1. University College London

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    1. Mentioned In 246 Articles

    2. Hyper-reflectivity on optical coherence tomography in macular telangiectasia type 2

      Explore LWW Online Ophthalmology
      Hyper-reflectivity on optical coherence tomography in macular telangiectasia type 2
      Purpose: To define, characterize and classify hyper-reflectivity on optical coherence tomography (OCT) and report its prevalence in macular telangiectasia type 2 (MacTel). Methods: In a primary cross-sectional analysis, multimodal imaging data were retrospectively analyzed. The definition of hyper-reflectivity and neovascularization on OCT followed OCT-angiography-based criteria. Eyes were graded for the presence of hyper-reflectivity and neovascularization and further categorized into three classes based on position and extent of hyper-reflectivity. In a ...
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      Mentions: University College London University of Bonn Frank G. Holz

    3. Optical coherence tomography (OCT) in neuro-ophthalmology

      Explore Nature Publishing Group Ophthalmology
      Optical coherence tomography (OCT) in neuro-ophthalmology
      Optical coherence tomography (OCT) is a non-invasive medical imaging technology that is playing an increasing role in the routine assessment and management of patients with neuro-ophthalmic conditions. Its ability to characterise the optic nerve head, peripapillary retinal nerve fibre layer and cellular layers of the macula including the ganglion cell layer enables qualitative and quantitative assessment of optic nerve disease. In this review, we discuss technical features of OCT and ...
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      Mentions: University College London Academic Medical Center at the University of Amsterdam Axel Petzold

    4. Optical coherence tomography in the 2020s—outside the eye clinic

      Explore Nature Publishing Group Ophthalmology
      Optical coherence tomography in the 2020s—outside the eye clinic
      Optical coherence tomography (OCT) is a paragon of success in the translation of biophotonics science to clinical practice. OCT systems have become ubiquitous in eye clinics but access beyond this is limited by their cost, size and the skill required to operate the devices. Remarkable progress has been made in the development of OCT technology to improve the speed of acquisition, the quality of images and into functional extensions of ...
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      Mentions: University College London Pearse A. Keane

    5. Investigation of the efficacy of an online tool for improving the diagnosis of macular lesions imaged by optical coherence tomography

      Explore ScienceDirect Ophthalmology
      Investigation of the efficacy of an online tool for improving the diagnosis of macular lesions imaged by optical coherence tomography
      Purpose: Optical coherence tomography (OCT) is a non-invasive method for diagnosis and monitoring of retinal (typically, macular) conditions. The unfamiliar nature of OCT images can present considerable challenges for some community optometrists. The purpose of this research is to develop and assess the efficacy of a novel internet resource designed to assist optometrists in using OCT for diagnosis of macular disease and patient management. Methods: An online tool (OCTAID) has ...
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      Mentions: University College London Praveen J. Patel

    6. Artificial Intelligence Algorithms to Diagnose Glaucoma and Detect Glaucoma Progression: Translation to Clinical Practice

      Explore TVST Journal Ophthalmology
      Artificial Intelligence Algorithms to Diagnose Glaucoma and Detect Glaucoma Progression: Translation to Clinical Practice
      Purpose : This concise review aims to explore the potential for the clinical implementation of artificial intelligence (AI) strategies for detecting glaucoma and monitoring glaucoma progression. Methods : Nonsystematic literature review using the search combinations Artificial Intelligence, Deep Learning, Machine Learning, Neural Networks, Bayesian Networks, Glaucoma Diagnosis, and Glaucoma Progression. Information on sensitivity and specificity regarding glaucoma diagnosis and progression analysis as well as methodological details were extracted. Results : Numerous AI strategies ...
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      Mentions: University of Toronto University College London Johannes Kepler University of Linz

    7. Electrically pumped continuous-wave O-band quantum-dot superluminescent diode on silicon

      Explore OSA | OSA Publishing Broadband Sources
      Electrically pumped continuous-wave O-band quantum-dot superluminescent diode on silicon
      High-power, broadband quantum-dot (QD) superluminescent diodes (SLDs) are ideal light sources for optical coherence tomography (OCT) imaging systems but have previously mainly been fabricated on native GaAs- or InP-based substrates. Recently, significant progress has been made to emigrate QD SLDs from native substrates to silicon substrates. Here, we demonstrate electrically pumped continuous-wave InAs QD SLDs monolithically grown on silicon substrates with significantly improved performance thanks to the achievement of a ...
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      Mentions: University College London Cardiff University

    9. Deep iterative vessel segmentation in OCT angiography

      Explore OSA | OSA Publishing Ophthalmology
      Deep iterative vessel segmentation in OCT angiography
      This paper addresses retinal vessel segmentation on optical coherence tomography angiography (OCT-A) images of the human retina. Our approach is motivated by the need for high precision image-guided delivery of regenerative therapies in vitreo-retinal surgery. OCT-A visualizes macular vasculature, the main landmark of the surgically targeted area, at a level of detail and spatial extent unattainable by other imaging modalities. Thus, automatic extraction of detailed vessel maps can ultimately inform ...
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      Mentions: University College London Kings College London

    10. The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons

      Explore Home Page Cardiology , Ophthalmology , Urology
      The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons
      Chronic kidney disease (CKD) is common, with hypertension and diabetes mellitus acting as major risk factors for its development. Cardiovascular disease is the leading cause of death worldwide and the most frequent end point of CKD. There is an urgent need for more precise methods to identify patients at risk of CKD and cardiovascular disease. Alterations in microvascular structure and function contribute to the development of hypertension, diabetes, CKD, and ...
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      Mentions: University College London Pearse A. Keane

