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1. Mentioned In 43 Articles
2. Effects of the PCSK9 Antibody Alirocumab on Coronary Atherosclerosis in Patients with Acute Myocardial Infarction: A Serial, Multivessel, Intravascular Ultrasound, Near-Infrared Spectroscopy and Optical Coherence Tomography Imaging Study Rationale and Des
  
  Explore ScienceDirect May 6 2021 Cardiology
  
  Background: The risk for cardiovascular adverse events after acute myocardial infarction (AMI) remains high despite potent medical treatment including low-density lipoprotein cholesterol (LDL-C) lowering with statins. Proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies substantially reduce LDL-C when added to statin. Alirocumab, a momoclonal antibody to PCSK9, reduces major adverse cardiovascular events after AMI. The effects of alirocumab on coronary atherosclerosis including plaque burden, plaque composition and fibrous cap thickness ...
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  Mentions: University of Toronto Medical University of Vienna University Hospital Zurich
3. Investigating Microangiopathy using Swept-Source Optical Coherence Tomography Angiography in Patients with Susac Syndrome
  
  Explore LWW Online Mar 25 2021 Ophthalmology
  
  Purpose: To determine whether optical coherence tomography angiography is of diagnostic utility for Susac syndrome (SuS) by quantifying microvascular retinal changes. Methods: We enrolled 18 eyes of 9 healthy controls and 18 eyes of 9 patients with chronic SuS (12 had previous branch retinal artery occlusions and 6 were clinically unaffected). Images of the fovea were taken using an optical coherence tomography angiography system. Analysis included vessel density, fractal dimension ...
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  Mentions: University of British Columbia University Hospital Zurich
4. Optical coherence tomography of patients with Parkinson’s disease and progressive supranuclear palsy
  
  Explore ScienceDirect Dec 12 2019 Neurology , Ophthalmology
  
  Objectives To determine if Parkinsons disease (PD) and progressive supranuclear palsy (PSP) differed on retinal measurements using optical coherence tomography (OCT). Patients and methods In a prospective, controlled, cross-sectional cohort study, we recruited patients with PD or PSP for more than three years, as well as control subjects. We measured peripapillary retinal nerve fiber layer (RNFL) thickness and macular volume using spectral-domain OCT. The association between these OCT measures and ...
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  Mentions: University of British Columbia University Hospital Zurich University of Zurich
5. En Face Optical Coherence Tomography Imaging Ellipsoid Zone Regeneration in Laser-Induced and Solar Maculopathies
  
  Explore Hindawi Publishing Corporation Nov 26 2019 Ophthalmology
  
  The purpose of the study was to analyze imaging findings in spectral domain en face optical coherence tomography (SD OCT) in patients with laser‐induced and solar maculopathies focusing on the possible regeneration of the ellipsoid zone. In a retrospective case series of 3 patients (4 eyes) with solar maculopathy and 2 patients (3 eyes) with laser‐induced maculopathy who underwent a comprehensive ocular examination, ellipsoid zone (EZ) was segmented ...
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  Mentions: University Hospital Zurich
6. Intravascular Polarimetry in Patients With Coronary Artery Disease
  
  Explore ScienceDirect Nov 22 2019 Cardiology
  
  Objectives The aims of this first-in-human pilot study of intravascular polarimetry were to investigate polarization properties of coronary plaques in patients and to examine the relationship of these features with established structural characteristics available to conventional optical frequency domain imaging (OFDI) and with clinical presentation. Background Polarization-sensitive OFDI measures birefringence and depolarization of tissue together with conventional cross-sectional optical frequency domain images of subsurface microstructure. Methods Thirty patients undergoing polarization-sensitive ...
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  Mentions: Massachusetts Institute of Technology Leiden University Massachusetts General Hospital
7. Refining the management of acute coronary and aortic syndromes
  
  Explore Journals Jun 21 2019 Cardiology
  
  ... I): clinical characteristics, diagnostic criteria, and pathophysiology’ by Christian Templin et al. from the University Hospital Zurich in Switzerland.35,36,6 Templin et al respond in a separate comment.37 The editors h...
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  Mentions: Cornell University University of Sheffield Cardiovascular Research Foundation
8. Intraoperative Endoluminal Quality Control of Saphenous Vein Grafts with Optical Coherence Tomography in Coronary Artery Bypass Grafting
  
  Explore Thieme Feb 13 2019 Cardiology
  
  Introduction: During bypass surgery, saphenous vein grafts (SVGs) remain a widely used conduit. From earlier studies, we know that graft harvesting can lead to endothelial lesions which result in graft failure or poor quality of anastomosis. There is no intraoperative endothelial quality control durable, which enables the assessment of the inner layer of the vein, the inner diameter, and morphologic disorders endoluminal including venous valves. We need a fast, dynamic ...
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  Mentions: University Hospital Zurich
9. Optical coherence tomography as a means to characterize visual pathway involvement in multiple sclerosis
  
