1. University College London

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    1. Mentioned In 251 Articles

    2. Association of ambient air pollution with age-related macular degeneration and retinal thickness in UK Biobank

      Association of ambient air pollution with age-related macular degeneration and retinal thickness in UK Biobank
      Aim To examine the associations of air pollution with both self-reported age-related macular degeneration (AMD), and in vivo measures of retinal sublayer thicknesses. Methods We included 115954 UK Biobank participants aged 4069 years old in this cross-sectional study. Ambient air pollution measures included particulate matter, nitrogen dioxide (NO 2 ) and nitrogen oxides (NO x ). Participants with self-reported ocular conditions, high refractive error ( 6 or +6 diopters) and poor spectral-domain optical ...
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    3. Optical Coherence Tomography Angiography (OCTA) in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

      Optical Coherence Tomography Angiography (OCTA) in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder
      Vascular changes are increasingly recognized as important factors in the pathophysiology of neuroinflammatory disease, especially in multiple sclerosis (MS). The relatively novel technology of optical coherence tomography angiography (OCTA) images the retinal and choroidal vasculature non-invasively and in a depth-resolved manner. OCTA provides an alternative quantitative measure of retinal damage, by measuring vascular density instead of structural atrophy. Preliminary results suggest OCTA is sensitive to retinal damage in early disease ...
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    4. AI-supported test predicts eye disease three years before symptoms

      AI-supported test predicts eye disease three years before symptoms
      A pioneering new eye test, developed by scientists at UCL in collaboration with the Western Eye Hospital, London, may predict wet AMD, a leading cause of severe sight loss, three years before symptoms develop. Researchers hope their test could be used to identify the disease early enough so that treatment can effectively prevent any vision loss. The findings of the study, funded by Wellcome, are published today in Expert Review ...
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    5. Phenotyping of retinal neovascularization in ischemic retinal vein occlusion using wide field OCT angiography

      Phenotyping of retinal neovascularization in ischemic retinal vein occlusion using wide field OCT angiography
      Background/objectives Abnormal retinal neovascularization caused by ischemic retinal vein occlusion (RVO) is a frequent cause of visually significant vitreous hemorrhage. The early detection of new vessels may be challenging and often requires the use of invasive tests such as fundus fluorescein angiography (FA). We demonstrate the use of wide-field optical coherence tomography angiography (WF-OCTA) in the detection and characterization of neovascularization secondary to ischemic RVO. Subjects/methods We conducted ...
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    6. Hyper-reflectivity on optical coherence tomography in macular telangiectasia type 2

      Hyper-reflectivity on optical coherence tomography in macular telangiectasia type 2
      Purpose: To define, characterize and classify hyper-reflectivity on optical coherence tomography (OCT) and report its prevalence in macular telangiectasia type 2 (MacTel). Methods: In a primary cross-sectional analysis, multimodal imaging data were retrospectively analyzed. The definition of hyper-reflectivity and neovascularization on OCT followed OCT-angiography-based criteria. Eyes were graded for the presence of hyper-reflectivity and neovascularization and further categorized into three classes based on position and extent of hyper-reflectivity. In a ...
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    7. Optical coherence tomography (OCT) in neuro-ophthalmology

      Optical coherence tomography (OCT) in neuro-ophthalmology
      Optical coherence tomography (OCT) is a non-invasive medical imaging technology that is playing an increasing role in the routine assessment and management of patients with neuro-ophthalmic conditions. Its ability to characterise the optic nerve head, peripapillary retinal nerve fibre layer and cellular layers of the macula including the ganglion cell layer enables qualitative and quantitative assessment of optic nerve disease. In this review, we discuss technical features of OCT and ...
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    8. Optical coherence tomography in the 2020s—outside the eye clinic

      Optical coherence tomography in the 2020s—outside the eye clinic
      Optical coherence tomography (OCT) is a paragon of success in the translation of biophotonics science to clinical practice. OCT systems have become ubiquitous in eye clinics but access beyond this is limited by their cost, size and the skill required to operate the devices. Remarkable progress has been made in the development of OCT technology to improve the speed of acquisition, the quality of images and into functional extensions of ...
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    9. Investigation of the efficacy of an online tool for improving the diagnosis of macular lesions imaged by optical coherence tomography

