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2. Vasculature of a minipig eye (microCT Group, Institute of Anatomy, University of Bern)
  
  Explore YouTube Aug 12 2020 Ophthalmology
  
  MicroangioCT of a minipig eye (collaboration with Vetsuisse Faculty, University of Zurich and OCTlab Research Laboratory, Department of Ophthalmology, University of Basel). Contrast agent used: Angiofil (Fumedica AG, Switzerland). Scanner: desktop microCT-scanner Skyscan 1172 (Bruker microCT, Belgium). Isotrpic voxel size: 6.56m.
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  Mentions: University of Zurich University of Bern
3. Conjunctival Microangiopathy in Diabetes Mellitus Assessed with Optical Coherence Tomography Angiography
  
  Explore TVST Journal May 19 2020 Ophthalmology
  
  Purpose : To detect and quantify conjunctival microangiopathy with optical coherence tomography angiography (OCTA). Methods : Imaging was performed in the temporal and nasal quadrant of the conjunctiva using a Heidelberg Spectralis spectral domain-OCT in OCTA mode adding a 25D lens to the standard 30 fundus lens. Images were acquired within a 10 5 cube at the limbus. Binary images were analyzed using ImageJ (Fiji software version 2.0) and an average ...
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  Mentions: University of Bern Bern University Hospital
4. Utility of Multimodality Intravascular Imaging and the Local Hemodynamic Forces to Predict Atherosclerotic Disease Progression
  
  Explore imaging.onlinejacc.org Apr 1 2020 Cardiology
  
  Objectives This study sought to examine the utility of multimodality intravascular imaging and of the endothelial shear stress (ESS) distribution to predict atherosclerotic evolution. Background There is robust evidence that intravascular ultrasound (IVUS)-derived plaque characteristics and ESS distribution can predict, with however limited accuracy, atherosclerotic evolution; nevertheless, it is yet unclear whether multimodality imaging and ESS mapping enable more accurate prediction of coronary plaque progression. Methods A total of ...
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  Mentions: Imperial College London University College London University of Copenhagen
5. Randomized comparison of optical coherence tomography versus angiography to guide Bioresorbable vascular scaffold implantation: The OPTICO BVS stud
  
  Explore ScienceDirect Mar 24 2020 Cardiology
  
  Purpose We investigated whether optical coherence tomography (OCT)-guided bioresorbable vascular scaffolds (BVS) implantation can improve in-scaffold minimal lumen area (MLA) at 6-month compared with angiography guidance. Methods The OPTICO BVS was a randomized, international multicenter, assessor blind, superiority trial comparing OCT- versus angiography-guided percutaneous coronary intervention (PCI) (1:1 allocation) in patients with coronary artery disease undergoing Absorb BVS 1.1 implantation. The primary endpoint was in-scaffold MLA at ...
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  Mentions: University of Bern Stephan Windecker Fernando Alfonso
6. Optical Coherence Tomography Analysis of Cystoid Macular Edema in Retinal Dystrophy Treated with Oral Acetazolamide: Two Cases
  
  Explore thieme-connect.de Feb 25 2020 Ophthalmology
  
  Enhanced S-cone syndrome (ESCS) is an autosomal recessive retinal dystrophy associated with a NR2E3 mutation, causing night blindness, decreased visual acuity, and visual field defects [ 1 ]. Clinically, ESCS is characterized by annular pigmentation along the vascular arcades and macular abnormalities [ 2 ]. Best vitelliform macular dystrophy (BVMD) is also an autosomal but dominant hereditary retinal dystrophy associated with the BEST1 gene, which affects central vision with a relatively good prognosis and ...
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  Mentions: University of Bern
7. Differences in the presentation of stage 1 macular holes illustration by optical coherence tomography
  
  Explore SAGE Journals Feb 16 2020 Ophthalmology
  
  Objective: To present two different phases of progression of Gass stage 1 foveolar detachment to lamellar or full-thickness macular holes revealed with spectral domain optical coherence tomography. Design: This is an observational study. Participants: The medical records of four patients (four eyes) with foveolar detachment that had evolved into stage 1 macular holes were compared. The patients manifested neither co-existing myopia nor any other ocular pathology. Methods: At each consultation ...
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  Mentions: University of Bern Francesco Bandello Università Vita-Salute San Raffaele
8. In vivo relationship between near-infrared spectroscopy-detected lipid-rich plaques and morphological plaque characteristics by optical coherence tomography and intravascular ultrasound: a multimodality intravascular imaging study
  
  Explore Journals Feb 2 2020 Cardiology
  
  Aims We assessed morphological features of near-infrared spectroscopy (NIRS)-detected lipid-rich plaques (LRPs) by using optical coherence tomography (OCT) and intravascular ultrasound (IVUS). Methods and results IVUS-NIRS and OCT were performed in the two non-infarct-related arteries (non-IRAs) in patients undergoing percutaneous coronary intervention for treatment of an acute coronary syndrome. A lesion was defined as the 4mm segment with the maximum amount of lipid core burden index (maxLCBI 4mm ) of ...
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  Mentions: Medical University of Vienna University of Bern Joost Daemen
9. Efficacy and Reproducibility of Attenuation-Compensated Optical Coherence Tomography for Assessing External Elastic Membrane Border and Plaque Composition in Native and Stented Segments ― An In Vivo and Histology-Based Study ―
  
