1. University College London

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    1. Mentioned In 165 Articles

    2. Feature Of The Week 05/28/2017: In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements

      Feature Of The Week 05/28/2017: In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements
      Glaucoma is characterized by an irreversible damage of retinal ganglion cells within the optic nerve head (ONH) at the back of the eye. Currently we know that elevated intraocular pressure (IOP) is associated with increased prevalence of glaucoma but not all glaucoma patients have an elevated IOP. The biomechanical theory of glaucoma hypothesizes that elevated (or fluctuating) IOP deforms the ONH tissues, including the lamina cribrosa (LC), and that these ...
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    3. Quantitative Analysis of Retinal Structure using Spectral Domain Optical Coherence Tomography in RPGR-associated Retinopathy

      Quantitative Analysis of Retinal Structure using Spectral Domain Optical Coherence Tomography in RPGR-associated Retinopathy
      Purpose Quantification of retinal structure and progression using spectral-domain optical coherence tomography (SDOCT) in patients with retinitis pigmentosa (RP) associated with retinitis pigmentosa GTPase regulator gene ( RPGR ) mutations Design Retrospective observational case series Methods Setting: Moorfields Eye Hospital, London, United Kingdom. Subjects: Both eyes of 32 patients. SDOCT follow-up period of 1 year (3.11.4 years). Outcome measures: Ellipsoid zone (EZ) width (EZW), outer nuclear layer (ONL) and inner ...
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    4. Visualization of extensive intraplaque neovascularization by optical coherence tomography

      Visualization of extensive intraplaque neovascularization by optical coherence tomography
      Inflammation plays a key role in pathogenesis and progression of atherosclerosis (1) . Advent of novel intravascular imaging tools such as Optical Coherence Tomography (OCT) has led to visualization of coronary atherosclerotic plaque characteristics in vivo that were previously seen only on histology. Herein we discuss a case of extensive neovascularization, a feature that imparts vulnerability to atherosclerotic plaque in the coronary artery, as seen by two- and three-dimensional OCT images ...
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    5. Intracoronary optical coherence tomography: Clinical and research applications and intravascular imaging software overview

      Intracoronary optical coherence tomography: Clinical and research applications and intravascular imaging software overview
      By providing valuable information about the coronary artery wall and lumen, intravascular imaging may aid in optimizing interventional procedure results and thereby could improve clinical outcomes following percutaneous coronary intervention (PCI). Intravascular optical coherence tomography (OCT) is a light-based technology with a tissue penetration of approximately 1 to 3 mm and provides near histological resolution. It has emerged as a technological breakthrough in intravascular imaging with multiple clinical and research ...
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    6. Spectral Domain Optical Coherence Tomography: An In Vivo Imaging Protocol for Assessing Retinal Morphology in Adult Zebrafish

      Spectral Domain Optical Coherence Tomography: An In Vivo Imaging Protocol for Assessing Retinal Morphology in Adult Zebrafish
      The present study outlines a protocol for examining retinal structure in zebrafish, a popular model organism for ocular studies, using spectral domain optical coherence tomography (SD-OCT). We demonstrate how this live imaging modality can be used to obtain high quality images of several retinal features, including the optic nerve, retinal vasculature, and the cone photoreceptor mosaic. Retinal histology sections were obtained from imaged fish for comparison with SD-OCT cross-sectional B-scans ...
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    7. Optical coherence tomography angiography of foveal hypoplasia

      Optical coherence tomography angiography of foveal hypoplasia
      Aims To discuss foveal development in the context of detailed retinal vasculature imaging in foveal hypoplasia using optical coherence tomography angiography. Methods In this case series, the optical coherence tomography angiography results of four patients with idiopathic foveal hypoplasia and two patients with foveal hypoplasia secondary to oculocutaneous albinism are presented. Results Cases with intact visual acuity demonstrated lower grades of foveal hypoplasia on optical coherence tomography, while those with ...
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    8. Three-dimensional full wave model of image formation in optical coherence tomography

      Three-dimensional full wave model of image formation in optical coherence tomography
      We demonstrate, what we believe to be, the first mathematical model of image formation in optical coherence tomography, based on Maxwells equations, applicable to general three-dimensional samples. It is highly realistic and represents a significant advance on a previously developed model, which was applicable to two-dimensional samples only. The model employs an electromagnetic description of light, made possible by using the pseudospectral time-domain method for calculating the light scattered by ...
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    9. Optical Coherence Tomography Angiography Findings in Dengue-Related Maculopathy: A Case Report

