1. University College London

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    1. Mentioned In 296 Articles

    2. The Role of OCT Criteria and Machine Learning in Multiple Sclerosis and Optic Neuritis Diagnosis

      The Role of OCT Criteria and Machine Learning in Multiple Sclerosis and Optic Neuritis Diagnosis
      Background and objectives: Recent studies have suggested that inter-eye differences (IEDs) in peripapillary retinal nerve fiber layer (pRNFL) or ganglion cell+inner plexiform (GCIPL) thickness by spectral-domain optical coherence tomography (SD-OCT) may identify people with a history of unilateral optic neuritis (ON). However, this requires further validation. Machine learning classification may be useful for validating thresholds for OCT IEDs and for examining added utility for visual function tests, such as ...
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    3. Deep Learning to Detect OCT-derived Diabetic Macular Edema from Color Retinal Photographs

      Deep Learning to Detect OCT-derived Diabetic Macular Edema from Color Retinal Photographs
      Purpose To validate the generalizability of a deep learning system (DLS) that detects diabetic macular edema (DME) from 2-dimensional color fundus photographs (CFP), for which the reference standard for retinal thickness and fluid presence is derived from 3-dimensional OCT. Design Retrospective validation of a DLS across international datasets. Participants Paired CFP and OCT of patients from diabetic retinopathy (DR) screening programs or retina clinics. The DLS was developed using data ...
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    4. Neuroimaging and cognitive correlates of retinal Optical Coherence Tomography (OCT) measures at late middle age in a twin sample

      Neuroimaging and cognitive correlates of retinal Optical Coherence Tomography (OCT) measures at late middle age in a twin sample
      Sharing in embryology and function between the eye and brain has led to interest in whether assessments of the eye reflect brain changes seen in neurodegeneration. We aimed to examine the associations between measures of retinal layer thickness using optical coherence tomography (OCT) and multimodal measures of brain structure and function. Using a convenient sample of twins discordant for type 2 diabetes, we performed cognitive testing, structural brain MRI (tissue ...
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    5. Correlation of Optical Coherence Tomography Angiography Characteristics with Visual Function to Define Vision-Threatening Diabetic Macular Ischemia

      Correlation of Optical Coherence Tomography Angiography Characteristics with Visual Function to Define Vision-Threatening Diabetic Macular Ischemia
      The thresholds of macular microvasculature parameters associated with mild visual impairment in diabetic macular ischemia (DMI) patients are unclear. Therefore, this prospective observational study is aimed at demonstrating the optical coherence tomography angiography parameters that best correlate with mild visual impairment (70 Early Treatment Diabetic Retinopathy Study (ETDRS) letters, Snellen equivalent 20/40) in DMI. The study was completed at the Moorfields Eye Hospital from December 2019 to August 2021 ...
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    6. Artificial Intelligence and Imaging Processing in Optical Coherence Tomography and Digital Images in Uveitis

      Artificial Intelligence and Imaging Processing in Optical Coherence Tomography and Digital Images in Uveitis
      Introduction: Computer vision, understood as the area of science that trains computers to interpret digital images through both artificial intelligence (AI) and classical algorithms, has significantly advanced the analysis and interpretation of optical coherence tomography (OCT) in retina research. The aim of this review is to summarise the recent advances of computer vision in imaging processing in uveitis, with a particular focus in optical coherence tomography images. Material and methods ...
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    7. Numerical calibration method for a multiple spectrometer-based OCT system

      Numerical calibration method for a multiple spectrometer-based OCT system
      The present paper introduces a numerical calibration method for the easy and practical implementation of multiple spectrometer-based spectral-domain optical coherence tomography (SD-OCT) systems. To address the limitations of the traditional hardware-based spectrometer alignment across more than one spectrometer, we applied a numerical spectral calibration algorithm where the pixels corresponding to the same wavelength in each unit are identified through spatial- and frequency-domain interferometric signatures of a mirror sample. The utility ...
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    8. Intravascular imaging assessment of pharmacotherapies targeting atherosclerosis: advantages and limitations in predicting their prognostic implications

      Intravascular imaging assessment of pharmacotherapies targeting atherosclerosis: advantages and limitations in predicting their prognostic implications
      Intravascular imaging has been often used over the recent years to examine the efficacy of emerging therapies targeting plaque evolution. Serial intravascular ultrasound, optical coherence tomography, or near infrared spectroscopy-intravascular ultrasound studies have allowed us to evaluate the effects of different therapies on plaque burden and morphology, providing unique mechanistic insights about the mode of action of these treatments. Plaque burden reduction, a decrease in necrotic core component or macrophages ...
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    9. Surgical biomicroscopy-guided intra-operative optical coherence tomography (iOCT) image super-resolution

