1. University Hospital Zurich

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    1. Mentioned In 22 Articles

    2. The bumpy road to evidence: why many research findings are lost in translation

      The bumpy road to evidence: why many research findings are lost in translation

      We have come a long way When, more than 2500 years ago, Thales of Milet (624–547 BC) claimed that nature was ruled by laws and not by gods, he changed the world. 1 Such a concept allowed for the discovery and mathematical proof of impersonal causation of what, until then, had been a mystery ruled by unpredictable gods. Indeed, ever since then the understanding of nature—today we would call it the natural sciences—has become a major activity of mankind. With this strategy, we have come a long way. Initially, it allowed us to use the position of ...

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    3. Optical coherence tomography to reveal vascular lesions after catheter-based renal nerve ablation with a novel multi-electrode EnligHTNTM system

      Optical coherence tomography to reveal vascular lesions after catheter-based renal nerve ablation with a novel multi-electrode EnligHTNTM system

      A 72-year-old female with a history of sleep apnoea syndrome was referred to the Andreas Gruentzig Catheterisation Laboratories for catheter-based renal nerve ablation (RNA) due to drug-resistant, uncontrolled hypertension. After intravenously loading with aspirin, the RNA was obtained using the first generation multi-electrode EnligHTNTM system (St. Jude Medical, Westford, MA, USA) delivering 8 ablation runs on both the left and the right renal artery. Before and after the RNA procedure, optical coherence tomography (OCT) was performed using the C7-XR imaging system (LightLab Imaging, Inc., Westford, MA, USA) with a non-occlusive technique and a single-mode optical fibre catheter (frequency domain-OCT-catheter, DragonFlyTM ...

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    4. Geometrically correct three-dimensional optical coherence tomography: first self-expanding bifurcation stent evaluation

      Geometrically correct three-dimensional optical coherence tomography: first self-expanding bifurcation stent evaluation

      A 78-year-old female was referred to the Andreas Gruentzig Catheterization Laboratories suffering from angina pain CCS II. Coronary angiography demonstrated a bifurcation lesion in the middle left anterior descending and the first diagonal branch ( Panel A ). Based on these findings, percutaneous coronary intervention (PCI) was performed with implantation of a

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    5. Vascular lesions induced by renal nerve ablation as assessed by optical coherence tomography: pre- and post-procedural comparison with the Simplicity® catheter system and the EnligHTN™ multi-electrode renal denervation catheter

      Vascular lesions induced by renal nerve ablation as assessed by optical coherence tomography: pre- and post-procedural comparison with the Simplicity® catheter system and the EnligHTN™ multi-electrode renal denervation catheter
      ...aul Erne3, 10. Georg Noll1 and 11. Thomas F. Lüscher1,* 1. ^1Department of Cardiology, Cardiovascular Center, University Hospital Zurich, Raemistrasse 100, Zurich CH-8091, Switzerland 2. ^2Division of Cardiology, Altstät...
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    6. Differentiation of Early from Advanced Coronary Atherosclerotic Lesions: Systematic Comparison of CT, Intravascular US, and Optical Frequency Domain Imaging with Histopathologic Examination in ex Vivo Human Heart

      Differentiation of Early from Advanced Coronary Atherosclerotic Lesions: Systematic Comparison of CT, Intravascular US, and Optical Frequency Domain Imaging with Histopathologic Examination in ex Vivo Human Heart
      ...t, Hungary (P.M.); CV Path Institute, Gaithersburg, Md (M.N., M.V., R.V.); Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland (H.A., P.S., H.S); Department of Clinical Radiology, Ludwig Ma...
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    7. Inter-observer agreement for spectral- and time-domain optical coherence tomography image grading: a prospective study

      Inter-observer agreement for spectral- and time-domain optical coherence tomography image grading: a prospective study

      Abstract  The purpose of this study was to compare inter-observer agreement of Stratus™ OCT versus Spectralis™ OCT image grading in patients with neovascular age-related macular degeneration (AMD). Thirty eyes with neovascular AMD were examined with Stratus™ OCT and Spectralis™ OCT. Four different scan protocols were used for imaging. Three observers graded the images for the presence of various pathologies. Inter-observer agreement between OCT models was assessed by calculating intra-class correlation coefficients (ICC). In Stratus™ OCT highest interobserver agreement was found for subretinal fluid (ICC: 0.79), and in Spectralis™ OCT for intraretinal cysts (IRC) (ICC: 0.93). Spectralis™ OCT showed ...