    11. Quantifying the Separation Between the Retinal Pigment Epithelium and Bruch's Membrane using Optical Coherence Tomography in Patients with Inherited Macular Degeneration

      Explore TVST Journal Ophthalmology
      Quantifying the Separation Between the Retinal Pigment Epithelium and Bruch's Membrane using Optical Coherence Tomography in Patients with Inherited Macular Degeneration
      Purpose : To describe and quantify Bruch's membrane (BM) and retinal pigment epithelium (RPE) separation using spectral-domain (SD) optical coherence tomography (OCT) in patients affected by inherited macular degenerations associated with BM thickening. Methods : Patients with molecularly confirmed Sorsby fundus dystrophy (SFD), dominant drusen (DD), and late-onset retinal degeneration (L-ORD) were included in this retrospective study. Each disease was classed as early stage if subjects were asymptomatic, intermediate stage if ...
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      Mentions: University College London UCSD William R. Freeman

    12. Segmented Macular Layer Volumes from Spectral Domain Optical Coherence Tomography in 184 Adult Twins: Associations With Age and Heritability

      Explore IOVS Journal Ophthalmology
      Segmented Macular Layer Volumes from Spectral Domain Optical Coherence Tomography in 184 Adult Twins: Associations With Age and Heritability
      Purpose : To investigate segmented macular layer volumes from a healthy adult twin cohort (TwinsUK), exploring changes with age and heritability. Methods : Macular spectral domain optical coherence tomography images were acquired from monozygotic (MZ) and dizygotic (DZ) twins in a cross-sectional study. The following layer volumes were derived for circles of 3 and 6 mm diameter around the foveal center, using automated segmentation software: retinal nerve fiber layer (RNFL), ganglion cellinner ...
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      Mentions: University College London

    13. Predicting conversion to wet age-related macular degeneration using deep learning

      Explore Nature Publishing Group Ophthalmology
      Predicting conversion to wet age-related macular degeneration using deep learning
      Progression to exudative wet age-related macular degeneration (exAMD) is a major cause of visual deterioration. In patients diagnosed with exAMD in one eye, we introduce an artificial intelligence (AI) system to predict progression to exAMD in the second eye. By combining models based on three-dimensional (3D) optical coherence tomography images and corresponding automatic tissue maps, our system predicts conversion to exAMD within a clinically actionable 6-month time window, achieving a ...
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      Mentions: University College London Pearse A. Keane

    14. Utility of Multimodality Intravascular Imaging and the Local Hemodynamic Forces to Predict Atherosclerotic Disease Progression

      Explore imaging.onlinejacc.org Cardiology
      Utility of Multimodality Intravascular Imaging and the Local Hemodynamic Forces to Predict Atherosclerotic Disease Progression
      Objectives This study sought to examine the utility of multimodality intravascular imaging and of the endothelial shear stress (ESS) distribution to predict atherosclerotic evolution. Background There is robust evidence that intravascular ultrasound (IVUS)-derived plaque characteristics and ESS distribution can predict, with however limited accuracy, atherosclerotic evolution; nevertheless, it is yet unclear whether multimodality imaging and ESS mapping enable more accurate prediction of coronary plaque progression. Methods A total of ...
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      Mentions: Imperial College London University College London University of Copenhagen

    15. Widefield optical coherence tomography angiography for early detection and objective evaluation of proliferative diabetic retinopathy

      Explore BJO Online Ophthalmology
      Widefield optical coherence tomography angiography for early detection and objective evaluation of proliferative diabetic retinopathy
      Purpose To evaluate the utility of widefield optical coherence tomography angiography (WF-OCTA) compared with clinical examination in grading diabetic retinopathy in patients diagnosed clinically with proliferative diabetic retinopathy (PDR) or severe non-proliferative diabetic retinopathy (NPDR). Design This retrospective observational case series included patients diagnosed clinically with PDR or severe NPDR. Patients underwent standard clinical examination and WF-OCTA imaging (PLEX Elite 9000, Carl Zeiss Meditec AG) using 1212 montage scans between ...
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      Mentions: University College London Carl Zeiss Meditec Praveen J. Patel

    16. Automated Pupillometry using a Prototype Binocular Optical Coherence Tomography System

      Explore American Journal of Ophthalmology Ophthalmology
      Automated Pupillometry using a Prototype Binocular Optical Coherence Tomography System
      Purpose To determine the test-retest reliability and diagnostic accuracy of a binocular optical coherence tomography (OCT) prototype (Envision Diagnostics, USA) for pupillometry. Design Assessment of diagnostic reliability and accuracy. Methods Fifty participants with RAPD confirmed using the swinging flashlight method (mean age 49.6 years) and 50 healthy controls (mean age 31.3 years) were examined. Participants twice underwent an automated pupillometry exam using a binocular OCT system that presents ...
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      Mentions: University College London Axel Petzold Pearse A. Keane
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  4. About University College London

    University College London

    University College London is the oldest multi-faculty constituent college of the University of London and is one of the two original founding colleges. With 21,800 staff and students, UCL is one of the largest colleges of the University and is larger than most other universities in the United Kingdom. The Department of Medical Physics and Bioengineering has been for many years a joint department of University College London (UCL) and the UCL Hospitals Trust (UCLH).

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    2. Topographic variation and interocular symmetry of macular choroidal thickness using enhanced depth imaging optical coherence tomography
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    3. The Physiological Variation of the Retinal Nerve Fiber Layer Thickness and Macular Volume in Humans as Assessed by Spectral Domain–Optical Coherence Tomography
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