1. University College London

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    1. Mentioned In 172 Articles

    2. Secondary glaucoma in uveitis: comparison of the optic nerve head morphology among a nonmydriatic fundus camera, HRT, and SD-OCT

      Secondary glaucoma in uveitis: comparison of the optic nerve head morphology among a nonmydriatic fundus camera, HRT, and SD-OCT
      To assess the correlation between the disc damage likelihood scale (DDLS) objectively measured by a nonmydriatic fundus camera, confocal laser scanning ophthalmoscopy (HRT3), and spectral-domain optical coherence tomography (SD-OCT) in uveitic glaucoma. A total of 59 patients with uveitic glaucoma (21 female, 38 male; mean age 56.8 18.7 years) were included in this prospective cross-sectional study. All patients were measured by the Kowa Nonmyd WX 3D camera (2D ...
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    3. The Optic Disc Drusen Studies Consortium Recommendations for Diagnosis of Optic Disc Drusen Using Optical Coherence Tomography

      The Optic Disc Drusen Studies Consortium Recommendations for Diagnosis of Optic Disc Drusen Using Optical Coherence Tomography
      Background: Making an accurate diagnosis of optic disc drusen (ODD) is important as part of the work-up for possible life-threatening optic disc edema. It also is important to follow the slowly progressive visual field defects many patients with ODD experience. The introduction of enhanced depth imaging optical coherence tomography (EDI-OCT) has improved the visualization of more deeply buried ODD. There is, however, no consensus regarding the diagnosis of ODD using ...
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    4. Diagnostic accuracy of optical coherence tomography for diagnosing glaucoma: secondary analyses of the GATE study

      Diagnostic accuracy of optical coherence tomography for diagnosing glaucoma: secondary analyses of the GATE study
      Background/Aims To assess the diagnostic performance of retinal nerve fibre layer (RNFL) data of optical coherence tomography (OCT) for detecting glaucoma. Methods Secondary analyses of a prospective, multicentre diagnostic study (Glaucoma Automated Tests Evaluation (GATE)) referred to hospital eye services in the UK were conducted. We included data from 899 of 966 participants referred to hospital eye services with suspected glaucoma or ocular hypertension. We used both eyes data ...
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    5. Optical coherence tomography angiography of foveal hypoplasia

      Optical coherence tomography angiography of foveal hypoplasia
      Aims To discuss foveal development in the context of detailed retinal vasculature imaging in foveal hypoplasia using optical coherence tomography angiography. Methods In this case series, the optical coherence tomography angiography results of four patients with idiopathic foveal hypoplasia and two patients with foveal hypoplasia secondary to oculocutaneous albinism are presented. Results Cases with intact visual acuity demonstrated lower grades of foveal hypoplasia on optical coherence tomography, while those with ...
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    6. An overview of the clinical applications of optical coherence tomography angiography

      An overview of the clinical applications of optical coherence tomography angiography
      Optical coherence tomography angiography (OCTA) has emerged as a novel, non-invasive imaging modality that allows the detailed study of flow within the vascular structures of the eye. Compared to conventional dye angiography, OCTA can produce more detailed, higher resolution images of the vasculature without the added risk of dye injection. In our review, we discuss the advantages and disadvantages of this new technology in comparison to conventional dye angiography. We ...
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    7. Diagnostic accuracy of optical coherence tomography Inter-Eye Percentage Difference (IEPD) for optic neuritis in multiple sclerosis - Coric - 2017 - European Journal of Neurology - Wiley Online Library

      Diagnostic accuracy of optical coherence tomography Inter-Eye Percentage Difference (IEPD) for optic neuritis in multiple sclerosis - Coric - 2017 - European Journal of Neurology - Wiley Online Library
      Background Multiple sclerosis (MS) associated optic neuritis (MSON) causes atrophy of the inner retinal layers, which can be quantified by optical coherence tomography (OCT). It has been suggested that the Inter-Eye Percentage Difference (IEPD) of atrophy may be of diagnostic value in MSON. Methods Prospective, cross-sectional study in MS patients and healthy controls (HC). Spectral-domain OCT of both eyes was performed, followed by automated retinal layer segmentation of the peripapillary ...
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    8. Human Factor and Usability Testing of a Binocular Optical Coherence Tomography System

      Human Factor and Usability Testing of a Binocular Optical Coherence Tomography System
      Purpose : To perform usability testing of a binocular optical coherence tomography (OCT) prototype to predict its function in a clinical setting, and to identify any potential user errors, especially in an elderly and visually impaired population. Methods : Forty-five participants with chronic eye disease (mean age 62.7 years) and 15 healthy controls (mean age 53 years) underwent automated eye examination using the prototype. Examination included whole-eye' OCT, ocular motility, visual ...
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    9. Feature Of The Week 05/28/2017: In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements

