1. University of Alabama

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    1. Mentioned In 133 Articles

    2. Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium

      Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium
      Purpose: By optical coherence tomography (OCT) imaging, hyperreflective foci (HRF) indicate progression risk for advanced age-related macular degeneration (AMD) and are in part attributable to ectopic retinal pigment epithelium (RPE). We hypothesized that ectopic RPE are molecularly distinct from in-layer cells and that their cross-retinal course follows Mller glia. Methods: In clinical OCT (61 eyes, 44 patients with AMD, 79.4 7.7 years; 29 female; follow-up = 4.7 0 ...
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    3. Strain by virtual extensometers and video-imaging optical coherence tomography as a repeatable metric for IOP-Induced optic nerve head deformations

      Strain by virtual extensometers and video-imaging optical coherence tomography as a repeatable metric for IOP-Induced optic nerve head deformations
      Purpose: To determine if in vivo strain response of the Optic Nerve Head (ONH) to IOP elevation visualized using Optical Coherence Tomography (OCT) video imaging and quantified using novel virtual extensometers was able to be provided repeatable measurements of tissue specific deformations. Methods: The ONHs of 5 eyes from 5 non-human primates (NHPs) were imaged by Spectralis OCT. A vertical and a horizontal B-scan of the ONH were continuously recorded ...
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    4. University of Alabama Receives NIH Grant for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease

      University of Alabama Receives NIH Grant  for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease
      ...evelopment novel treatments that address mechanisms of tear film instability.

      University of Alabama at Birmingham Receives a 2021 NIH Grant for $258,726 for Development of a supercontinuum...

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    5. MULTIMODAL IMAGING AND HISTOLOGIC EVIDENCE OF A NOVEL OPTICAL COHERENCE TOMOGRAPHY TERMINOLOGY

      MULTIMODAL IMAGING AND HISTOLOGIC EVIDENCE OF A NOVEL OPTICAL COHERENCE TOMOGRAPHY TERMINOLOGY
      Purpose: To clarify the histologic basis of bacillary layer detachment (BALAD) through a review of current literature and an analysis of retinal imaging. Methods: We reviewed the literature for previous reports of BALAD. An analysis of retinal images was performed to support anatomic conclusions. Results: A total of 164 unique patients with BALAD on optical coherence tomography (OCT) were identified from the published literature. Twenty-two underlying etiologies, all associated with ...
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    6. Inpainting for Saturation Artifacts in Optical Coherence Tomography using Dictionary-based Sparse Representation

      Inpainting for Saturation Artifacts in Optical Coherence Tomography using Dictionary-based Sparse Representation
      Saturation artifacts in optical coherence tomography (OCT) occur when received signal exceeds the dynamic range of spectrometer. Saturation artifact shows a streaking pattern and could impact the quality of OCT images, leading to inaccurate medical diagnosis. In this paper, we automatically localize saturation artifacts and propose an artifact correction method via inpainting. We adopt a dictionary-based sparse representation scheme for inpainting. Experimental results demonstrate that, in both case of synthetic ...
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    7. Histologic validation of optical coherence tomography-based three-dimensional morphometric measurements of the human optic nerve head: Methodology and preliminary results

      Histologic validation of optical coherence tomography-based three-dimensional morphometric measurements of the human optic nerve head: Methodology and preliminary results
      Purpose To compare the three-dimensional (3D) morphology of the deep load-bearing structures of the human optic nerve head (ONH) as revealed in vivo by spectral domain optical coherence tomography (SDOCT) with ex vivo quantitative 3D histology. Methods SDOCT imaging of the ONH was performed in six eyes from three brain-dead organ donors on life-support equipment awaiting organ procurement (in vivo conditions). Following organ procurement (ex vivo conditions), the eyes were ...
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    8. Effect of spectral leakage on the image formation of Fourier-domain optical coherence tomography

      Effect of spectral leakage on the image formation of Fourier-domain optical coherence tomography
      We report on the investigation of spectral leakages impact on the reconstruction of Fourier-domain optical coherence tomography (FD-OCT). We discuss the shift-variant nature introduced by the spectral leakage and develop a novel spatial-domain FD-OCT image formation model. A proof-of-concept phantom experiment is conducted to validate our model. Compared with previous models, the proposed framework could better describe the image formation process, especially when the fineness of the axial structure approaches ...
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    9. Atlas of Human Retinal Pigment Epithelium Organelles Significant for Clinical Imaging

