1. University of Cambridge

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    1. Mentioned In 24 Articles

    2. DNA Damage and Repair in Patients with Coronary Artery Disease: Correlation with Plaque Morphology Using Optical Coherence Tomography (DECODE Study)

      DNA Damage and Repair in Patients with Coronary Artery Disease: Correlation with Plaque Morphology Using Optical Coherence Tomography (DECODE Study)
      Objective The aim of this study was to examine DNA ligase activity and expression of DNA damage response pathway (DDR) genes in patients with stable angina (SA) and non-ST elevation myocardial infarction (NSTEMI) and determine whether they correlate with plaque morphology. Background Patients with coronary artery disease (CAD) have evidence of deoxyribonucleic acid (DNA) damage in peripheral blood mononuclear cells (PBMCs). It is unclear whether this represents excess damage or ...
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    3. Optical Coherence Tomography Doppler Vibrometry Measurement of Stapes Vibration in Patients With Stapes Fixation and Normal Controls

      Optical Coherence Tomography Doppler Vibrometry Measurement of Stapes Vibration in Patients With Stapes Fixation and Normal Controls
      Hypothesis: Ears with otosclerotic stapes fixation will exhibit lower-than-normal levels of ossicular mobility as measured by Optical Coherence Tomography Doppler Vibrometry (OCT-DV). Background: OCT-DV measures the vibration of middle ear structures in response to sound non-invasively through the intact tympanic membrane. This allows, in particular, direct measurement of the vibration at the lenticular process of the incus which is expected to be lower in patients with otosclerotic stapes fixation. Methods ...
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    4. Plaque Rupture in Coronary Atherosclerosis Is Associated With Increased Plaque Structural Stress

      Plaque Rupture in Coronary Atherosclerosis Is Associated With Increased Plaque Structural Stress
      Objectives The aim of this study was to identify the determinants of plaque structural stress (PSS) and the relationship between PSS and plaques with rupture. Background Plaque rupture is the most common cause of myocardial infarction , occurring particularly in higher risk lesions such as fibroatheromas. However, prospective intravascular ultrasoundvirtual histology studies indicate that 10% higher risk plaques cause clinical events over 3 years, indicating that other factors also determine plaque ...
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    5. Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography

      Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography
      Spectral domain optical coherence tomography (SD-OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for direct quantification of thin film coatings that cannot easily be resolved with other techniques. While previous studies with SD-OCT have estimated the intra-tablet coating uniformity, the estimates were based on limited number of B-scans. In order to obtain a more accurate estimate, a greater number of ...
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    6. Pharmaceutical film coating catalogue for spectral-domain optical coherence tomography

      Pharmaceutical film coating catalogue for spectral-domain optical coherence tomography
      Optical coherence tomography (OCT) has recently been demonstrated to measure the film coating thickness of pharmaceutical tablets and pellets directly. The results enable the analysis of inter- and intra-tablet coating variability at an off-line and in-line setting. To date, only a few coating formulations have been tried and there is very little information on the applicability of OCT to other coatings. As it is well documented that optical methods including ...
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    7. Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography

      Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography
      Spectral domain optical coherence tomography (SD-OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for direct quantification of thin film coatings that cannot easily be resolved with other techniques. While previous studies with SD-OCT have estimated the intra-tablet coating uniformity, the estimates were based on limited number of B-scans. In order to obtain a more accurate estimate, a greater number of ...
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    8. In vivo light fluence correction for determination of tissue absorption coefficient using multispectral optoacoustic tomography

      In vivo light fluence correction for determination of tissue absorption coefficient using multispectral optoacoustic tomography
      Optoacoustic Tomography is a fast developing imaging modality, combining the high resolution and penetration depth of ultrasound detection with the high contrast available from optical absorption in tissue. The spectral profile of near infrared excitation light used in optoacoustic tomography instruments is modified by absorption and scattering as it propagates deep into biological tissue. The resulting images therefore provide only qualitative insight into the distribution of tissue chromophores. Knowledge of ...
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    9. Direct Comparison of Virtual-Histology Intravascular Ultrasound and Optical Coherence Tomography Imaging for Identification of Thin-Cap Fibroatheroma

