1. University College London

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    1. Mentioned In 228 Articles

    2. Evaluation of Age-related Macular Degeneration With Optical Coherence Tomography

      Evaluation of Age-related Macular Degeneration With Optical Coherence Tomography
      Abstract: Age-related macular degeneration (AMD) is the leading cause of severe visual loss in people aged 50 years or older in the developed world. In recent years, major advances have been made in the treatment of AMD, with the introduction of anti-angiogenic agents, offering the first hope of significant visual recovery for patients with neovascular AMD. In line with these advances, a new imaging modalityoptical coherence tomography (OCT)has emerged ...
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    3. Theoretical, Experimental, and Optical Coherence Tomography (OCT) Studies of Graft Apposition and Adhesion in Descemets Stripping Automated Endothelial Keratoplasty (DSAEK)

      Theoretical, Experimental, and Optical Coherence Tomography (OCT) Studies of Graft Apposition and Adhesion in Descemets Stripping Automated Endothelial Keratoplasty (DSAEK)
      ...don, United Kingdom; and the 4. ^4 Department of Mechanical Engineering and 5. ^5 Institute of Ophthalmology, University College London, London, United Kingdom. 1. Corresponding author: Maninder Bhogal, Department of Cor...
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    4. Structural validation of oral mucosal tissue using optical coherence tomography

      Structural validation of oral mucosal tissue using optical coherence tomography
      Background Optical coherence tomography (OCT) is a non-invasive optical technology using near-infrared light to produce cross-sectional tissue images with lateral resolution. Objectives The overall aims of this study was to generate a bank of normative and pathological OCT data of the oral tissues to allow identification of cellular structures of normal and pathological processes with the aim to create a diagnostic algorithm which can be used in the early detection ...
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    5. Analysis of Normal Retinal Nerve Fiber Layer Thickness by Age, Sex, and Race Using Spectral Domain Optical Coherence Tomography

      Analysis of Normal Retinal Nerve Fiber Layer Thickness by Age, Sex, and Race Using Spectral Domain Optical Coherence Tomography
      Purpose: To determine the effects of age, sex, and race on the retinal nerve fiber layer (RNFL) in the normal human eye as measured by the spectral domain optical coherence tomography (SD-OCT) Spectralis machine (Heidelberg Engineering). Methods: Peripapillary SD-OCT RNFL thickness measurements were determined in normal subjects seen at a university-based clinic. One randomly selected eye per subject was used for analysis in this cross-sectional study. Multiple regression analysis was ...
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    6. The OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment

      The OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment
      Background Retinal optical coherence tomography (OCT) is an imaging biomarker for neurodegeneration in multiple sclerosis (MS). In order to become validated as an outcome measure in multicenter studies, reliable quality control (QC) criteria with high inter-rater agreement are required. Methods/Principal Findings A prospective multicentre study on developing consensus QC criteria for retinal OCT in MS: (1) a literature review on OCT QC criteria; (2) application of these QC criteria ...
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    7. Impact of scanning density on spectral domain optical coherence tomography assessments in neovascular age-related macular degeneration

      Impact of scanning density on spectral domain optical coherence tomography assessments in neovascular age-related macular degeneration
      Purpose:  To determine the effect of optical coherence tomography (OCT) B-scan density on the qualitative assessment of neovascular age-related macular degeneration (AMD). Methods:  Data were collected from 59 patients imaged with Topcon 3D OCT-1000 (128 B-scans × 512 A-scans). Custom software was used to generate less dense subsets of scans: 1/16 (eight B-scans), 1/8 (16 B-scans), 1/4 (32 B-scans) and 1/2 (64 B-scans). At each B-scan density ...
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    8. The Physiological Variation of the Retinal Nerve Fiber Layer Thickness and Macular Volume in Humans as Assessed by Spectral Domain–Optical Coherence Tomography

      The Physiological Variation of the Retinal Nerve Fiber Layer Thickness and Macular Volume in Humans as Assessed by Spectral Domain–Optical Coherence Tomography
      Purpose. With the introduction of spectral domain–optical coherence tomography (SD-OCT), changes in retinal nerve fiber layer (RNFL) thickness and macular volume (MV) can be detected with high precision. The aim of this study was to determine whether there is a physiological quantifiable degree of variation of these structures in humans. Methods. This study took place during a 10-km charity run at VU University Medical Center Amsterdam. Weight, height, hydration ...
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    9. Advances in Imaging to Support the Development of Novel Therapies for Multiple Sclerosis

