1. University College London

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    1. Mentioned In 283 Articles

    2. Optical coherence tomography angiography findings in pigmented paravenous chorioretinal atrophy

      Optical coherence tomography angiography findings in pigmented paravenous chorioretinal atrophy
      Purpose: To analyze the retino-choroidal vascular characteristics of patients affected by pigmented paravenous chorio-retinal atrophy (PPCRA) by means of optical coherence tomography angiography (OCTA). Methods: The study was designed as an observational, cross-sectional case series. Multimodal imaging included fundus autofluorescence (FAF), structural optical coherence tomography (OCT) and OCT angiography (OCTA). The quantitative OCTA analyses included the calculation of the vessel density (VD) and choriocapillaris porosity. Results: Overall, 12 patients (24 ...
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    3. Deep learning to detect optical coherence tomography-derived diabetic macular edema from retinal photographs: a multicenter validation study

      Deep learning to detect optical coherence tomography-derived diabetic macular edema from retinal photographs: a multicenter validation study
      Purpose: To validate the generalizability of a deep learning system (DLS) that detects diabetic macular edema (DME) from two-dimensional color fundus photography (CFP), where the reference standard for retinal thickness and fluid presence is derived from three-dimensional optical coherence tomography (OCT). Design: Retrospective validation of a DLS across international datasets. Participants: Paired CFP and OCT of patients from diabetic retinopathy (DR) screening programs or retina clinics. The DLS was developed ...
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    4. Handheld optical coherence tomography removes barriers to imaging the eyes of young children

      Handheld optical coherence tomography removes barriers to imaging the eyes of young children
      Optical coherence tomography (OCT) has revolutionised the clinical practice of ophthalmology. Its use has become widespread across most major branches of ophthalmology, including medical retina, surgical retina, glaucoma, neuro-ophthalmology, uveitis, cornea, anterior segment and refractive surgery, primary care ophthalmology and ocular oncology. However, conventional table-mounted OCT devices are not designed for infants and young children, who have previously been deprived of this technology and its many clinical benefits. Furthermore, many ...
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    5. OCT Assisted Quantification of Vitreous Inflammation in Uveitis

      OCT Assisted Quantification of Vitreous Inflammation in Uveitis
      Purpose: Vitreous haze (VH) is a key marker of inflammation in uveitis but limited by its subjectivity. Optical coherence tomography (OCT) has potential as an objective, noninvasive method for quantifying VH. We test the hypotheses that OCT can reliably quantify VH and the measurement is associated with slit-lamp based grading of VH. Methods: In this prospective study, participants underwent three repeated OCT macular scans to evaluate the within-eye reliability of ...
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    6. Predicting visual fields from optical coherence tomography via an ensemble of deep representation learners

      Predicting visual fields from optical coherence tomography via an ensemble of deep representation learners
      Purpose To develop and validate a deep learning (DL) method of predicting visual function from spectral domain optical coherence tomography (SDOCT) derived retinal nerve fiber layer thickness (RNFLT) measurements and corresponding SDOCT images. Design Development and evaluation of diagnostic technology. Methods Two DL ensemble models to predict pointwise VF sensitivity from SDOCT images (model 1 RNFLT profile only; model 2 RNFLT profile plus SDOCT image), and two reference models were ...
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    7. Macular thickness varies with age-related macular degeneration genetic risk variants in the UK Biobank cohort

      Macular thickness varies with age-related macular degeneration genetic risk variants in the UK Biobank cohort
      To evaluate the influence AMD risk genomic variants have on macular thickness in the normal population. UK Biobank participants with no significant ocular history were included using the UK Biobank Resource (project 2112). Spectral-domain optical coherence tomography (SD-OCT) images were taken and segmented to define retinal layers. The influence of AMD risk single-nucleotide polymorphisms (SNP) on retinal layer thickness was analysed. AMD risk associated SNPs were strongly associated with outer-retinal ...
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    8. Combining OCT and OCTA for Focal Structure-Function Modeling in Early Primary Open-Angle Glaucoma

      Combining OCT and OCTA for Focal Structure-Function Modeling in Early Primary Open-Angle Glaucoma
      Purpose: To investigate modeling of the focal visual field (VF) loss by combining structural measurements and vascular measurements in eyes with early primary open-angle glaucoma (POAG). Methods: In this cross-sectional study, subjects with early glaucoma (VF mean deviation, -6 dB) underwent optical coherence tomography (OCT) imaging, optical coherence tomography angiography (OCTA) imaging, and Humphrey 24-2 VF tests. Capillary perfusion densities (CPDs) were calculated after the removal of large vessels in ...
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    9. ADVANCED OCT ANALYSIS OF BIOPSY PROVEN VITREORETINAL LYMPHOMA: OCT findings in vitreo-retinal lymphoma