      Surgical biomicroscopy-guided intra-operative optical coherence tomography (iOCT) image super-resolution
      Purpose: Intra-retinal delivery of novel sight-restoring therapies will require the precision of robotic systems accompanied by excellent visualisation of retinal layers. Intra-operative Optical Coherence Tomography (iOCT) provides cross-sectional retinal images in real time but at the cost of image quality that is insufficient for intra-retinal therapy delivery.This paper proposes a super-resolution methodology that improves iOCT image quality leveraging spatiotemporal consistency of incoming iOCT video streams. Methods: To overcome the ...
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    10. Quantitative and qualitative assessment of anterior segment optical coherence tomography capture of disease state in childhood anterior uveitis

      Quantitative and qualitative assessment of anterior segment optical coherence tomography capture of disease state in childhood anterior uveitis
      Background/aims: Anterior segment optical coherence tomography (AS-OCT) assessment of anterior chamber inflammation is an emerging tool. We describe the performance of AS-OCT in a paediatric population. Methods: A mixed-methods prospective study, using routine clinical assessment as reference standard, and AS-OCT, with Tomey CASIA2 or Heidelberg Spectralis HS1, as index test, with data collected on patient perceptions of imaging. Repeatability, diagnostic indices, responsiveness to clinical change and clinical correlations of ...
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    11. Identification of venular capillary remodelling: a possible link to the development of periodontitis?

      Identification of venular capillary remodelling: a possible link to the development of periodontitis?
      Purpose The present study measured changes in arteriolar and venular capillary flow and structure in the gingival tissues during the development of plaque-induced gingival inflammation by combining dynamic optical coherence tomography (OCT), laser perfusion, and capillaroscopic video imaging. Methods Gingival inflammation was induced in 21 healthy volunteers over a 3-week period. Gingival blood flow and capillary morphology were measured by dynamic OCT, laser perfusion imaging, and capillaroscopy, including a baseline ...
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    12. The utility of wide-field optical coherence tomography angiography in diagnosis and monitoring of proliferative diabetic retinopathy in pregnancy

      The utility of wide-field optical coherence tomography angiography in diagnosis and monitoring of proliferative diabetic retinopathy in pregnancy
      Diabetic retinopathy is an increasingly common complication of diabetes mellitus that benefits from early diagnosis and frequent monitoring, especially in pregnancy where there is a greater risk of progression. Fundus fluorescein angiography is currently the gold standard method of investigation for neovascularization. However, this has risks of unpleasant and potentially dangerous side effects, with an added theoretical risk to the fetus in pregnancy. Wide-field optical coherence tomography angiography (PLEX Elite ...
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    13. 4 year funded PhD studentship in Dental OCT at University College London

      4 year funded PhD studentship in Dental OCT at University College London
      Transforming Dental Imaging using Optical Coherence Tomography Primary Supervisor: Dr Peter Munro Clinical Supervisor : Prof Francesco D'Aiuto A 4 year PhD studentship funded by the Royal Society and Department of Medical Physics and Biomedical Engineering is available jointly in the UCL Department of Medical Physics and Biomedical Engineering and the UCL Eastman Dental Institute . Funding will be at least the UCL minimum (17,609). Ideally, the successful applicant would ...
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    14. Optical coherence tomography angiography findings in pigmented paravenous chorioretinal atrophy

      Optical coherence tomography angiography findings in pigmented paravenous chorioretinal atrophy
      Purpose: To analyze the retino-choroidal vascular characteristics of patients affected by pigmented paravenous chorio-retinal atrophy (PPCRA) by means of optical coherence tomography angiography (OCTA). Methods: The study was designed as an observational, cross-sectional case series. Multimodal imaging included fundus autofluorescence (FAF), structural optical coherence tomography (OCT) and OCT angiography (OCTA). The quantitative OCTA analyses included the calculation of the vessel density (VD) and choriocapillaris porosity. Results: Overall, 12 patients (24 ...
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    15. Deep learning to detect optical coherence tomography-derived diabetic macular edema from retinal photographs: a multicenter validation study

      Deep learning to detect optical coherence tomography-derived diabetic macular edema from retinal photographs: a multicenter validation study
      Purpose: To validate the generalizability of a deep learning system (DLS) that detects diabetic macular edema (DME) from two-dimensional color fundus photography (CFP), where the reference standard for retinal thickness and fluid presence is derived from three-dimensional optical coherence tomography (OCT). Design: Retrospective validation of a DLS across international datasets. Participants: Paired CFP and OCT of patients from diabetic retinopathy (DR) screening programs or retina clinics. The DLS was developed ...
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  2. About University College London

    University College London

    University College London is the oldest multi-faculty constituent college of the University of London and is one of the two original founding colleges. With 21,800 staff and students, UCL is one of the largest colleges of the University and is larger than most other universities in the United Kingdom. The Department of Medical Physics and Bioengineering has been for many years a joint department of University College London (UCL) and the UCL Hospitals Trust (UCLH).