1. University of Coimbra

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    1. Mentioned In 36 Articles

    2. Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease

      Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease
      The retina, as part of the central nervous system (CNS), can be the perfect target for in vivo, in situ , and noninvasive neuropathology diagnosis and assessment of therapeutic efficacy. It has long been established that several age-related brain changes are more pronounced in Alzheimer's disease (AD). Nevertheless, in the retina such link is still under-explored. This study investigates the differences in the aging of the CNS through the retina ...
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    3. Automatic Segmentation of the Optic Nerve Head Region in Optical Coherence Tomography

      Automatic Segmentation of the Optic Nerve Head Region in Optical Coherence Tomography
      The optic nerve head (ONH) represents the intraocular section of the optic nerve, which is prone to damage by intraocular pressure (IOP). The advent of optical coherence tomography (OCT) has enabled the evaluation of novel ONH parameters, namely the depth and curvature of the lamina cribrosa (LC). Together with the Bruch's membrane minimum-rim-width (BMO-MRW), these seem to be promising ONH parameters for diagnosis and monitoring of retinal diseases such ...
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    4. Signal-carrying speckle in optical coherence tomography: a methodological review on biomedical applications

      Signal-carrying speckle in optical coherence tomography: a methodological review on biomedical applications
      Significance: Speckle has historically been considered a source of noise in coherent light imaging. However, a number of works in optical coherence tomography (OCT) imaging have shown that speckle patterns may contain relevant information regarding subresolution and structural properties of the tissues from which it is originated. Aim: The objective of this work is to provide a comprehensive overview of the methods developed for retrieving speckle information in biomedical OCT ...
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    5. Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy-3-Year Longitudinal Study

      Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy-3-Year Longitudinal Study
      To examine retinal vessel closure metrics and neurodegenerative changes occurring in the initial stages of nonproliferative diabetic retinopathy (NPDR) and severity progression in a three-year period. Methods: Three-year prospective longitudinal observational cohort of individuals with type 2 diabetes (T2D), one eye per person, using spectral domain-optical coherence tomography (SD-OCT) and OCT-Angiography (OCTA). Eyes were examined four times with one-year intervals. OCTA vessel density maps of the retina were used to ...
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    6. Ensemble Learning Approach to Retinal Thickness Assessment in Optical Coherence Tomography

      Ensemble Learning Approach to Retinal Thickness Assessment in Optical Coherence Tomography
      Manual assessment of the retinal thickness in optical coherence tomography images is a time-consuming task, prone to error and inter-observer variability. The wide variability of the retinal appearance makes the automation of retinal image processing a challenging problem to tackle. The difficulty is even more accentuated in practice when the retinal tissue exhibits large structural changes due to disruptive pathology. In this work, we propose an ensemble-learning-based method for the ...
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    7. Looking in the mirror: An unusual optical coherence tomography image

      Looking in the mirror: An unusual optical coherence tomography image
      A 75-year-old male underwent primary angioplasty of a subocclusive proximal to medial left anterior descending artery (LAD) stenosis, involving the origin of the first diagonal (D1). A provisional stenting technique was used, with two guidewires in the distal LAD and D1 and implantation of 3 mm30 mm and 2.75 mm28 mm drug-eluting stents (DES) in the LAD. Withdrawal of the jailed D1 guidewire caused a deep intubation of the ...
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    8. Age-Related Macular Degeneration Staging by Color Fundus Photography vs. Multimodal Imaging—Epidemiological Implications (The Coimbra Eye Study—Report 6)

      Age-Related Macular Degeneration Staging by Color Fundus Photography vs. Multimodal Imaging—Epidemiological Implications (The Coimbra Eye Study—Report 6)
      Epidemiology of age-related macular degeneration (AMD) is based on staging systems relying on color fundus photography (CFP). We aim to compare AMD staging using CFP to multimodal imaging with optical coherence tomography (OCT), infra-red (IR), and fundus autofluorescence (FAF), in a large cohort from the Epidemiologic AMD Coimbra Eye Study. All imaging exams from the participants of this population-based study were classified by a central reading center. CFP images were ...
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    9. An optical coherence tomography-based grading of diabetic maculopathy proposed by an international expert panel: The European School for Advanced Studies in Ophthalmology classification

      An optical coherence tomography-based grading of diabetic maculopathy proposed by an international expert panel: The European School for Advanced Studies in Ophthalmology classification
      Aims: To present an authoritative, universal, easy-to-use morphologic classification of diabetic maculopathy based on spectral domain optical coherence tomography. Methods: The first draft of the project was developed based on previously published classifications and a literature search regarding the spectral domain optical coherence tomography quantitative and qualitative features of diabetic maculopathy. This draft was sent to an international panel of retina experts for a first revision. The panel met at ...
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    10. Sexual Dimorphism of the Adult Human Retina Assessed by Optical Coherence Tomography

      Sexual Dimorphism of the Adult Human Retina Assessed by Optical Coherence Tomography
      In this work, we imaged the retina of healthy age-matched female and male subjects with optical coherence tomography to assess the existence of localised sex-related differences in the retina. Texture analysis revealed statistically significant differences spread over the different layers of the neuroretina, particularly at the ganglion cell, inner plexiform and inner nuclear layers, and also spread in the macula. These results suggest that sexual dimorphism is expressed in the ...
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    11. Microperimetry in age-related macular degeneration: association with macular morphology assessed by optical coherence tomography

      Microperimetry in age-related macular degeneration: association with macular morphology assessed by optical coherence tomography
      Background/aims Microperimetry is a technique that is increasingly used to assess visual function in age-related macular degeneration (AMD). In this study, we aimed to evaluate the relationship between retinal sensitivity measured with macular integrity assessment (MAIA) microperimetry and optical coherence tomography (OCT)-based macular morphology in AMD. Methods Prospective, cross-sectional study. All participants were imaged with colour fundus photographs used for AMD staging (Age-Related Eye Disease Study scale), spectral-domain ...
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    12. 1-15 of 36 1 2 3 »
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  2. About University of Coimbra

    University of Coimbra

    University of Coimbra is a Portuguese public university in Coimbra, Portugal. It is one of the oldest universities in continuous operation in Europe and the world, the oldest university of Portugal, and one of its largest higher education and research institutions.