      Feature Of The Week 05/28/2017: In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements
      Glaucoma is characterized by an irreversible damage of retinal ganglion cells within the optic nerve head (ONH) at the back of the eye. Currently we know that elevated intraocular pressure (IOP) is associated with increased prevalence of glaucoma but not all glaucoma patients have an elevated IOP. The biomechanical theory of glaucoma hypothesizes that elevated (or fluctuating) IOP deforms the ONH tissues, including the lamina cribrosa (LC), and that these ...
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    10. Quantitative Analysis of Retinal Structure using Spectral Domain Optical Coherence Tomography in RPGR-associated Retinopathy

      Quantitative Analysis of Retinal Structure using Spectral Domain Optical Coherence Tomography in RPGR-associated Retinopathy
      Purpose Quantification of retinal structure and progression using spectral-domain optical coherence tomography (SDOCT) in patients with retinitis pigmentosa (RP) associated with retinitis pigmentosa GTPase regulator gene ( RPGR ) mutations Design Retrospective observational case series Methods Setting: Moorfields Eye Hospital, London, United Kingdom. Subjects: Both eyes of 32 patients. SDOCT follow-up period of 1 year (3.11.4 years). Outcome measures: Ellipsoid zone (EZ) width (EZW), outer nuclear layer (ONL) and inner ...
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    11. Visualization of extensive intraplaque neovascularization by optical coherence tomography

      Visualization of extensive intraplaque neovascularization by optical coherence tomography
      Inflammation plays a key role in pathogenesis and progression of atherosclerosis (1) . Advent of novel intravascular imaging tools such as Optical Coherence Tomography (OCT) has led to visualization of coronary atherosclerotic plaque characteristics in vivo that were previously seen only on histology. Herein we discuss a case of extensive neovascularization, a feature that imparts vulnerability to atherosclerotic plaque in the coronary artery, as seen by two- and three-dimensional OCT images ...
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    12. Intracoronary optical coherence tomography: Clinical and research applications and intravascular imaging software overview

      Intracoronary optical coherence tomography: Clinical and research applications and intravascular imaging software overview
      By providing valuable information about the coronary artery wall and lumen, intravascular imaging may aid in optimizing interventional procedure results and thereby could improve clinical outcomes following percutaneous coronary intervention (PCI). Intravascular optical coherence tomography (OCT) is a light-based technology with a tissue penetration of approximately 1 to 3 mm and provides near histological resolution. It has emerged as a technological breakthrough in intravascular imaging with multiple clinical and research ...
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    13. Spectral Domain Optical Coherence Tomography: An In Vivo Imaging Protocol for Assessing Retinal Morphology in Adult Zebrafish

      Spectral Domain Optical Coherence Tomography: An In Vivo Imaging Protocol for Assessing Retinal Morphology in Adult Zebrafish
      The present study outlines a protocol for examining retinal structure in zebrafish, a popular model organism for ocular studies, using spectral domain optical coherence tomography (SD-OCT). We demonstrate how this live imaging modality can be used to obtain high quality images of several retinal features, including the optic nerve, retinal vasculature, and the cone photoreceptor mosaic. Retinal histology sections were obtained from imaged fish for comparison with SD-OCT cross-sectional B-scans ...
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    14. Optical coherence tomography angiography of foveal hypoplasia

      Optical coherence tomography angiography of foveal hypoplasia
      Aims To discuss foveal development in the context of detailed retinal vasculature imaging in foveal hypoplasia using optical coherence tomography angiography. Methods In this case series, the optical coherence tomography angiography results of four patients with idiopathic foveal hypoplasia and two patients with foveal hypoplasia secondary to oculocutaneous albinism are presented. Results Cases with intact visual acuity demonstrated lower grades of foveal hypoplasia on optical coherence tomography, while those with ...
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    15. Three-dimensional full wave model of image formation in optical coherence tomography

      Three-dimensional full wave model of image formation in optical coherence tomography
      We demonstrate, what we believe to be, the first mathematical model of image formation in optical coherence tomography, based on Maxwells equations, applicable to general three-dimensional samples. It is highly realistic and represents a significant advance on a previously developed model, which was applicable to two-dimensional samples only. The model employs an electromagnetic description of light, made possible by using the pseudospectral time-domain method for calculating the light scattered by ...
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  2. About University College London

    University College London

    University College London is the oldest multi-faculty constituent college of the University of London and is one of the two original founding colleges. With 21,800 staff and students, UCL is one of the largest colleges of the University and is larger than most other universities in the United Kingdom. The Department of Medical Physics and Bioengineering has been for many years a joint department of University College London (UCL) and the UCL Hospitals Trust (UCLH).