1. University College London

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    1. Mentioned In 271 Articles

    2. In vivo optical coherence tomography-guided photodynamic therapy for skin pre-cancer and cancer

      In vivo optical coherence tomography-guided photodynamic therapy for skin pre-cancer and cancer
      Background: The primary aim of this prospective study is to demonstrate the technical feasibility of OCT to map real tumor margins and to monitor skin changes that occurred post- PDT. Moreover, to optimize PDT efficacy based on the relationship between measured OCT features and treatment outcome. Material and methods: A series of 12 patients with overall 18 facial skin lesions were investigated by OCT before surface illumination by PDT to ...
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    3. In vivo optical coherence tomography in assessment of suspicious facial lesions: A prospective study

      In vivo optical coherence tomography in assessment of suspicious facial lesions: A prospective study
      Background: Skin cancer continues to be the most common cancer in the Caucasian population. Over the past two decades, researchers around the world started assessing the possibility of diagnosing tissue pathologies by using optical systems. In this study, we aimed to use in vivo optical coherence tomography (OCT) technology to describe the morphologic features of normal and pathologic skin conditions. Materials and methods: In this study, 72 patients with suspected ...
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    4. Dependency of hydration and growth conditions on the mechanical properties of oral biofilms

      Dependency of hydration and growth conditions on the mechanical properties of oral biofilms
      Within the oral cavity, dental biofilms experience dynamic environments, in part due to changes in dietary content, frequency of intake and health conditions. This can impact bacterial diversity and morpho-mechanical properties. While phenotypic properties of oral biofilms are closely related to their composition, these can readily change according to dynamic variations in the growth environment and nutrient availability. Understanding the interlink between phenotypic properties, variable growth conditions, and community characterization ...
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    5. Swept-source optical coherence tomography changes and visual acuity among Palestinian retinitis Pigmentosa patients: a cross-sectional study

      Swept-source optical coherence tomography changes and visual acuity among Palestinian retinitis Pigmentosa patients: a cross-sectional study
      Background: Retinitis pigmentosa (RP) is a heterogeneous group of inherited ocular diseases that result in progressive retinal degeneration. This study aims to describe different Swept-source Optical Coherence Tomographic (SS-OCT) changes in Palestinian RP patients and to explore possible correlations with Visual Acuity (VA). Methods: A cross-sectional observational study was conducted on Retinitis Pigmentosa patients diagnosed with RP in a tertiary eye hospital. Full history and ocular examination were made. SS-OCT ...
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    6. Adoption of a new automated optical coherence tomography software to obtain a lipid plaque spread-out plot

      Adoption of a new automated optical coherence tomography software to obtain a lipid plaque spread-out plot
      Purpose: Near infrared spectroscopy-Intravascular ultrasound (NIRS-IVUS) provide a fully automated Lipid Core Burden Index (LCBI). Optical coherence tomography (OCT) is potentially capable of measuring lipid longitudinal extension in a dedicated two-dimensional LCBI spread-out plot. The present study has been designed to validate an automated approach to assess OCT images, able of providing a dedicated LCBI spread-out plot. Methods: We compared results obtained with conventional (manual) OCT, with those obtained with ...
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    7. An ERG and OCT study of neuronal ceroid lipofuscinosis CLN2 Battens retinopathy

      An ERG and OCT study of neuronal ceroid lipofuscinosis CLN2 Battens retinopathy
      Background: Late infantile neuronal ceroid lipofuscinosis (CLN2 Batten disease) is a rare, progressive neurodegenerative disease of childhood. The natural history of motor and language regression is used to monitor the efficacy of CNS treatments. Less is known about CLN2 retinopathy. Our aim is to elaborate the nature, age of onset, and symmetry of CLN2 retinopathy using visual electrophysiology and ophthalmic imaging. Subjects and methods: We reviewed 22 patients with genetically ...
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    8. Validation and Clinical Applicability of Whole-Volume Automated Segmentation of Optical Coherence Tomography in Retinal Disease Using Deep Learning

      Validation and Clinical Applicability of Whole-Volume Automated Segmentation of Optical Coherence Tomography in Retinal Disease Using Deep Learning
      Importance: Quantitative volumetric measures of retinal disease in optical coherence tomography (OCT) scans are infeasible to perform owing to the time required for manual grading. Expert-level deep learning systems for automatic OCT segmentation have recently been developed. However, the potential clinical applicability of these systems is largely unknown. Objective: To evaluate a deep learning model for whole-volume segmentation of 4 clinically important pathological features and assess clinical applicability. Design, setting ...
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    9. Re-evaluating diabetic papillopathy using optical coherence tomography and inner retinal sublayer analysis

