1. University of Alabama

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    1. Mentioned In 74 Articles

    2. Quantitative Analysis of Outer Retinal Tubulation in Age-Related Macular Degeneration From Spectral-Domain Optical Coherence Tomography and Histology

      Quantitative Analysis of Outer Retinal Tubulation in Age-Related Macular Degeneration From Spectral-Domain Optical Coherence Tomography and Histology
      Purpose : To assess outer retinal tubulation (ORT) morphology from spectral-domain optical coherence tomography (SD-OCT) volumes and donor eye histology, analyze ORT reflectivity, and estimate the number of cones surviving in ORT. Methods : In SD-OCT volumes from nine patients with advanced AMD, ORT was analyzed en face and in B-scans. The hyperreflective ORT border in cross-section was delineated and surface area calculated. Reflectivity was compared between ORT types (Closed, Open, Forming ...
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    3. Optical Coherence Tomography and neurodegeneration: are eyes the windows to the brain?

      Optical Coherence Tomography and neurodegeneration: are eyes the windows to the brain?
      Central nervous system (CNS) pathologies have ocular manifestations due to direct and/or retrograde degeneration of the visual pathways, most often related to a direct injury to the optic nerve, retinal ganglion cells and/or its surrounding cells. These ocular manifestations can be recognized and monitored by a non-invasive technique called Optical Coherence Tomography (OCT). OCT helps in the measurement of retinal nerve fiber layer (RNFL) thickness and macular thickness ...
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    4. Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy

      Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy
      Recently approved therapies that modulate CFTR function have shown significant clinical benefit, but recent investigations regarding their molecular mechanism when used in combination have not been consistent with clinical results. We employed Micro-Optical Coherence Tomography (OCT) as a novel means to assess the mechanism of action of CFTR modulators, focusing on the effects on mucociliary clearance. Primary human airway monolayers from patients with a G551D mutation responded to ivacaftor treatment ...
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    5. The role of vascular imaging in guiding routine Percutaneous Coronary Interventions: A meta-analysis of Bare Metal Stent and Drug-Eluting Stent trials

      The role of vascular imaging in guiding routine Percutaneous Coronary Interventions: A meta-analysis of Bare Metal Stent and Drug-Eluting Stent trials
      Background The routine use of vascular imaging including intravascular ultrasound (IVUS) and Optical Coherence Tomography (OCT) in guiding percutaneous coronary interventions (PCI) is still controversial especially when using drug-eluting stents. A meta-analysis of trials using bare metal stents was previously published Methods We conducted a meta-analysis of available published trials that compared imaging-guided PCI and angiography-guided PCI in patients undergoing routine PCI only. Trials that enrolled patients with acute coronary ...
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    6. University of Alabama at Birmingham Receives NIH Grant to Study Functional Anatomic Imaging of Cystic Fibrosis Patients with Early Lung Disease using Micro-OCT.

      University of Alabama at Birmingham Receives NIH Grant to Study Functional Anatomic Imaging of Cystic Fibrosis Patients with Early Lung Disease using Micro-OCT.
      ...ng disease and the efficacy of drugs administered to combat mucus stasis.

      The University of Alabama at Birmingham Receives a 2015 NIH Grant for $498,330 to Study Functional Anatomic Imagin...

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    7. RefMoB, a Reflectivity Feature Model-Based Automated Method for Measuring Four Outer Retinal Hyperreflective Bands in Optical Coherence Tomography

      RefMoB, a Reflectivity Feature Model-Based Automated Method for Measuring Four Outer Retinal Hyperreflective Bands in Optical Coherence Tomography
      Purpose. : To validate a model-driven method (RefMoB) of automatically describing the four outer retinal hyperreflective bands revealed by spectral-domain optical coherence tomography (SDOCT), for comparison with histology of normal macula; to report thickness and position of bands, particularly band 2 (ellipsoid zone [EZ], commonly called IS/OS). Methods. : Foveal and superior perifoveal scans of seven SDOCT volumes of five individuals aged 28 to 69 years with healthy maculas were used ...
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    8. University of Alabama Receives NIH Grant for Developing a Clinical and Translation Core Related to Cystic Fibrosis