  Explore jstage.jst.go.jp Nov 21 2019 Cardiology
  
  Background: Attenuation-compensated (AC) technique was recently introduced to improve the plaque characterization of optical coherence tomography (OCT). Histological validation demonstrated promising results but the efficacy and reproducibility of this technique for assessing in-vivo tissue composition remains unclear. Methods and Results: OCT images portraying native (n=200) and stented (n=200) segments and 31 histological cross-sections were analyzed. AC-OCT appeared superior to conventional (C)-OCT in detecting the external elastic lamina ...
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  Mentions: Imperial College London Leiden University University College London
10. Correlation between in vivo near-infrared spectroscopy and optical coherence tomography detected lipid-rich plaques with post-mortem histology
  
  Explore eurointervention.pcronline.com Nov 14 2019 Cardiology
  
  A 67-year-old female presented with an acute anterior STEMI and underwent percutaneous coronary intervention of the mid-left anterior descending (LAD) coronary artery. Following successful implantation of two drug-eluting stents with TIMI III flow, multimodality imaging using near-infrared spectroscopy with intravascular ultrasound (NIRS-IVUS) and optical coherence tomography (OCT) was performed in the LAD and right coronary artery (RCA) in the setting of an imaging study (A1 and B1).
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  Mentions: University of Bern Bern University Hospital
11. Expert-level Automated Biomarker Identification in Optical Coherence Tomography Scans
  
  Explore Nature Publishing Group Sep 24 2019 Ophthalmology
  
  In ophthalmology, retinal biological markers, or biomarkers , play a critical role in the management of chronic eye conditions and in the development of new therapeutics. While many imaging technologies used today can visualize these, Optical Coherence Tomography (OCT) is often the tool of choice due to its ability to image retinal structures in three dimensions at micrometer resolution. But with widespread use in clinical routine, and growing prevalence in chronic ...
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  Mentions: Sebastian Wolf University of Bern Martin S. Zinkernagel
12. Optical coherence tomography diagnostic signs in posterior uveitis
  
  Explore ScienceDirect Sep 14 2019 Ophthalmology
  
  A diagnostic sign refers to a quantifiable biological parameter that is measured and evaluated as an indicator of normal biological, pathogenic, or pharmacologic responses to a therapeutic intervention. When used in translational research discussions, the term itself often alludes to a signs used to accelerate or aid in diagnosis or monitoring and provide insight into personalized medicine. Many new diagnostic signs are being developed that involve imaging technology. Optical coherence ...
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  Mentions: Case Western Reserve University Northwestern University University of Sydney
13. Repeatability of Wide-field Optical Coherence Tomography Angiography in Normal Retina
  
  Explore TVST Journal May 7 2019 Ophthalmology
  
  Purpose : We evaluated the repeatability of wide-field en face swept-source optical coherence tomography angiography (SS-OCTA) in healthy subjects. Methods : Healthy subjects underwent two imaging sessions, on average 8 days apart, with a 100 kHz SS-OCTA instrument. The imaging protocol included a central 3 3 and 12 12 mm scans of the four quadrants resulting in more than a 70 wide-field OCTA of the posterior pole. Quantitative analysis was performed using ...
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  Mentions: University of Bern Bern University Hospital
14. Comparison of Choroidal Thickness Measurements Using Spectral Domain Optical Coherence Tomography in Six Different Settings and With Customized Automated Segmentation Software
  
  Explore TVST Journal May 7 2019 Ophthalmology
  
  Purpose : We investigate which spectral domain-optical coherence tomography (SD-OCT) setting is superior when measuring subfoveal choroidal thickness (CT) and compared results to an automated segmentation software. Methods : Thirty patients underwent enhanced depth imaging (EDI)-OCT. B-scans were extracted in six different settings (W+N = white background/normal contrast 9; W+H = white background/maximum contrast 16; B+N = black background/normal contrast 12; B+H = black background/maximum contrast 16 ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
15. Radiofrequency ablation lesion assessment using optical coherence tomography – a proof‐of‐concept study
  
  Explore Wiley Online Library Mar 23 2019 Cardiology
  
  Background Radiofrequency catheter ablation (RFA) is an effective treatment for atrial fibrillation. However, ablation lesions are usually only assessed functionally. The immediate effect of RFA on the tissue is not directly visualized. Optical coherence tomography (OCT) is an imaging technique that uses light to capture high‐resolution images with histology‐like quality. Therefore, it might be used for high‐precision imaging of ablation lesions. Methods and Results Radiofrequency ablation lesions ...
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  Mentions: University of Bern Bern University Hospital
16. Swept‐source optical coherence tomography angiography reveals vascular changes in intermediate uveitis
  
  Explore Wiley Online Library Feb 13 2019 Ophthalmology
  
  Purpose To evaluate retinal and choroidal vascular changes in patients with intermediate uveitis with/without concomitant retinal vasculitis using wide field swept‐source optical coherence tomography angiography (OCTA). Methods In this study consecutive patients with intermediate uveitis vasculitis and healthy age‐matched controls were evaluated using central 3 3 mm OCTA scans and montage scans. Differences among the groups as well as the association between central changes assessed by 3 ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
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