1. University College London

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    1. Mentioned In 186 Articles

    2. Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation

      Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation
      Realistic simulation of image formation in optical coherence tomography, based on Maxwells equations, has recently been demonstrated for sample volumes of practical significance. Yet, there remains a limitation whereby reducing the size of cells used to construct a computational grid, thus allowing for a more realistic representation of scatterer microstructure, necessarily reduces the overall sample size that can be modelled. This is a significant problem since, as is well known ...
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    3. Use of a Binocular Optical Coherence Tomography System to Evaluate Strabismus in Primary Position

      Use of a Binocular Optical Coherence Tomography System to Evaluate Strabismus in Primary Position
      Importance Current clinical methods for assessing strabismus can be prone to error. Binocular optical coherence tomography (OCT) has the potential to assess and quantify strabismus objectively and in an automated manner. Objective To evaluate the use of a binocular OCT prototype to assess the presence and size of strabismus. Design, Setting, and Participants Fifteen participants with strabismus were recruited in 2016 as part of the EASE study from Moorfields Eye ...
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    4. All-optical intravascular probe for dual-mode photoacoustic imaging and optical coherence tomography

      All-optical intravascular probe for dual-mode photoacoustic imaging and optical coherence tomography
      Intravascular (IV) imaging in percutaneous coronary interventions can be invaluable to treat coronary artery disease, to facilitate decision making and to guide stent placement. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are both established IV imaging modalities. However, achieving contrast for specific structures such as lipid plaques can be challenging; with OCT, visualisation is typically limited to tissue depths less than 2 mm. Photoacoustic (PA) imaging provides contrast that ...
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    5. Multicenter reliability of semiautomatic retinal layer segmentation using OCT

      Multicenter reliability of semiautomatic retinal layer segmentation using OCT
      Objective To evaluate the inter-rater reliability of semiautomated segmentation of spectral domain optical coherence tomography (OCT) macular volume scans. Methods Macular OCT volume scans of left eyes from 17 subjects (8 patients with MS and 9 healthy controls) were automatically segmented by Heidelberg Eye Explorer (v1.9.3.0) beta-software (Spectralis Viewing Module v6.0.0.7), followed by manual correction by 5 experienced operators from 5 different academic centers ...
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    6. Features of choroidal naevi on swept source optical coherence tomography angiography and structural reverse flow optical coherence tomography

      Features of choroidal naevi on swept source optical coherence tomography angiography and structural reverse flow optical coherence tomography
      Purpose The purpose of our study was to describe features of choroidal naevi as seen on swept source optical coherence tomography angiography (OCTA) and also on en face images derived from structural data from OCTA. Methods A prospective observational cohort study was carried out. Patients attending a specialised choroidal naevomelanocytic with known naevi were imaged with swept source OCTA. Results Seventy-one eyes of 70 patients were imaged. Forty-three patients and ...
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    7. WIDEFIELD SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING OF PERIPHERAL ROUND RETINAL HOLES WITH OR WITHOUT RETINAL DETACHMENT

      WIDEFIELD SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING OF PERIPHERAL ROUND RETINAL HOLES WITH OR WITHOUT RETINAL DETACHMENT
      Purpose: To describe the widefield spectral-domain optical coherence tomography features of peripheral round retinal holes, with or without associated retinal detachment (RD). Methods: Retrospective, observational study of 28 eyes with peripheral round retinal holes, with and without RD. Patients underwent imaging with a widefield 50-degree spectral-domain optical coherence tomography (Heidelberg Engineering, Germany) and Optos ultra-widefield imaging systems (Optos, United Kingdom). Results: Vitreous attachment at the site of the retinal hole ...
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    8. DRUNET: A Dilated-Residual U-Net Deep Learning Network to Digitally Stain Optic Nerve Head Tissues in Optical Coherence Tomography Images

      DRUNET: A Dilated-Residual U-Net Deep Learning Network to Digitally Stain Optic Nerve Head Tissues in Optical Coherence Tomography Images
      Given that the neural and connective tissues of the optic nerve head (ONH) exhibit complex morphological changes with the development and progression of glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images may be of great interest for the clinical diagnosis and management of this pathology. A deep learning algorithm was designed and trained to digitally stain (i.e. highlight) 6 ONH tissue layers by capturing both the local ...
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    9. Heart rate sensitive optical coherence angiography

