1. University of Dundee

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    1. Mentioned In 23 Articles

    2. Spatial resolution in dynamic optical coherence elastography

      Spatial resolution in dynamic optical coherence elastography
      Dynamic optical coherence elastography (OCE) tracks elastic wave propagation speed within tissue, enabling quantitative three-dimensional imaging of the elastic modulus. We show that propagating mechanical waves are mode converted at interfaces, creating a finite region on the order of an acoustic wavelength where there is not a simple one-to-one correspondence between wave speed and elastic modulus. Depending on the details of a boundarys geometry and elasticity contrast, highly complex propagating ...
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    3. Visualizing choriocapillaris using swept-source optical coherence tomography angiography with various probe beam sizes

      Visualizing choriocapillaris using swept-source optical coherence tomography angiography with various probe beam sizes
      Imaging choriocapillaris (CC) is a long-term challenge for commercial OCT angiography (OCTA) systems due to limited transverse resolution. Effects of transverse resolution on the visualization of a CC microvascular network are explored and demonstrated in this paper. We use three probe beams with sizes of ~1.12 mm, ~2.51 mm and ~3.50 mm at the pupil plane, which deliver an estimated transverse resolution at the retina of 17 ...
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    4. Development of a clinical prototype of a miniature hand-held optical coherence tomography probe for prematurity and pediatric ophthalmic imaging

      Development of a clinical prototype of a miniature hand-held optical coherence tomography probe for prematurity and pediatric ophthalmic imaging
      We report a novel design and operation of a highly integrated miniature handheld OCT probe, with high-speed angiography function that can be used in clinical settings for young children and infants, providing rapid, non-invasive structural and angiographic imaging of the retina and choroid. The imaging system is operated at 200 kHz, with 3D OCT and OCTA scan time of 0.8 and 3.2 seconds, respectively, and the scanning angle ...
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    5. Feasibility study of using the dispersion of surface acoustic wave (SAW) impulse for viscoelasticity characterization in tissue mimicking phantoms

      Feasibility study of using the dispersion of surface acoustic wave (SAW) impulse for viscoelasticity characterization in tissue mimicking phantoms
      The aim of this study was to investigate the feasibility of utilizing the phase velocity dispersion of impulse surface acoustic wave (SAW) for viscoelasticity characterization of soft materials. The focused ultrasound transducer and the phase sensitive optical coherence tomography (PhS‐OCT) were applied as the impulse SAW inducer and tracker respectively. Three types of liquid‐paraffin‐based cream‐in‐agar phantoms were tested. Phase velocity dispersion curve was extracted using ...
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    6. The potential of high intensity focused ultrasound (HIFU) combine phase-sensitive optical coherence tomography (PhS-OCT) for diseases diagnosis, treatment and monitoring

      The potential of high intensity focused ultrasound (HIFU) combine phase-sensitive optical coherence tomography (PhS-OCT) for diseases diagnosis, treatment and monitoring
      HIFU is a truly noninvasive, acoustic therapeutic technique that utilizes high intensity acoustic field in the focus to kill the targeted tissue for disease treatment purpose. The mechanical properties of targeted tissue changes before and after treatment, and this change can be accurately detected by shear wave elastography. Hence, shear wave elastography is usually used for monitoring HIFU treatment asynchronously. To improve the low spatial resolution in ultrasound shear wave ...
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    7. Structural characterization on in vitro porcine skin treated by ablative fractional laser using optical coherence tomography

      Structural characterization on in vitro porcine skin treated by ablative fractional laser using optical coherence tomography
      Ablative fractional skin laser is widely applied for various skin conditions, especially for cosmetic repairing and promoting the located drug delivery. Although the influence of laser treatment over the skin has been explored before in means of excision and biopsy with microscopy, these approaches are invasive, only morphological and capable of distorting the skin. In this paper the authors use fresh porcine skin samples irradiated by the lasers, followed by ...
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    8. Quantitative assessment of the mechanical properties of prostate tissue with optical coherence elastography

      Quantitative assessment of the mechanical properties of prostate tissue with optical coherence elastography
      Prostate cancer (PCa) is a heterogeneous disease with multifocal origin. In current clinical care, the Gleason scoring system is the well-established diagnosis by microscopic evaluation of the tissue from trans-rectal ultrasound (TRUS) guided biopsies. Nevertheless, the sensitivity and specificity in detecting PCa can range from 40 to 50% for conventional TRUS B-mode imaging. Tissue elasticity is associated with the disease progression and elastography technique has recently shown promise in aiding ...
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    9. High intensity focused ultrasound (HIFU) and phase-sensitive optical coherence tomography (PhS-OCT) for high resolution surface acoustic wave (SAW) elastography