      Optical Coherence Tomography Angiography Findings in Dengue-Related Maculopathy: A Case Report
      The ophthalmic manifestations of dengue fever include a visually impairing maculopathy, where patients are left with a central or paracentral relative scotoma. The authors present a case of a 26-year-old female patient returning from Thailand with unilateral reduction in visual acuity and a central scotoma associated with dengue fever. The authors report the use of the optical coherence tomography angiography (OCTA) as a noninvasive imaging platform to demonstrate its value ...
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    10. Enhanced Depth Imaging Optical Coherence Tomography of Optic Nerve Head Drusen

      Enhanced Depth Imaging Optical Coherence Tomography of Optic Nerve Head Drusen
      Purpose Enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD OCT) has been recognized as the most sensitive tool to diagnose optic nerve head drusen (ONHD). The relationship between OCT characteristics and visual loss has not been well documented. This study compares EDI SD OCTdetermined morphologic characteristics of drusen in eyes with or without visual field (VF) defects. Design Descriptive study of patients attending the neuro-ophthalmology service of Moorfields Eye ...
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    11. Axial Alignment for Anterior Segment Swept Source Optical Coherence Tomography via Robust Low-Rank Tensor Recovery

      Axial Alignment for Anterior Segment Swept Source Optical Coherence Tomography via Robust Low-Rank Tensor Recovery
      We present a one-step approach based on low-rank tensor recovery for axial alignment in 360-degree anterior chamber optical coherence tomography. Achieving translational alignment and rotation correction of cross-sections simultaneously, this technique obtains a better anterior segment topographical representation and improves quantitative measurement accuracy and reproducibility of disease related parameters. Through its use of global information, the proposed method is more robust compared to using only individual or paired slices, and ...
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    12. MULTIMODALITY IMAGING OF TORPEDO MACULOPATHY WITH SWEPT-SOURCE, EN FACE OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      MULTIMODALITY IMAGING OF TORPEDO MACULOPATHY WITH SWEPT-SOURCE, EN FACE OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
      Purpose: Multimodality image analysis of two cases of torpedo maculopathy. Methods: Imaging with fundus photography, autofluorescence (AF), swept-source optical coherence tomography (OCT), en face OCT, and OCT angiography. Results: The basal diameter of the torpedo lesions was 1 mm x 2 mm. One case had a satellite lesion. Autofluorescence indicated variable loss of signal. Swept-source OCT and en face OCT demonstrated fundus excavation, attenuation of nuclear layers and disruption of ...
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    13. The use of transdermal optical coherence tomography to image the superficial temporal arteries

      The use of transdermal optical coherence tomography to image the superficial temporal arteries
      Purpose The diagnosis of Giant Cell Arteritis (GCA) is an area of major challenge. This is the first reported use of the directed use of transdermal optical coherence tomography (OCT) to image the superficial temporal artery (STA). Methods This proof of concept study used a commercially available transdermal OCT instrument to identify and image the STA in eight patients (suspected GCA, confirmed GCA, and in healthy controls). Three cases are ...
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    14. Optical Coherence Tomography in the UK Biobank Study – Rapid Automated Analysis of Retinal Thickness for Large Population-Based Studies

      Optical Coherence Tomography in the UK Biobank Study – Rapid Automated Analysis of Retinal Thickness for Large Population-Based Studies
      Purpose To describe an approach to the use of optical coherence tomography (OCT) imaging in large, population-based studies, including methods for OCT image acquisition, storage, and the remote, rapid, automated analysis of retinal thickness. Methods In UK Biobank, OCT images were acquired between 2009 and 2010 using a commercially available spectral domain OCT device (3D OCT-1000, Topcon). Images were obtained using a raster scan protocol, 6 mm x 6 mm ...
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    15. Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography

      Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography
      Studies have proven the relationship between cutaneous vasculature abnormalities and dermatological disorders, but to image vasculature noninvasively in vivo , advanced optical imaging techniques are required. In this study, we imaged a palm of a healthy volunteer and three subjects with cutaneous abnormalities with photoacoustic tomography (PAT) and optical coherence tomography with angiography extension (OCTA). Capillaries in the papillary dermis that are too small to be discerned with PAT are visualized ...
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    16. 1-15 of 165 1 2 3 4 ... 9 10 11 »
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  2. About University College London

    University College London

    University College London is the oldest multi-faculty constituent college of the University of London and is one of the two original founding colleges. With 21,800 staff and students, UCL is one of the largest colleges of the University and is larger than most other universities in the United Kingdom. The Department of Medical Physics and Bioengineering has been for many years a joint department of University College London (UCL) and the UCL Hospitals Trust (UCLH).