1. University of Alabama

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    1. Mentioned In 79 Articles

    2. Evaluation of Segmentation of the Superficial and Deep Vascular Layers of the Retina By Optical Coherence Tomography Angiography Instruments in Normal Eyes

      Evaluation of Segmentation of the Superficial and Deep Vascular Layers of the Retina By Optical Coherence Tomography Angiography Instruments in Normal Eyes
      Importance Correct attribution of vascular features in optical coherence tomography (OCT) angiography depends on accurate segmentation of retinal layers. Objective To evaluate the segmentation of retinal layers among 3 OCT angiography instruments in the central macula, an area where the superficial and deep vascular plexuses terminate. Design, Setting, and Participants A retrospective review of a representative OCT angiogram from 1 patient and an evaluation of the vascular pattern in an ...
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    3. University of Alabam Receives NIH Grant for In Vivo Ultrastruture of Chorioretinal Disease

      University of Alabam Receives NIH Grant for In Vivo Ultrastruture of Chorioretinal Disease
      University of Alabam at Birmingham Receives a 2017 NIH Grant for $330,750 for In Vivo Ultrastruture of Chorioretinal Disease. The principal investigator is Yuhua Zhang. The program began in 2015 and ends in 2019. Below is a summary of the proposed work. Age-related macular degeneration (AMD) is a leading cause of vision loss in more than 10 million older Americans. For decades, AMD has been characterized by accumulation of ...
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    4. Assessing the effects of riboflavin/UV-A crosslinking on porcine corneal mechanical anisotropy with optical coherence elastography

      Assessing the effects of riboflavin/UV-A crosslinking on porcine corneal mechanical anisotropy with optical coherence elastography
      In this work we utilize optical coherence elastography (OCE) to assess the effects of UV-A/riboflavin corneal collagen crosslinking (CXL) on the mechanical anisotropy of in situ porcine corneas at various intraocular pressures (IOP). There was a distinct meridian of increased Youngs modulus in all samples, and the mechanical anisotropy increased as a function of IOP and also after CXL. The presented noncontact OCE technique was able to quantify the ...
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    5. OCT Expanded Clinical Data Analysis (OCT Aboard Space Station)

      OCT Expanded Clinical Data Analysis (OCT Aboard Space Station)
      Vision changes identified in long duration space fliers has led to a more comprehensive clinical monitoring protocol. Optical Coherence Tomography (OCT) was recently implemented on board the International Space Station in 2013. NASA is collaborating with Heidelberg Engineering to expand our current OCT data analysis capability by implementing a volumetric approach. Volumetric maps will be created by combining the circle scan, the disc block scan, and the radial scan. This ...
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    6. In vivo imaging of airway cilia and mucus clearance with micro-optical coherence tomography

      In vivo imaging of airway cilia and mucus clearance with micro-optical coherence tomography
      We have designed and fabricated a 4 mm diameter rigid endoscopic probe to obtain high resolution micro-optical coherence tomography (OCT) images from the tracheal epithelium of living swine. Our common-path fiber-optic probe used gradient-index focusing optics, a selectively coated prism reflector to implement a circular-obscuration apodization for depth-of-focus enhancement, and a common-path reference arm and an ultra-broadbrand supercontinuum laser to achieve high axial resolution. Benchtop characterization demonstrated lateral and axial ...
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    7. Quantitative Analysis of Outer Retinal Tubulation in Age-Related Macular Degeneration From Spectral-Domain Optical Coherence Tomography and Histology

      Quantitative Analysis of Outer Retinal Tubulation in Age-Related Macular Degeneration From Spectral-Domain Optical Coherence Tomography and Histology
      Purpose : To assess outer retinal tubulation (ORT) morphology from spectral-domain optical coherence tomography (SD-OCT) volumes and donor eye histology, analyze ORT reflectivity, and estimate the number of cones surviving in ORT. Methods : In SD-OCT volumes from nine patients with advanced AMD, ORT was analyzed en face and in B-scans. The hyperreflective ORT border in cross-section was delineated and surface area calculated. Reflectivity was compared between ORT types (Closed, Open, Forming ...
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    8. Optical Coherence Tomography and neurodegeneration: are eyes the windows to the brain?