      Atlas of Human Retinal Pigment Epithelium Organelles Significant for Clinical Imaging
      Purpose : To quantify organelles impacting imaging in the cell body and intact apical processes of human retinal pigment epithelium (RPE), including melanosomes, lipofuscinmelanolipofuscin (LM), mitochondria, and nuclei. Methods : A normal perifovea of a 21-year-old white male was preserved after rapid organ recovery. An aligned image stack was generated using serial block-face scanning electron microscopy and was annotated by expert readers (TrakEM, ImageJ). Acquired measures included cell body and nuclear volume ...
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    10. Clinical Corneal Optical Coherence Elastography Measurement Precision: Effect of Heartbeat and Respiration

      Clinical Corneal Optical Coherence Elastography Measurement Precision: Effect of Heartbeat and Respiration
      Purpose : Normal physiological movements (e.g., respiration and heartbeat) induce eye motions during clinical measurements of human corneal biomechanical properties using optical coherence elastography (OCE). We quantified the effects of respiratory and cardiac-induced eye motions on clinical corneal OCE measurement precision and repeatability. Methods : Corneal OCE was performed using low-force, micro-air-pulse tissue stimulation and high-resolution phase-sensitive optical coherence tomography (OCT) imaging. Axial surface displacements of the corneal apex were measured ...
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    11. University of Alabama at Birmingham Receives NIH Grant for The Mechanisms Underlying Abnormal Mucus and Its Clearance in the cystic Fibrosis Rat

      University of Alabama at Birmingham Receives NIH Grant for The Mechanisms Underlying Abnormal Mucus and Its Clearance in the cystic Fibrosis Rat
      ...vestigating disorders of mucociliary clearance using cutting edge techniques.

      University of Alabama at Birmingham Receives a 2020 NIH Grant for $135,570 for The Mechanisms Underlying Abnor...

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    12. Beyond Fourier transform: break the axial resolution limit in optical coherence tomography

      Beyond Fourier transform: break the axial resolution limit in optical coherence tomography
      Optical coherence tomography (OCT) is a volumetric imaging modality that empowers the clinicians and scientists to noninvasively visualize and examine the microscopic cross-sectional architectures of biological samples. By taking advantages of the coherence gating, OCT could achieve micrometer-level axial sectioning with high sensitivity. In the past decade, substantial efforts have been made to push the axial resolution of Fourier-domain OCT (FD-OCT) further into the sub-micron regime via physically extending the ...
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    13. University of Alabama at Birmingham Receives NIH Grant for Functional Categorization of Ciliary motion in PCD

      University of Alabama at Birmingham Receives NIH Grant for Functional Categorization of Ciliary motion in PCD
      ...s, successfully obtain future independent funding, and make important differences in the lives of PCD patient University of Alabama at Birmingham Receives a 2020 NIH Grant for $159,882 for Functional Categorization of Ci...
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    14. 1-15 of 133 1 2 3 4 5 6 7 8 9 »
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  2. About University of Alabama

    University of Alabama

    The University of Alabama (also known as Alabama, UA, or colloquially as 'Bama) is a public coeducational university located in Tuscaloosa, Alabama, USA. Founded in 1831, UA is the flagship school of the University of Alabama System. Within Alabama, it is often called the Capstone. UA is the senior and the largest in terms of enrollment of the state's major research universities, the others being academic and athletic rival Auburn University and fellow UA System institutions the University of Alabama in Huntsville (UAH) and the University of Alabama at Birmingham (UAB). Outside the state, it is well known for the fact that its athletic teams are nicknamed the "Crimson Tide" (crimson being one of the school colors).   The University of Alabama offers programs of study in 12 academic divisions leading to bachelor's, master's, Education Specialist, and doctoral degrees. The only publicly-supported law school in Alabama is at UA. Other academic programs unavailable elsewhere in Alabama include doctoral programs in anthropology, library and information studies, metallurgical and material engineering, music, Romance languages, and social work.  As of fall 2007, Alabama has an enrollment of 25,580 students and its president is Dr. Robert Witt. The University of Alabama has the highest ranking in the 2008 edition of the US News and World Report: America's Best Colleges of any university in the state of Alabama."