1. University of Bonn

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    1. Mentioned In 50 Articles

    2. Imaging of Therapeutic Effects of Anti-Vascular Endothelial Growth Factor Inhibitors by Optical Coherence Tomography Angiography in a Rat Model

      Imaging of Therapeutic Effects of Anti-Vascular Endothelial Growth Factor Inhibitors by Optical Coherence Tomography Angiography in a Rat Model
      Purpose : The aim of the study was to investigate optical coherence tomography angiography (OCTA) as a high-resolution in vivo imaging modality for monitoring therapeutic response to different vascular endothelial growth factor inhibitors in the rat model of laser-induced choroidal neovascularization (CNV). Further, OCTA findings were compared with fluorescein angiography (FA) and fluorescence microscopy. Methods : Laser treatment at day (D)0 was followed by intravitreal injection of aflibercept, AF564, and NaCl ...
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    3. Optical coherence tomography-angiography for monitoring neovascularisations in macular telangiectasia type 2

      Optical coherence tomography-angiography for monitoring neovascularisations in macular telangiectasia type 2
      Purpose To evaluate the utility of optical coherence tomography-angiography (OCT-A) for monitoring activity, progression and response to therapy of neovascularisations (NVs) secondary to macular telangiectasia type 2 (MacTel). Methods In a retrospective analysis, eyes with NVs secondary to MacTel were reviewed over a period of 8 months. Examinations at monthly intervals included visual acuity testing, dilated funduscopy, spectral domain-OCT and OCT-A. Eyes were treated with intravitreal VEGF (vascular endothelial growth ...
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    4. Replication and Refinement of an Algorithm for Automated Drusen Segmentation on Optical Coherence Tomography

      Replication and Refinement of an Algorithm for Automated Drusen Segmentation on Optical Coherence Tomography
      Here, we investigate the extent to which re-implementing a previously published algorithm for OCT-based drusen quantification permits replicating the reported accuracy on an independent dataset. We refined that algorithm so that its accuracy is increased. Following a systematic literature search, an algorithm was selected based on its reported excellent results. Several steps were added to improve its accuracy. The replicated and refined algorithms were evaluated on an independent dataset with ...
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    5. Automated thresholding algorithms outperform manual thresholding in macular optical coherence tomography angiography image analysis

      Automated thresholding algorithms outperform manual thresholding in macular optical coherence tomography angiography image analysis
      ... Bonn, Germany, between April and August 2018. Ethical approval was obtained from the ethics committee of the University of Bonn (approval ID 089/08) and informed consent was obtained from all study participants prior to...
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    6. Novel biomarker of sphericity and cylindricity indices in volume-rendering optical coherence tomography angiography in normal and diabetic eyes: a preliminary study

      Novel biomarker of sphericity and cylindricity indices in volume-rendering optical coherence tomography angiography in normal and diabetic eyes: a preliminary study
      Purpose Preliminary to evaluate geometric indices (vessel sphericity and cylindricity) for volume-rendered optical coherence tomography angiography (OCTA) in healthy and diabetic eyes. Methods Twenty-six eyes of 13 healthy subjects and 12 eyes of patients with central ischemic, non-proliferative diabetic retinopathy were included. OCTA volume and surface area of the foveal vessels were measured and compared to determine OCTA sphericity and cylindricity indices and surface efficiency (SE). Results The overall average ...
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    7. Validation of automated artificial intelligence segmentation of optical coherence tomography images

      Validation of automated artificial intelligence segmentation of optical coherence tomography images
      Purpose To benchmark the human and machine performance of spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) image segmentation, i.e., pixel-wise classification, for the compartments vitreous, retina, choroid, sclera. Methods A convolutional neural network (CNN) was trained on OCT B-scan images annotated by a senior ground truth expert retina specialist to segment the posterior eye compartments. Independent benchmark data sets (30 SDOCT and 30 SSOCT) were manually segmented ...
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    8. Estimating Retinal Sensitivity Using Optical Coherence Tomography With Deep-Learning Algorithms in Macular Telangiectasia Type 2

      Estimating Retinal Sensitivity Using Optical Coherence Tomography With Deep-Learning Algorithms in Macular Telangiectasia Type 2
      Importance As currently used, microperimetry is a burdensome clinical testing modality for testing retinal sensitivity requiring long testing times and trained technicians. Objective To create a deep-learning network that could directly estimate function from structure de novo to provide an en face high-resolution map of estimated retinal sensitivity. Design, Setting, and Participants A cross-sectional imaging study using data collected between January 1, 2016, and November 30, 2017, from the Natural ...
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    9. Retinal imaging including OCT angiography for detecting active choroidal neovascularization in pseudoxanthoma elasticum

