1. University of Copenhagen

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    1. Mentioned In 168 Articles

    2. Characterization of Hyperreflective Dots by Structural and Angiographic Optical Coherence Tomography in Patients with Diabetic Retinopathy and Healthy Subjects

      Characterization of Hyperreflective Dots by Structural and Angiographic Optical Coherence Tomography in Patients with Diabetic Retinopathy and Healthy Subjects
      Hyperreflective dots are a common but highly variable feature of optical coherence tomography (OCT) scans of the retina. We studied the spatial characteristics and perfusion of hyperreflective dots using both structural and angiographic OCT B-scans of the macula in 16 eyes in 8 healthy subjects and 8 patients with diabetic retinopathy without macular edema. Hyperreflective dots were manually graded in a 1000 m parafoveal area by number, diameter, location and ...
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    3. Investigating the Efficacy and Safety of Calcipotriol/Betamethasone Dipropionate Foam and Laser Microporation for Psoriatic Nail Disease - a Hybrid Trial using a Smartphone Application, Optical Coherence Tomography, and Patient-Reported Outcome Measures

      Investigating the Efficacy and Safety of Calcipotriol/Betamethasone Dipropionate Foam and Laser Microporation for Psoriatic Nail Disease - a Hybrid Trial using a Smartphone Application, Optical Coherence Tomography, and Patient-Reported Outcome Measures
      Background: There is a lack of efficacious topical treatments for patients suffering from psoriatic nail disease (PND). Objectives: We investigated the efficacy of Calcipotriol-Betamethasone Dipropionate (Cal/BD) foam with and without ablative fractional laser (AFL) in patients with PND. Methods: A total of 144 nails from eleven patients were treated in a 24-week long, open-label, randomized, intra-patient controlled proof-of-concept hybrid trial. In addition to daily Cal/BD foam application, half ...
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    4. Comparison of Spectral-Domain OCT versus Swept-Source OCT for the Detection of Deep Optic Disc Drusen

      Comparison of Spectral-Domain OCT versus Swept-Source OCT for the Detection of Deep Optic Disc Drusen
      Abstract: Deep optic disc drusen (ODD) are located below Bruchs membrane opening (BMO) and may go undetected due to the challenges in imaging them. The purpose of this study is a head-to-head comparison of currently widely used imaging technologies: swept-source optical coherence tomography (SS-OCT; DRI OCT-1 Triton, Topcon) and enhanced depth imaging spectral- domain optical coherence tomography (EDI SD-OCT; Spectralis OCT, Heidelberg Engineering) for the detection of deep ODD and ...
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    5. Repeated exposure to fractional CO2 laser delays squamous cell carcinoma formation and prevents clinical and subclinical photodamage visualized by line-field confocal optical coherence tomography and histology

      Repeated exposure to fractional CO2 laser delays squamous cell carcinoma formation and prevents clinical and subclinical photodamage visualized by line-field confocal optical coherence tomography and histology
      Objectives: Ablative fractional laser (AFL) is a well-established modality for treating ultraviolet radiation (UVR)-induced skin photodamage. We aimed to investigate the potential of AFL to delay squamous cell carcinoma (SCC) formation and prevent photodamage in a preclinical UVR-induced SCC model. Materials and methods: Hairless C3.Cg-Hr hr /TifBomTac mice (n = 50) were exposed to UVR three times weekly throughout the study. UV-exposed mice were randomized to two groups that ...
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    6. Optical coherence tomography systems for evaluation of marginal and internal fit of ceramic reconstructions

      Optical coherence tomography systems for evaluation of marginal and internal fit of ceramic reconstructions
      Purpose: To evaluate the marginal and internal fit of lithium disilicate and zirconia crowns using two optical coherence tomography (OCT) systems in order to estimate inter-system variations. Materials and methods: Ten lithium disilicate and 10 cubic stabilized zirconia crowns were placed on prepared artificial teeth without cement. Marginal discrepancy and internal cement gap of the crowns were assessed on images obtained using a swept source OCT (SS-OCT) and a spectral ...
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    7. Peripapillary Vessel Density in Relation to Optic Disc Drusen: A Multimodal Optical Coherence Tomography Study

      Peripapillary Vessel Density in Relation to Optic Disc Drusen: A Multimodal Optical Coherence Tomography Study
      Background: Optic disc drusen (ODD) are acellular calcified deposits within the optic nerve head known to cause visual field defects. An emerging gold standard for the diagnosis of ODD is enhanced depth imaging optical coherence tomography (EDI-OCT). The presence of ODD affects the adjacent peripapillary vasculature, which can be visualized using OCT angiography (OCTA). This study investigates the association between peripapillary vessel density and anatomical ODD location and volume using ...
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    8. Multi-modal and multi-scale clinical retinal imaging system with pupil and retinal tracking

      Multi-modal and multi-scale clinical retinal imaging system with pupil and retinal tracking
      We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCTA) imaging modalities and provides multi-scale fields of view. For high resolution, and high lateral resolution in particular, cellular imaging correction of aberrations by adaptive optics (AO) is employed. The entire instrument has a compact design and the ...
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    9. Assessment of Anterior Uveitis Through Anterior-Segment Optical Coherence Tomography and Artificial Intelligence-Based Image Analyses

      Assessment of Anterior Uveitis Through Anterior-Segment Optical Coherence Tomography and Artificial Intelligence-Based Image Analyses
      Purpose : The purpose of this study was to develop an automated artificial intelligence (AI) based method to quantify inflammation in the anterior chamber (AC) using anterior-segment optical coherence tomography (AS-OCT) and to explore the correlation between AI assisted AS-OCT based inflammation analyses and clinical grading of anterior uveitis by Standardization of Uveitis Nomenclature (SUN). Methods : A prospective double blinded study of AS-OCT images of 32 eyes of 19 patients acquired ...
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    10. NA-AION Risk Factors: New Perspectives

