1. University of British Columbia

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    1. Mentioned In 102 Articles

    2. software development TO OPTIMIZE THE minimal detectable difference IN huMAN AIRWAY IMAGES CAPTURED USING optical coherence tomography

      software development TO OPTIMIZE THE minimal detectable difference IN huMAN AIRWAY IMAGES CAPTURED USING optical coherence tomography
      Optical coherence tomography (OCT) is an imaging methodology that can be used to assess human airways. OCT avoids the harmful effects of ionizing radiation and has a high spatial resolution making it well suited for imaging the structure of small airways. Analysis of OCT airway images has typically been performed manually by tracing the airway with a relatively high coefficient of variation. The purpose of this study was to develop ...
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    3. Numerical calibration method for a multiple spectrometer-based OCT system

      Numerical calibration method for a multiple spectrometer-based OCT system
      The present paper introduces a numerical calibration method for the easy and practical implementation of multiple spectrometer-based spectral-domain optical coherence tomography (SD-OCT) systems. To address the limitations of the traditional hardware-based spectrometer alignment across more than one spectrometer, we applied a numerical spectral calibration algorithm where the pixels corresponding to the same wavelength in each unit are identified through spatial- and frequency-domain interferometric signatures of a mirror sample. The utility ...
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    4. Patterns of Early Coronary Artery Changes in Pediatric Heart Transplant Recipients Detected Using Optical Coherence Tomography

      Patterns of Early Coronary Artery Changes in Pediatric Heart Transplant Recipients Detected Using Optical Coherence Tomography
      Background: Cardiac allograft vasculopathy, the leading cause of graft failure in pediatric heart transplant recipients, is characterized by diffuse and concentric coronary intimal thickening. Early treatment yields better outcomes. While coronary angiography is the standard for cardiac allograft vasculopathy screening and diagnosis, it only identifies luminal narrowing, which occurs in more severe disease. Coronary optical coherence tomography (OCT) is a high-definition intravascular imaging modality that may offer earlier diagnosis. We ...
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    5. Effect of optical coherence tomography and angiography sampling rate towards diabetic retinopathy severity classification

      Effect of optical coherence tomography and angiography sampling rate towards diabetic retinopathy severity classification
      Optical coherence tomography (OCT) and OCT angiography (OCT-A) may benefit the screening of diabetic retinopathy (DR). This study investigated the effect of laterally subsampling OCT/OCT-A en face scans by up to a factor of 8 when using deep neural networks for automated referable DR classification. There was no significant difference in the classification performance across all evaluation metrics when subsampling up to a factor of 3, and only minimal ...
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    6. Airway luminal area and the resistive work of breathing during exercise in healthy young females and males

      Airway luminal area and the resistive work of breathing during exercise in healthy young females and males
      We examined the relationship between the work of breathing (W b ) during exercise and in vivo measures of airway size in healthy females and males. We hypothesized that sex-differences in airway luminal area (Ai) would explain the larger resistive W b during exercise in females. Healthy participants (n=11 females and n=11 males; 19-30 y) completed a cycle exercise test to exhaustion where W b was assessed using an ...
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    7. Polarization-Sensitive Optical Coherence Tomography for Tissue Imaging

      Polarization-Sensitive Optical Coherence  Tomography for Tissue Imaging
      Abstract Polarization - sensitive optical coher ence tomography (PS - OCT) is a high - resolution, real - time, and 3D imaging technique for acquiring morphological and functional information of tissues. The multiple contrasts from PS - OCT can provide comprehensive information about tissue such as layered tiss ue structure, tissue birefringence, and depolarization. The real - time imaging capability enable s PS - OCT as a powerful tool for in vivo characterization of tissue properties and ...
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    8. LF-UNet - A Novel Anatomical-Aware Dual-Branch Cascaded Deep Neural Network for Segmentation of Retinal Layers and Fluid from Optical Coherence Tomography Images

      LF-UNet - A Novel Anatomical-Aware Dual-Branch Cascaded Deep Neural Network for Segmentation of Retinal Layers and Fluid from Optical Coherence Tomography Images
      Computer-assistant diagnosis of retinal disease relies heavily on the accurate detection of retinal boundaries and other pathological features such as fluid accumulation. Optical coherence tomography (OCT) is a non-invasive ophthalmological imaging technique that has become a standard modality in the field due to its ability to detect cross-sectional retinal pathologies at the micrometer level. In this work, we presented a novel framework to achieve simultaneous retinal layers and fluid segmentation ...
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    9. Long-term assessment of internal limiting membrane peeling for full-thickness macular hole using en face adaptive optics and conventional optical coherence tomography

