1. University of British Columbia

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    1. Mentioned In 85 Articles

    2. Retinal capillary perfusion heterogeneity in diabetic retinopathy detected by optical coherence tomography angiography

      Retinal capillary perfusion heterogeneity in diabetic retinopathy detected by optical coherence tomography angiography
      Purpose : To investigate the ability of a commercially available optical coherence tomography angiography (OCTA) machine to describe retinal capillary perfusion heterogeneity in diabetic retinopathy (DR) patients. Methods : Ten consecutive en face 6x6mm foveal OCTA images were obtained from both eyes of 13 DR patients and 5 healthy controls using a Zeiss PLEX Elite 9000. Fifteen DR and eight healthy eyes met the inclusion criteria: a centered fovea, little motion artifacts ...
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    3. Imaging intracellular motion with dynamic micro-optical coherence tomography

      Imaging intracellular motion with dynamic micro-optical coherence tomography
      This paper describes a new technology that uses 1-m-resolution optical coherence tomography (OCT) to obtain cross-sectional images of intracellular dynamics with dramatically enhanced image contrast. This so-called dynamic OCT (d-OCT) is accomplished by acquiring a time series of OCT images and conducting power frequency analysis of the temporal fluctuations that arise from intracellular motion on a pixel-per-pixel basis. Here, we demonstrate d-OCT imaging of freshly excised human esophageal and cervical ...
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    4. Detecting human articular cartilage degeneration in its early stage with polarization-sensitive optical coherence tomography

      Detecting human articular cartilage degeneration in its early stage with polarization-sensitive optical coherence tomography
      Detecting articular cartilage (AC) degeneration in its early stage plays a critical role in the diagnosis and treatment of osteoarthritis (OA). Polarization-sensitive optical coherence tomography (PS-OCT) is sensitive to the alteration and disruption of collagen organization that happens during OA progression. This study proposes an effective OA evaluating method based on PS-OCT imaging. A slope-based analysis is applied on the phase retardation images to segment articular cartilage into three zones ...
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    5. ADAPTIVE OPTICS OPTICAL COHERENCE TOMOGRAPHY IN A CASE OF ACUTE ZONAL OCCULT OUTER RETINOPATHY

      ADAPTIVE OPTICS OPTICAL COHERENCE TOMOGRAPHY IN A CASE OF ACUTE ZONAL OCCULT OUTER RETINOPATHY
      Purpose: To report a case of acute zonal occult outer retinopathy in which adaptive optics (AO) facilitated visualization of abnormal photoreceptors previously thought to be in an area of normal retina on conventional optical coherence tomography ( OCT ). Methods: Case report. Results: A 51-year-old woman presents with 11-month history of photopsias and scotoma in the temporal visual field of her left eye. Ocular imaging including fluorescein angiography, fundus autofluorescence and OCT ...
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    6. Optical coherence tomography of patients with Parkinson’s disease and progressive supranuclear palsy

      Optical coherence tomography of patients with Parkinson’s disease and progressive supranuclear palsy
      Objectives To determine if Parkinsons disease (PD) and progressive supranuclear palsy (PSP) differed on retinal measurements using optical coherence tomography (OCT). Patients and methods In a prospective, controlled, cross-sectional cohort study, we recruited patients with PD or PSP for more than three years, as well as control subjects. We measured peripapillary retinal nerve fiber layer (RNFL) thickness and macular volume using spectral-domain OCT. The association between these OCT measures and ...
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    7. Optical Coherence Tomography for the Early Detection of Coronary Vascular Changes in Children and Adolescents After Cardiac Transplantation: Findings From the International Pediatric OCT Registry

      Optical Coherence Tomography for the Early Detection of Coronary Vascular Changes in Children and Adolescents After Cardiac Transplantation: Findings From the International Pediatric OCT Registry
      Objectives This study sought to describe the initial findings from the International Pediatric Optical Coherence Tomography (OCT) registry in pediatric heart transplant recipients. Background Cardiac allograft vasculopathy (CAV) is a common cause of late graft failure and mortality in pediatric heart transplant recipients. Early diagnosis may improve outcomes. OCT is a high-resolution intravascular imaging technique that has the potential to identify CAV earlier than angiography. Methods OCT and angiography of ...
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    8. Etching-enabled extreme miniaturization of graded-index fiber-based optical coherence tomography probes

      Etching-enabled extreme miniaturization of graded-index fiber-based optical coherence tomography probes
      We introduced and validated a method to miniaturize graded-index (GRIN) fiber-based optical coherence tomography (OCT) probes down to 70m in diameter. The probes consist in an assembly of single-mode (SM), coreless (CL), and graded-index (GRIN) fibers. We opted for a probe design enabling controlled size reduction by hydrogen fluoride etching. The fabrication approach prevents nonuniform etching for both the GRIN and SM fiber components, while it requires no probe polishing ...
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    9. Enhanced depth imaging in swept-source optical coherence tomography: Improving visibility of choroid and sclera, a masked study

