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2. Optical coherence tomography- vs. intravascular ultrasound-guided percutaneous coronary intervention (Editorial)
  
  Explore Home Jul 26 2017 Cardiology
  
  Coronary angiography is routinely used to guide percutaneous coronary interventions (PCI) despite obvious limitations of this lumen based approach. Intravascular imaging including intravascular ultrasound (IVUS) and optical coherence tomography (OCT) represent two techniques that provide essential information on pre-procedural lesion characteristics (i.e., lesion severity, landing zone, and plaque composition) and the result after stent implantation (i.e., stent expansion and eccentricity, strut apposition, lesion coverage, tissue protrusion, and dissections ...
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  Mentions: University of Bern
3. Efficient OCT volume reconstruction from slitlamp microscopes
  
  Explore IEEE Xplore Feb 2 2017 Ophthalmology
  
  Since its introduction 25 years ago, Optical Coherence Tomography (OCT) has contributed tremendously to diagnostic and monitoring capabilities of pathologies in the field of ophthalmology. Despite rapid progress in hardware and software technology however, the price of OCT devices has remained high, limiting their use in private practice and in screening examinations. In this paper, we present a slitlamp-integrated OCT device, built with off-the-shelf components, which can generate high-quality volumetric ...
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  Mentions: University of Bern
4. Imaging of macrophage dynamics with optical coherence tomography in anterior ischemic optic neuropathy
  
  Explore ScienceDirect Dec 7 2016 Ophthalmology
  
  Anterior ischemic optic neuropathy (AION) is a relatively common cause of visual loss and results from hypoperfusion of the small arteries of the anterior portion of the optic nerve. AION is the leading cause of sudden optic nerve related vision loss with approximately 10 cases per 100000 in the population over 50 years. To date there is no established treatment for AION and therefore a better understanding of the events ...
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  Mentions: University of Bern Bern University Hospital Martin S. Zinkernagel
5. En face Optical Coherence Tomography Imaging for the Detection of Nascent Geographic Atrophy
  
  Explore Elsevier Health Nov 15 2016 Ophthalmology
  
  Purpose To determine if en face optical coherence tomography (OCT) imaging can identify nascent geographic atrophy (nGA) in eyes with intermediate age-related macular degeneration (iAMD). Design Retrospective observational case series. Methods Patients with iAMD from the COMPLETE study at the Bascom Palmer Eye Institute were evaluated to determine if nGA was present at baseline and at follow-up using high density Spectralis OCT B-scans and en face OCT images from the ...
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  Mentions: Giovanni Gregori Philip J. Rosenfeld University of Miami
6. Variability in the measurement of minimum fibrous cap thickness and reproducibility of fibroatheroma classification by optical coherence tomography using manual versus semi-automatic assessment
  
  Explore eurointervention.org Oct 18 2016 Cardiology
  
  Aims: The minimum fibrous cap thickness (FCT) is considered a major criterion of coronary plaque vulnerability according to autopsy studies. We aimed to assess the reproducibility in the measurement of the optical coherence tomography (OCT)-detected minimum FCT and the agreement in the classification of thin-cap fibroatheroma (TCFA), by a software-based semi-automatic method compared with the manual method. Methods and results: A total of 50 frames with fibroatheromas (FA) were ...
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  Mentions: Imperial College London Case Western Reserve University Leiden University
7. Relationship Between Presumptive Inner Nuclear Layer Thickness and Geographic Atrophy Progression in Age-Related Macular Degeneration
  
  Explore IOVS Journal Jul 14 2016 Ophthalmology
  
  Purpose : To analyze inner retinal changes in patients with geographic atrophy (GA) secondary to age-related macular degeneration and identify morphological cues for progression. Methods : A total of 100 eyes with GA were assessed in this longitudinal, observational case series. Patients with GA and absent confounding pathology were compared with age-matched controls. The retinal layers on spectral-domain optical coherence tomography, acquired in tracking mode, were segmented manually on central scans through ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
8. Automatic assessment of time-resolved OCT images for selective retina therapy
  
  Explore Home - Springer Apr 21 2016 Ophthalmology
  
  Purpose In recent years, selective retina laser treatment (SRT), a sub-threshold therapy method, avoids widespread damage to all retinal layers by targeting only a few. While these methods facilitate faster healing, their lack of visual feedback during treatment represents a considerable shortcoming as induced lesions remain invisible with conventional imaging and make clinical use challenging. To overcome this, we present a new strategy to provide location-specific and contact-free automatic feedback ...
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  Mentions: Sebastian Wolf University of Bern Patrick Steiner
9. Mechanisms of Very Late Drug-Eluting Stent Thrombosis Assessed by Optical Coherence Tomography
  
  Explore Circulation Jan 15 2016 Cardiology
  
  Background The pathomechanisms underlying very late stent thrombosis (VLST) after implantation of drug-eluting stents (DES) are incompletely understood. Using optical coherence tomography (OCT), we investigated potential causes of this adverse event. Methods and Results Between August 2010 and December 2014, 64 patients were investigated at the time-point of VLST as part of an international OCT registry. OCT pullbacks were performed after restoration of flow and analyzed at 0.4mm. A ...
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  Mentions: Case Western Reserve University University of Copenhagen Hector M. Garcia-Garcia
10. Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy
  