      Re-evaluating diabetic papillopathy using optical coherence tomography and inner retinal sublayer analysis
      Background/Objectives To re-evaluate diabetic papillopathy using optical coherence tomography (OCT) for quantitative analysis of the peripapillary retinal nerve fibre layer (pRNFL), macular ganglion cell layer (mGCL) and inner nuclear layer (mINL) thickness. Subjects/Methods In this retrospective observational case series between June 2008 and July 2019 at Moorfields Eye hospital, 24 eyes of 22 patients with diabetes and optic disc swelling with confirmed diagnosis of NAION or diabetic papillopathy ...
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    10. Diagnostic accuracy of AS-OCT vs gonioscopy for detecting angle closure: a systematic review and meta-analysis

      Diagnostic accuracy of AS-OCT vs gonioscopy for detecting angle closure: a systematic review and meta-analysis
      Purpose: This study aims to review the literature that compares the accuracy of Anterior Segment-Optical Coherence Tomography (AS-OCT) against gonioscopy in detecting eyes with angle closure. It is currently unclear how AS-OCT fits into clinical practice for detecting angle closure. This is a systematic review and meta-analysis. Methods: A literature search was performed on Medline, Embase, Scopus and the Cochrane Central Register of Controlled Trials to identify studies that investigated ...
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    11. Navigated single-capture 3D and cross-sectional wide-field OCT of the mid and peripheral retina and vitreoretinal interface

      Navigated single-capture 3D and cross-sectional wide-field OCT of the mid and peripheral retina and vitreoretinal interface
      Purpose: Assess the mid and peripheral neuroretina and vitreoretinal interface using a novel Navigated Single-Capture 3D and Cross-Sectional Wide-Field Swept-Source Optical Coherence Tomography (WF SS-OCT) technology with correlation to Multi-Wavelength Ultra-Widefield Imaging (MW UWFI) and Histopathology reference. Methods: Retrospective observational study. A total of 74 patients (148 eyes) were imaged using WF SS-OCT and Navigated Single-Capture twelve 23 mm cross-sectional radial scan pattern at 15 intervals. Image diagnosis included: congenital ...
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    12. Approximate image synthesis in optical coherence tomography

      Approximate image synthesis in optical coherence tomography
      Full-wave models of OCT image formation, which are based on Maxwells equations, are highly realistic. However, such models incur a high computational cost, particularly when modelling sample volumes consistent with those encountered in practice. Here, we present an approximate means of synthesizing volumetric image formation to reduce this computational burden. Instead of performing a full-wave scattered light calculation for each A-scan, we perform a full-wave scattered light calculation for a ...
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    13. Smartphone-based remote monitoring of vision in macular disease enables early detection of worsening pathology and need for intravitreal therapy

      Smartphone-based remote monitoring of vision in macular disease enables early detection of worsening pathology and need for intravitreal therapy
      Background/aims To assess the outcomes of home monitoring of distortion caused by macular diseases using a smartphone-based application (app), and to examine them with hospital-based assessments of visual acuity (VA), optical coherence tomography-derived central macular thickness (CMT) and the requirement of intravitreal injection therapy. Design Observational study with retrospective analysis of data. Methods Participants were trained in the correct use of the app (Alleye, Oculocare, Zurich, Switzerland) in person ...
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    14. Speckle-dependent accuracy in phase-sensitive optical coherence tomography

      Speckle-dependent accuracy in phase-sensitive optical coherence tomography
      Phase-sensitive optical coherence tomography (OCT) is used to measure motion in a range of techniques, such as Doppler OCT and optical coherence elastography (OCE). In phase-sensitive OCT, motion is typically estimated using a model of the OCT signal derived from a single reflector. However, this approach is not representative of turbid samples, such as tissue, which exhibit speckle. In this study, for the first time, we demonstrate, through theory and ...
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    15. Critical evaluation of stents in coronary angioplasty: a systematic review

      Critical evaluation of stents in coronary angioplasty: a systematic review
      Background Coronary stents are routinely placed in the treatment and prophylaxis of coronary artery disease (CAD). Current coronary stent designs are prone to developing blockages: in-stent thrombosis (IST) and in-stent re-stenosis (ISR). This is a systematic review of the design of current coronary stent models, their structural properties and their modes of application, with a focus on their associated risks of IST and ISR. The primary aim of this review ...
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    16. The APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies

      The APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies
      Objective: To update the consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results, thus revising the previously published Advised Protocol for OCT Study Terminology and Elements (APOSTEL) recommendations. Methods: To identify studies reporting quantitative OCT results, we performed a PubMed search for the terms "quantitative" and "optical coherence tomography" from 2015 to 2017. Corresponding authors of the identified publications were invited to provide feedback on the initial ...
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    17. 1-15 of 271 1 2 3 4 ... 16 17 18 »
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  2. About University College London

    University College London

    University College London is the oldest multi-faculty constituent college of the University of London and is one of the two original founding colleges. With 21,800 staff and students, UCL is one of the largest colleges of the University and is larger than most other universities in the United Kingdom. The Department of Medical Physics and Bioengineering has been for many years a joint department of University College London (UCL) and the UCL Hospitals Trust (UCLH).