1. University Medical Center Utrecht

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    1. Mentioned In 13 Articles

    2. Combination of optical coherence tomography and near infrared spectroscopy enhances determination of articular cartilage composition and structure

      Combination of optical coherence tomography and near infrared spectroscopy enhances determination of articular cartilage composition and structure
      Conventional arthroscopic evaluation of articular cartilage is subjective and poorly reproducible. Therefore, implementation of quantitative diagnostic techniques, such as near infrared spectroscopy (NIRS) and optical coherence tomography (OCT), is essential. Locations ( n =44) with various cartilage conditions were selected from mature equine fetlock joints ( n =5). These locations and their surroundings were measured with NIRS and OCT ( n =530). As a reference, cartilage proteoglycan (PG) and collagen contents, and collagen ...
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    3. Targeted Near-Infrared Fluorescence Imaging of Atherosclerosis

      Targeted Near-Infrared Fluorescence Imaging of Atherosclerosis
      Objectives This study sought to determine whether indocyanine green (ICG)enhanced near-infrared fluorescence (NIRF) imaging can illuminate high-risk histologic plaque features of human carotid atherosclerosis, and in coronary atheroma of living swine, using intravascular NIRF-optical coherence tomography (OCT) imaging. Background New translatable imaging approaches are needed to identify high-risk biological signatures of atheroma. ICG is a U.S. Food and Drug Administrationapproved NIRF imaging agent that experimentally targets plaque macrophages ...
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    4. Optical coherence tomography enables accurate measurement of equine cartilage thickness for determination of speed of sound

      Optical coherence tomography enables accurate measurement of equine cartilage thickness for determination of speed of sound
      Background and purpose Arthroscopic estimation of articular cartilage thickness is important for scoring of lesion severity, and measurement of cartilage speed of sound (SOS)a sensitive index of changes in cartilage composition. We investigated the accuracy of optical coherence tomography (OCT) in measurements of cartilage thickness and determined SOS by combining OCT thickness and ultrasound (US) time-of-flight (TOF) measurements. Material and methods Cartilage thickness measurements from OCT and microscopy images ...
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    5. Dual modality intravascular optical coherence tomography (OCT) and near-infrared fluorescence (NIRF) imaging: a fully automated algorithm for the distance-calibration of NIRF signal intensity for quantitative molecular imaging

      Dual modality intravascular optical coherence tomography (OCT) and near-infrared fluorescence (NIRF) imaging: a fully automated algorithm for the distance-calibration of NIRF signal intensity for quantitative molecular imaging
      ...l and Massachusetts General Hospital, Boston, MA, USA Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands Department of Biomedical Engineering, Boston Univ...
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    6. Serial Morphological and Functional Assessment of Drug-Eluting Balloon for In-Stent Restenotic Lesions : Mechanisms of Action Evaluated With Angiography, Optical Coherence Tomography, and Fractional Flow Reserve

      Serial Morphological and Functional Assessment of Drug-Eluting Balloon for In-Stent Restenotic Lesions : Mechanisms of Action Evaluated With Angiography, Optical Coherence Tomography, and Fractional Flow Reserve
      ... M. Nathoe, MD, PhD, * Pieter A. Doevendans, MD, PhD, * Pieter R. Stella, MD, PhD * Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands Received 3 December 2012 Revised 14 December 2012 ...
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    7. Intravascular optical coherence tomography imaging at 3200 frames per second

      Intravascular optical coherence tomography imaging at 3200 frames per second
      We demonstrate intravascular optical coherence tomography (OCT) imaging with frame rate up to 3.2 kHz (192,000 rpm scanning). This was achieved by using a custom-built catheter in which the circumferential scanning was actuated by a 1.0 mm diameter synchronous motor. The OCT system, with an imaging depth of 3.7 mm (in air), is based on a Fourier domain mode locked laser operating at an A-line rate ...
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    8. Optimizing the Information Yield of 3-D OCT in Glaucoma

