1. University of Calgary

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    1. Mentioned In 20 Articles

    2. Functional-Optical Coherence Tomography: A non-invasive approach to assess the sympathetic nervous system and intrinsic vascular regulation

      Functional-Optical Coherence Tomography: A non-invasive approach to assess the sympathetic nervous system and intrinsic vascular regulation
      Sympathetic nervous system dysregulation and vascular impairment in neuronal tissue beds are hallmarks of prominent cardiorespiratory diseases. However, an accurate and convenient method of assessing SNA and local vascular regulation is lacking, hindering routine clinical and research assessments. To address this, we investigated whether spectral domain optical coherence tomography (OCT), that allows investigation of retina and choroid vascular responsiveness, reflects sympathetic activity in order to develop a quick, easy and ...
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    3. Measurement of Normative Foveal Avascular Zone Parameters in Healthy Adults Using Optical Coherence Tomography Angiography

      Measurement of Normative Foveal Avascular Zone Parameters in Healthy Adults Using Optical Coherence Tomography Angiography
      Background and Objective: The purpose of this study was to quantify the geometric dimension of the foveal avascular zone (FAZ) area and its index measurement of morphology as a circle (acircularity index) in healthy participants according to age and sex, using optical coherence tomography angiography (OCTA). Study Design/Materials and Method: This is a cross-sectional descriptive study conducted at LV Prasad Eye Institute, India. Written informed consent was obtained from ...
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    4. The Optic Disc Drusen Studies Consortium Recommendations for Diagnosis of Optic Disc Drusen Using Optical Coherence Tomography

      The Optic Disc Drusen Studies Consortium Recommendations for Diagnosis of Optic Disc Drusen Using Optical Coherence Tomography
      Background: Making an accurate diagnosis of optic disc drusen (ODD) is important as part of the work-up for possible life-threatening optic disc edema. It also is important to follow the slowly progressive visual field defects many patients with ODD experience. The introduction of enhanced depth imaging optical coherence tomography (EDI-OCT) has improved the visualization of more deeply buried ODD. There is, however, no consensus regarding the diagnosis of ODD using ...
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    5. Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

      Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study
      Background Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available. Methods In this multicentre, cohort study ...
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    6. The investigation of acute optic neuritis: a review and proposed protocol

      The investigation of acute optic neuritis: a review and proposed protocol
      Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of MS-associated optic neuritis from other autoimmune and inflammatory optic neuropathies is vital for treatment choice and further patient management, but is not always straightforward. Over the past decade, a number of new imaging, laboratory and electrophysiological techniques have entered the clinical arena. To ...
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    7. Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer Thickness in NMO Patients

      Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer Thickness in NMO Patients
      Background: Neuromyelitis optica (NMO) is a demyelinating syndrome of the central nervous system. NMO might be underdiagnosed at early stages when patients have not yet developed the full spectrum of disease. The aim of this study was to analyze the retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) and to compare RNFL measurements between NMO patients, patients with relapsing-remitting multiple sclerosis (RRMS), and healthy controls to determine whether ...
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    8. Reproducibility of Retinal Nerve Fiber Layer Measurements with Manual and Automated Centration in Healthy Subjects Using Spectralis Spectral-Domain Optical Coherence Tomography

      Reproducibility of Retinal Nerve Fiber Layer Measurements with Manual and Automated Centration in Healthy Subjects Using Spectralis Spectral-Domain Optical Coherence Tomography
      Objective . The aim of this study was to test the reproducibility of the Heidelberg Spectralis SD-OCT and to determine if provided software retest function for follow-up exam is superior to manual centration. Design. Prospective, cross-sectional study. Participants . 20 healthy subjects. Methods. All subjects underwent SD-OCT testing to determine retinal nerve fiber layer (RNFL) measurements sequentially on two di fferent days and with two different centration techniques.Within-subject standard deviation, coe ...
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    9. Time-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy Controls

      Time-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy Controls
      Objective. The aim of this study was to compare retinal nerve fiber layer thickness (RNFLT) between spectral-domain (SD-) and time-domain optical coherence tomography (TD-OCT) in MS patients and healthy controls (HC). Furthermore, RNFLT between MS eyes with and without optic neuritis (ON) and HC should be explored. Finally, the relationship between RNFLT, disease duration, EDSS, and disease modifying therapy (DMT) should be established. Design. Prospective, cross-sectional study. Participants. 28 MS ...
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    10. The OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment

      The OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment
      Background Retinal optical coherence tomography (OCT) is an imaging biomarker for neurodegeneration in multiple sclerosis (MS). In order to become validated as an outcome measure in multicenter studies, reliable quality control (QC) criteria with high inter-rater agreement are required. Methods/Principal Findings A prospective multicentre study on developing consensus QC criteria for retinal OCT in MS: (1) a literature review on OCT QC criteria; (2) application of these QC criteria ...
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    11. Evaluating the Use of Optical Coherence Tomography in Optic Neuritis

      Evaluating the Use of Optical Coherence Tomography in Optic Neuritis
      Optic neuritis (ON) is an inflammatory optic nerve injury, which is strongly associated with multiple sclerosis (MS). Axonal damage in the optic nerve manifests as retinal nerve fiber layer (RNFL) deficits, which can be readily quantified with optical coherence tomography (OCT). The RNFL represents the most proximal region of the afferent visual pathway; and, as such, is a unique region of the central nervous system (CNS) because it lacks myelin ...
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  2. About University of Calgary

    University of Calgary

    The University of Calgary is a medium to large sized research-intensive public university located in Calgary, Alberta, Canada. The University is composed of approximately 24,000 undergraduate and 5,500 graduate students, totaling approximately 29,500 students.

    Initially the Calgary Branch of the University of Alberta in the first half of the century, the University of Calgary separated from the University of Alberta, and was officially founded in 1966. The University of Calgary, or "U of C" is currently composed of 16 faculties including a teachers college, law school, and medical school. In 2008 the University of Calgary will be opening a veterinary school bringing the total number of faculties to 17. The campus is located in the north-west quadrant of Calgary.

    The University of Calgary is one of the top research-intensive universities in Canada as it holds the seventh most Canada Research Chairs. It is a member of the G13 (Group of Thirteen), Association of Commonwealth Universities, International Association of Universities, and the Association of Universities and Colleges of Canada. The University of Calgary has a sponsored research revenue of $282 million, with total revenues exceeding $800 million. Being located in Calgary, with Canada's highest concentration of Engineers and Geoscientists, both the Faculty of Science, Department of Geosciences and the Faculty of Engineering maintain close ties to the Petroleum and Geoscience industry.