      Heart rate sensitive optical coherence angiography
      Optical coherence angiography (OCA) enables visualisation of three-dimensional micro-vasculature from optical coherence tomography data volumes. Typically, various statistical methods are used to discriminate static tissue from blood flow within vessels. In this paper, we introduce a new method that relies upon the beating heart frequency to isolate blood vessels from the surrounding tissue. Vascular blood flow is assumed to be more strongly modulated by the heart-beat compared to surrounding tissue ...
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    10. COMPARING FUNDUS FLUORESCEIN ANGIOGRAPHY AND SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN THE EVALUATION OF DIABETIC MACULAR PERFUSION

      COMPARING FUNDUS FLUORESCEIN ANGIOGRAPHY AND SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN THE EVALUATION OF DIABETIC MACULAR PERFUSION
      Purpose: To compare fundus fluorescein angiography (FFA) and swept-source optical coherence tomography angiography (SS-OCTA) in the evaluation of macular perfusion in diabetic patients. Methods: Forty-one eyes (21 diabetic patients) seen at Moorfields Eye Hospital (London) over a 1-month interval underwent color fundus photography, FFA, and SS-OCTA imaging of the capillary superficial plexus using 2 different protocols: 3 3 mm and 4.5 4.5 mm. Quantitative assessment (foveal avascular zone ...
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    11. Researchers use non-visible imaging approach to reveal secrets of ancient Egyptian mummies

      Researchers use non-visible imaging approach to reveal secrets of ancient Egyptian mummies
      In addition to the multispectral camera, the team of researchers utilized optical coherence tomography (OCT), which uses similar wavelengths to multispectral imaging, but works at a much smaller scale, according to UCL. The system is arranged so that light travels a similar distance along two paths, one a reference arm and the other interrogating the sample. As light penetrates the sample and reflects back off different layers, the distance it ...
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    12. Optical coherence tomography angiography: a review of current and future clinical applications

      Optical coherence tomography angiography: a review of current and future clinical applications
      Optical coherence tomography angiography is a non-invasive imaging technique that now allows for simultaneous in vivo imaging of the morphology as well as the vasculature in the eye. In this review, we provide an update on the existing clinical applications of optical coherence tomography angiography technology from the anterior to posterior segment of the eye. We also discuss the limitations of optical coherence tomography angiography technology, as well as the ...
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    13. Characteristic optical coherence tomography findings in patients with primary vitreoretinal lymphoma: a novel aid to early diagnosis

      Characteristic optical coherence tomography findings in patients with primary vitreoretinal lymphoma: a novel aid to early diagnosis
      Background The diagnosis of primary vitreoretinal lymphoma (PVRL) poses significant difficulties; presenting features are non-specific and confirmation usually necessitates invasive vitreoretinal biopsy. Diagnosis is often delayed, resulting in increased morbidity and mortality. Non-invasive imaging modalities such as spectral domain optical coherence tomography (SD-OCT) offer simple and rapid aids to diagnosis. We present characteristic SD-OCT images of patients with biopsy-positive PVRL and propose a number of typical features, which we believe ...
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    14. Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension

      Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension
      Background Optical Coherence Tomography (OCT) imaging is being increasingly used in clinical practice for the monitoring of papilloedema. The aim is to characterise the extent and location of the Retinal Nerve Fibre Layer (RNFL) Thickness automated segmentation error (SegE) by manual refinement, in a cohort of Idiopathic Intracranial Hypertension (IIH) patients with papilloedema and compare this to controls. Methods Baseline Spectral Domain OCT (SDOCT) scans from patients with IIH, and ...
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    15. Secondary glaucoma in uveitis: comparison of the optic nerve head morphology among a nonmydriatic fundus camera, HRT, and SD-OCT

      Secondary glaucoma in uveitis: comparison of the optic nerve head morphology among a nonmydriatic fundus camera, HRT, and SD-OCT
      To assess the correlation between the disc damage likelihood scale (DDLS) objectively measured by a nonmydriatic fundus camera, confocal laser scanning ophthalmoscopy (HRT3), and spectral-domain optical coherence tomography (SD-OCT) in uveitic glaucoma. A total of 59 patients with uveitic glaucoma (21 female, 38 male; mean age 56.8 18.7 years) were included in this prospective cross-sectional study. All patients were measured by the Kowa Nonmyd WX 3D camera (2D ...
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  2. About University College London

    University College London

    University College London is the oldest multi-faculty constituent college of the University of London and is one of the two original founding colleges. With 21,800 staff and students, UCL is one of the largest colleges of the University and is larger than most other universities in the United Kingdom. The Department of Medical Physics and Bioengineering has been for many years a joint department of University College London (UCL) and the UCL Hospitals Trust (UCLH).