1. University of Cantabria

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    1. Mentioned In 14 Articles

    2. Imaging biomarkers for Alzheimer’s disease and glaucoma: Current and future practices

      Imaging biomarkers for Alzheimer’s disease and glaucoma: Current and future practices
      Glaucoma is a leading cause of blindness worldwide. Although intraocular pressure is the main risk factor for glaucoma, several intraocular pressure independent factors have been associated with the risk of developing the disease and its progression. The diagnosis of glaucoma relies on clinical features of the optic nerve, visual field test, and optical coherence tomography. However, the multidisciplinary aspect of the disease suggests that other biomarkers may be useful for ...
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    3. Characterization of Optical Coherence Tomography Images for Colon Lesion Differentiation under Deep Learning

      Characterization of Optical Coherence Tomography Images for Colon Lesion Differentiation under Deep Learning
      Background: Clinicians demand new tools for early diagnosis and improved detection of colon lesions that are vital for patient prognosis. Optical coherence tomography (OCT) allows microscopical inspection of tissue and might serve as an optical biopsy method that could lead to in-situ diagnosis and treatment decisions; (2) Methods: A database of murine (rat) healthy, hyperplastic and neoplastic colonic samples with more than 94,000 images was acquired. A methodology that ...
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    4. Identification of Human Pathological Mitral Chordae Tendineae Using Polarization-sensitive Optical Coherence Tomography

      Identification of Human Pathological Mitral Chordae Tendineae Using Polarization-sensitive Optical Coherence Tomography
      Defects of the mitral valve complex imply heart malfunction. The chordae tendineae (CTs) are tendinous strands connecting the mitral and tricuspid valve leaflets to the papillary muscles. These CTs are composed of organized, wavy collagen bundles, making them a strongly birefringent material. Disorder of the collagen structure due to different diseases (rheumatic, degenerative) implies the loss or reduction of tissue birefringence able to be characterized with Polarization Sensitive Optical Coherence ...
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    5. Hessian analysis for the delineation of amorphous anomalies in optical coherence tomography images of the aortic wall

      Hessian analysis for the delineation of amorphous anomalies in optical coherence tomography images of the aortic wall
      The aortic aneurysm is a disease originated mainly in the media layer of the aortic wall due to the occurrence of degraded areas of altered biological composition. These anomalous regions affect the structure and strength of the aorta artery, being their occurrence and extension proportional to the arterial vessel health. Optical Coherence Tomography (OCT) is applied to obtain cross-sectional images of the artery wall. The backscattering mechanisms in tissue make ...
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    6. Identification of vessel wall anomalies in thoracic aortic aneurysms through optical coherence tomography and gradient-based strategies

      Identification of vessel wall anomalies in thoracic aortic aneurysms through optical coherence tomography and gradient-based strategies
      Optical Coherence Tomography is a natural candidate for imaging biological structures just under tissue surface. Human thoracic aorta from aneurysms reveal elastin disorders and smooth muscle cell alterations when visualizing the media layer of the aortic wall, which is only some tens of microns in depth from surface. The resulting images require a suitable processing to enhance interesting disorder features and to use them as indicators for wall degradation, converting ...
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    7. Optical coherence tomography assessment of vessel wall degradation in thoracic aortic aneurysms

      Optical coherence tomography assessment of vessel wall degradation in thoracic aortic aneurysms
      Optical coherence tomography images of human thoracic aorta from aneurysms reveal elastin disorders and smooth muscle cell alterations when visualizing the media layer of the aortic wall. These disorders can be employed as indicators for wall degradation and, therefore, become a hallmark for diagnosis of risk of aneurysm under intraoperative conditions. Two approaches are followed to evaluate this risk: the analysis of the reflectivity decay along the penetration depth and ...
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    8. Optical coherence tomography assessment of vessel wall degradation in aneurysmatic thoracic aortas

      Optical coherence tomography assessment of vessel wall degradation in aneurysmatic thoracic aortas
      Optical coherence tomographic images of ascending thoracic human aortas from aneurysms exhibit disorders on the smooth muscle cell structure of the media layer of the aortic vessel as well as elastin degradation. Ex-vivo measurements of human samples provide results that correlate with pathologist diagnosis in aneurysmatic and control aortas. The observed disorders are studied as possible hallmarks for aneurysm diagnosis. To this end, the backscattering profile along the vessel thickness ...
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    9. Polarimetry of birefringent biological tissues with arbitrary fibril orientation and variable incidence angle

      Polarimetry of birefringent biological tissues with arbitrary fibril orientation and variable incidence angle
      Polarimetric optical techniques such as polarization microscopy or polarization-sensitive optical coherence tomography normally assume that light is perpendicular to the sample surface and that fibrils of a birefringent biological tissue are arranged in a plane parallel to this surface. The approaches that describe quantitatively polarimetric data from tissues with nonparallel fibril orientation and/or off-axis incidence usually lack a rigorous theoretical analysis. We present a polarimetric model with arbitrary fibril ...
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    10. Comparative study between ultrasonography and optical coherence tomography in interventional cardiology

      In this work, we present clinical images of IVUS and OCT in the evaluation of pharmacological stent endothelization. These preliminary imaging results are analyzed and compared in order to determine the ability of these technologies to visualize relevant intravascular features of interest in interventional cardiology. The results enable to compare the performance of both techniques and to evaluate their potential for clinical purposes.
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    11. Modeling human corneal polarization properties and comparison with PS-OCT measurements

      Polarization sensitive optical techniques such as Scanning Laser Polarimetry (SLP) or Polarization Sensitive Optical Coherence Tomography (PS-OCT) must take into account corneal polarization changes when imaging the eye fundus. Information about corneal structure is also basic in the diagnosis of corneal disorders. Histological analysis shows that cornea is layered, with fibrils oriented at varying angles. However, this information does not refer to fibril orientation in a macrostructural sense. In this ...
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    12. In vivo burn imaging using Mueller optical coherence tomography

      Miloš Todorovic, Shuliang Jiao, Jun Ai, David Pereda-Cubián, George Stoica, Lihong V. Wang. We report on the use of a high-speed, fiber-based Mueller-matrix optical coherence tomography system with continuous source-polarization modulation for in vivo burn depth evaluation and healing monitoring. A homemade hand-held probe with integrated optical scanning and beam delivering optics was ... [Opt. Express 16, 10279-10284 (2008)]
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    13. Evaluation of the magneto-optical effect in biological tissue models using optical coherence tomography

      David Pereda-Cubian, Milos Todorovic, Jose Luis Arce-Diego et al. For the first time to our knowledge, an experimental evaluation of the Faraday effectinduced polarization rotation in a biological tissue phantom is reported. The rotation of the polarization plane produced in the optical beam propagating through an Intralipid solution was evaluated using polarizati ... [J. Biomed. Opt. 12, 060502 (2007)] published Tue Dec 11, 2007.
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  2. About University of Cantabria

    University of Cantabria

    The Applied Optical Techniques Group (TOA), ascribed to the Electronics Technology, Systems and Automation Engineering Department (TEISA) of the University of Cantabria (UC) is a research group formed in 2002 and coordinated by Prof. José Luis Arce Diego.  The main research areas of our group are the following: Fiber-optic-based devices and networks Non-linear effects; Optical reflectometry; interferometry and polarimetry; Optical techniques for the molecular characterization of biological tissues; Optical techniques for the structural characterization of biological tissues Optical techniques for biological tissues treatment applications; Endoscopes and fiber optic probes for biomedical applications .