  Explore IOVS Journal Oct 27 2015 Ophthalmology
  
  Purpose : Selective retina therapy (SRT) is a novel treatment for retinal pathologies, solely targeting the RPE. During SRT, the detection of an immediate tissue reaction is challenging, as tissue effects remain limited to intracellular RPE photodisruption. Time-resolved ultra-high axial resolution optical coherence tomography (OCT) is thus evaluated for the monitoring of dynamic optical changes at and around the RPE during SRT. Methods : An experimental OCT system with an ultra-high axial ...
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  Mentions: Sebastian Wolf University of Bern Boris Považay
11. Quantitative Analysis of Mouse Retinal Layers Using Automated Segmentation of Spectral Domain Optical Coherence Tomography Images
  
  Explore TVST Journal Aug 29 2015 Ophthalmology
  
  Purpose : Quantification of retinal layers using automated segmentation of optical coherence tomography (OCT) images allows for longitudinal studies of retinal and neurological disorders in mice. The purpose of this study was to compare the performance of automated retinal layer segmentation algorithms with data from manual segmentation in mice using the Spectralis OCT. Methods : Spectral domain OCT images from 55 mice from three different mouse strains were analyzed in total. The ...
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  Mentions: University of Bern Bern University Hospital Martin S. Zinkernagel
12. Imaging of the Sclera in Patients with Scleritis and Episcleritis using Anterior Segment Optical Coherence Tomography
  
  Explore Informa Healthcare Aug 10 2015 Ophthalmology
  
  Purpose : To evaluate the sclera and episclera in patients with scleritis and episcleritis using anterior segment optical coherence tomography (AS-OCT). Methods : Cross-sectional prospective case series of 11 consecutive patients with episcleral or scleral inflammatory disease located anterior to the equator. The thickness of the ocular wall (sclera and the episclera) was measured using AS-OCT and compared to the contralateral healthy eye. Results : Eleven patients with a mean age of 49 ...
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  Mentions: University of Bern Bern University Hospital Martin S. Zinkernagel
13. Real-time optical coherence tomography observation of retinal tissue damage during laser photocoagulation therapy on ex-vivo porcine samples
  
  Explore Conference Proceedings Jul 14 2015 Ophthalmology
  
  Retinal laser photocoagulation represents a widely used treatment for retinal pathologies such as diabetic chorioretinopathy or diabetic edema. For effective treatment, an appropriate choice of the treatment energy dose is crucial to prevent excessive tissue damage caused by over-irradiation of the retina. In this manuscript we investigate simultaneous and time-resolved optical coherence tomography for its applicability to provide feedback to the ophthalmologist about the introduced retinal damage during laser photocoagulation ...
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  Mentions: University of Bern Boris Považay Christoph Meier
14. Metrics of the normal anterior sclera: imaging with optical coherence tomography
  
  Explore Home - Springer Jun 13 2015 Ophthalmology
  
  Background To investigate anterior scleral thickness in a cohort of healthy subjects using enhanced depth imaging anterior segment optical coherence tomography. Methods Observational case series. The mean scleral thickness in the inferonasal, inferotemporal, superotemporal, and superonasal quadrant was measured 2 mm from the scleral spur on optical coherence tomography in healthy volunteers. Results Fifty-three eyes of 53 Caucasian patients (25 male and 28 female) with an average age of 48 ...
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  Mentions: University of Bern Bern University Hospital Martin S. Zinkernagel
15. Enhanced-depth optical coherence tomography for imaging horizontal rectus muscles in Graves’ orbitopathy
  
  Explore Home - Springer Jun 12 2015 Ophthalmology
  
  Graves orbitopathy (GO) is an extraocular eye disease with symptoms ranging from minor discomfort from dry eyes to strabismus and visual loss. One of the hallmarks of active GO is visible hyperemia at the insertion of the extraocular muscles. The aim of the present study was to evaluate the use of enhanced-depth imaging spectral domain anterior segment optical coherence tomography (EDI SD AS-OCT) for detecting pathological changes in horizontal recti ...
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  Mentions: University of Bern Bern University Hospital Martin S. Zinkernagel
16. Enhanced-depth optical coherence tomography for imaging horizontal rectus muscles in Graves' orbitopathy
  
  Explore Home - Springer Jun 8 2015 Ophthalmology
  
  Purpose Graves orbitopathy (GO) is an extraocular eye disease with symptoms ranging from minor discomfort from dry eyes to strabismus and visual loss. One of the hallmarks of active GO is visible hyperemia at the insertion of the extraocular muscles. The aim of the present study was to evaluate the use of enhanced-depth imaging spectral domain anterior segment optical coherence tomography (EDI SD AS-OCT) for detecting pathological changes in horizontal ...
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  Mentions: University of Bern Bern University Hospital Martin S. Zinkernagel
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