      Long-term assessment of internal limiting membrane peeling for full-thickness macular hole using en face adaptive optics and conventional optical coherence tomography
      Objective: To evaluate the long-term structural and microvascular retinal effects of internal limiting membrane peeling for full-thickness macular hole (FTMH) using en face adaptive optics optical coherence tomography (AO-OCT), conventional OCT, and OCT angiography (OCTA). Design: Interventional case series. Participants: Patients with FTMH treated with vitrectomy, internal limiting membrane peeling, and gas tamponade. Methods: Eleven eyes with FTMH that had at least 12 months of postoperative follow-up were enrolled in ...
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    10. Phase-corrected buffer averaging for enhanced OCT angiography using FDML laser

      Phase-corrected buffer averaging for enhanced OCT angiography using FDML laser
      Megahertz-rate optical coherence tomography angiography (OCTA) is highly anticipated as an ultrafast imaging tool in clinical settings. However, shot-noise-limited sensitivity is inevitably reduced in high-speed imaging systems. In this Letter, we present a coherent buffer averaging technique for use with a Fourier-domain mode-locked (FDML) laser to improve OCTA contrast at 1060 nm MHz-rate retinal imaging. Full characterization of spectral variations among the FDML buffers and a numerical correction method are ...
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    11. Investigating the depolarization property of skin tissue by degree of polarization uniformity contrast using polarization-sensitive optical coherence tomography

      Investigating the depolarization property of skin tissue by degree of polarization uniformity contrast using polarization-sensitive optical coherence tomography
      The depolarization property of skin has been found to be important for skin cancer detection. Previous techniques based on light polarization lack the capability of depth differentiation. Polarization-sensitive optical coherence tomography (PS-OCT) has the advantage of both depth-resolved 3D imaging and high sensitivity to polarization. In this study, we investigate the depolarization property of skin tissue using PS-OCT, especially with the degree of polarization uniformity (DOPU) contrast. Well designed skin ...
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    12. Small airway dilation measured by endoscopic optical coherence tomography correlates with chronic lung allograft dysfunction

      Small airway dilation measured by endoscopic optical coherence tomography correlates with chronic lung allograft dysfunction
      Significance: Chronic lung allograft dysfunction (CLAD) is the leading cause of death in transplant patients who survive past the first year post-transplant. Current diagnosis is based on sustained decline in lung function; there is a need for tools that can identify CLAD onset. Aim: Endoscopic optical coherence tomography (OCT) can visualize structural changes in the small airways, which are of interest in CLAD progression. We aim to identify OCT features ...
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    13. Investigating Microangiopathy using Swept-Source Optical Coherence Tomography Angiography in Patients with Susac Syndrome

      Investigating Microangiopathy using Swept-Source Optical Coherence Tomography Angiography in Patients with Susac Syndrome
      Purpose: To determine whether optical coherence tomography angiography is of diagnostic utility for Susac syndrome (SuS) by quantifying microvascular retinal changes. Methods: We enrolled 18 eyes of 9 healthy controls and 18 eyes of 9 patients with chronic SuS (12 had previous branch retinal artery occlusions and 6 were clinically unaffected). Images of the fovea were taken using an optical coherence tomography angiography system. Analysis included vessel density, fractal dimension ...
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    14. Investigation of the Clinical Potential of Polarization-Sensitive Optical Coherence Tomography in a Laryngeal Tumor Model

      Investigation of the Clinical Potential of Polarization-Sensitive Optical Coherence Tomography in a Laryngeal Tumor Model
      BACKGROUND: The vocal cord tissue consists of three anatomical layers from the surface to deep inside: the epithelium that contains almost no collagen, the lamina propria that is composed of abundant collagen, and the vocalis muscle layer. It is clinically important to visualize the tissue microstructure using a non-invasive method, especially in the case of vocal cord nodules or cancer, since histological changes in each layer of the vocal cord ...
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    15. Fiber optic endoscopic optical coherence tomography (OCT) to assess human airways: The relationship between anatomy and physiological function during dynamic exercise

      Fiber optic endoscopic optical coherence tomography (OCT) to assess human airways: The relationship between anatomy and physiological function during dynamic exercise
      Airway luminal area (A i ) influences respiratory mechanics during dynamic exercise; however, previous studies have investigated the relationship between airway anatomy and physiological function in different groups of individuals. The purpose of this study was to determine the effect of A i on respiratory mechanics by making in vivo measures of airway dimensions and work of breathing (Wb) in the same individuals. Healthy participants (3F/2M; 23-45 years) completed a ...
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  2. About University of British Columbia

    University of British Columbia

    University of British Columbia, UBC, is a Canadian public research university with campuses in Vancouver and Kelowna. UBC is rated as one of Canada’s top universities, and is usually considered one of the top 50 universities in the world.