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    8. Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography

      Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography

      Background. Optical coherence tomography (OCT) has facilitated characterisation of retinal alterations in MS patients. Only scarce and in part conflicting data exists on different MS subtypes. Objective. To analyse patterns of retinal changes in different subtypes of MS with latest spectral-domain technology. Methods. In a three-centre cross-sectional study 414 MS patients and 94 healthy controls underwent spectral-domain OCT examination. Results. Eyes of MS patients without a previous optic neuritis showed a significant reduction of both retinal nerve fibre layer (RNFL) thickness and total macular volume (TMV) compared to healthy controls independent of the MS subtype (P < 0.001 for all ...

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    9. Optical coherence tomography (OCT) evaluation after coronary stenting: the “black hole” and other low OCT signal-intensity areas

      Optical coherence tomography (OCT) evaluation after coronary stenting: the “black hole” and other low OCT signal-intensity areas

      In this issue of EuroIntervention, Two interesting image reports describe OCT appearance of restenotic tissue of sirolimus-eluting stents and both refer to the "black hole" phenomenon that was first described as an observation in IVUS-studies of restenotic tissue of patients after radioactive stent implantion or brachytherapy. 

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    10. Prospective Study of Foveal Thickness Alterations after Cataract Surgery Assessed by Optical Coherence Tomography

      Prospective Study of Foveal Thickness Alterations after Cataract Surgery Assessed by Optical Coherence Tomography

      Background/Aims: To evaluate the alterations of mean foveal thickness (MFT) and visual acuity (VA) outcomes after uncomplicated cataract surgery in different groups of patients. Methods: This study included eyes of consecutive patients who underwent cataract surgery between November 2007 and June 2009. The patients included in the study were divided into 4 groups, as follows: history-free patients, patients with diabetes mellitus without macular involvement at baseline, patients with glaucoma, and patients with epiretinal membrane (ERM). Preoperatively and at 1, 3 and 6 months postoperatively, patients were evaluated for MFT by optical coherence tomography at the central 1-mm macular zone ...

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    11. Repeatability of nerve fiber layer thickness measurements in patients with glaucoma and without glaucoma using spectral-domain and time-domain OCT

      Repeatability of nerve fiber layer thickness measurements in patients with glaucoma and without glaucoma using spectral-domain and time-domain OCT
      Abstract Background  The aim of this work is to assess the repeatability of spectral-domain-OCT (SD-OCT) retinal nerve fiber layer thickness (RNFL) thickness measurements in a non-glaucoma group and patients with glaucoma and to compare these results to conventional time-domain-OCT (TD-OCT). Methods  In a prospective, comparative, observational case-control study, 50 eyes of 25 non-glaucoma and 22 eyes of 11 patients with primary open angle glaucoma (POAG) were included. SD-OCT and TD-OCT circle scans were centered on the optic disc. In each eye, OCT scans were performed three times by two independent observers. RNFL thickness was measured in four quadrants around the ...
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    12. Dizziness and Pre-Syncope: An Unusual Clinical Presentation of a Spontaneous Coronary Artery Dissection as Revealed by Optical Coherence Tomography

      Dizziness and Pre-Syncope: An Unusual Clinical Presentation of a Spontaneous Coronary Artery Dissection as Revealed by Optical Coherence Tomography
      .... The * indicates the optical coherence tomography catheter. Department of Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland Manuscript received November 12, 2010; accepted November 19, 2...
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    13. Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using the Eye Tracker and the Retest Function of Spectralis SD-OCT in Glaucomatous and Healthy Control Eyes

      Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using the Eye Tracker and the Retest Function of Spectralis SD-OCT in Glaucomatous and Healthy Control Eyes
      ...es 1. Stefan J. Langenegger, 2. Jens Funk and 3. Marc Töteberg-Harms 1. From the Department of Ophthalmology, University Hospital Zurich (USZ), Zurich, Switzerland. 1. Corresponding author: Marc Töteberg-Harms, Departmen...
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    14. 1-15 of 22 1 2 »
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  2. About University Hospital Zurich

    University Hospital Zurich

    University Hospital Zurich is one of the largest and most important teaching hospitals in Europe. With its 40 divisions and institutes, the hospital is renowned for its achievements in health care, research and teaching,  as well as for compassionate care. It offers state-of-the-art  treatment for a broad range of illnesses, provided by a dedicated team of leading consultants of the highes international standing.