1. University of Alabama

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    1. Mentioned In 97 Articles

    2. Modeling the foveal cone mosaic imaged with adaptive optics scanning laser ophthalmoscopy

      Modeling the foveal cone mosaic imaged with adaptive optics scanning laser ophthalmoscopy
      To better understand the limitations of high-resolution adaptive optics scanning laser ophthalmoscopy (AOSLO), we describe an imaging model that examines the smallest cone photoreceptors in the fovea of normal human subjects and analyze how different factors contribute to their resolution. The model includes basic optical factors such as wavelength and pupil size, and defines limits caused by source coherence which are specific to the AOSLO imaging modality as well as ...
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    3. Heterogeneous patterns of tissue injury in NARP syndrome

      Heterogeneous patterns of tissue injury in NARP syndrome
      Point mutations at m.8993TC and m.8993TG of the mtDNA ATPase 6 gene cause the neurogenic weakness, ataxia and retinitis pigmentosa (NARP) syndrome, a mitochondrial disorder characterized by retinal, central and peripheral neurodegeneration. We performed detailed neurological, neuropsychological and ophthalmological phenotyping of a mother and four daughters with NARP syndrome from the mtDNA m.8993TC ATPase 6 mutation, including 3-T brain MRI, spectral domain optical coherence tomography (SD-OCT), adaptive ...
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    4. Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis

      Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis
      Objective Cross-sectional studies of optical coherence tomography (OCT) show that retinal nerve fiber layer (RNFL) thickness is reduced in multiple sclerosis (MS) and correlates with visual function. We determined how longitudinal changes in RNFL thickness relate to visual loss. We also examined patterns of RNFL thinning over time in MS eyes with and without a prior history of acute optic neuritis (ON). Methods Patients underwent OCT measurement of RNFL thickness ...
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    5. Macular Volume Determined by Optical Coherence Tomography as a Measure of Neuronal Loss in Multiple Sclerosis

      Macular Volume Determined by Optical Coherence Tomography as a Measure of Neuronal Loss in Multiple Sclerosis
      ...wn University Medical Center, Washington, District of Columbia (Dr Osborne); and Department of Biostatistics, University of Alabama, Birmingham (Dr Cutter). CiteULike    Connotea    Del.icio.us    Digg    Reddit    Techn...
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    6. Optical coherence tomography of the retina and optic nerve – a review

      Optical coherence tomography (OCT) is a rapid non-contact method that allows in vivo imaging of the retina, optic nerve head and retinal nerve fibre layer (RNFL). Since its introduction in Ophthalmology approximately a decade ago, the use of this technology has disseminated into the clinical practice. OCT has proven to be a useful ancillary tool for assessing retinal diseases because of its capability to provide cross-sectional images of the retina ...
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    7. Artifacts on the Optic Nerve Head Analysis of the Optical Coherence Tomography in Glaucomatous and Nonglaucomatous Eyes

      Purpose: To determine the frequency and type of imaging artifacts in the optic nerve head (ONH) analysis protocol of the optical coherence tomograph (Stratus OCT) in healthy and glaucomatous eyes. Design: Retrospective study. Methods: Two experienced operators reviewed imaging obtained in 264 eyes from 264 participants (146 controls, 118 glaucoma patients). Each participant had a minimum of 3 scans using fast ONH protocol. Only scans with good quality were included ...
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    8. Optical coherence tomography: a window into the mechanisms of multiple sclerosis

      Optical coherence tomography: a window into the mechanisms of multiple sclerosis
      The pathophysiology of multiple sclerosis (MS) is characterized by demyelination, which culminates in a reduction in axonal transmission. Axonal and neuronal degeneration seem to be concomitant features of MS and are probably the pathological processes responsible for permanent disability in this disease. The retina is unique within the CNS in that it contains axons and glia but no myelin, and it is, therefore, an ideal structure within which to visualize ...
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    9. Adaptive Optics Scanning Laser Ophthalmoscopy Images Demonstrate Abnormal Cone Structure in a Family with the Mitochondrial DNA T8993C Mutation

      Purpose: To study the effect of mitochondrial DNA (mtDNA) mutation T8993C on cone structure in a family expressing neurogenic muscle weakness, ataxia, retinitis pigmentosa (NARP) syndrome. Methods: Five family members were studied, using clinical examination, nerve conduction studies, perimetry, optical coherence tomography (OCT) measures of central retinal thickness and electroretinography. High-resolution images of cone structure using adaptive optics scanning laser ophthalmoscopy (AOSLO) were obtained in 4 subjects with stable fixation ...
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    10. Reproducibility of Optical Coherence Tomography in Multiple Sclerosis

      Background  Optical coherence tomography (OCT) is a promising new method of quantifying axon thickness in the retinal nerve fiber layer (RNFL) that has been used predominantly by ophthalmologists to monitor glaucoma. Optical coherence tomography is being considered as a potential outcome measure in multiple sclerosis (MS) clinical trials, but no data exist on the reproducibility of this technique in MS centers.Objective  To determine the reproducibility of OCT measurement of ...
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    11. Retinal Imaging by Laser Polarimetry and Optical Coherence Tomography Evidence of Axonal Degeneration in Multiple Sclerosis

      Background Optical coherence tomography (OCT) and scanning laser polarimetry with variable corneal compensation (GDx) are similar yet provide information on different aspects of retinal nerve fiber layer (RNFL) structure (thickness values similar to histology for OCT vs birefringence of microtubules for GDx). Objectives To compare the ability of OCT and GDx to distinguish eyes of patients with multiple sclerosis (MS) from eyes of disease-free controls and thus identify RNFL abnormalities ...
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    12. 76-90 of 97 « 1 2 3 4 5 6 7 »
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  2. About University of Alabama

    University of Alabama

    The University of Alabama (also known as Alabama, UA, or colloquially as 'Bama) is a public coeducational university located in Tuscaloosa, Alabama, USA. Founded in 1831, UA is the flagship school of the University of Alabama System. Within Alabama, it is often called the Capstone. UA is the senior and the largest in terms of enrollment of the state's major research universities, the others being academic and athletic rival Auburn University and fellow UA System institutions the University of Alabama in Huntsville (UAH) and the University of Alabama at Birmingham (UAB). Outside the state, it is well known for the fact that its athletic teams are nicknamed the "Crimson Tide" (crimson being one of the school colors).   The University of Alabama offers programs of study in 12 academic divisions leading to bachelor's, master's, Education Specialist, and doctoral degrees. The only publicly-supported law school in Alabama is at UA. Other academic programs unavailable elsewhere in Alabama include doctoral programs in anthropology, library and information studies, metallurgical and material engineering, music, Romance languages, and social work.  As of fall 2007, Alabama has an enrollment of 25,580 students and its president is Dr. Robert Witt. The University of Alabama has the highest ranking in the 2008 edition of the US News and World Report: America's Best Colleges of any university in the state of Alabama."