1. University College London

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    1. Mentioned In 160 Articles

    2. Spectral Domain Optical Coherence Tomography: An In Vivo Imaging Protocol for Assessing Retinal Morphology in Adult Zebrafish

      Spectral Domain Optical Coherence Tomography: An In Vivo Imaging Protocol for Assessing Retinal Morphology in Adult Zebrafish
      The present study outlines a protocol for examining retinal structure in zebrafish, a popular model organism for ocular studies, using spectral domain optical coherence tomography (SD-OCT). We demonstrate how this live imaging modality can be used to obtain high quality images of several retinal features, including the optic nerve, retinal vasculature, and the cone photoreceptor mosaic. Retinal histology sections were obtained from imaged fish for comparison with SD-OCT cross-sectional B-scans ...
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    3. Optical coherence tomography angiography of foveal hypoplasia

      Optical coherence tomography angiography of foveal hypoplasia
      Aims To discuss foveal development in the context of detailed retinal vasculature imaging in foveal hypoplasia using optical coherence tomography angiography. Methods In this case series, the optical coherence tomography angiography results of four patients with idiopathic foveal hypoplasia and two patients with foveal hypoplasia secondary to oculocutaneous albinism are presented. Results Cases with intact visual acuity demonstrated lower grades of foveal hypoplasia on optical coherence tomography, while those with ...
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    4. Three-dimensional full wave model of image formation in optical coherence tomography

      Three-dimensional full wave model of image formation in optical coherence tomography
      We demonstrate, what we believe to be, the first mathematical model of image formation in optical coherence tomography, based on Maxwells equations, applicable to general three-dimensional samples. It is highly realistic and represents a significant advance on a previously developed model, which was applicable to two-dimensional samples only. The model employs an electromagnetic description of light, made possible by using the pseudospectral time-domain method for calculating the light scattered by ...
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    5. Optical Coherence Tomography Angiography Findings in Dengue-Related Maculopathy: A Case Report

      Optical Coherence Tomography Angiography Findings in Dengue-Related Maculopathy: A Case Report
      The ophthalmic manifestations of dengue fever include a visually impairing maculopathy, where patients are left with a central or paracentral relative scotoma. The authors present a case of a 26-year-old female patient returning from Thailand with unilateral reduction in visual acuity and a central scotoma associated with dengue fever. The authors report the use of the optical coherence tomography angiography (OCTA) as a noninvasive imaging platform to demonstrate its value ...
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    6. Enhanced Depth Imaging Optical Coherence Tomography of Optic Nerve Head Drusen

      Enhanced Depth Imaging Optical Coherence Tomography of Optic Nerve Head Drusen
      Purpose Enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD OCT) has been recognized as the most sensitive tool to diagnose optic nerve head drusen (ONHD). The relationship between OCT characteristics and visual loss has not been well documented. This study compares EDI SD OCTdetermined morphologic characteristics of drusen in eyes with or without visual field (VF) defects. Design Descriptive study of patients attending the neuro-ophthalmology service of Moorfields Eye ...
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    7. Axial Alignment for Anterior Segment Swept Source Optical Coherence Tomography via Robust Low-Rank Tensor Recovery

      Axial Alignment for Anterior Segment Swept Source Optical Coherence Tomography via Robust Low-Rank Tensor Recovery
      We present a one-step approach based on low-rank tensor recovery for axial alignment in 360-degree anterior chamber optical coherence tomography. Achieving translational alignment and rotation correction of cross-sections simultaneously, this technique obtains a better anterior segment topographical representation and improves quantitative measurement accuracy and reproducibility of disease related parameters. Through its use of global information, the proposed method is more robust compared to using only individual or paired slices, and ...
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    8. MULTIMODALITY IMAGING OF TORPEDO MACULOPATHY WITH SWEPT-SOURCE, EN FACE OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      MULTIMODALITY IMAGING OF TORPEDO MACULOPATHY WITH SWEPT-SOURCE, EN FACE OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
      Purpose: Multimodality image analysis of two cases of torpedo maculopathy. Methods: Imaging with fundus photography, autofluorescence (AF), swept-source optical coherence tomography (OCT), en face OCT, and OCT angiography. Results: The basal diameter of the torpedo lesions was 1 mm x 2 mm. One case had a satellite lesion. Autofluorescence indicated variable loss of signal. Swept-source OCT and en face OCT demonstrated fundus excavation, attenuation of nuclear layers and disruption of ...
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    9. The use of transdermal optical coherence tomography to image the superficial temporal arteries

      The use of transdermal optical coherence tomography to image the superficial temporal arteries
      Purpose The diagnosis of Giant Cell Arteritis (GCA) is an area of major challenge. This is the first reported use of the directed use of transdermal optical coherence tomography (OCT) to image the superficial temporal artery (STA). Methods This proof of concept study used a commercially available transdermal OCT instrument to identify and image the STA in eight patients (suspected GCA, confirmed GCA, and in healthy controls). Three cases are ...
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    10. Optical Coherence Tomography in the UK Biobank Study – Rapid Automated Analysis of Retinal Thickness for Large Population-Based Studies

