1. University of British Columbia

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    1. Mentioned In 67 Articles

    2. Strip-based registration of serially acquired optical coherence tomography angiography

      Strip-based registration of serially acquired optical coherence tomography angiography
      The visibility of retinal microvasculature in optical coherence tomography angiography (OCT-A) images is negatively affected by the small dimension of the capillaries, pulsatile blood flow, and motion artifacts. Serial acquisition and time-averaging of multiple OCT-A images can enhance the definition of the capillaries and result in repeatable and consistent visualization. We demonstrate an automated method for registration and averaging of serially acquired OCT-A images. Ten OCT-A volumes from six normal ...
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    3. Anterior Segment Optical Coherence Tomography for Targeted Transconjunctival Suture Placement in Overfiltering Trabeculectomy Blebs

      Anterior Segment Optical Coherence Tomography for Targeted Transconjunctival Suture Placement in Overfiltering Trabeculectomy Blebs
      Purpose: To demonstrate the utility of swept-source anterior segment optical coherence tomography (SS-AS-OCT) in guiding placement of transconjunctival sutures in hypotonous patients after a trabeculectomy. Patients and Methods: This is a longitudinal case series of 10 eyes from 10 patients who required transconjunctival sutures after a trabeculectomy. SS-AS-OCT was used to aid in the placement of the sutures to improve the function of the overfiltering bleb. Results: SS-AS-OCT reliably identified ...
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    4. Correlation between polarization sensitive optical coherence tomography and SHG microscopy in articular cartilage

      Correlation between polarization sensitive optical coherence tomography and SHG microscopy in articular cartilage
      Polarization-sensitive optical coherence tomography (PS-OCT) and second harmonic generation (SHG) microscopy are two imaging modalities with different resolutions, field-of-views (FOV), and contrasts, while they both have the capability of imaging collagen fibers in biological tissues. PS-OCT can measure the tissue birefringence which is induced by highly organized fibers while SHG can image the collagen fiber organization with high resolution. Articular cartilage, with abundant structural collagen fibers, is a suitable sample ...
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    5. Spectral domain optical coherence tomography-guided versus 1-week facedown-posturing after macular hole surgery

      Spectral domain optical coherence tomography-guided versus 1-week facedown-posturing after macular hole surgery
      Objective To compare idiopathic full-thickness macular hole (FTMH) closure rates and postoperative best-corrected visual acuity (BCVA) between spectral domain optical coherence tomography (SD-OCT)guided facedown posturing and conventional 1-week facedown posturing after macular hole surgery. Design A retrospective comparative study. Participants Thirty-one consecutive eyes that underwent surgery for FTMH between July 2013 and September 2014 were divided into 2 groups. Methods In the SD-OCT-guided group, SD-OCT was performed on the ...
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    6. Failure Mechanisms and Neoatherosclerosis Patterns in Very Late Drug-Eluting and Bare-Metal Stent Thrombosis

      Failure Mechanisms and Neoatherosclerosis Patterns in Very Late Drug-Eluting and Bare-Metal Stent Thrombosis
      Background There are few clinical studies on the pathophysiological mechanisms of very late stent thrombosis (VLST). We report optical coherence tomography findings in patients with VLST and compare the findings between bare-metal stents (BMS) and drug-eluting stents (DES). Methods and Results We conducted a registry of stent thrombosis at 4 North American centers with optical coherence tomography imaging programs SAFE registry (The Study of Late Stent Failure Evaluated by OCT ...
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    7. Culprit plaque morphology in STEMI – an optical coherence tomography study: insights from the TOTAL-OCT substudy

      Culprit plaque morphology in STEMI – an optical coherence tomography study: insights from the TOTAL-OCT substudy
      Aims: Our aim was to compare stenosis severity and plaque content between STEMI culprit lesions with intact fibrous cap (IFC) and those with plaque rupture (PR) in a prospective study. Methods and results: We evaluated 93 patients undergoing OCT and thrombectomy as part of a prospective substudy of the TOTAL (ThrOmbecTomy versus PCI ALone) trial. Culprit lesion morphology was assessable by OCT in 70/93 (75.3%). IFC was found ...
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    8. Optical Coherence Tomography-Based Quantification of Photoreceptor Injury and Recovery in Vogt–Koyanagi–Harada Uveitis

      Optical Coherence Tomography-Based Quantification of Photoreceptor Injury and Recovery in Vogt–Koyanagi–Harada Uveitis
      Purpose : To determine if the inflammatory composition of subretinal fluid in VogtKoyanagiHarada (VKH) serous retinal detachments is predictive of photoreceptor injury, and to quantify photoreceptor recovery, following resolution of these detachments. Methods : Optical density (OD) measurements of spectral-domain optical coherence tomography (SD-OCT) scans were used to derive the fibrinous index, a measure of the inflammatory composition of subretinal fluid. In order to assess photoreceptor status, photoreceptor outer segment (PROS) volume ...
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    9. Retinal optical coherence tomography at 1  μm with dynamic focus control and axial motion tracking