      Optical Coherence Tomography and neurodegeneration: are eyes the windows to the brain?
      Central nervous system (CNS) pathologies have ocular manifestations due to direct and/or retrograde degeneration of the visual pathways, most often related to a direct injury to the optic nerve, retinal ganglion cells and/or its surrounding cells. These ocular manifestations can be recognized and monitored by a non-invasive technique called Optical Coherence Tomography (OCT). OCT helps in the measurement of retinal nerve fiber layer (RNFL) thickness and macular thickness ...
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    9. Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy

      Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy
      Recently approved therapies that modulate CFTR function have shown significant clinical benefit, but recent investigations regarding their molecular mechanism when used in combination have not been consistent with clinical results. We employed Micro-Optical Coherence Tomography (OCT) as a novel means to assess the mechanism of action of CFTR modulators, focusing on the effects on mucociliary clearance. Primary human airway monolayers from patients with a G551D mutation responded to ivacaftor treatment ...
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    10. The role of vascular imaging in guiding routine Percutaneous Coronary Interventions: A meta-analysis of Bare Metal Stent and Drug-Eluting Stent trials

      The role of vascular imaging in guiding routine Percutaneous Coronary Interventions: A meta-analysis of Bare Metal Stent and Drug-Eluting Stent trials
      Background The routine use of vascular imaging including intravascular ultrasound (IVUS) and Optical Coherence Tomography (OCT) in guiding percutaneous coronary interventions (PCI) is still controversial especially when using drug-eluting stents. A meta-analysis of trials using bare metal stents was previously published Methods We conducted a meta-analysis of available published trials that compared imaging-guided PCI and angiography-guided PCI in patients undergoing routine PCI only. Trials that enrolled patients with acute coronary ...
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    11. University of Alabama at Birmingham Receives NIH Grant to Study Functional Anatomic Imaging of Cystic Fibrosis Patients with Early Lung Disease using Micro-OCT.

      University of Alabama at Birmingham Receives NIH Grant to Study Functional Anatomic Imaging of Cystic Fibrosis Patients with Early Lung Disease using Micro-OCT.
      ...ng disease and the efficacy of drugs administered to combat mucus stasis.

      The University of Alabama at Birmingham Receives a 2015 NIH Grant for $498,330 to Study Functional Anatomic Imagin...

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    12. RefMoB, a Reflectivity Feature Model-Based Automated Method for Measuring Four Outer Retinal Hyperreflective Bands in Optical Coherence Tomography

      RefMoB, a Reflectivity Feature Model-Based Automated Method for Measuring Four Outer Retinal Hyperreflective Bands in Optical Coherence Tomography
      Purpose. : To validate a model-driven method (RefMoB) of automatically describing the four outer retinal hyperreflective bands revealed by spectral-domain optical coherence tomography (SDOCT), for comparison with histology of normal macula; to report thickness and position of bands, particularly band 2 (ellipsoid zone [EZ], commonly called IS/OS). Methods. : Foveal and superior perifoveal scans of seven SDOCT volumes of five individuals aged 28 to 69 years with healthy maculas were used ...
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    13. University of Alabama Receives NIH Grant for Developing a Clinical and Translation Core Related to Cystic Fibrosis

      University of Alabama Receives NIH Grant  for Developing a Clinical and Translation Core Related to Cystic Fibrosis
      ...tudies, new clinical insight regarding disease mechanisms, and clinical translation of novel CF therapeutics. University of Alabama Receives a 2015 NIH Grant for $193,380 for Developing a Clinical and Translation Core re...
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  2. About University of Alabama

    University of Alabama

    The University of Alabama (also known as Alabama, UA, or colloquially as 'Bama) is a public coeducational university located in Tuscaloosa, Alabama, USA. Founded in 1831, UA is the flagship school of the University of Alabama System. Within Alabama, it is often called the Capstone. UA is the senior and the largest in terms of enrollment of the state's major research universities, the others being academic and athletic rival Auburn University and fellow UA System institutions the University of Alabama in Huntsville (UAH) and the University of Alabama at Birmingham (UAB). Outside the state, it is well known for the fact that its athletic teams are nicknamed the "Crimson Tide" (crimson being one of the school colors).   The University of Alabama offers programs of study in 12 academic divisions leading to bachelor's, master's, Education Specialist, and doctoral degrees. The only publicly-supported law school in Alabama is at UA. Other academic programs unavailable elsewhere in Alabama include doctoral programs in anthropology, library and information studies, metallurgical and material engineering, music, Romance languages, and social work.  As of fall 2007, Alabama has an enrollment of 25,580 students and its president is Dr. Robert Witt. The University of Alabama has the highest ranking in the 2008 edition of the US News and World Report: America's Best Colleges of any university in the state of Alabama."