1. University College London

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    1. Mentioned In 217 Articles

    2. Objective evaluation of proliferative diabetic retinopathy using optical coherence tomography

      Objective evaluation of proliferative diabetic retinopathy using optical coherence tomography
      Purpose To present the routine use of optical coherence tomography (OCT) and OCT angiography (OCTA) for the objective diagnosis and monitoring of proliferative diabetic retinopathy (PDR). Design Retrospective observational case series. Subjects Patients with diabetic retinopathy imaged using a standardized PDR-protocol Methods Patients routinely imaged with a standardized PDR-protocol between March 2017 and January 2019 were included. This included a 12x9 mm structural OCT volume centered on the macula and ...
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    3. Epithelial tissue thickness improves optical coherence tomography’s ability in detecting oral cancer

      Epithelial tissue thickness improves optical coherence tomography’s ability in detecting oral cancer
      Background OCT is a non-invasive imaging technique that enables the measurement of epithelial thickness and architectural changes, which can help in the diagnosis of pre-cancerous and cancerous lesions. The purpose of the study was to assess whether epithelial tissue thickness improves optical coherence tomographys ability in detecting oral cancer. Patients and Methods Surgically resected oral margins from 60 patients diagnosed with oral squamous cell carcinoma were subjected to OCT. Three ...
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    4. OCT Angiography in Acute Posterior Multifocal Placoid Pigment Epitheliopathy

      OCT Angiography in Acute Posterior Multifocal Placoid Pigment Epitheliopathy
      BACKGROUND AND OBJECTIVE: To describe retinal and choroidal findings in different stages of acute posterior multifocal placoid pigment epitheliopathy (APMPPE). PATIENTS AND METHODS: Retrospective, noncomparative case series studied by fundus biomicroscopy, fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography (ICGA), spectral-domain optical coherence tomographic (SD-OCT), and swept-source OCT angiography (SS-OCTA). RESULTS: Six eyes of three patients with bilateral APMPPE were included. FAF showed multifocal, branched patches of hyperautofluorescence with ...
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    5. OCT in the diagnosis of head and neck pre-cancerous and cancerous cutaneous lesions: An immediate ex vivo study

      OCT in the diagnosis of head and neck pre-cancerous and cancerous cutaneous lesions: An immediate ex vivo study
      Background Optical coherence tomography (OCT) has been shown to reliably identify skin changes with the combined advantage of resolution and penetration depth. The objective of this study was to assess the accuracy of OCT in diagnosing various skin pathologies, using pre-set diagnostic criteria, by two reviewers blinded to the actual diagnosis. Material and methods This immediate ex-vivo study included skin specimens from 103 patients with suspicious skin lesions. In total ...
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    6. Characterisation of microvascular abnormalities using OCT angiography in patients with biallelic variants in USH2A and MYO7A

      Characterisation of microvascular abnormalities using OCT angiography in patients with biallelic variants in USH2A and MYO7A
      Aims Using optical coherence tomography angiography (OCTA) to characterise microvascular changes in the retinal plexuses and choriocapillaris (CC) of patients with MYO7A and USH2A mutations and correlate with genotype, retinal structure and function. Methods Twenty-seven patients with molecularly confirmed USH2A (n=21) and MYO7A (n=6) mutations underwent macular 66 mm OCTA using the AngioVue. Heidelberg spectral-domain OCT scans and MAIA microperimetry were also performed, the preserved ellipsoid zone (EZ ...
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    7. Anterior segment optical coherence tomographic angiography assessment of acute chemical injury

      Anterior segment optical coherence tomographic angiography assessment of acute chemical injury
      Purpose To compare routine clinical examination with optical coherence tomography angiography (OCTA) for the assessment of limbal conjunctival ischemia following a chemical burn. Setting Validity analysis Methods We assessed ten participants (15 eyes) with an acute chemical injury. Clinical photographs were used to determine the extent of any limbal conjunctival epithelial defect and ischemia. These were compared with the extent of limbal ischemia identified on OCTA images of the ocular ...
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    8. Early Phase Disease Modification Trials with Selisistat and Optical Coherence Tomography as a Biomarker in Huntington’s Disease (Thesis)

      Early Phase Disease Modification Trials with Selisistat and Optical Coherence Tomography as a Biomarker in Huntington’s Disease (Thesis)
      Huntingtons disease (HD) is a monogenic neurodegenerative disorder with no known cure. Selisistat is a novel, highly potent Sirt1 inhibitor with supportive pre-clinical data. Facilitation of autophagy and amelioration of transcriptional dysregulation are proposed as mechanisms of action. A first in disease Phase 1B study showed safety and tolerability. The peripheral immune dysfunction in HD could be modulated by Sirtuins which have both pro and anti-inflammatory activities. However selisistat did ...
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    9. Meibography and corneal volume optical coherence tomography to quantify damage to ocular structures in children with blepharokeratoconjunctivitis

