1. University of Auckland

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    1. Mentioned In 39 Articles

    2. Optical coherence tomography complements confocal microscopy for investigation of multicellular tumour spheroids

      Optical coherence tomography complements confocal microscopy for investigation of multicellular tumour spheroids
      Knowledge of optical properties, such as the refractive index (RI), of biological tissues is important in optical imaging, as they influence the distribution and propagation of light in tissue. To accurately study the response of cancerous cells to drugs, optimised imaging protocols are required. This study uses a simple custom-built spectral domain optical coherence tomography (OCT) system to conduct RI measurements of multicellular spheroids, three-dimensional (3D) in-vitro culture systems, of ...
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    3. Refractive index measurements of multicellular tumour spheroids using optical coherence tomography: dependence on growth phase and size

      Refractive index measurements of multicellular tumour spheroids using optical coherence tomography: dependence on growth phase and size
      Knowledge of optical properties, such as the refractive index (RI), of biological tissues is important in optical imaging, as they influence the distribution and propagation of light in tissue. To accurately study the response of cancerous cells to drugs, optimised imaging protocols are required. This study uses a simple custom-built spectral domain optical coherence tomography (OCT) system to conduct RI measurements of multicellular spheroids, three-dimensional in-vitro culture systems, of the ...
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    4. Effect of phacoemulsification incision size on incision repair and remodeling: Optical coherence tomography assessment

      Effect of phacoemulsification incision size on incision repair and remodeling: Optical coherence tomography assessment
      Purpose To characterize the effect of incision size on corneal incision repair and remodeling over 3 months after cataract surgery. Setting Department of Ophthalmology, Auckland District Health Board, Auckland, New Zealand. Design Prospective case series. Methods Eyes having routine cataract surgery were randomized to receive 2.20 mm or 2.85 mm uniplanar clear corneal incisions. Anterior segment optical coherence tomography of incision thickness, length, width, gaping, and angle and ...
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    5. Quantifying birefringence in the bovine model of early osteoarthritis using polarisation-sensitive optical coherence tomography and mechanical indentation

      Quantifying birefringence in the bovine model of early osteoarthritis using polarisation-sensitive optical coherence tomography and mechanical indentation
      Recent studies have shown potential for using polarisation sensitive optical coherence tomography (PS-OCT) to study cartilage morphology, and to be potentially used as an in vivo , non-invasive tool for detecting osteoarthritic changes. However, there has been relatively limited ability of this method to quantify the subtle changes that occur in the early stages of cartilage degeneration. An established mechanical indenting technique that has previously been used to examine the microstructural ...
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    6. Extracting morphometric information from rat sciatic nerve using optical coherence tomography

      Extracting morphometric information from rat sciatic nerve using optical coherence tomography
      We apply three optical coherence tomography (OCT) image analysis techniques to extract morphometric information from OCT images obtained on peripheral nerves of rat. The accuracy of each technique is evaluated against histological measurements accurate to +/-1 m. The three OCT techniques are: 1) average depth resolved profile (ADRP); 2) autoregressive spectral estimation (AR-SE); and, 3) correlation of the derivative spectral estimation (CoD-SE). We introduce a scanning window to the ADRP ...
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    7. Using polarisation-sensitive optical coherence tomography and mechanical indentation to assess cartilage degeneration in the bovine model of early osteoarthritis

      Using polarisation-sensitive optical coherence tomography and mechanical indentation to assess cartilage degeneration in the bovine model of early osteoarthritis
      Recent studies have shown potential for using polarisation sensitive optical coherence tomography (PS-OCT) to study cartilage morphology, and this presents a useful real-time non-invasive tool for detecting osteoarthritic changes. However, there has been relatively limited ability of this method to quantify the subtle changes in the early stages of joint degeneration. In this study, we investigate the ability of PS-OCT to detect microscale degenerative changes in cartilage, following compression, using ...
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    8. Dispersion mapping as a simple postprocessing step for Fourier domain Optical Coherence Tomography data

      Dispersion mapping as a simple postprocessing step for Fourier domain Optical Coherence Tomography data
      Optical Coherence Tomography (OCT) was originally conceived as a volumetric imaging method. Quickly, OCT images went beyond structural data and started to provide functional information about an object enabling for example visualization of blood flow or tissue elasticity. Minimal or no need for system alterations make functional OCT techniques useful in performing multimodal imaging, where differently contrasted images are produced in a single examination. We propose a method that further ...
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    9. Dispersion measurements in ocular media using a dual-wavelength swept source optical coherence tomography system