      Enhanced depth imaging in swept-source optical coherence tomography: Improving visibility of choroid and sclera, a masked study
      Purpose To compare enhanced depth imaging in swept-source optical coherence tomography and nonenhanced depth imaging optical coherence tomography in their ability to capture choroidal and scleral details. Methods Averaged foveal B-Scans were obtained from 40 eyes of 20 healthy volunteers by swept-source optical coherence tomography with and without enhanced depth imaging. Visibility and contrast of vascular details within the choroid, choroidoscleral junction, and sclera were evaluated by masked readers using ...
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    10. Application of optical coherence tomography angiography in diabetic retinopathy: a comprehensive review

      Application of optical coherence tomography angiography in diabetic retinopathy: a comprehensive review
      Optical coherence tomography angiography (OCTA) is a noninvasive method that enables visualization of blood flow within retinal vessels down to the size of capillaries by detecting motion contrast from moving blood cells. OCTA provides a fast and safe procedure to assess retinal microvasculature with higher contrast and resolution than conventional fluorescence angiography . The different capillary plexuses are displayed separately and their perfusion density can be quantified. Imaging capabilities such as ...
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    11. Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image

      Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image
      A segmentation method based on phase retardation measurements from polarization-sensitive optical coherence tomography (PS-OCT) is developed to differentiate the structural zones of articular cartilage. The organization of collagen matrix in articular cartilage varies over the different structural zones, generating different tissue birefringence. Analyzing the slope of the accumulated phase retardation at different depths can detect the variation in tissue birefringence and be used to segment the structural zones. The method ...
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    12. Deep-Learning based Multiclass Retinal Fluid Segmentation and Detection in Optical Coherence Tomography Images using a Fully Convolutional Neural Network

      Deep-Learning based Multiclass Retinal Fluid Segmentation and Detection in Optical Coherence Tomography Images using a Fully Convolutional Neural Network
      As a non-invasive imaging modality, optical coherence tomography (OCT) can provide micrometer-resolution 3D images of retinal structures. These images can help reveal disease-related alterations below the surface of the retina, such as the presence of edema, or accumulation of fluid which can distort vision, and are an indication of disruptions in the vasculature of the retina. In this paper, a new framework is proposed for multiclass fluid segmentation and detection ...
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    13. Colloidal silver toxicity with absence of choroidal signal on optical coherence tomography

      Colloidal silver toxicity with absence of choroidal signal on optical coherence tomography
      Silver, aside from its physical properties making it popular for electric applications and in jewellery, has a history of being used to treat various medical conditions. 1 It has been used to treat mental illness, epilepsy, gastrointestinal disorders, and infectious diseases and in surgical prostheses. 1 A review performed by Drake and Hazelwood in 2005 suggested that metallic silver posed minimal risk to healththe most common side effects being argyria ...
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    14. EN FACE OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF INNER RETINAL DIMPLES AFTER INTERNAL LIMITING MEMBRANE PEELING FOR FULL-THICKNESS MACULAR HOLES

      EN FACE OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF INNER RETINAL DIMPLES AFTER INTERNAL LIMITING MEMBRANE PEELING FOR FULL-THICKNESS MACULAR HOLES
      Purpose: To quantitatively and qualitatively evaluate the microvascular and structural abnormalities associated with inner retinal dimpling after internal limiting membrane peeling for full-thickness macular holes using sequential en face optical coherence tomography ( OCT ) and OCT angiography. Methods: Thirteen eyes of 13 patients with idiopathic full-thickness macular holes were enrolled in the study. Patients were treated with pars plana vitrectomy , internal limiting membrane peeling, and gas tamponade. Subjects were evaluated preoperatively ...
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    15. Macular Involvement in Diabetic Retinopathy Evaluated With Swept-Source OCT

      Macular Involvement in Diabetic Retinopathy Evaluated With Swept-Source OCT
      The prevalence of diabetes mellitus (DM) is increasing worldwide. Diabetic retinopathy is the most prevalent complication of DM and a leading cause of visual impairment due to closure of capillaries. High-resolution imaging techniques of the retina and its supplying vascular networks can allow novel insight to subtle changes that cannot be appreciated in standard fundus examination. In this study capillary changes of patients with different severity levels of diabetic retinopathy ...
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    16. Automated identification of cone photoreceptors in adaptive optics optical coherence tomography images using transfer learning

      Automated identification of cone photoreceptors in adaptive optics optical coherence tomography images using transfer learning
      Automated measurements of the human cone mosaic requires the identification of individual cone photoreceptors. The current gold standard, manual labeling, is a tedious process and can not be done in a clinically useful timeframe. As such, we present an automated algorithm for identifying cone photoreceptors in adaptive optics optical coherence tomography (AO-OCT) images. Our approach fine-tunes a pre-trained convolutional neural network originally trained on AO scanning laser ophthalmoscope (AO-SLO) images ...
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    17. 1-15 of 85 1 2 3 4 5 6 »
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  2. About University of British Columbia

    University of British Columbia

    University of British Columbia, UBC, is a Canadian public research university with campuses in Vancouver and Kelowna. UBC is rated as one of Canada’s top universities, and is usually considered one of the top 50 universities in the world.