence tomography angiography (OCTA) is a promising imaging modality for microvasculature studies. Meanwhile, deep learning has achieved rapid development in image-to-image translation tasks. Some studies have proposed applying deep learning models to OCTA reconstruction and have obtained preliminary results. However, current studies are mostly limited to a few specific deep neural networks. In this paper, we conducted a comparative study to investigate OCTA reconstruction using deep learning models. Four ...
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    4. Compressed Sensing for Optical Coherence Tomography Angiography Volume Generation

      Compressed Sensing for Optical Coherence Tomography Angiography Volume Generation
      Optical coherence tomography angiography (OCTA) is an increasingly popular modality for imaging of the retinal vasculature. Repeated optical coherence tomography (OCT) scans of the retina allow the computation of motion contrast to display the retinal vasculature. To the best of our knowledge, we present the first application of compressed sensing for the generation of OCTA volumes. Using a probabilistic signal model for the computation of OCTA volumes and a 3D ...
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    5. Swept source cross-polarized optical coherence tomography for any input polarized light

      Swept source cross-polarized optical coherence tomography for any input polarized light
      Cross polarized optical coherence tomography offers enhanced contrast in certain pathological conditions. Traditional cross-polarized optical coherence tomography systems require a defined input polarization and thus require several polarization controlling elements increasing the overall complexity of the system. Our proposed system requires a single quarter wave plate as a polarization controller thus simplifying the system significantly. Majority of Cross-polarized optical coherence tomography systems are spectrometer based which suffers from slow speed ...
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    6. Noise reduction in optical coherence tomography images using a deep neural network with perceptually-sensitive loss function

      Noise reduction in optical coherence tomography images using a deep neural network with perceptually-sensitive loss function
      Optical coherence tomography (OCT) is susceptible to the coherent noise, which is the speckle noise that deteriorates contrast and the detail structural information of OCT images, thus imposing significant limitations on the diagnostic capability of OCT. In this paper, we propose a novel OCT image denoising method by using an end-to-end deep learning network with a perceptually-sensitive loss function. The method has been validated on OCT images acquired from healthy ...
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    7. Deep OCT Angiography Image Generation for Motion Artifact Suppression

      Deep OCT Angiography Image Generation for Motion Artifact Suppression
      Eye movements, blinking and other motion during the acquisition of optical coherence tomography (OCT) can lead to artifacts, when processed to OCT angiography (OCTA) images. Affected scans emerge as high intensity (white) or missing (black) regions, resulting in lost information. The aim of this research is to fill these gaps using a deep generative model for OCT to OCTA image translation relying on a single intact OCT scan. Therefore, a ...
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    8. Application of Corneal Optical Coherence Tomography Angiography for Assessment of Vessel Depth in Corneal Neovascularization

      Application of Corneal Optical Coherence Tomography Angiography for Assessment of Vessel Depth in Corneal Neovascularization
      Purpose: To map and measure the depths of corneal neovascularization (NV) using 3-dimensional optical coherence tomography angiography (OCTA) at 2 different wavelengths. Methods: Corneal NV of varying severity, distribution, and underlying etiology was examined. Average NV depth and vessel density were measured using 840-nm spectral-domain OCTA and 1050-nm swept-source OCTA. The OCTA results were compared with clinical slit-lamp estimation of NV depth. Results: Twelve eyes with corneal NV from 12 ...
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    9. Quantitative Phase Imaging Using Digital Holographic Microscopy Reliably Assesses Morphology and Reflects Elastic Properties of Fibrotic Intestinal Tissue

      Quantitative Phase Imaging Using Digital Holographic Microscopy Reliably Assesses Morphology and Reflects Elastic Properties of Fibrotic Intestinal Tissue
      Intestinal strictures are a frequent complication in patients with Crohns Disease (CD) and the presence of fibrosis within strictures impacts the therapeutic treatment approach. Here, we evaluate quantitative phase imaging (QPI) using digital holographic microscopy (DHM) for the evaluation of fibrosis within CD strictures. 30 full thickness resection specimens were obtained from non-stenotic and stenotic tissue areas of 15 CD patients. Cryostat sections were analyzed by DHM to measure the ...
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    10. Characterization of dry eye disease in a mouse model by optical coherence tomography and fluorescein staining

