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2. Use of En Face Swept-Source Optical Coherence Tomography Angiography in Identifying Choroidal Flow Voids in 3 Patients With Birdshot Chorioretinopathy
  
  Explore The JAMA Network Aug 21 2018 Ophthalmology
  
  Importance Patients with birdshot chorioretinopathy (BSCR) can experience a delay in diagnosis owing to the challenges of identifying the condition prior to evolution of characteristic choroidal scars. An objective, noninvasive method for detecting early lesions in BSCR might have an effect on preventing vision loss in these patients. Objective To test the feasibility of swept-source optical coherence tomography angiography (SS-OCTA) in the detection of BSCR choroidal lesions and to use ...
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  Mentions: University of Washington Ruikang K. Wang University of Bern
3. Selective retina therapy enhanced with optical coherence tomography for dosimetry control and monitoring: a proof of concept study
  
  Explore OSA | OSA Publishing Jul 1 2018 Ophthalmology
  
  Selective treatment of the retinal pigment epithelium (RPE) by using short-pulse lasers leads to a less destructive treatment for certain retinal diseases in contrast to conventional photocoagulation. The introduction of selective retina therapy (SRT) to clinical routine is still precluded by the challenges to reliably monitor treatment success and to automatically adjust dose within the locally varying therapeutic window. Combining micrometer-scale depth resolving capabilities of optical coherence tomography (OCT) with ...
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  Mentions: University of Bern Boris Považay Christoph Meier
4. Spectral-Domain Optical Coherence Tomography Associations of Neovascular Conversion in Age-Related Macular Degeneration
  
  Explore SAGE Journals Feb 6 2018 Ophthalmology
  
  Purpose: To identify spectral-domain optical coherence tomography (SD-OCT) features associated with exudative conversion in fellow eyes of patients treated for neovascular age-related macular degeneration (nAMD) in their first eye. Methods: Retrospective observational study. Spectral-domain optical coherence tomography images of converting fellow eyes (study eyes) from 83 patients with nAMD were compared to fellow eyes of age- and sex-matched patients with nAMD who did not convert (control eyes). Parameters related to ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
5. Müller Glia Cell Activation in a Laser-induced Retinal Degeneration and Regeneration Model in Zebrafish
  
  Explore jove.com Nov 28 2017 Developmental Biology , Ophthalmology
  
  A fascinating difference between teleost and mammals is the lifelong potential of the teleost retina for retinal neurogenesis and regeneration after severe damage. Investigating the regeneration pathways in zebrafish might bring new insights to develop innovative strategies for the treatment of retinal degenerative diseases in mammals. Herein, we focused on the induction of a focal lesion to the outer retina in adult zebrafish by means of a 532 nm diode ...
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  Mentions: University of Bern Volker Enzmann Bern University Hospital
6. In Vivo Imaging of Cx3cr1 Reporter Mice with Spectral-domain Optical Coherence Tomography ...
  
  Explore jove.com Nov 11 2017 Ophthalmology
  
  ...Zinkernagel 1 1 Department of Ophthalmology and Department of Clinical Research, Bern University Hospital and University of Bern Correspondence to: Despina Kokona at Despina.Kokona@insel.ch URL: https://www.jove.com/vide...
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  Mentions: Heidelberg Engineering University of Bern Bern University Hospital
7. Optical coherence tomography- vs. intravascular ultrasound-guided percutaneous coronary intervention (Editorial)
  
  Explore Home Jul 26 2017 Cardiology
  
  Coronary angiography is routinely used to guide percutaneous coronary interventions (PCI) despite obvious limitations of this lumen based approach. Intravascular imaging including intravascular ultrasound (IVUS) and optical coherence tomography (OCT) represent two techniques that provide essential information on pre-procedural lesion characteristics (i.e., lesion severity, landing zone, and plaque composition) and the result after stent implantation (i.e., stent expansion and eccentricity, strut apposition, lesion coverage, tissue protrusion, and dissections ...
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  Mentions: University of Bern
8. Efficient OCT volume reconstruction from slitlamp microscopes
  
  Explore IEEE Xplore Feb 2 2017 Ophthalmology
  
  Since its introduction 25 years ago, Optical Coherence Tomography (OCT) has contributed tremendously to diagnostic and monitoring capabilities of pathologies in the field of ophthalmology. Despite rapid progress in hardware and software technology however, the price of OCT devices has remained high, limiting their use in private practice and in screening examinations. In this paper, we present a slitlamp-integrated OCT device, built with off-the-shelf components, which can generate high-quality volumetric ...
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  Mentions: University of Bern
9. Imaging of macrophage dynamics with optical coherence tomography in anterior ischemic optic neuropathy
  