      Dispersion measurements in ocular media using a dual-wavelength swept source optical coherence tomography system
      Optical coherence tomography (OCT) has proved to be a powerful tool for the detection of microstructure in tissue. Label-free tissue differentiation on a micron scale is a promising and powerful technique for segmentation. This Letter describes a technique using a dual-wavelength OCT system to image the eye. We measure the walk-off between interfaces in A-scans, taken at two different wavelengths, to calculate the average group velocity dispersion parameter of each ...
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    10. Assessment of Optic Pathway Structure and Function in Patients With Compression of the Optic Chiasm: A Correlation With Optical Coherence Tomography

      Assessment of Optic Pathway Structure and Function in Patients With Compression of the Optic Chiasm: A Correlation With Optical Coherence Tomography
      Purpose : The purpose of this study was to investigate correlations between retinal fiber thickness measured by optical coherence tomography (OCT) and anterograde functional and structural differences in the optic pathway of patients with compression of the optic chiasm. Our hypothesis was that loss of visual acuity caused by chronic compressive pathologies may lead to an irreversible decline in vision because of permanent neurodegeneration of the optic radiations and visual cortex ...
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    11. 4D imaging of cardiac trabeculae contracting in vitro using gated OCT

      4D imaging of cardiac trabeculae contracting in vitro using gated OCT
      Cardiac trabeculae are widely used as experimental muscle preparations for studying heart muscle. However, their geometry (diameter, length, and shape) can vary not only amongst samples, but also within a sample, leading to inaccuracies in estimating their stress production, volumetric energy output, and/or oxygen consumption. Hence, it is desirable to have a system that can accurately image each trabecula in vitro during an experiment. To this end, we constructed ...
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    12. Optical coherence tomography findings in a patient with type 1 sialidosis

      Optical coherence tomography findings in a patient with type 1 sialidosis
      Type 1 sialidosis is a metabolic storage disorder characterised by the accumulation of sialylated oligosaccharides. The condition is also known as macular cherry-red spot and myoclonus syndrome due to the characteristic macular appearance in affected individuals. This case outlines the presentation of a patient with type 1 sialidosis, including ophthalmological assessment with retinal photography and spectral domain optical coherence tomography (OCT). OCT scans showed thickening of the perimacular and peripapillary ...
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    13. Comparison of retinal nerve fiber layer and macular thickness for discriminating primary open-angle glaucoma and normal-tension glaucoma using optical coherence tomography

      Comparison of retinal nerve fiber layer and macular thickness for discriminating primary open-angle glaucoma and normal-tension glaucoma using optical coherence tomography
      Purpose The aim of this study was to evaluate the discrimination capabilities of macular and peripapillary retinal nerve fiber layer (pRNFL) thickness parameters as measured using spectral domain optical coherence tomography (SD-OCT) between primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG). Methods A total of 90 subjects were enrolled: 30 healthy subjects, 30 subjects with POAG and 30 subjects with NTG, consecutively. Retinal nerve fiber layer thickness, macular thickness and ...
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    14. Simple and versatile long range swept source for optical coherence tomography applications

      Simple and versatile long range swept source for optical coherence tomography applications
      We present a versatile long coherence length swept-source laser design for optical coherence tomography applications. This design consists of a polygonal spinning mirror and an optical gain chip in a modified LittmanMetcalf cavity. A narrowband intra-cavity filter is implemented through multiple passes off a diffraction grating set at grazing incidence. The key advantage of this design is that it can be readily adapted to any wavelength regions for which broadband ...
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    15. Optical coherence tomography findings in Huntington’s disease: a potential biomarker of disease progression

      Optical coherence tomography findings in Huntington’s disease: a potential biomarker of disease progression
      Previous reports of ocular abnormalities in Huntingtons disease (HD) have detailed eye movement disorders. The objective of this casecontrol study was to investigate optic nerve and macular morphology in HD using optical coherence tomography (OCT). A total of 26 HD patients and 29 controls underwent a thorough ophthalmic examination including spectral domain OCT scans of the macula and peripapillary retinal nerve fibre layer (RNFL). Genetic testing results, disease duration, HD ...
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  2. About University of Auckland

    University of Auckland

    University of Auckland is New Zealand's largest university and the top-ranked New Zealand university. Established in 1883 as a constituent college of the University of New Zealand, the university is now made up of eight faculties over six campuses, and has more than 39,000 students at April 2006.   Also see the Department of Physics at the University of Auckland.