      NA-AION Risk Factors: New Perspectives
      Non-arteritic anterior ischemic optic neuropathy (NA-AION) is the most common acute optic neuropathy in the middle-aged and elderly population and can also occur in children and young adults. NA-AION leads to irreversible vision loss, and there is currently no effective treatment. In recent years, acellular calcified deposits in the optic nerve head called optic disc drusen (ODD) have been investigated as an important risk factor for NA-AION in patients under ...
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    11. 2021 international consensus statement on optical coherence tomography for basal cell carcinoma: image characteristics, terminology and educational needs

      2021 international consensus statement on optical coherence tomography for basal cell carcinoma: image characteristics, terminology and educational needs
      Background: Despite the widespread use of optical coherence tomography (OCT) for imaging of keratinocyte carcinoma, we lack an expert consensus on the characteristic OCT features of basal cell carcinoma (BCC), an internationally vetted set of OCT terms to describe various BCC subtypes, and an educational needs assessment. Objectives: To identify relevant BCC features in OCT images, propose terminology based on inputs from an expert panel and identify content for a ...
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    12. Biophysical properties at patch scale shape the metabolism of biofilm landscapes

      Biophysical properties at patch scale shape the metabolism of biofilm landscapes
      Phototrophic biofilms form complex spatial patterns in streams and rivers, yet, how community patchiness, structure and function are coupled and contribute to larger-scale metabolism remains unkown. Here, we combined optical coherence tomography with automated O 2 microprofiling and amplicon sequencing in a flume experiment to show how distinct community patches interact with the hydraulic environment and how this affects the internal distribution of oxygen. We used numerical simulations to derive ...
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    13. Novel application of optical coherence tomography and capillaroscopy in psoriatic arthritis in relation to psoriasis & hand osteoarthritis

      Novel application of optical coherence tomography and capillaroscopy in psoriatic arthritis in relation to psoriasis & hand osteoarthritis
      Objectives Nailfold video capillaroscopy (NVC) and angiographic optical coherence tomography (OCTA) have potential in diagnosing psoriatic arthritis (PsA) and differentiating it from psoriasis vulgaris (PsO) and hand osteoarthritis (OA). We aimed to assess the diagnostic properties of NVC and OCTA in patients with PsA compared with patients with PsO and hand OA based on nailfold capillary patterns. Methods Patients with distal interphalangeal-joint PsA and nail involvement ( n =50), PsO with ...
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    14. Delineating papillary dermis around basal cell carcinomas by high and ultrahigh resolution optical coherence tomography

      Delineating papillary dermis around basal cell carcinomas by high and ultrahigh resolution optical coherence tomography
      Bedside diagnosis of skin cancer remains a challenging task. The real-time non-invasive technology of optical coherence tomography (OCT) masters a high diagnostic accuracy in basal cell carcinoma (BCC) but a lower specificity in recognizing imitators and other carcinomas. We investigate the delicate signal of papillary dermis using an in-house developed ultrahigh resolution OCT (UHR-OCT) system with shadow compensation and a commercial multi-focus high resolution OCT (HR-OCT) system for clinical BCC ...
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    15. Discordance in the diagnostic assessment of vulnerable plaques between radiofrequency intravascular ultrasound versus optical coherence tomography among patients with acute myocardial infarction: insights from the IBIS-4 study

      Discordance in the diagnostic assessment of vulnerable plaques between radiofrequency intravascular ultrasound versus optical coherence tomography among patients with acute myocardial infarction: insights from the IBIS-4 study
      We aimed to evaluate the diagnostic agreement between radiofrequency (RF) intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for thin-cap fibroatheroma (TCFA) in non-infarct-related coronary arteries (non-IRA) in patients with ST-segment elevation myocardial infarction (STEMI). In the Integrated Biomarker Imaging Study (IBIS-4), 103 STEMI patients underwent OCT and RF-IVUS imaging of non-IRA after successful primary percutaneous coronary intervention and at 13-month follow-up. A coronary lesion was defined as a segment ...
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    16. OCT Based Interpretation of the Optic Nerve Head Anatomy and Prevalence of Optic Disc Drusen in Patients with Idiopathic Intracranial Hypertension (IIH)

      OCT Based Interpretation of the Optic Nerve Head Anatomy and Prevalence of Optic Disc Drusen in Patients with Idiopathic Intracranial Hypertension (IIH)
      We aimed to systematically examine the optic nerve head anatomy in patients with idiopathic intracranial hypertension (IIH) using a standardized optical coherence tomography (OCT) protocol. The study retrospectively included 32 patients diagnosed from 2014 to 2021 with IIH. Using OCT, in accordance with a standardized scanning protocol for patients with optic disc drusen, the presence of optic disc drusen, prelaminar hyperreflective lines, peripapillary hyperreflective ovoid mass-like structures, the retinal nerve ...
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  2. About University of Copenhagen

    University of Copenhagen

    The University of Copenhagen is the oldest and largest university and research institution in Denmark. Founded in 1479, it has more than 37,000 students, a majority of whom are female (59%), and more than 7,000 employees. The University has several campuses located in and around Copenhagen, with the oldest located in central Copenhagen. Most courses are taught in Danish; however, more and more courses are offered in English and some in German. The University is a member of the International Alliance of Research Universities (IARU).