  Explore LWW Online Aug 7 2018 Neurology , Ophthalmology
  
  Purpose of review Optical coherence tomography (OCT) is a noninvasive in-vivo imaging tool that enables the quantification of the various retinal layer thicknesses. Given the frequent involvement of the visual pathway in multiple sclerosis , OCT has become an important tool in clinical practice, research and clinical trials. In this review, the role of OCT as a means to investigate visual pathway damage in multiple sclerosis is discussed. Recent findings Evidence ...
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  Mentions: University Hospital Zurich University of Zurich
10. Safety and Feasibility of a Novel Sparse Optical Coherence Tomography Device for Patient-Delivered Retina Home Monitoring
  
  Explore TVST Journal Jul 28 2018 Ophthalmology
  
  Purpose : To study a novel and fast optical coherence tomography (OCT) device for home-based monitoring in age-related macular degeneration (AMD) in a small sample yielding sparse OCT (spOCT) data and to compare the device to a commercially available reference device. Methods : In this prospective study, both eyes of 31 participants with AMD were included. The subjects underwent scanning with an OCT prototype and a spectral-domain OCT to compare the accuracy ...
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  Mentions: University Hospital Zurich
11. Frontiers in cardiac imaging: diagnostic and prognostic validity and safety
  
  Explore Journals Jan 21 2018 Cardiology
  
  The heart is a hidden organ and was not accessible for clinicians until the discovery of the stethoscope by Ren Laennec in 1821.1Thereafter, there was little progress until the discovery of radiation by Wilhelm Rntgen in 18982and its application for chest X-rays and later angiography. In the 1970s, echocardiography was developed followed by magnetic resonance imaging or MRI3,4and computed tomography or CT.5These imaging tools have revolutionized the ...
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  Mentions: Leiden University University of Manchester University Hospital Zurich
12. THREE-DIMENSIONAL ANALYSIS OF SUBMACULAR PERFORATING SCLERAL VESSELS BY ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY
  
  Explore LWW Online May 16 2017 Ophthalmology
  
  Purpose: To analyze submacular perforating scleral vessels (PSVs) using enhanced depth imaging spectral domain optical coherence tomography (EDI-SDOCT). Methods: Twenty-two eyes of 11 healthy women were included in this retrospective study. Central EDI-SDOCT scans (3 x 4.5 x 1.9 mm, 13.5 mm2 scan area) were acquired and postprocessed by denoising, manual sclera segmentation, and PSV investigated by five graders. Results: Mean age was 22.4 +/- 6.2 ...
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  Mentions: Johns Hopkins University University Hospital Zurich University of Zurich
13. The REMEDEE-OCT Study : An Evaluation of the Bioengineered COMBO Dual-Therapy CD34 Antibody–Covered Sirolimus-Eluting Coronary Stent Compared With a Cobalt-Chromium Everolimus-Eluting Stent in Patients With Acute Coronary Syndromes: Insights From Optical
  
  Explore ScienceDirect Mar 11 2017 Cardiology
  
  Objectives The aim of the present study was to evaluate vascular healing of the bioengineered COMBO Dual Therapy Stent compared with a cobalt-chromium (CoCr) everolimus-eluting stent (EES) as assessed by optical coherence tomography in patients with acute coronary syndromes. Background CD34+ cells promote endothelial repair after vascular injury. The bioengineered COMBO Dual Therapy Stent combines CD34+ cellcapturing technology with abluminal sirolimus release, but more data from clinical studies evaluating the ...
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  Mentions: Case Western Reserve University Cardiovascular Research Foundation Academic Medical Center at the University of Amsterdam
14. Intracoronary optical coherence tomography: Clinical and research applications and intravascular imaging software overview
  
  Explore Wiley Online Library Jan 21 2017 Cardiology
  
  By providing valuable information about the coronary artery wall and lumen, intravascular imaging may aid in optimizing interventional procedure results and thereby could improve clinical outcomes following percutaneous coronary intervention (PCI). Intravascular optical coherence tomography (OCT) is a light-based technology with a tissue penetration of approximately 1 to 3 mm and provides near histological resolution. It has emerged as a technological breakthrough in intravascular imaging with multiple clinical and research ...
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  Mentions: Imperial College London Leiden University University College London
15. Optical Coherence Tomography and Magnetic Resonance Imaging in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder
  
  Explore MDPI Open Access Journals Platform Nov 15 2016 Neurology , Ophthalmology
  
  Irreversible disability in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) is largely attributed to neuronal and axonal degeneration, which, along with inflammation, is one of the major pathological hallmarks of these diseases. Optical coherence tomography (OCT) is a non-invasive imaging tool that has been used in MS, NMOSD, and other diseases to quantify damage to the retina, including the ganglion cells and their axons. The fact that these ...
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  Mentions: University Hospital Zurich University of Zurich
16. Optical Coherence Tomography in Multiple Sclerosis
  
  Explore Thieme Apr 27 2016 Neurology , Ophthalmology
  
  Retinal optical coherence tomography (OCT) has recently become a vital tool for clinicians and researchers in ophthalmology and, increasingly, in neurology. Optical coherence tomography is quickly and easily performed, well-tolerated by patients, and allows high-resolution viewing of unmyelinated axons and other retinal structures in vivo. These factors have led OCT to find favor as a method of quantifying neuroaxonal loss in multiple sclerosis (MS), and the increasing acceptance of the ...
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  Mentions: University Hospital Zurich University of Zurich
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