1. University of Alabama

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    1. Mentioned In 140 Articles

    2. Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia

      Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia
      We report the design and fabrication of a flexible, longitudinally scanning high-resolution micro-optical coherence tomography (OCT) endobronchial probe, optimized for micro-anatomical imaging in airways. The 2.4 mm diameter and flexibility of the probe allows it to be inserted into the instrument channel of a standard bronchoscope, enabling real-time video guidance of probe placement. To generate a depth-of-focus enhancing annular beam, we utilized a new fabrication method, whereby a hollow ...
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    3. Distribution of macular pigments in macular telangiectasia type 2 and correlation with optical coherence tomography characteristics and visual acuity

      Distribution of macular pigments in macular telangiectasia type 2 and correlation with optical coherence tomography characteristics and visual acuity
      Background: To estimate macular pigment values in macular telangiectasia (MacTel) Type 2 in comparison with healthy subjects in the South Indian population across different spatial profiles and to quantify the regional differences of macular pigment optical density (MPOD) in MacTel Type 2. Methods: In this prospective cross-sectional study, healthy controls and patients diagnosed with various stages of MacTel Type 2 underwent MPOD measurement using dual-wavelength autofluorescence technique with Spectralis HRA ...
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    4. Multi-scale reconstruction of undersampled spectral-spatial OCT data for coronary imaging using deep learning

      Multi-scale reconstruction of undersampled spectral-spatial OCT data for coronary imaging using deep learning
      Coronary artery disease (CAD) is a cardiovascular condition with high morbidity and mortality. Intravascular optical coherence tomography (IVOCT) has been considered as an optimal imagining system for the diagnosis and treatment of CAD. Constrained by Nyquist theorem, dense sampling in IVOCT attains high resolving power to delineate cellular structures/features. There is a trade-off between high spatial resolution and fast scanning rate for coronary imaging. In this paper, we propose ...
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    5. Correlation of Optical Coherence Tomography Angiography of Type 3 Macular Neovascularization With Corresponding Histology

      Correlation of Optical Coherence Tomography Angiography of Type 3 Macular Neovascularization With Corresponding Histology
      Importance By validating optical coherence tomography angiography (OCTA) in the analysis of type 3 macular neovascularization secondary to age-related macular degeneration, the overall value of clinical OCTA for disease observation, diagnosis, and staging is increased. Objective To assess the association of in vivo OCTA of type 3 macular neovascularization secondary to age-related macular degeneration with corresponding ex vivo histology. Design, Setting, and Participants This study included clinical imaging, laboratory microscopy ...
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    6. Nonlinear distortion correction for posterior eye segment optical coherence tomography with application to tree shrews

      Nonlinear distortion correction for posterior eye segment optical coherence tomography with application to tree shrews
      We propose an empirical distortion correction approach for optical coherence tomography (OCT) devices that use a fan-scanning pattern to image the posterior eye segment. Two types of reference markers were used to empirically estimate the distortion correction approach in tree shrew eyes: retinal curvature from MRI images and implanted glass beads of known diameter. Performance was tested by correcting distorted images of the optic nerve head. In small animal eyes ...
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    7. Mitochondrial distribution in the outer plexiform layer of human retina - Does it correlate with reflectivity in OCT?

      Mitochondrial distribution in the outer plexiform layer of human retina - Does it correlate with reflectivity in OCT?
      Mitochondria are organelles essential for cellular metabolism that also contribute reflectivity to optical coherence tomography (OCT) via Mie scattering. To find reflectivity sources, we assessed mitochondrial distribution of outer plexiform layer (OPL) using comprehensive volume electron microscopy. Parafoveal retina of a 21-year-old male donor was subject to serial block-face scanning electron microscopy in 5550 nm voxels. A convolutional neural network (U-Net) was used to train and generate a deep learning ...
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    8. Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium

      Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium
      Purpose: By optical coherence tomography (OCT) imaging, hyperreflective foci (HRF) indicate progression risk for advanced age-related macular degeneration (AMD) and are in part attributable to ectopic retinal pigment epithelium (RPE). We hypothesized that ectopic RPE are molecularly distinct from in-layer cells and that their cross-retinal course follows Mller glia. Methods: In clinical OCT (61 eyes, 44 patients with AMD, 79.4 7.7 years; 29 female; follow-up = 4.7 0 ...
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    9. Strain by virtual extensometers and video-imaging optical coherence tomography as a repeatable metric for IOP-Induced optic nerve head deformations