  Explore ScienceDirect Dec 7 2016 Ophthalmology
  
  Anterior ischemic optic neuropathy (AION) is a relatively common cause of visual loss and results from hypoperfusion of the small arteries of the anterior portion of the optic nerve. AION is the leading cause of sudden optic nerve related vision loss with approximately 10 cases per 100000 in the population over 50 years. To date there is no established treatment for AION and therefore a better understanding of the events ...
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  Mentions: University of Bern Bern University Hospital Martin S. Zinkernagel
10. En face Optical Coherence Tomography Imaging for the Detection of Nascent Geographic Atrophy
  
  Explore Elsevier Health Nov 15 2016 Ophthalmology
  
  Purpose To determine if en face optical coherence tomography (OCT) imaging can identify nascent geographic atrophy (nGA) in eyes with intermediate age-related macular degeneration (iAMD). Design Retrospective observational case series. Methods Patients with iAMD from the COMPLETE study at the Bascom Palmer Eye Institute were evaluated to determine if nGA was present at baseline and at follow-up using high density Spectralis OCT B-scans and en face OCT images from the ...
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  Mentions: Giovanni Gregori Philip J. Rosenfeld University of Miami
11. Variability in the measurement of minimum fibrous cap thickness and reproducibility of fibroatheroma classification by optical coherence tomography using manual versus semi-automatic assessment
  
  Explore eurointervention.org Oct 18 2016 Cardiology
  
  Aims: The minimum fibrous cap thickness (FCT) is considered a major criterion of coronary plaque vulnerability according to autopsy studies. We aimed to assess the reproducibility in the measurement of the optical coherence tomography (OCT)-detected minimum FCT and the agreement in the classification of thin-cap fibroatheroma (TCFA), by a software-based semi-automatic method compared with the manual method. Methods and results: A total of 50 frames with fibroatheromas (FA) were ...
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  Mentions: Imperial College London Case Western Reserve University Leiden University
12. Relationship Between Presumptive Inner Nuclear Layer Thickness and Geographic Atrophy Progression in Age-Related Macular Degeneration
  
  Explore IOVS Journal Jul 14 2016 Ophthalmology
  
  Purpose : To analyze inner retinal changes in patients with geographic atrophy (GA) secondary to age-related macular degeneration and identify morphological cues for progression. Methods : A total of 100 eyes with GA were assessed in this longitudinal, observational case series. Patients with GA and absent confounding pathology were compared with age-matched controls. The retinal layers on spectral-domain optical coherence tomography, acquired in tracking mode, were segmented manually on central scans through ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
13. Automatic assessment of time-resolved OCT images for selective retina therapy
  
  Explore Home - Springer Apr 21 2016 Ophthalmology
  
  Purpose In recent years, selective retina laser treatment (SRT), a sub-threshold therapy method, avoids widespread damage to all retinal layers by targeting only a few. While these methods facilitate faster healing, their lack of visual feedback during treatment represents a considerable shortcoming as induced lesions remain invisible with conventional imaging and make clinical use challenging. To overcome this, we present a new strategy to provide location-specific and contact-free automatic feedback ...
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  Mentions: Sebastian Wolf University of Bern Patrick Steiner
14. Mechanisms of Very Late Drug-Eluting Stent Thrombosis Assessed by Optical Coherence Tomography
  
  Explore Circulation Jan 15 2016 Cardiology
  
  Background The pathomechanisms underlying very late stent thrombosis (VLST) after implantation of drug-eluting stents (DES) are incompletely understood. Using optical coherence tomography (OCT), we investigated potential causes of this adverse event. Methods and Results Between August 2010 and December 2014, 64 patients were investigated at the time-point of VLST as part of an international OCT registry. OCT pullbacks were performed after restoration of flow and analyzed at 0.4mm. A ...
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  Mentions: Case Western Reserve University University of Copenhagen Hector M. Garcia-Garcia
15. Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy
  
  Explore IOVS Journal Oct 27 2015 Ophthalmology
  
  Purpose : Selective retina therapy (SRT) is a novel treatment for retinal pathologies, solely targeting the RPE. During SRT, the detection of an immediate tissue reaction is challenging, as tissue effects remain limited to intracellular RPE photodisruption. Time-resolved ultra-high axial resolution optical coherence tomography (OCT) is thus evaluated for the monitoring of dynamic optical changes at and around the RPE during SRT. Methods : An experimental OCT system with an ultra-high axial ...
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  Mentions: Sebastian Wolf University of Bern Boris Považay
16. Quantitative Analysis of Mouse Retinal Layers Using Automated Segmentation of Spectral Domain Optical Coherence Tomography Images
  
  Explore TVST Journal Aug 29 2015 Ophthalmology
  
  Purpose : Quantification of retinal layers using automated segmentation of optical coherence tomography (OCT) images allows for longitudinal studies of retinal and neurological disorders in mice. The purpose of this study was to compare the performance of automated retinal layer segmentation algorithms with data from manual segmentation in mice using the Spectralis OCT. Methods : Spectral domain OCT images from 55 mice from three different mouse strains were analyzed in total. The ...
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  Mentions: University of Bern Volker Enzmann Bern University Hospital
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