1. University of Arizona

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    1. Mentioned In 114 Articles

    2. Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue

      Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue
      Ovarian cancer has the lowest survival rate among all gynecologic cancers due to predominantly late diagnosis. Early detection of ovarian cancer can increase 5-year survival rates from 40% up to 92%, yet no reliable early detection techniques exist. Optical coherence tomography (OCT) is an emerging technique that provides depthresolved, high-resolution images of biological tissue in real time and demonstrates great potential for imaging of ovarian tissue. Mouse models are crucial ...
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    3. Structural and functional optical coherence tomography imaging of the colon (Thesis)

      Structural and functional optical coherence tomography imaging of the colon  (Thesis)
      Colorectal cancer (CRC) remains the second deadliest cancer in the United States, despite steady reduction in mortality rate over the last three decades. Colonoscopy is the gold-standard screening modality with high sensitivity and specificity to mature polyps. However, the miss rate for small ( 5 mm) lesions is estimated to be as high as 26%. Because the five-year survival rate for CRC detected at the local stage is 90%, there is ...
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    4. University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes

      University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes
      ...alpingo-oophorectomy. The salpingoscope may also find broad utility for imaging of other pelvic disorders.

      University of Arizona Receives a 2017 NIH Grant for $334,425 for Advanced Salpingoscope for Minimally-Invasive...

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    5. A group of 28 students affiliated with the University of Arizona has received the prestigious National Science Foundation Graduate Research Fellowship.

      A group of 28 students affiliated with the University of Arizona has received the prestigious National Science Foundation Graduate Research Fellowship.
      David Vega , a doctoral student finishing his first year in the optical sciences program. Vega's research is based on early detection of ovarian cancer using optical coherence tomography and multiphoton microscopy. The breakthrough technologies he is developing are transferable to numerous applications and offer broad impacts in several other fields, ranging from other medical diagnostics to astronomy
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    6. Measurement of the lipid and aqueous layers of a tear film

      Measurement of the lipid and aqueous layers of a tear film
      Systems and methods for determining thickness of lipid and aqueous layers of a tear film in which a spectrum array is generated from optical coherence tomography and input into a statistical estimator, which determines the thickness of the lipid and/or aqueous layers at a nanometer resolution based on the inputted spectrum and other information, such as information about a laser intensity noise, Poisson noise, and dark noise associated with ...
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    7. Single lens system for forward-viewing navigation and scanning side-viewing optical coherence tomography

      Single lens system for forward-viewing navigation and scanning side-viewing optical coherence tomography
      The optical design for a dual modality endoscope based on piezo scanning fiber technology is presented including a novel technique to combine forward-viewing navigation and side viewing OCT. Potential applications include navigating body lumens such as the fallopian tube, biliary ducts and cardiovascular system. A custom cover plate provides a rotationally symmetric double reflection of the OCT beam to deviate and focus the OCT beam out the side of the ...
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    8. In vivo endoscopic Doppler optical coherence tomography imaging of the colon

      In vivo endoscopic Doppler optical coherence tomography imaging of the colon
      Background and Objective Colorectal cancer (CRC) remains the second deadliest cancer in the United States. Several screening methods exist; however, detection of small polyps remains a challenge. Optical coherence tomography (OCT) has been demonstrated to be capable of detecting lesions as small as 1mm in the mouse colon, but detection is based on measuring a doubling of the mucosa thickness. The colon microvasculature may be an attractive biomarker of early ...
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    9. Optical coherence tomography imaging of colonic crypts in a mouse model of colorectal cancer

      Optical coherence tomography imaging of colonic crypts in a mouse model of colorectal cancer
      Aberrant crypt foci (ACF) are abnormal epithelial lesions that precede development of colonic polyps. As the earliest morphological change in the development of colorectal cancer, ACF is a highly studied phenomenon. The most common method of imaging ACF is chromoendoscopy using methylene blue as a contrast agent. Narrow- band imaging is a contrast-agent-free modality for imaging the colonic crypts. Optical coherence tomography (OCT) is an attractive alternative to chromoendoscopy and ...
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    10. In vivo endoscopic Doppler optical coherence tomography imaging of mouse colon

      In vivo endoscopic Doppler optical coherence tomography imaging of mouse colon
      Colorectal cancer remains the second deadliest cancer in the United States, despite the high sensitivity and specificity of colonoscopy and sigmoidoscopy. While these standard imaging procedures can accurately detect medium and large polyps, some studies have shown miss rates up to 25% for polyps less than 5 mm in diameter. An imaging modality capable of detecting small lesions could potentially improve patient outcomes. Optical coherence tomography (OCT) has been shown ...
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    11. Imaging colon cancer development in mice: IL-6 deficiency prevents adenoma in azoxymethane-treated Smad3 knockouts

      Imaging colon cancer development in mice: IL-6 deficiency prevents adenoma in azoxymethane-treated Smad3 knockouts
      The development of colorectal cancer in the azoxymethane-induced mouse model can be observed by using a miniaturized optical coherence tomography (OCT) imaging system. This system is uniquely capable of tracking disease development over time, allowing for the monitoring of morphological changes in the distal colon due to tumor development and the presence of lymphoid aggregates. By using genetically engineered mouse models deficient in Interleukin 6 (IL-6) and Smad family member ...
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    12. Temporal Trends in Strut-Level Optical Coherence Tomography Evaluation of Coronary Stent Coverage

      Temporal Trends in Strut-Level Optical Coherence Tomography Evaluation of Coronary Stent Coverage
      Objectives We sought to pool data from all studies with reported strut-level data in human subjects evaluated by optical coherence tomography (OCT) surveillance and to compare the aggregate data of stent strut coverage on a longitudinal temporal timeline from initial implantation for different coronary stent subtypes. Background Delayed strut coverage following drug-eluting stent (DES) implantation is an important contributor to late stent thrombosis (LST). OCT can detect stent strut coverage ...
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  2. About University of Arizona

    University of Arizona

    University of Arizona is a public institution of higher education and research located in Tucson, Arizona, United States. The University of Arizona was the first university in the state of Arizona, founded in 1885. The Tissue Optics Laboratory is an interdisciplinary effort located at the University of Arizona in the Keating Biosciences Building of the BIO5 Institute.  The Arizona Cancer Center is part of the University of Arizona.