      Meibography and corneal volume optical coherence tomography to quantify damage to ocular structures in children with blepharokeratoconjunctivitis
      Our particular thanks go to the children who took part in this study and their families, who gave their time to help other children in the future. The research was funded by Moorfields Eye Charity (ST 15 07 J) and supported by the National Institute for Health Research (NIHR) Moorfields Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR ...
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    10. Prediction of Causative Genes in Inherited Retinal Disorders from Spectral-Domain Optical Coherence Tomography Utilizing Deep Learning Techniques

      Prediction of Causative Genes in Inherited Retinal Disorders from Spectral-Domain Optical Coherence Tomography Utilizing Deep Learning Techniques
      Purpose . To illustrate a data-driven deep learning approach to predicting the gene responsible for the inherited retinal disorder (IRD) in macular dystrophy caused by ABCA4 and RP1L1 gene aberration in comparison with retinitis pigmentosa caused by EYS gene aberration and normal subjects. Methods . Seventy-five subjects with IRD or no ocular diseases have been ascertained from the database of Japan Eye Genetics Consortium; 10 ABCA4 retinopathy, 20 RP1L1 retinopathy, 28 EYS ...
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    11. Impact of segmentation density on spectral domain optical coherence tomography assessment in Stargardt disease

      Impact of segmentation density on spectral domain optical coherence tomography assessment in Stargardt disease
      Purpose Automated spectral domain optical coherence tomography (SD-OCT) segmentation algorithms currently do not perform well in segmenting individual intraretinal layers in eyes with Stargardt disease (STGD). We compared selective B-scan segmentation strategies for generating mean retinal layer thickness and preserved area data from SD-OCT scans in patients with STGD1. Methods Forty-five eyes from 40 Stargardt patients were randomly selected from the ongoing Natural History of the Progression of Atrophy Secondary ...
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    12. Optical coherence tomography substudy of a prospective multicentre randomised post-market trial to assess the safety and effectiveness of the Firehawk cobalt-chromium coronary stent (rapamycin target-eluting) system for the treatment of atherosclerotic le

      Optical coherence tomography substudy of a prospective multicentre randomised post-market trial to assess the safety and effectiveness of the Firehawk cobalt-chromium coronary stent (rapamycin target-eluting) system for the treatment of atherosclerotic le
      Aims: Durable polymer drug-eluting stents (DP-DES) may contribute to persistent inflammation, delayed endothelial healing and subsequent late DES thrombosis. The aim of this optical coherence tomography (OCT) substudy was to compare healing and neointimal coverage of a novel bioabsorbable polymer sirolimus-eluting stent (Firehawk ) (BP-DES) versus the DP-DES (XIENCE) at 90 days in an all-comers patient population. Methods and results: The TARGET All Comers study is a prospective multicentre randomised post-market ...
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    13. The International Multiple Sclerosis Visual System Consortium: Advancing Visual System Research in Multiple Sclerosis

      The International Multiple Sclerosis Visual System Consortium: Advancing Visual System Research in Multiple Sclerosis
      ...ork University School of Medicine, New York University, New York, New York; and Department of Neurology (AP), University College London, the National Hospital for Neurology and Neurosurgery, Moorfields Eye Hospital, Lond...
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    14. A flow cytometric and optical coherence analysis of the role of microparticles as determinants of plaque instability in acute coronary syndrome (FOAM study) (Thesis)

      A flow cytometric and optical coherence analysis of the role of microparticles as determinants of plaque instability in acute coronary syndrome (FOAM study) (Thesis)
      Introduction: Microparticles (MPs) are implicated in the pathogenesis of coronary artery disease (CAD). / Aims: To determine whether circulating MPs correlate with high-risk coronary atherosclerotic plaque phenotype. / Methods: 25 patients with CAD undergoing percutaneous coronary intervention (PCI) were recruited; 13 were diagnosed to have acute coronary syndrome (ACS) 12 with stable angina (SA). We characterized and compared coronary atherosclerotic plaque burden and vulnerable plaque phenotype by three-vessel optical coherence tomography (OCT ...
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  2. About University College London

    University College London

    University College London is the oldest multi-faculty constituent college of the University of London and is one of the two original founding colleges. With 21,800 staff and students, UCL is one of the largest colleges of the University and is larger than most other universities in the United Kingdom. The Department of Medical Physics and Bioengineering has been for many years a joint department of University College London (UCL) and the UCL Hospitals Trust (UCLH).