1. University of Cambridge

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    1. Mentioned In 29 Articles

    2. Automated Deep Learning-based Multi-class Fluid Segmentation in Swept-Source Optical Coherence Tomography Images

      Automated Deep Learning-based Multi-class Fluid Segmentation in Swept-Source Optical Coherence Tomography Images
      Purpose: To evaluate the performance of a deep learning-based, fully automated, multi-class, macular fluid segmentation algorithm relative to expert annotations in a heterogeneous population of confirmed wet age-related macular degeneration (wAMD) subjects. Methods: Twenty-two swept-source optical coherence tomography (SS-OCT) volumes of the macula from 22 from different individuals with wAMD were manually annotated by two expert graders. These results were compared using cross-validation (CV) to automated segmentations using a deep ...
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    3. Comparison of plaque distribution and wire-free functional assessment in patients with stable angina and non-ST elevation myocardial infarction: an optical coherence tomography and quantitative flow ratio study

      Comparison of plaque distribution and wire-free functional assessment in patients with stable angina and non-ST elevation myocardial infarction: an optical coherence tomography and quantitative flow ratio study
      Background Data comparing plaque characteristics and wire-free physiological assessment in the target vessel in patients with stable angina versus acute coronary syndrome are sparse. Therefore, we investigated the difference in plaque distribution between stable angina and non-ST-elevation myocardial infarction (NSTEMI) and explored the relationship between target vessel vulnerability by optical coherence tomography (OCT) and wire-free functional assessment with quantitative flow ratio (QFR). Methods Patients with stable angina ( n =25) and ...
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    4. 3D-printed corals could improve bioenergy and help coral reefs

      3D-printed corals could improve bioenergy and help coral reefs
      Researchers from Cambridge University and University of California San Diego have 3D printed coral-inspired structures that are capable of growing dense populations of microscopic algae. Their results, reported in the journal Nature Communications , open the door to new bio-inspired materials and their applications for coral conservation. In the ocean, corals and algae have an intricate symbiotic relationship. The coral provides a host for the algae, while the algae produce sugars ...
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    5. Biophotonics and Imaging Graduate Summer School to be held on August 2020 at National University of Ireland, Galway

      Biophotonics and  Imaging  Graduate  Summer  School to be held on August 2020 at National University of Ireland, Galway
      Dates: August 25th - 29th 2020 This is our eight Biophotonics and Imaging Graduate Summer School. It is an important opportunity for graduate students in 2020 to access the kind of close contact with leading professors that only this kind of environment facilitates. Tutors for BIGSS 2020 will include: Martin Booth (Oxford): Advanced Microscopy Steve Jacques (Washington): Tissue Optics Caroline Boudoux (Montreal): Endoscopy David Sampson (Surrey): OCT Sarah Bohndiek (Cambridge): Photoacoustics ...
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    6. At-line Validation of Optical Coherence Tomography as In-line/At-line Coating Thickness Measurement Method

      At-line Validation of Optical Coherence Tomography as In-line/At-line Coating Thickness Measurement Method
      Optical Coherence Tomography (OCT) is a promising technology for monitoring of pharmaceutical coating processes. However, the pharmaceutical development and manufacturing require a periodic validation of the sensors accuracy. For this purpose, we propose polyethylene terephthalate (PET) films as a model system, which can be periodically measured during manufacturing coating monitoring via OCT. This study proposes a new approach addressing the method validation requirement in the pharmaceutical industry and presents results ...
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    7. DNA Damage and Repair in Patients with Coronary Artery Disease: Correlation with Plaque Morphology Using Optical Coherence Tomography (DECODE Study)

      DNA Damage and Repair in Patients with Coronary Artery Disease: Correlation with Plaque Morphology Using Optical Coherence Tomography (DECODE Study)
      Objective The aim of this study was to examine DNA ligase activity and expression of DNA damage response pathway (DDR) genes in patients with stable angina (SA) and non-ST elevation myocardial infarction (NSTEMI) and determine whether they correlate with plaque morphology. Background Patients with coronary artery disease (CAD) have evidence of deoxyribonucleic acid (DNA) damage in peripheral blood mononuclear cells (PBMCs). It is unclear whether this represents excess damage or ...
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    8. Optical Coherence Tomography Doppler Vibrometry Measurement of Stapes Vibration in Patients With Stapes Fixation and Normal Controls