      Strain by virtual extensometers and video-imaging optical coherence tomography as a repeatable metric for IOP-Induced optic nerve head deformations
      Purpose: To determine if in vivo strain response of the Optic Nerve Head (ONH) to IOP elevation visualized using Optical Coherence Tomography (OCT) video imaging and quantified using novel virtual extensometers was able to be provided repeatable measurements of tissue specific deformations. Methods: The ONHs of 5 eyes from 5 non-human primates (NHPs) were imaged by Spectralis OCT. A vertical and a horizontal B-scan of the ONH were continuously recorded ...
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    10. University of Alabama Receives NIH Grant for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease

      University of Alabama Receives NIH Grant  for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease
      ...evelopment novel treatments that address mechanisms of tear film instability.

      University of Alabama at Birmingham Receives a 2021 NIH Grant for $258,726 for Development of a supercontinuum...

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    11. MULTIMODAL IMAGING AND HISTOLOGIC EVIDENCE OF A NOVEL OPTICAL COHERENCE TOMOGRAPHY TERMINOLOGY

      MULTIMODAL IMAGING AND HISTOLOGIC EVIDENCE OF A NOVEL OPTICAL COHERENCE TOMOGRAPHY TERMINOLOGY
      Purpose: To clarify the histologic basis of bacillary layer detachment (BALAD) through a review of current literature and an analysis of retinal imaging. Methods: We reviewed the literature for previous reports of BALAD. An analysis of retinal images was performed to support anatomic conclusions. Results: A total of 164 unique patients with BALAD on optical coherence tomography (OCT) were identified from the published literature. Twenty-two underlying etiologies, all associated with ...
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    12. Inpainting for Saturation Artifacts in Optical Coherence Tomography using Dictionary-based Sparse Representation

      Inpainting for Saturation Artifacts in Optical Coherence Tomography using Dictionary-based Sparse Representation
      Saturation artifacts in optical coherence tomography (OCT) occur when received signal exceeds the dynamic range of spectrometer. Saturation artifact shows a streaking pattern and could impact the quality of OCT images, leading to inaccurate medical diagnosis. In this paper, we automatically localize saturation artifacts and propose an artifact correction method via inpainting. We adopt a dictionary-based sparse representation scheme for inpainting. Experimental results demonstrate that, in both case of synthetic ...
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    13. Histologic validation of optical coherence tomography-based three-dimensional morphometric measurements of the human optic nerve head: Methodology and preliminary results

      Histologic validation of optical coherence tomography-based three-dimensional morphometric measurements of the human optic nerve head: Methodology and preliminary results
      Purpose To compare the three-dimensional (3D) morphology of the deep load-bearing structures of the human optic nerve head (ONH) as revealed in vivo by spectral domain optical coherence tomography (SDOCT) with ex vivo quantitative 3D histology. Methods SDOCT imaging of the ONH was performed in six eyes from three brain-dead organ donors on life-support equipment awaiting organ procurement (in vivo conditions). Following organ procurement (ex vivo conditions), the eyes were ...
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  2. About University of Alabama

    University of Alabama

    The University of Alabama (also known as Alabama, UA, or colloquially as 'Bama) is a public coeducational university located in Tuscaloosa, Alabama, USA. Founded in 1831, UA is the flagship school of the University of Alabama System. Within Alabama, it is often called the Capstone. UA is the senior and the largest in terms of enrollment of the state's major research universities, the others being academic and athletic rival Auburn University and fellow UA System institutions the University of Alabama in Huntsville (UAH) and the University of Alabama at Birmingham (UAB). Outside the state, it is well known for the fact that its athletic teams are nicknamed the "Crimson Tide" (crimson being one of the school colors).   The University of Alabama offers programs of study in 12 academic divisions leading to bachelor's, master's, Education Specialist, and doctoral degrees. The only publicly-supported law school in Alabama is at UA. Other academic programs unavailable elsewhere in Alabama include doctoral programs in anthropology, library and information studies, metallurgical and material engineering, music, Romance languages, and social work.  As of fall 2007, Alabama has an enrollment of 25,580 students and its president is Dr. Robert Witt. The University of Alabama has the highest ranking in the 2008 edition of the US News and World Report: America's Best Colleges of any university in the state of Alabama."