      Optimizing the Information Yield of 3-D OCT in Glaucoma
      Purpose. To determine, first, which regions of 3-D optical coherence tomography (OCT) volumes can be segmented completely in the majority of subjects and, second, the relationship between analyzed area and thickness measurement testretest variability. Methods. Three-dimensional OCT volumes (6 6 mm) centered around the fovea and optic nerve head (ONH) of 925 Rotterdam Study participants were analyzed; 44 participants were scanned twice. Volumes were segmented into 10 layers, and we ...
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    9. Numerical analysis of astigmatism correction in gradient refractive index lens based optical coherence tomography catheters

      Numerical analysis of astigmatism correction in gradient refractive index lens based optical coherence tomography catheters
      Endoscopic optical coherence tomography (OCT) catheters comprise a transparent tube to separate the imaging instrument from tissues. This tube acts as a cylindrical lens, introducing astigmatism into the beam. In this report, we quantified this negative effect using optical simulations of OCT catheter devices, and discuss possible compensation strategies. For esophageal imaging, the astigmatism is aggravated by the long working distance. For intracoronary imaging, the beam quality is degraded due ...
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    10. Optical coherence tomography assessment of early stent strut coverage in patients treated with a thin-strut bare cobalt-chromium stent coated with silicon carbide

      Optical coherence tomography assessment of early stent strut coverage in patients treated with a thin-strut bare cobalt-chromium stent coated with silicon carbide
      ...R. Stella Affiliations + Corresponding Author Information Corresponding authors at: Department of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands. Tel.: + 31 88 7558312;...
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    11. Diagnostic Modalities for Diseased Articular Cartilage—From Defect to Degeneration

      Diagnostic Modalities for Diseased Articular Cartilage—From Defect to Degeneration
      The progression of cartilage matrix damage to generalized degeneration is associated with specific pathophysiological and clinical aspects. Reliable detection of stage-related characteristics of cartilage disease serves both a therapeutic and prognostic goal. Over the past years, several (pre)clinical diagnostic modalities for cartilage pathologies have been advocated. Each modality focuses on different aspects of the disease. Early diagnosis, before irreversible damage has occurred, opens up the possibility for better treatment ...
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    12. Progressive Loss of Cones in Achromatopsia: An Imaging Study using Spectral-Domain Optical Coherence Tomography

      Progressive Loss of Cones in Achromatopsia: An Imaging Study using Spectral-Domain Optical Coherence Tomography
      Purpose: Achromatopsia (ACHM) is a congenital autosomal recessive cone disorder with a presumed stationary nature and only a few causative genes. Animal studies suggest that ACHM may be a good candidate for corrective gene therapy. Future implementation of this therapy in humans requires the presence of viable cone cells in the retina. We investigated the presence of cone cells in ACHM as a function of age. Methods: We evaluated the ...
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    13. Methods and devices for registering optical measurement datasets of an optical system

      The present invention provides methods, systems and software for registering a first dataset of an object with a second dataset of an object. In one embodiment, the present invention measures refractive errors of an optical system. The method comprises obtaining a first and second optical measurement of the optical system. The first and second optical measurements are registered with each other and may improve the diagnosis and/or treatment of ...
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    14. 1-13 of 13
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  2. About University Medical Center Utrecht

    University Medical Center Utrecht

    University Medical Center Utrecht or UMCU is the main hospital of the city of Utrecht . It is affiliated with the Utrecht University . Since the foundation of the university in 1636 an academic hospital has existed in various forms. Nowadays the UMC Utrecht comprises the academic hospital, the faculty of Medicine as well as the Wilhelmina Children's hospital. In total approximately 10,000 people work at the UMCU including medical staff, nursing staff, residents, support personnel and researchers, making it one of the largest hospitals in the Netherlands. Special units include: * Neurosurgery * Cardiothoracic surgery * Neonatal and pediatric surgery and intensive care * Pediatric oncology * Level I trauma center Adjacent to the UMCU lies an underground military facility known as the Centraal Militair Hospitaal (Central Military Hospital), or CMH. This facility is also occasionally used in peacetime for treating groups of patients in case of major catastrophes or who might have been infected with contagious diseases (for example, repatriated wounded Dutch citizens after the 2004 Indian Ocean earthquake and tsunami) .