      Optical Coherence Tomography Doppler Vibrometry Measurement of Stapes Vibration in Patients With Stapes Fixation and Normal Controls
      Hypothesis: Ears with otosclerotic stapes fixation will exhibit lower-than-normal levels of ossicular mobility as measured by Optical Coherence Tomography Doppler Vibrometry (OCT-DV). Background: OCT-DV measures the vibration of middle ear structures in response to sound non-invasively through the intact tympanic membrane. This allows, in particular, direct measurement of the vibration at the lenticular process of the incus which is expected to be lower in patients with otosclerotic stapes fixation. Methods ...
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    9. Plaque Rupture in Coronary Atherosclerosis Is Associated With Increased Plaque Structural Stress

      Plaque Rupture in Coronary Atherosclerosis Is Associated With Increased Plaque Structural Stress
      Objectives The aim of this study was to identify the determinants of plaque structural stress (PSS) and the relationship between PSS and plaques with rupture. Background Plaque rupture is the most common cause of myocardial infarction , occurring particularly in higher risk lesions such as fibroatheromas. However, prospective intravascular ultrasoundvirtual histology studies indicate that 10% higher risk plaques cause clinical events over 3 years, indicating that other factors also determine plaque ...
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    10. Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography

      Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography
      Spectral domain optical coherence tomography (SD-OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for direct quantification of thin film coatings that cannot easily be resolved with other techniques. While previous studies with SD-OCT have estimated the intra-tablet coating uniformity, the estimates were based on limited number of B-scans. In order to obtain a more accurate estimate, a greater number of ...
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    11. Pharmaceutical film coating catalogue for spectral-domain optical coherence tomography

      Pharmaceutical film coating catalogue for spectral-domain optical coherence tomography
      Optical coherence tomography (OCT) has recently been demonstrated to measure the film coating thickness of pharmaceutical tablets and pellets directly. The results enable the analysis of inter- and intra-tablet coating variability at an off-line and in-line setting. To date, only a few coating formulations have been tried and there is very little information on the applicability of OCT to other coatings. As it is well documented that optical methods including ...
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    12. Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography

      Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography
      Spectral domain optical coherence tomography (SD-OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for direct quantification of thin film coatings that cannot easily be resolved with other techniques. While previous studies with SD-OCT have estimated the intra-tablet coating uniformity, the estimates were based on limited number of B-scans. In order to obtain a more accurate estimate, a greater number of ...
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    13. In vivo light fluence correction for determination of tissue absorption coefficient using multispectral optoacoustic tomography

      In vivo light fluence correction for determination of tissue absorption coefficient using multispectral optoacoustic tomography
      Optoacoustic Tomography is a fast developing imaging modality, combining the high resolution and penetration depth of ultrasound detection with the high contrast available from optical absorption in tissue. The spectral profile of near infrared excitation light used in optoacoustic tomography instruments is modified by absorption and scattering as it propagates deep into biological tissue. The resulting images therefore provide only qualitative insight into the distribution of tissue chromophores. Knowledge of ...
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    14. Direct Comparison of Virtual-Histology Intravascular Ultrasound and Optical Coherence Tomography Imaging for Identification of Thin-Cap Fibroatheroma

      Direct Comparison of Virtual-Histology Intravascular Ultrasound and Optical Coherence Tomography Imaging for Identification of Thin-Cap Fibroatheroma
      Background Although rupture of thin-cap fibroatheroma (TCFA) underlies most myocardial infarctions, reliable TCFA identification remains challenging. Virtual-histology intravascular ultrasound (VH-IVUS) and optical coherence tomography (OCT) can assess tissue composition and classify plaques. However, direct comparisons between VH-IVUS and OCT are lacking and it remains unknown whether combining these modalities improves TCFA identification. Methods and Results Two hundred fifty-eight regions-of-interest were obtained from autopsied human hearts, with plaque composition and classification ...
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    15. Optical coherence tomography imaging of coronary atherosclerosis is affected by intraobserver and interobserver variability

      Optical coherence tomography imaging of coronary atherosclerosis is affected by intraobserver and interobserver variability
      Aims: Optical coherence tomography (OCT) has emerged as a novel imaging modality that allows plaque classification through identification of features including lipid, calcification and fibrous cap. However, subtle changes in light attenuation as the optical beam traverses the plaque in vivo are challenging to interpret and data on strength of observer agreement are minimal. Thus, we sought to assess both the intra and interobserver variability for plaque composition/classification using ...
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  2. About University of Cambridge

    University of Cambridge

    University of Cambridge (informally Cambridge University or Cambridge) is a public research university located in Cambridge, United Kingdom. It is the second-oldest university in the English-speaking world (after the University of Oxford), and the seventh-oldest globally. In post-nominals the university's name is abbreviated as Cantab, a shortened form of Cantabrigiensis (an adjective derived from Cantabrigia, the Latinised form of Cambridge).