      High intensity focused ultrasound (HIFU) and phase-sensitive optical coherence tomography (PhS-OCT) for high resolution surface acoustic wave (SAW) elastography
      Elastography has the ability of quantitatively evaluating the mechanical properties of soft tissue, thus is helpful for diagnosis and treatment monitoring for many diseases, e.g. skin diseases. Surface acoustic waves (SAWs) have been proven to be a non-invasive, non-destructive method for accurate characterization of tissue elastic properties.Current surface acoustic wave elastography using high energy laser pulse or mechanical shaker still have some problems. In order to improve SAW ...
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    10. Quantitative measurement and real-time tracking of high intensity focused ultrasound using phase-sensitive optical coherence tomography: Feasibility study

      Quantitative measurement and real-time tracking of high intensity focused ultrasound using phase-sensitive optical coherence tomography: Feasibility study
      Purpose: Phase-sensitive optical coherence tomography (PhS-OCT) is proposed, as a new high intensity focused ultrasound (HIFU) imaging guidance to detect and track HIFU focus inside 1% agar samples in this work. The experiments studied the effect of varying HIFU power on the induction of shear wave, which can be implemented as a new technique to monitor focused ultrasound surgery (FUS). Method: A miniature HIFU transducer (1.02MHz, 20mm aperture diameter ...
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    11. Effects of fixation and preservation on tissue elastic properties measured by quantitative optical coherence elastography (OCE)

      Effects of fixation and preservation on tissue elastic properties measured by quantitative optical coherence elastography (OCE)
      Fixed and preserved tissues have been massively used in the development of biomedical equipment and instrumentation. Not only the tissue morphology, but also its mechanical properties need to be considered in the fixation and preservation procedures since mechanical properties have significant influence on the design and performance of such instruments. Understanding the effects of storage and preservation conditions on the mechanical properties of soft tissue has both clinical and experimental ...
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    12. Quantitative shear-wave optical coherence elastography with a programmable phased array ultrasound as the wave source

      Quantitative shear-wave optical coherence elastography with a programmable phased array ultrasound as the wave source
      The purpose of this study is to implement a beam-steering ultrasound as the wave source for shear-wave optical coherence elastography (SW-OCE) to achieve an extended range of elastic imaging of the tissue sample. We introduce a linear phased array ultrasound transducer (LPAUT) as the remote and programmable wave source and a phase-sensitive optical coherence tomography (OCT) as the sensitive shear-wave detector. The LPAUT is programmed to launch acoustic radiation force ...
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    13. Micro-motion detection by optical coherence tomography (OCT) and its clinical applications (Thesis)

      Micro-motion detection by optical coherence tomography (OCT) and its clinical applications (Thesis)
      Detection of micro-motion on biological tissues has various applications such as ultrasound elastography and magnetic resonance elastography (MRE). Ultrasound transducers, the most commonly used tool to detect endogenous and exogenous micro-motions, have a number of drawbacks: including the requirements of the physical contact with the sample and limited spatial resolution (millimetre scale). The aim of this thesis is to develop a non-contact phase-sensitive imaging technique which is suitable for functional ...
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    14. Quantitative shear wave optical coherence elastography (SW-OCE) with acoustic radiation force impulses (ARFI) induced by phase array transducer

      Quantitative shear wave optical coherence elastography (SW-OCE) with acoustic radiation force impulses (ARFI) induced by phase array transducer
      Shear Wave Optical Coherence Elastography (SW-OCE) uses the speed of propagating shear waves to provide a quantitative measurement of localized shear modulus, making it a valuable technique for the elasticity characterization of tissues such as skin and ocular tissue. One of the main challenges in shear wave elastography is to induce a reliable source of shear wave; most of nowadays techniques use external vibrators which have several drawbacks such as ...
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    15. Feature Of The Week 01/25/15: Detection and characterisation of biopsy tissue using quantitative optical coherence elastogaphy (OCE) in men with suspected prostate cancer.

      Feature Of The Week 01/25/15: Detection and characterisation of biopsy tissue using quantitative optical coherence elastogaphy (OCE) in men with suspected prostate cancer.
      ...ict the percentage involvement of PCa. For more information see recent Article . Courtesy of Ghulam Nabi from University of Dundee . Prostate cancer (PCa) is the most common non-cutaneous malignancy in men. Men suspected...
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  2. About University of Dundee

    University of Dundee

    University of Dundee  is a public research university based in the city and Royal burgh of Dundee on the east coast of the central Lowlands of Scotland . It is consistently ranked within the Top 200 universities in the world and inside the Top 100 for some subject areas. It is broadly recognised as a red brick university