      Retinal imaging including OCT angiography for detecting active choroidal neovascularization in pseudoxanthoma elasticum
      Importance The diagnostic accuracy of different retinal imaging modalities to detect active choroidal neovascularization (CNV) in pseudoxanthoma elasticum (PXE) is essential to enable a correct diagnosis but currently poorly understood. Background Optical coherence tomography (OCT), fluorescein angiography (FA) and optical coherence tomography angiography (OCT‐A) are employed in daily practice but a systematic comparison of these imaging techniques is lacking. Design Retrospective, observational study. Participants Twenty patients (31 eyes) with ...
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    10. Optical coherence tomography angiography in intermediate uveitis

      Optical coherence tomography angiography in intermediate uveitis
      Purpose To investigate the involvement of the retinal and choriocapillaris microvasculature in intermediate uveitis on optical coherence tomography angiography (OCT-A) Design Case-control study Methods Patients and age-matched controls were imaged with swept-source OCT-A (PLEX Elite 9000, Zeiss). Using ImageJ superficial and deep retinal vasculature were semi-automatically analyzed for vessel (VD) and skeleton density (SD), vessel diameter index (VDI) and fractal dimension (FD). Choriocapillaris layer was automatically graded for mean signal ...
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    11. Longitudinal Analysis of Drusen Volume in Intermediate Age-Related Macular Degeneration Using Two Spectral-Domain Optical Coherence Tomography Scan Patterns

      Longitudinal Analysis of Drusen Volume in Intermediate Age-Related Macular Degeneration Using Two Spectral-Domain Optical Coherence Tomography Scan Patterns
      Purpose: To evaluate two different spectral-domain optical coherence tomography (SD-OCT) scan patterns in eyes with intermediate age-related macular degeneration (AMD) for the longitudinal assessment of drusen volume. Methods: The data of 38 eyes of 38 AMD patients (age 69.97 6.08 years) were included. The longitudinal drusen volume over 4 years was analyzed by annual SD-OCT raster scanning (field size 20 15). Two raster scan patterns (A/B) differed ...
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    12. MINIMAL OPTICAL COHERENCE TOMOGRAPHY B-SCAN DENSITY FOR RELIABLE DETECTION OF INTRARETINAL AND SUBRETINAL FLUID IN MACULAR DISEASES

      MINIMAL OPTICAL COHERENCE TOMOGRAPHY B-SCAN DENSITY FOR RELIABLE DETECTION OF INTRARETINAL AND SUBRETINAL FLUID IN MACULAR DISEASES
      Purpose: To determine the minimal optical coherence tomography B-scan density for reliable detection of intraretinal and subretinal fluid. Methods: Spectral domain optical coherence tomography raster scanning (Spectralis; Heidelberg Engineering, Heidelberg, Germany) using a scan field of 20 20 of 97 B-scans with an interscan distance (ISD) of 60 m was performed in 150 eyes of 150 consecutive patients at monitoring visits for intravitreal antivascular endothelial growth factor therapy. Using custom ...
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    13. CNNs Enable Accurate and Fast Segmentation of Drusen in Optical Coherence Tomography

      CNNs Enable Accurate and Fast Segmentation of Drusen in Optical Coherence Tomography
      Optical coherence tomography (OCT) is used to diagnose and track progression of age-related macular degeneration (AMD). Drusen, which appear as bumps between Bruchs membrane (BM) and the retinal pigment epithelium (RPE) layer, are among the most important biomarkers for staging AMD. In this work, we develop and compare three automated methods for Drusen segmentation based on the U-Net convolutional neural network architecture. By cross-validating on more than 50, 000 annotated ...
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    14. Quantitative Features of the Choriocapillaris in Healthy Individuals Using Swept-Source Optical Coherence Tomography Angiography

      Quantitative Features of the Choriocapillaris in Healthy Individuals Using Swept-Source Optical Coherence Tomography Angiography
      ...Akram Hospital, Iran University of Medical Sciences, Tehran, Iran (KGF); and the Department of Ophthalmology, University of Bonn, Bonn, Germany (MP). Dr. Sadda is a consultant for Carl Zeiss Meditec, Optos, Allergan, Gen...
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  2. About University of Bonn

    University of Bonn

    University of Bonn was founded almost 200 years ago and is considered to be one of Germany's and indeed Europe's most important institutes of higher education. As home of learning to over 27,000 students, we enjoy an outstanding reputation both at home and abroad.  The University of Bonn is one of the world's leading research based Universities and therefore it is no surprise that we operate on an international level. We particularly specialize in the fields of research and teaching and this has led to our evolving into the position of a truly prominent international institution.