1. University of Alberta

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    1. Mentioned In 17 Articles

    2. OCT: A Modality for Identifying Stent Failure in Pediatric Patients With Angiographically Silent Coronary Arteries

      OCT: A Modality for Identifying Stent Failure in Pediatric Patients With Angiographically Silent Coronary Arteries
      We present the case of a 16-year-old patient with anomalous left coronary artery from the left pulmonary artery requiring percutaneous coronary intervention in infancy who presented with ventricular fibrillation arrest. A coronary angiogram revealed 40% narrowing of the stent relative to the remainder of the left main coronary artery. Optical coherence tomography was performed and revealed an area stenosis of 70% relative to the native left main coronary artery. The ...
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    3. Three-dimensional virtual histology in unprocessed resected tissues with photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT)

      Three-dimensional virtual histology in unprocessed resected tissues with photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT)
      Histological images are critical in the diagnosis and treatment of cancers. Unfortunately, current methods for capturing these microscopy images require resource intensive tissue preparation that may delay diagnosis for days or weeks. To streamline this process, clinicians are limited to assessing small macroscopically representative subsets of tissues. Here, a combined photoacoustic remote sensing (PARS) microscope and swept source optical coherence tomography system designed to circumvent these diagnostic limitations is presented ...
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    4. Fiber-based photoacoustic remote sensing microscopy and spectral-domain optical coherence tomography with a dual-function 1050-nm interrogation source

      Fiber-based photoacoustic remote sensing microscopy and spectral-domain optical coherence tomography with a dual-function 1050-nm interrogation source
      Significance: Spectral-domain optical coherence tomography (SD-OCT) offers depth-resolved imaging of optical scattering contrast but is limited in sensitivity to optical absorption. Dual-modality imaging combined with the noncontact absorption contrast of photoacoustic remote sensing (PARS) microscopy can augment SD-OCT applications with specific molecular and functional contrasts in an all-optical, fiber-based platform. Aim: To develop a fiber-based multimodal PARS and SD-OCT imaging system, which efficiently uses a common 1050-nm light source for ...
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    5. Multimodal imaging with spectral-domain optical coherence tomography and photoacoustic remote sensing microscopy

      Multimodal imaging with spectral-domain optical coherence tomography and photoacoustic remote sensing microscopy
      We develop a multimodal imaging platform, combining depth-resolved scattering contrast from spectral-domain optical coherence tomography (SD-OCT) with complementary, non-contact absorption contrast using photoacoustic remote sensing (PARS) microscopy. The system provides a widefield OCT mode using a telecentric scan lens, and a high-resolution, dual-contrast mode using a 0.26 numerical aperture apochromatic objective. An interlaced acquisition approach is used to achieve simultaneous, co-registered imaging. The SD-OCT modality provides a 9.7 ...
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    6. Deep learning in ophthalmology: a review

      Deep learning in ophthalmology: a review
      Deep learning is an emerging technology with numerous potential applications in Ophthalmology. Deep learning tools have been applied to different diagnostic modalities including digital photographs, optical coherence tomography, and visual fields. These tools have demonstrated utility in assessment of various disease processes including cataracts, glaucoma, age-related macular degeneration, and diabetic retinopathy. Deep learning techniques are evolving rapidly, and will become more integrated into ophthalmic care. This article reviews the current ...
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    7. Temporal evolution of low-coherence reflectrometry signals in photoacoustic remote sensing microscopy

      Temporal evolution of low-coherence reflectrometry signals in photoacoustic remote sensing microscopy
      Recently, a new noncontact reflection-mode imaging modality called photoacoustic remote sensing (PARS) microscopy was introduced providing optical absorption contrast. Unlike previous modalities, which rely on interferometric detection of a probe beam to measure surface oscillations, the PARS technique detects photoacoustic initial pressures induced by a pulsed laser at their origin by monitoring intensity modulations of a reflected probe beam. In this paper, a model describing the temporal evolution from a ...
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    8. Caught between a doc and a hard place

      Caught between a doc and a hard place
      The Optical Coherence Tomography is vital to assessing the need for an eye inoculation to prevent the disease’s escalation, and further loss of sight: Cutting the cost and frequency of these tests will not only further elevate patient stress, but increase future health care costs by having to provide costly magnifiers and specialized eyewear, with government providing 75 per cent of the cost. I am loathe to criticize without ...
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    9. Optical Coherence Tomography in the Diagnosis and Management of Optic Neuritis and Multiple Sclerosis

      Optical Coherence Tomography in the Diagnosis and Management of Optic Neuritis and Multiple Sclerosis
      Optic neuritis (ON) is an inflammatory optic nerve injury, which is strongly associated with multiple sclerosis (MS). Optical coherence tomography (OCT) has the potential to provide a reliable means of capturing axonal deficits, which can be paired to tests of visual function to provide a structuralfunctional paradigm of brain injury. In this respect, the eye provides a unique view into the effects of central nervous system inflammation, which may enhance ...
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    10. Progressive Loss of Cones in Achromatopsia: An Imaging Study using Spectral-Domain Optical Coherence Tomography

      Progressive Loss of Cones in Achromatopsia: An Imaging Study using Spectral-Domain Optical Coherence Tomography
      Purpose: Achromatopsia (ACHM) is a congenital autosomal recessive cone disorder with a presumed stationary nature and only a few causative genes. Animal studies suggest that ACHM may be a good candidate for corrective gene therapy. Future implementation of this therapy in humans requires the presence of viable cone cells in the retina. We investigated the presence of cone cells in ACHM as a function of age. Methods: We evaluated the ...
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    11. Retinal nerve fiber layer and future risk of multiple sclerosis.

      BACKGROUND: Optical coherence tomography (OCT)--measured retinal nerve fiber layer (RNFL) values may represent a surrogate biomarker for axonal integrity in multiple sclerosis (MS). The purpose of this study was to determine whether RNFL measurements obtained within two years of an optic neuritis (ON) event distinguish patients at increased risk of developing clinically-definite MS (CDMS). METHODS: Fifty consecutively sampled patients who experienced a single ON event were followed prospectively for ...
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    12. Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomography

      Introduction Optic neuritis causes retinal nerve fiber layer damage, which can be quantified with optical coherence tomography. Optical coherence tomography may be used to track nerve fiber layer changes and to establish a time-dependent relationship between retinal nerve fiber layer thickness and visual function after optic neuritis. Methods This prospective case series included 78 patients with optic neuritis, who underwent optical coherence tomography and visual testing over a mean period ...
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  2. About University of Alberta

    University of Alberta

    University of Alberta  is a public research university located in Edmonton , Alberta , Canada . Founded in 1908 by Alexander Cameron Rutherford , the first premier of Alberta and Henry Marshall Tory , its first president, it is widely recognized as one of the best universities in Canada. The main campus covers 50 city blocks with over 90 buildings directly across the North Saskatchewan River from downtown Edmonton . The enabling legislation is the Post-secondary Learning Act.