1. University of Bern

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    1. Mentioned In 38 Articles

    2. Investigation of Retinal Morphology Alterations Using Spectral Domain Optical Coherence Tomography in a Mouse Model of Retinal Branch and Central Retinal Vein Occlusion

      Investigation of Retinal Morphology Alterations Using Spectral Domain Optical Coherence Tomography in a Mouse Model of Retinal Branch and Central Retinal Vein Occlusion
      ...tzerland ⨯ * Cavit Agca, Affiliation: Department of Ophthalmology, Bern University Hospital, Inselspital, and University of Bern, Bern, Switzerland ⨯ * Chantal Dysli, Affiliation: Department of Ophthalmology, Bern Univer...
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    3. Assessment of ultra-high resolution optical coherence tomography for monitoring tissue effects caused by laser photocoagulation of ex-vivo porcine retina

      Assessment of ultra-high resolution optical coherence tomography for monitoring tissue effects caused by laser photocoagulation of ex-vivo porcine retina

      Retinal laser photocoagulation is an established and successful treatment for a variety of retinal diseases. While being a valuable treatment modality, laser photocoagulation shows the drawback of employing high energy lasers which are capable of physically destroying the neural retina. For reliable therapy, it is therefore crucial to closely monitor the therapy effects caused in the retinal tissue. A depth resolved representation of optical tissue properties as provided by optical coherence tomography may provide valuable information about the treatment effects in the retinal layers if recorded simultaneously to laser coagulation. Therefore, in this work, the use of ultra-high resolution optical ...

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    4. Landmark Detection for Fusion of Fundus and MRI Toward a Patient-Specific Multimodal Eye Model

      Landmark Detection for Fusion of Fundus and MRI Toward a Patient-Specific Multimodal Eye Model

      Ophthalmologists typically acquire different image modalities to diagnose eye pathologies. They comprise, e.g., Fundus photography, optical coherence tomography, computed tomography, and magnetic resonance imaging (MRI). Yet, these images are often complementary and do express the same pathologies in a different way. Some pathologies are only visible in a particular modality. Thus, it is beneficial for the ophthalmologist to have these modalities fused into a single patient-specific model. The goal of this paper is a fusion of Fundus photography with segmented MRI volumes. This adds information to MRI that was not visible before like vessels and the macula. This paper ...

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    5. Spectral-domain Optical Coherence Tomography Findings after Severe Exogenous Endophthalmitis

      Spectral-domain Optical Coherence Tomography Findings after Severe Exogenous Endophthalmitis

      Purpose : To report outcomes and assess structural changes in the retina in patients with severe endophthalmitis . Methods : Retrospective, nonrandomized, interventional case series at a tertiary referral centre. Spectral domain optical coherence tomography (OCT) images of both eyes were acquired at least 5 months after pars plana vitrectomy. OCT images were analyzed using retinal layer segmentation. Results : Nine patients (46–80 years of age) were included in this study. Average ETDRS visual acuity before treatment was 23 letters and improved to 74 letters. In our cohort we did not find a generalized reduction of retinal layers using automated layer segmentation. Conclusion ...

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    6. Noninvasive referencing of intraocular tumors for external beam radiation therapy using optical coherence tomography: A proof of concept

      Noninvasive referencing of intraocular tumors for external beam radiation therapy using optical coherence tomography: A proof of concept
      ... of Bern, Bern 3010, Switzerland 4 Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern 3010, Switzerland 5 ARTORG Center for Biomedical Engineering Research, University of ...
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    7. Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria

      Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria

      Background: Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment of neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use of OCT to MS research. Objective: An expert task force convened with the aim to provide guidance on the use of validated quality control (QC) criteria for the use of OCT in MS research and clinical trials. Methods: A prospective multi-centre ( n = 13) study. Peripapillary ring scan QC rating of an OCT training set ( n = 50) was followed by a test set ( n = 50). Inter-rater agreement was calculated using kappa statistics. Results were ...

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    8. Flow disturbances in stent-related coronary evaginations: a computational fluid-dynamic simulation study

      Flow disturbances in stent-related coronary evaginations: a computational fluid-dynamic simulation study

      Aims: Angiographic ectasias and aneurysms in stented segments have been associated with late stent thrombosis. Using optical coherence tomography (OCT), some stented segments show coronary evaginations reminiscent of ectasias. The purpose of this study was to explore, using computational fluid-dynamic (CFD) simulations, whether OCT-detected coronary evaginations can induce local changes in blood flow. Methods and results: OCT-detected evaginations are defined as outward bulges in the luminal vessel contour between struts, with the depth of the bulge exceeding the actual strut thickness. Evaginations can be characterised cross ectionally by depth and along the stented segment by total length. Assuming an ellipsoid ...

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    9. Classification of Drusen Positions in Optical Coherence Tomography Data from Patients with Age-Related Macular Degeneration

      Classification of Drusen Positions in Optical Coherence Tomography Data from Patients with Age-Related Macular Degeneration

      Quantitative analysis of optical coherence tomography volumes is an important tool for both clinicians and researchers. Until now, most work has focused on segmentation of the intraretinal cell layers, but the segmentation of pathological datasets remains challenging. We propose the application of random forest to detect the locations of drusen in the retinal pigment epithelium. This is an important step for further analysis of optical coherence tomography data, for segmentation or otherwise. The presented combination of Bruch’s Membrane segmentation with subsequent sampling around the retinal pigment epithelium is a way to quickly compute discriminative features for classification. The proposed ...

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    10. Pathology Hinting as the Combination of Automatic Segmentation with a Statistical Shape Model

      Pathology Hinting as the Combination of Automatic Segmentation with a Statistical Shape Model

      With improvements in acquisition speed and quality, the amount of medical image data to be screened by clinicians is starting to become challenging in the daily clinical practice. To quickly visualize and find abnormalities in medical images, we propose a new method combining segmentation algorithms with statistical shape models. A statistical shape model built from a healthy population will have a close fit in healthy regions. The model will however not fit to morphological abnormalities often present in the areas of pathologies. Using the residual fitting error of the statistical shape model, pathologies can be visualized very quickly. This idea ...

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    11. 1-15 of 38 1 2 3 »
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  2. About University of Bern

    University of Bern

    University of Bern offers top quality across the board: it enjoys special recognition in leading-edge disciplines, is reputed for the excellent quality of its teaching, offers a delightful setting, and a campus environment intimately linked to the social, economic and political life of the city.