1. University College London

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    1. Mentioned In 224 Articles

    2. Nailfold capillaroscopy with a commercially available optical coherence tomography angiography for ophthalmic use

      Nailfold capillaroscopy with a commercially available optical coherence tomography angiography for ophthalmic use
      Visualising capillaries in the retina and the nailfold provides an opportunity to improve our understanding of various systemic disorders including cardiovascular, metabolic, rheumatic, and eye diseases.15 Traditional nailfold capillaroscopy has been primarily utilised, during the last 40 years, to study the vascular components of connective tissue diseases.6,7 It has been established as a safe and noninvasive diagnostic tool that allows high magnification view of skin microcirculation as ...
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    3. Comparison of angle-to-angle distance using three devices in normal eyes

      Comparison of angle-to-angle distance using three devices in normal eyes
      Purpose To compare the angle-to-angle (ATA) distance, and the repeatability and the reproducibility of these measurements among the three devices. Methods We performed the ATA measurements in 26 healthy subjects using anterior segment optical coherence tomography (CASIA2, Tomey, Japan), the Scheimpflug camera (Pentacam HR, Oculus, Wetzlar, Germany), and the combined Placido-ring corneal topography and Scheimpflug camera (TMS-5, Tomey). We also compared the repeatability and the reproducibility of the ATA measurements ...
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    4. Pearse Keane Q&A: how open access AI is bringing ophthalmology into focus

      Pearse Keane Q&A: how open access AI is bringing ophthalmology into focus
      Since 2016, Moorfields Eye Hospital in London has been working with DeepMind, one of the worlds leading artificial intelligence companies. Through the partnership, researchers hope to use over one million anonymised retinal images to train artificial intelligence (AI) in the automated diagnosis of optical coherence tomography (OCT) images. OCT images are extremely complex and can take clinicians a long time to analyse, which can impact how quickly patients can receive ...
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    5. Precision Microfabrication of Optical Probes for Intravascular Diagnostics (Thesis)

      Precision Microfabrication of Optical Probes for Intravascular Diagnostics (Thesis)
      This thesis details a collection of design, optimisation, fabrication and characterisation work to form fiber-optic probes and optical phantom devices for intravascular diagnostics in minimally invasive surgery (MIS). Optically generated ultrasound is an emerging technique to create broadband high frequency ultrasound via the photoacoustic effect. In the first segment of this thesis, the development of a novel miniature fiber-optic ultrasound transmitter is detailed. A morphologically controlled coating was formed at ...
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    6. Objective evaluation of proliferative diabetic retinopathy using optical coherence tomography

      Objective evaluation of proliferative diabetic retinopathy using optical coherence tomography
      Purpose To present the routine use of optical coherence tomography (OCT) and OCT angiography (OCTA) for the objective diagnosis and monitoring of proliferative diabetic retinopathy (PDR). Design Retrospective observational case series. Subjects Patients with diabetic retinopathy imaged using a standardized PDR-protocol Methods Patients routinely imaged with a standardized PDR-protocol between March 2017 and January 2019 were included. This included a 12x9 mm structural OCT volume centered on the macula and ...
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    7. Epithelial tissue thickness improves optical coherence tomography’s ability in detecting oral cancer

      Epithelial tissue thickness improves optical coherence tomography’s ability in detecting oral cancer
      Background OCT is a non-invasive imaging technique that enables the measurement of epithelial thickness and architectural changes, which can help in the diagnosis of pre-cancerous and cancerous lesions. The purpose of the study was to assess whether epithelial tissue thickness improves optical coherence tomographys ability in detecting oral cancer. Patients and Methods Surgically resected oral margins from 60 patients diagnosed with oral squamous cell carcinoma were subjected to OCT. Three ...
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    8. Two-dimensional simulation of optical coherence tomography images