      Direct Comparison of Virtual-Histology Intravascular Ultrasound and Optical Coherence Tomography Imaging for Identification of Thin-Cap Fibroatheroma
      Background Although rupture of thin-cap fibroatheroma (TCFA) underlies most myocardial infarctions, reliable TCFA identification remains challenging. Virtual-histology intravascular ultrasound (VH-IVUS) and optical coherence tomography (OCT) can assess tissue composition and classify plaques. However, direct comparisons between VH-IVUS and OCT are lacking and it remains unknown whether combining these modalities improves TCFA identification. Methods and Results Two hundred fifty-eight regions-of-interest were obtained from autopsied human hearts, with plaque composition and classification ...
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    10. Optical coherence tomography imaging of coronary atherosclerosis is affected by intraobserver and interobserver variability

      Optical coherence tomography imaging of coronary atherosclerosis is affected by intraobserver and interobserver variability
      Aims: Optical coherence tomography (OCT) has emerged as a novel imaging modality that allows plaque classification through identification of features including lipid, calcification and fibrous cap. However, subtle changes in light attenuation as the optical beam traverses the plaque in vivo are challenging to interpret and data on strength of observer agreement are minimal. Thus, we sought to assess both the intra and interobserver variability for plaque composition/classification using ...
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    11. Comparison of Corneal Epithelial Thickness Measurement Between Fourier-Domain OCT and Very High-Frequency Digital Ultrasound

      Comparison of Corneal Epithelial Thickness Measurement Between Fourier-Domain OCT and Very High-Frequency Digital Ultrasound
      To compare measurements of corneal epithelial thickness using optical coherence tomography (OCT) and very high-frequency digital ultrasound (VHFDU). METHODS: Retrospective analysis of 189 virgin corneas and 175 post-laser refractive surgery (LRS) corneas that had corneal epithelial thickness measurement with RTVue Fourier-domain OCT (Optovue, Inc., Fremont, CA) (tear film included) and Artemis VHFDU (ArcScan Inc., Morrison, CO) (tear film excluded). Averages were calculated for the central 2-mm diameter zone and for ...
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    12. Intravascular ultrasound and optical coherence tomography imaging of coronary atherosclerosis

      Intravascular ultrasound and optical coherence tomography imaging of coronary atherosclerosis
      Invasive imaging modalities, in particular intravascular ultrasound (IVUS) and optical coherence tomography (OCT), have become established tools for the in vivo study of coronary atherosclerosis. Their use in clinical studies has confirmed histopathological observations that certain important plaque features, such as thin fibrous caps and large lipid cores, are associated with plaque rupture, the precipitating event for the majority of myocardial infarctions. Serial imaging studies have also successfully been used ...
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    13. Cholesterol crystals identified using optical coherence tomography and virtual histology intravascular ultrasound

      Cholesterol crystals identified using optical coherence tomography and virtual histology intravascular ultrasound
      The deposition and accumulation of lipid within the arterial wall leads to the development and progression of atherosclerotic plaques. Cholesterol crystals (CCs) are formed from these lipid pools and both augment the inflammatory response and promote plaque rupture, possibly through inducing mechanical instability. Accordingly, identification of these structures is important for plaque risk stratification. Optical coherence tomography (OCT) and virtual histology intravascular ultrasound (VH-IVUS) are invasive imaging modalities that permit ...
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    14. Quantifying pharmaceutical film coating with optical coherence tomography and terahertz pulsed imaging: an evaluation

      Quantifying pharmaceutical film coating with optical coherence tomography and terahertz pulsed imaging: an evaluation
      Spectral domain optical coherence tomography (SD-OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for quantification of thin film coatings that cannot easily be resolved with other techniques. Due to the relative infancy of this technique, much of the research to date has focused on developing the in-line measurement technique for assessing film coating thickness. To better assess OCT for pharmaceutical ...
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  2. About University of Cambridge

    University of Cambridge

    University of Cambridge (informally Cambridge University or Cambridge) is a public research university located in Cambridge, United Kingdom. It is the second-oldest university in the English-speaking world (after the University of Oxford), and the seventh-oldest globally. In post-nominals the university's name is abbreviated as Cantab, a shortened form of Cantabrigiensis (an adjective derived from Cantabrigia, the Latinised form of Cambridge).