      ADVANCED OCT ANALYSIS OF BIOPSY PROVEN VITREORETINAL LYMPHOMA: OCT findings in vitreo-retinal lymphoma
      Importance: Although the diagnosis of vitreoretinal lymphoma (VRL) can be challenging, early detection is critical for visual prognosis. Objective: To analyze the spectrum of optical coherence tomography (OCT) findings in patients with biopsy-proven VRL and correlate these features with clinical parameters. Design: Retrospective cross-sectional study SETTING: Multicenter chart review from 13 retina, uveitis and ocular oncology clinics worldwide over an 11-year period (2008-2019). Participants: Patients with a diagnosis of biopsy-proven ...
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    10. Optical coherence tomography in multiple sclerosis: A 3-year prospective multicenter study

      Optical coherence tomography in multiple sclerosis: A 3-year prospective multicenter study
      Objective: To evaluate changes over 3 years in the thickness of inner retinal layers including the peripapillary retinal nerve fiber layer (pRNFL), and combined macular ganglion cell and inner plexiform layers (mGCIPL), in individuals with relapsing-remitting multiple sclerosis (RRMS) versus healthy controls; to determine whether optical coherence tomography (OCT) is sufficiently sensitive and reproducible to detect small degrees of neuroaxonal loss over time that correlate with changes in brain volume ...
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    11. Fraunhofer Technology Revolutionises 3D Printing of Prosthetic Eyes

      Fraunhofer Technology Revolutionises 3D Printing of Prosthetic Eyes
      Prosthetic eye replacements will be manufactured by 3D printers in the future. Fraunhofer IGD has developed a number of technologies that supersedes the current and entirely manual production of individual prostheses. Fraunhofer's Cuttlefish:Eye software utilises a 3D scan of the eye socket and a colour-calibrated photo of the healthy eye to create the prosthetic eye's 3D model. Fraunhofer's Cuttlefish 3D printing driver is used to print ...
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    12. Dynamic volume-rendered optical coherence tomography pupillometry

      Dynamic volume-rendered optical coherence tomography pupillometry
      Purpose: To assess intrapupillary space (IPS) changes in healthy subjects with regard to decreased iris motility in patients with pseudoexfoliation glaucoma (PEXG) or non-arteritic anterior ischaemic optic neuropathy (NAION) in a feasibility study in a clinical environment. Methods: Scotopic and photopic IPS measurements using three-dimensionally rendered swept-source optical coherence tomography (SS-OCT) data were obtained and compared for all subjects. Intrapupillary space (IPS) parameters were evaluated such as absolute volumetric differences ...
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    13. Clinically relevant deep learning for detection and quantification of geographic atrophy from optical coherence tomography: a model development and external validation study

      Clinically relevant deep learning for detection and quantification of geographic atrophy from optical coherence tomography: a model development and external validation study
      Background: Geographic atrophy is a major vision-threatening manifestation of age-related macular degeneration, one of the leading causes of blindness globally. Geographic atrophy has no proven treatment or method for easy detection. Rapid, reliable, and objective detection and quantification of geographic atrophy from optical coherence tomography (OCT) retinal scans is necessary for disease monitoring, prognostic research, and to serve as clinical endpoints for therapy development. To this end, we aimed to ...
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    14. In vivo optical coherence tomography-guided photodynamic therapy for skin pre-cancer and cancer

      In vivo optical coherence tomography-guided photodynamic therapy for skin pre-cancer and cancer
      Background: The primary aim of this prospective study is to demonstrate the technical feasibility of OCT to map real tumor margins and to monitor skin changes that occurred post- PDT. Moreover, to optimize PDT efficacy based on the relationship between measured OCT features and treatment outcome. Material and methods: A series of 12 patients with overall 18 facial skin lesions were investigated by OCT before surface illumination by PDT to ...
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    15. In vivo optical coherence tomography in assessment of suspicious facial lesions: A prospective study

      In vivo optical coherence tomography in assessment of suspicious facial lesions: A prospective study
      Background: Skin cancer continues to be the most common cancer in the Caucasian population. Over the past two decades, researchers around the world started assessing the possibility of diagnosing tissue pathologies by using optical systems. In this study, we aimed to use in vivo optical coherence tomography (OCT) technology to describe the morphologic features of normal and pathologic skin conditions. Materials and methods: In this study, 72 patients with suspected ...
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    16. Dependency of hydration and growth conditions on the mechanical properties of oral biofilms

      Dependency of hydration and growth conditions on the mechanical properties of oral biofilms
      Within the oral cavity, dental biofilms experience dynamic environments, in part due to changes in dietary content, frequency of intake and health conditions. This can impact bacterial diversity and morpho-mechanical properties. While phenotypic properties of oral biofilms are closely related to their composition, these can readily change according to dynamic variations in the growth environment and nutrient availability. Understanding the interlink between phenotypic properties, variable growth conditions, and community characterization ...
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    17. 1-15 of 283 1 2 3 4 ... 17 18 19 »
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  2. About University College London

    University College London

    University College London is the oldest multi-faculty constituent college of the University of London and is one of the two original founding colleges. With 21,800 staff and students, UCL is one of the largest colleges of the University and is larger than most other universities in the United Kingdom. The Department of Medical Physics and Bioengineering has been for many years a joint department of University College London (UCL) and the UCL Hospitals Trust (UCLH).