      Two-dimensional simulation of optical coherence tomography images
      An algorithm for the simulation of two-dimensional spectral domain optical coherence tomography images based on Maxwells equations is presented. A recently developed and modified time-harmonic numerical solution of Maxwells equations is used to obtain scattered far fields for many wave numbers contained in the calculated spectrum. The interferometer setup with its lenses is included rigorously with Fresnel integrals and the Debye-Wolf integral. The implemented model is validated with an existing ...
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    9. OCT Angiography in Acute Posterior Multifocal Placoid Pigment Epitheliopathy

      OCT Angiography in Acute Posterior Multifocal Placoid Pigment Epitheliopathy
      BACKGROUND AND OBJECTIVE: To describe retinal and choroidal findings in different stages of acute posterior multifocal placoid pigment epitheliopathy (APMPPE). PATIENTS AND METHODS: Retrospective, noncomparative case series studied by fundus biomicroscopy, fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography (ICGA), spectral-domain optical coherence tomographic (SD-OCT), and swept-source OCT angiography (SS-OCTA). RESULTS: Six eyes of three patients with bilateral APMPPE were included. FAF showed multifocal, branched patches of hyperautofluorescence with ...
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    10. OCT in the diagnosis of head and neck pre-cancerous and cancerous cutaneous lesions: An immediate ex vivo study

      OCT in the diagnosis of head and neck pre-cancerous and cancerous cutaneous lesions: An immediate ex vivo study
      Background Optical coherence tomography (OCT) has been shown to reliably identify skin changes with the combined advantage of resolution and penetration depth. The objective of this study was to assess the accuracy of OCT in diagnosing various skin pathologies, using pre-set diagnostic criteria, by two reviewers blinded to the actual diagnosis. Material and methods This immediate ex-vivo study included skin specimens from 103 patients with suspicious skin lesions. In total ...
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    11. Characterisation of microvascular abnormalities using OCT angiography in patients with biallelic variants in USH2A and MYO7A

      Characterisation of microvascular abnormalities using OCT angiography in patients with biallelic variants in USH2A and MYO7A
      Aims Using optical coherence tomography angiography (OCTA) to characterise microvascular changes in the retinal plexuses and choriocapillaris (CC) of patients with MYO7A and USH2A mutations and correlate with genotype, retinal structure and function. Methods Twenty-seven patients with molecularly confirmed USH2A (n=21) and MYO7A (n=6) mutations underwent macular 66 mm OCTA using the AngioVue. Heidelberg spectral-domain OCT scans and MAIA microperimetry were also performed, the preserved ellipsoid zone (EZ ...
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    12. Anterior segment optical coherence tomographic angiography assessment of acute chemical injury

      Anterior segment optical coherence tomographic angiography assessment of acute chemical injury
      Purpose To compare routine clinical examination with optical coherence tomography angiography (OCTA) for the assessment of limbal conjunctival ischemia following a chemical burn. Setting Validity analysis Methods We assessed ten participants (15 eyes) with an acute chemical injury. Clinical photographs were used to determine the extent of any limbal conjunctival epithelial defect and ischemia. These were compared with the extent of limbal ischemia identified on OCTA images of the ocular ...
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    13. Early Phase Disease Modification Trials with Selisistat and Optical Coherence Tomography as a Biomarker in Huntington’s Disease (Thesis)

      Early Phase Disease Modification Trials with Selisistat and Optical Coherence Tomography as a Biomarker in Huntington’s Disease (Thesis)
      Huntingtons disease (HD) is a monogenic neurodegenerative disorder with no known cure. Selisistat is a novel, highly potent Sirt1 inhibitor with supportive pre-clinical data. Facilitation of autophagy and amelioration of transcriptional dysregulation are proposed as mechanisms of action. A first in disease Phase 1B study showed safety and tolerability. The peripheral immune dysfunction in HD could be modulated by Sirtuins which have both pro and anti-inflammatory activities. However selisistat did ...
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  2. About University College London

    University College London

    University College London is the oldest multi-faculty constituent college of the University of London and is one of the two original founding colleges. With 21,800 staff and students, UCL is one of the largest colleges of the University and is larger than most other universities in the United Kingdom. The Department of Medical Physics and Bioengineering has been for many years a joint department of University College London (UCL) and the UCL Hospitals Trust (UCLH).