      Retinal optical coherence tomography at 1  μm with dynamic focus control and axial motion tracking
      High-resolution optical coherence tomography (OCT) retinal imaging is important to noninvasively visualize the various retinal structures to aid in better understanding of the pathogenesis of vision-robbing diseases. However, conventional OCT systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking OCT system with automatic focus optimization for high-resolution, extended-focal-range clinical retinal imaging by incorporating a variable-focus liquid lens into the sample ...
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    10. Spectral-domain optical coherence tomography in mitochondrial encephalopathy, lactic acidosis, and strokelike episodes

      Spectral-domain optical coherence tomography in mitochondrial encephalopathy, lactic acidosis, and strokelike episodes
      The point mutation in mitochondrial DNA (mtDNA) 3243AG is associated with many clinical disorders such as MELAS (mitochondrial encephalomyopathy with lactic acidosis and stroke like episodes) and MIDD (maternally inherited diabetes and deafness). 1 MELAS is characterized by strokelike episodes with headache, episodic nausea and vomiting, and lactic acidosis. Other findings include renal failure, neurosensory hearing loss, diabetes mellitus, and short stature. 1 Ocular findings include pigmentary retinopathy, retinal pigment ...
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    11. Quantitative Assessment of Retinal Degeneration in Birdshot Chorioretinopathy Using Optical Coherence Tomography

      Quantitative Assessment of Retinal Degeneration in Birdshot Chorioretinopathy Using Optical Coherence Tomography
      BACKGROUND AND OBJECTIVE: Retinal degeneration in birdshot chorioretinopathy (BSCR) has been assessed qualitatively using spectral-domain optical coherence tomography (SD-OCT). The purpose of this study was to determine whether these changes could be quantified. PATIENTS AND METHODS: The charts of 22 eyes of 11 patients with BSCR and 22 eyes of 22 controls were reviewed. SD-OCT was used to determine the photoreceptor outer segment (PROS) volume and choroidal thickness. RESULTS: PROS ...
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    12. Quantitative Fundus Autofluorescence and Optical Coherence Tomography in ABCA4 Carriers

      Quantitative Fundus Autofluorescence and Optical Coherence Tomography in ABCA4 Carriers
      Purpose : To assess whether carriers of ABCA4 mutations have increased RPE lipofuscin levels based on quantitative fundus autofluorescence (qAF) and whether spectral-domain optical coherence tomography (SD-OCT) reveals structural abnormalities in this cohort. Methods : Seventy-five individuals who are heterozygous for ABCA4 mutations (mean age, 47.3 years; range, 982 years) were recruited as family members of affected patients from 46 unrelated families. For comparison, 57 affected family members with biallelic ABCA4 ...
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    13. Reproducibility of optical coherence tomography airway imaging

      Reproducibility of optical coherence tomography airway imaging
      Optical coherence tomography (OCT) is a promising imaging technique to evaluate small airway remodeling. However, the short-term insertion-reinsertion reproducibility of OCT for evaluating the same bronchial pathway has yet to be established. We evaluated 74 OCT data sets from 38 current or former smokers twice within a single imaging session. Although the overall insertion-reinsertion airway wall thickness (WT) measurement coefficient of variation (CV) was moderate at 12%, much of the ...
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    14. Quantitative Noninvasive Angiography of the Fovea Centralis Using Speckle Variance Optical Coherence Tomography

      Quantitative Noninvasive Angiography of the Fovea Centralis Using Speckle Variance Optical Coherence Tomography
      Purpose : To demonstrate the utility of speckle variance optical coherence tomography (svOCT), a noninvasive angiographic technique, for evaluating the foveal vasculature. Methods : Twelve normal human eyes were imaged with svOCT (1060-nm, 100-kHz custom-built system) and fluorescein angiography (FA; Topcon TRC-50DX with 5.0 megapixel resolution camera). Manual tracing techniques were used to quantify the foveal vasculature, including foveal avascular zone (FAZ) metrics (area, perimeter, greatest diameter, and lowest diameter). Reproducibility ...
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    15. Wide-field in vivo oral OCT imaging

      Wide-field in vivo oral OCT imaging
      We have built a polarization-sensitive swept source Optical Coherence Tomography (OCT) instrument capable of wide-field in vivo imaging in the oral cavity. This instrument uses a hand-held side-looking fiber-optic rotary pullback catheter that can cover two dimensional tissue imaging fields approximately 2.5 mm wide by up to 90 mm length in a single image acquisition. The catheter spins at 100 Hz with pullback speeds up to 15 mm/s ...
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    16. Optical Coherence Tomography of Pulmonary Arterial Walls in Humans and Pigs (Sus scrofa domesticus)

      Optical Coherence Tomography of Pulmonary Arterial Walls in Humans and Pigs (Sus scrofa domesticus)
      Pulmonary arterial hypertension (PAH) is a devastating disorder characterized by progressive elevation of the pulmonary pressures that, in the absence of therapy, results in chronic right-heart failure and premature death. The vascular pathology of PAH is characterized by progressive loss of small (diameter, less than 50 m) peripheral pulmonary arteries along with abnormal medial thickening, neointimal formation, and intraluminal narrowing of the remaining pulmonary arteries. Vascular pathology correlates with disease ...
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  2. About University of British Columbia

    University of British Columbia

    University of British Columbia, UBC, is a Canadian public research university with campuses in Vancouver and Kelowna. UBC is rated as one of Canada’s top universities, and is usually considered one of the top 50 universities in the world.