      University of Alabama Receives NIH Grant  for Developing a Clinical and Translation Core Related to Cystic Fibrosis
      ...tudies, new clinical insight regarding disease mechanisms, and clinical translation of novel CF therapeutics. University of Alabama Receives a 2015 NIH Grant for $193,380 for Developing a Clinical and Translation Core re...
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    9. Functional optical coherence tomography enables in vivo physiological assessment of retinal rod and cone photoreceptors

      Functional optical coherence tomography enables in vivo physiological assessment of retinal rod and cone photoreceptors
      Transient intrinsic optical signal (IOS) changes have been observed in retinal photoreceptors, suggesting a unique biomarker for eye disease detection. However, clinical deployment of IOS imaging is challenging due to unclear IOS sources and limited signal-to-noise ratios (SNRs). Here, by developing high spatiotemporal resolution optical coherence tomography (OCT) and applying an adaptive algorithm for IOS processing, we were able to record robust IOSs from single-pass measurements. Transient IOSs, which might ...
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    10. The Project MACULA retinal pigment epithelium grading system for histology and optical coherence tomography in age-related macular degeneration

      The Project MACULA retinal pigment epithelium grading system for histology and optical coherence tomography in age-related macular degeneration
      ...ultants of New York, 460 park Avenue, New York, NY, 10022, United States 1. ↵* Department of Ophthalmology, University of Alabama at Birmingham, 1670 University Boulevard Volker Hall 360, Birmingham, AL, 35294-0019, Un...
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    11. Optical Coherence Tomography of Dialysis Graft after Angioplasty

      Optical Coherence Tomography of Dialysis Graft after Angioplasty
      Neointimal hyperplasia, the major cause of arteriovenous graft (AVG) stenosis, is not directly visualized by angiography. A 60-year-old woman on hemodialysis presented with a clotted AVG 30 days after its creation. Following percutaneous thrombectomy, angiography revealed severe ( 50%) stenosis at the graft (G)-vein (V) anastomosis (arrow in Fig 1 ). Optical coherence tomography performed using an intravascular Dragonfly catheter (St. Jude Medical, Westford, Massachusetts) delineated the intima in bright yellow.
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    12. Quantitative assessment of corneal viscoelasticity using optical coherence elastography and a modified Rayleigh–Lamb equation

      Quantitative assessment of corneal viscoelasticity using optical coherence elastography and a modified Rayleigh–Lamb equation
      ...Texas 77030, United States University of Houston, College of Optometry, Houston, Texas 77204, United States University of Alabama, School of Optometry, Birmingham, Alabama 35294, United States Abstract.  We demonstra...
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    13. University of Alabama Receives NIH Grant for Studying In Vivo Ultrastructure of Chorioretinal Disease.

      University of Alabama Receives NIH Grant for Studying In Vivo Ultrastructure of Chorioretinal Disease.
      .... We will accomplish our goals by use of AO high resolution imaging and standard multimodal clinical imaging. University of Alabama at Birmingham Receives a 2015 NIH Grant for $367,500 for Studying In Vivo Ultrastructure...
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    14. 1-15 of 74 1 2 3 4 5 »
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  2. About University of Alabama

    University of Alabama

    The University of Alabama (also known as Alabama, UA, or colloquially as 'Bama) is a public coeducational university located in Tuscaloosa, Alabama, USA. Founded in 1831, UA is the flagship school of the University of Alabama System. Within Alabama, it is often called the Capstone. UA is the senior and the largest in terms of enrollment of the state's major research universities, the others being academic and athletic rival Auburn University and fellow UA System institutions the University of Alabama in Huntsville (UAH) and the University of Alabama at Birmingham (UAB). Outside the state, it is well known for the fact that its athletic teams are nicknamed the "Crimson Tide" (crimson being one of the school colors).   The University of Alabama offers programs of study in 12 academic divisions leading to bachelor's, master's, Education Specialist, and doctoral degrees. The only publicly-supported law school in Alabama is at UA. Other academic programs unavailable elsewhere in Alabama include doctoral programs in anthropology, library and information studies, metallurgical and material engineering, music, Romance languages, and social work.  As of fall 2007, Alabama has an enrollment of 25,580 students and its president is Dr. Robert Witt. The University of Alabama has the highest ranking in the 2008 edition of the US News and World Report: America's Best Colleges of any university in the state of Alabama."