      Investigation of the efficacy of an online tool for improving the diagnosis of macular lesions imaged by optical coherence tomography
      Purpose: Optical coherence tomography (OCT) is a non-invasive method for diagnosis and monitoring of retinal (typically, macular) conditions. The unfamiliar nature of OCT images can present considerable challenges for some community optometrists. The purpose of this research is to develop and assess the efficacy of a novel internet resource designed to assist optometrists in using OCT for diagnosis of macular disease and patient management. Methods: An online tool (OCTAID) has ...
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    10. Artificial Intelligence Algorithms to Diagnose Glaucoma and Detect Glaucoma Progression: Translation to Clinical Practice

      Artificial Intelligence Algorithms to Diagnose Glaucoma and Detect Glaucoma Progression: Translation to Clinical Practice
      Purpose : This concise review aims to explore the potential for the clinical implementation of artificial intelligence (AI) strategies for detecting glaucoma and monitoring glaucoma progression. Methods : Nonsystematic literature review using the search combinations Artificial Intelligence, Deep Learning, Machine Learning, Neural Networks, Bayesian Networks, Glaucoma Diagnosis, and Glaucoma Progression. Information on sensitivity and specificity regarding glaucoma diagnosis and progression analysis as well as methodological details were extracted. Results : Numerous AI strategies ...
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    11. Electrically pumped continuous-wave O-band quantum-dot superluminescent diode on silicon

      Electrically pumped continuous-wave O-band quantum-dot superluminescent diode on silicon
      High-power, broadband quantum-dot (QD) superluminescent diodes (SLDs) are ideal light sources for optical coherence tomography (OCT) imaging systems but have previously mainly been fabricated on native GaAs- or InP-based substrates. Recently, significant progress has been made to emigrate QD SLDs from native substrates to silicon substrates. Here, we demonstrate electrically pumped continuous-wave InAs QD SLDs monolithically grown on silicon substrates with significantly improved performance thanks to the achievement of a ...
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    12. Deep iterative vessel segmentation in OCT angiography

      Deep iterative vessel segmentation in OCT angiography
      This paper addresses retinal vessel segmentation on optical coherence tomography angiography (OCT-A) images of the human retina. Our approach is motivated by the need for high precision image-guided delivery of regenerative therapies in vitreo-retinal surgery. OCT-A visualizes macular vasculature, the main landmark of the surgically targeted area, at a level of detail and spatial extent unattainable by other imaging modalities. Thus, automatic extraction of detailed vessel maps can ultimately inform ...
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    13. The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons

      The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons
      Chronic kidney disease (CKD) is common, with hypertension and diabetes mellitus acting as major risk factors for its development. Cardiovascular disease is the leading cause of death worldwide and the most frequent end point of CKD. There is an urgent need for more precise methods to identify patients at risk of CKD and cardiovascular disease. Alterations in microvascular structure and function contribute to the development of hypertension, diabetes, CKD, and ...
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    14. Quantifying the Separation Between the Retinal Pigment Epithelium and Bruch's Membrane using Optical Coherence Tomography in Patients with Inherited Macular Degeneration

      Quantifying the Separation Between the Retinal Pigment Epithelium and Bruch's Membrane using Optical Coherence Tomography in Patients with Inherited Macular Degeneration
      Purpose : To describe and quantify Bruch's membrane (BM) and retinal pigment epithelium (RPE) separation using spectral-domain (SD) optical coherence tomography (OCT) in patients affected by inherited macular degenerations associated with BM thickening. Methods : Patients with molecularly confirmed Sorsby fundus dystrophy (SFD), dominant drusen (DD), and late-onset retinal degeneration (L-ORD) were included in this retrospective study. Each disease was classed as early stage if subjects were asymptomatic, intermediate stage if ...
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    15. 1-15 of 251 1 2 3 4 ... 15 16 17 »
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  2. About University College London

    University College London

    University College London is the oldest multi-faculty constituent college of the University of London and is one of the two original founding colleges. With 21,800 staff and students, UCL is one of the largest colleges of the University and is larger than most other universities in the United Kingdom. The Department of Medical Physics and Bioengineering has been for many years a joint department of University College London (UCL) and the UCL Hospitals Trust (UCLH).