      Advances in Imaging to Support the Development of Novel Therapies for Multiple Sclerosis
      Multiple sclerosis (MS) is a common neurological disease in North America and Europe. Although most patients develop major locomotor disability over the course of 15–20 years, in approximately one-third of patients the long-term course is favorable, with minimal disability. Although current disease-modifying treatments reduce the relapse rate, their long-term effects are uncertain. MS treatment trials are challenging because of the variable clinical course and typically slow evolution of the ...
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    10. High Resolution Optical Imaging of Barrett's Esophagus Using Nvision Volumetric Laser Endomicroscopy (VLE)

      High Resolution Optical Imaging of Barrett's Esophagus Using Nvision Volumetric Laser Endomicroscopy (VLE)
      ... Investigator: Herbert C Wolfsen, MD Mayo Clinic, Jacksonville, FL Principal Investigator: Laurence Lovat, MD University College London, United Kingdom Principal Investigator: Emmanuel Coron, MD, PhD University Hospital,...
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    11. NinePoint Medical Initiates Clinical Trial of Nvision VLE Imaging System; Program On Track for Commercial Launch in 2013

      NinePoint Medical Initiates Clinical Trial of Nvision VLE Imaging System; Program On Track for Commercial Launch in 2013
      ...Rochester, Minn.; Kansas University Medical Center in Kansas City, Mo.; Academic Medical Center in Amsterdam; University College London; and University Hospital in Nantes, France. In January, NinePoint Medical announce...
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    12. Feature Of The Week 2/5/12: Queen Mary University of London Researchers Investigate Quantitative Analysis of OCT and Histopathology Images of Normal and Dysplastic Oral Mucosal Tissues

      Feature Of The Week 2/5/12: Queen Mary University of London Researchers Investigate Quantitative Analysis of OCT and Histopathology Images of Normal and Dysplastic Oral Mucosal Tissues
      Selecting the most representative site for biopsy is crucial in establishing a definitive diagnosis of oral epithelial dysplasia. The current process involves clinical examination that can be subjective and prone to sampling errors. The aim of this study was therefore to investigate the use of optical coherence tomography (OCT) for differentiation of normal and dysplastic oral epithelial samples, with a view to developing an objective and reproducible approach for biopsy ...
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    13. NinePoint Medical Announces Formation of Clinical and Technology Advisory Boards

      NinePoint Medical Announces Formation of Clinical and Technology Advisory Boards
      ...ultant gastroenterologist at University College Hospital and reader in gastroenterology and laser medicine at University College London. Dr. Lovat's research focuses on optical techniques for diagnosing and treating pre-...
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    14. Assessment of Differential Pharmacodynamic Effects using Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration

      Assessment of Differential Pharmacodynamic Effects using Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration
      Purpose: To assess the differential pharmacodynamic effects of bevacizumab (Avastin), pegaptanib (Macugen), and verteporfin photodynamic therapy (PDT), using novel OCT parameters, in a recently completed phase III/IV clinical trial. Methods: Data from 122 patients participating in the Avastin (Bevacizumab) for Choroidal neovascularization (ABC) trial, were evaluated. Stratus OCT images were analyzed using custom software - changes in volume of the neurosensory retina, subretinal fluid (SRF), pigment epithelium detachment (PED), and ...
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    15. The physiological variation of the retinal nerve fibre layer thickness and macular volume in humans as assessed by spectral-domain optical coherence tomography

      The physiological variation of the retinal nerve fibre layer thickness and macular volume in humans as assessed by spectral-domain optical coherence tomography
      Purpose With the introduction of spectral domain optical coherence tomography (SD-OCT), changes in the retinal nerve fibre layer (RNFL) thickness and macular volume (MV) can be detected with a high precision. This study aimed to determine whether there is a physiological quantifiable degree of variation of these structures in humans. Methods This study took place during a 10 km charity run at VU University Amsterdam. Weight, height, hydration status, RNFL ...
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  2. About University College London

    University College London

    University College London is the oldest multi-faculty constituent college of the University of London and is one of the two original founding colleges. With 21,800 staff and students, UCL is one of the largest colleges of the University and is larger than most other universities in the United Kingdom. The Department of Medical Physics and Bioengineering has been for many years a joint department of University College London (UCL) and the UCL Hospitals Trust (UCLH).