      Optical Coherence Tomography in the UK Biobank Study – Rapid Automated Analysis of Retinal Thickness for Large Population-Based Studies
      Purpose To describe an approach to the use of optical coherence tomography (OCT) imaging in large, population-based studies, including methods for OCT image acquisition, storage, and the remote, rapid, automated analysis of retinal thickness. Methods In UK Biobank, OCT images were acquired between 2009 and 2010 using a commercially available spectral domain OCT device (3D OCT-1000, Topcon). Images were obtained using a raster scan protocol, 6 mm x 6 mm ...
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    11. Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography

      Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography
      Studies have proven the relationship between cutaneous vasculature abnormalities and dermatological disorders, but to image vasculature noninvasively in vivo , advanced optical imaging techniques are required. In this study, we imaged a palm of a healthy volunteer and three subjects with cutaneous abnormalities with photoacoustic tomography (PAT) and optical coherence tomography with angiography extension (OCTA). Capillaries in the papillary dermis that are too small to be discerned with PAT are visualized ...
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    12. Visualizing the Choriocapillaris Under Drusen: Comparing 1050-nm Swept-Source Versus 840-nm Spectral-Domain Optical Coherence Tomography Angiography

      Visualizing the Choriocapillaris Under Drusen: Comparing 1050-nm Swept-Source Versus 840-nm Spectral-Domain Optical Coherence Tomography Angiography
      Purpose : To investigate the appearance of choriocapillaris (CC) flow under drusen by comparing long-wavelength (1050 nm) swept-source optical coherence tomography (SS-OCT) angiography with shorter-wavelength (840 nm) spectral-domain (SD) OCT angiography. Methods : Patients with drusen imaged on both devices on the same day were selected and graded. Ambiguous OCT angiography (OCTA) signal loss was defined as low OCTA signal on the en face OCTA CC image that also had low OCT ...
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    13. OCT angiography in the management of choroidal neovascular membrane secondary to Sorsby fundus dystrophy

      OCT angiography in the management of choroidal neovascular membrane secondary to Sorsby fundus dystrophy
      We describe the management of a woman aged 52 years with molecularly confirmed Sorsby fundus dystrophy, who presented with acute visual deterioration in her right eye. Fundus examination identified a right macular lesion suggestive of a choroidal neovascular membrane (CNVM). Optical coherence tomography angiography (OCTA) confirmed the presence of a CNVM. She was treated with 2 monthly intravitreal injections of bevacizumab, associated with OCTA evidence of regression of the CNVM ...
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    14. Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

      Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging
      Cutaneous blood flow accounts for approximately 5% of cardiac output in human and plays a key role in a number of a physiological and pathological processes. We show for the first time a multi-modal photoacoustic tomography (PAT), optical coherence tomography (OCT) and OCT angiography system with an articulated probe to extract human cutaneous vasculature in vivo in various skin regions. OCT angiography supplements the microvasculature which PAT alone is unable ...
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    15. Early coverage of drug-eluting stents analysed by optical coherence tomography: evidence of the impact of stent apposition and strut characteristics on the neointimal healing process

      Early coverage of drug-eluting stents analysed by optical coherence tomography: evidence of the impact of stent apposition and strut characteristics on the neointimal healing process
      Aims: Previous studies have associated issues such as incomplete stent apposition with delayed healing and adverse events (stent thrombosis). The aim of this study was to evaluate the impact of strut apposition and stent type on the progression of stent strut coverage. Methods and results: We evaluated in vivo in porcine models the follow-up response and coverage characteristics of well-apposed and malapposed segments of drug-eluting stents (DES) (CYPHER, PROMUS Element ...
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    16. Repeatability of swept-source optical coherence tomography retinal and choroidal thickness measurements in neovascular age-related macular degeneration

      Repeatability of swept-source optical coherence tomography retinal and choroidal thickness measurements in neovascular age-related macular degeneration
      Background The aim was to determine the intrasession repeatability of swept-source optical coherence tomography (SS-OCT)-derived retinal and choroidal thickness measurements in eyes with neovascular age-related macular degeneration (nAMD). Methods A prospective study consisting of patients with active nAMD enrolled in the Distance of Choroid Study at Moorfields Eye Hospital, London. Patients underwent three 129 mm macular raster scans using the deep range imaging (DRI) OCT-1 SS-OCT (Topcon) device in ...
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  2. About University College London

    University College London

    University College London is the oldest multi-faculty constituent college of the University of London and is one of the two original founding colleges. With 21,800 staff and students, UCL is one of the largest colleges of the University and is larger than most other universities in the United Kingdom. The Department of Medical Physics and Bioengineering has been for many years a joint department of University College London (UCL) and the UCL Hospitals Trust (UCLH).