      Characterization of dry eye disease in a mouse model by optical coherence tomography and fluorescein staining
      A custom-built ultrahigh-resolution optical coherence tomography (UHR-OCT) system and fluorescein staining were employed for investigation of a scopolamine induced dry eye mouse model. Acquired data was used to evaluate common and complementary findings of the two modalities. Central corneal thickness as measured by UHR-OCT increased significantly over the study period of 24 hours, from 89.03.57 m to 92.24.07 m. Both techniques were able to show corneal ...
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    11. OCT‐assessment of scaffold resorption: Analysis of strut intensity by a new resorption index for poly‐l‐lactic acid bioresorbable vascular scaffolds

      OCT‐assessment of scaffold resorption: Analysis of strut intensity by a new resorption index for poly‐l‐lactic acid bioresorbable vascular scaffolds
      Background The aim of this study was to analyze individual differences in resorption of bioresorbable vascular scaffolds (BRS) through optical coherence tomography (OCT) analysis and to identify factors potentially influencing the resorption process. Methods Between April 2016 and July 2017 clinically driven invasive coronary angiography and OCT examinations were performed in 36 patients who had previously been treated with a total of 48 BRS (ABSORB BVS, Abbott Vascular, Santa Clara ...
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    12. Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study

      Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study
      Purpose : To quantify peripapillary choroidal thickness (PCT) and the factors that influence it in healthy participants who represent the racial and ethnic composition of the U.S. population. Methods : A total of 362 healthy participants underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head with a 24 radial B-scan pattern aligned to the fovea to Bruch's membrane opening axis. Bruch's membrane, anterior scleral canal ...
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    13. Effect of plaque composition, morphology, and burden on DESolve novolimus-eluting bioresorbable vascular scaffold expansion and eccentricity — An optical coherence tomography analysis

      Effect of plaque composition, morphology, and burden on DESolve novolimus-eluting bioresorbable vascular scaffold expansion and eccentricity — An optical coherence tomography analysis
      Objective This study of patients treated with novolimus-eluting bioresorbable scaffold (BRS) investigated the impact of plaque burden on the acute mechanical performance of the BRS and the short-term outcome. Methods A total of 15 patients were enrolled. The following parameters were derived from optical coherence tomography (OCT) during the final pullback: mean and minimum area, residual area stenosis, incomplete strut apposition, tissue prolapse, scaffold expansion index (SEI), scaffold eccentricity index ...
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    14. Temporal and Volumetric Denoising via Quantile Sparse Image (QuaSI) Prior in Optical Coherence Tomography and Beyond

      Temporal and Volumetric Denoising via Quantile Sparse Image (QuaSI) Prior in Optical Coherence Tomography and Beyond
      This paper introduces an universal and structure-preserving regularization term, called quantile sparse image (QuaSI) prior. The prior is suitable for denoising images from various medical image modalities. We demonstrate its effectivness on volumetric optical coherence tomography (OCT) and computed tomography (CT) data, which show differnt noise and image characteristics. OCT offers high-resolution scans of the human retina but is inherently impaired by speckle noise. CT on the other hand has ...
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    15. Predictive Factors for Visual Field Conversion: Comparison of Scanning Laser Polarimetry and Optical Coherence Tomography

      Predictive Factors for Visual Field Conversion: Comparison of Scanning Laser Polarimetry and Optical Coherence Tomography
      Purpose: The purpose of this study was to compare the ability of scanning laser polarimetry (SLP) and spectral-domain optical coherence tomography (SD-OCT) to predict future visual field conversion of subjects with ocular hypertension and early glaucoma. Methods: All patients were recruited from the Erlangen glaucoma registry and examined using standard automated perimetry, 24-hour intraocular pressure profile, and optic disc photography. Peripapillary retinal nerve fiber layer thickness (RNFL) measurements were obtained ...
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    16. Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis

      Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis
      Purpose : To use a novel optical coherence tomography angiography (OCTA) algorithm termed variable interscan time analysis (VISTA) to evaluate relative blood flow speeds in polypoidal choroidal vasculopathy (PCV). Methods : Prospective cross-sectional study enrolling patients with confirmed diagnosis of PCV. OCTA of the retina and choroid was obtained with a prototype swept-source OCT system. The acquired OCT volumes were centered on the branching vascular network (BVN) and polyps as determined by ...
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  2. About University of Erlangen

    University of Erlangen

    University of Erlangen: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) is one of the largest universities in Germany. With its five faculties, FAU offers an almost unique scope of subjects ranging from the Humanities to Law and Economics as well as Sciences, Medicine and Engineering. The close collaboration between the single disciplines is reflected by the University’s Mission Statement "Advance through Networks". FAU thus offers perfect conditions for interdisciplinary research and learning to students and scientists alike.