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1. Mentioned In 239 Articles
2. Deep iterative vessel segmentation in OCT angiography
  
  Explore OSA | OSA Publishing Jun 6 2020 Ophthalmology
  
  This paper addresses retinal vessel segmentation on optical coherence tomography angiography (OCT-A) images of the human retina. Our approach is motivated by the need for high precision image-guided delivery of regenerative therapies in vitreo-retinal surgery. OCT-A visualizes macular vasculature, the main landmark of the surgically targeted area, at a level of detail and spatial extent unattainable by other imaging modalities. Thus, automatic extraction of detailed vessel maps can ultimately inform ...
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  Mentions: University College London Kings College London
3. The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons
  
  Explore Home Page May 31 2020 Cardiology , Ophthalmology , Urology
  
  Chronic kidney disease (CKD) is common, with hypertension and diabetes mellitus acting as major risk factors for its development. Cardiovascular disease is the leading cause of death worldwide and the most frequent end point of CKD. There is an urgent need for more precise methods to identify patients at risk of CKD and cardiovascular disease. Alterations in microvascular structure and function contribute to the development of hypertension, diabetes, CKD, and ...
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  Mentions: University College London Pearse A. Keane
4. Quantifying the Separation Between the Retinal Pigment Epithelium and Bruch's Membrane using Optical Coherence Tomography in Patients with Inherited Macular Degeneration
  
  Explore TVST Journal May 29 2020 Ophthalmology
  
  Purpose : To describe and quantify Bruch's membrane (BM) and retinal pigment epithelium (RPE) separation using spectral-domain (SD) optical coherence tomography (OCT) in patients affected by inherited macular degenerations associated with BM thickening. Methods : Patients with molecularly confirmed Sorsby fundus dystrophy (SFD), dominant drusen (DD), and late-onset retinal degeneration (L-ORD) were included in this retrospective study. Each disease was classed as early stage if subjects were asymptomatic, intermediate stage if ...
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  Mentions: University College London UCSD William R. Freeman
5. Segmented Macular Layer Volumes from Spectral Domain Optical Coherence Tomography in 184 Adult Twins: Associations With Age and Heritability
  
  Explore IOVS Journal May 24 2020 Ophthalmology
  
  Purpose : To investigate segmented macular layer volumes from a healthy adult twin cohort (TwinsUK), exploring changes with age and heritability. Methods : Macular spectral domain optical coherence tomography images were acquired from monozygotic (MZ) and dizygotic (DZ) twins in a cross-sectional study. The following layer volumes were derived for circles of 3 and 6 mm diameter around the foveal center, using automated segmentation software: retinal nerve fiber layer (RNFL), ganglion cellinner ...
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  Mentions: University College London
6. Predicting conversion to wet age-related macular degeneration using deep learning
  
  Explore Nature Publishing Group May 20 2020 Ophthalmology
  
  Progression to exudative wet age-related macular degeneration (exAMD) is a major cause of visual deterioration. In patients diagnosed with exAMD in one eye, we introduce an artificial intelligence (AI) system to predict progression to exAMD in the second eye. By combining models based on three-dimensional (3D) optical coherence tomography images and corresponding automatic tissue maps, our system predicts conversion to exAMD within a clinically actionable 6-month time window, achieving a ...
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  Mentions: University College London Pearse A. Keane
7. Utility of Multimodality Intravascular Imaging and the Local Hemodynamic Forces to Predict Atherosclerotic Disease Progression
  
  Explore imaging.onlinejacc.org Apr 1 2020 Cardiology
  
  Objectives This study sought to examine the utility of multimodality intravascular imaging and of the endothelial shear stress (ESS) distribution to predict atherosclerotic evolution. Background There is robust evidence that intravascular ultrasound (IVUS)-derived plaque characteristics and ESS distribution can predict, with however limited accuracy, atherosclerotic evolution; nevertheless, it is yet unclear whether multimodality imaging and ESS mapping enable more accurate prediction of coronary plaque progression. Methods A total of ...
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  Mentions: Imperial College London University College London University of Copenhagen
8. Widefield optical coherence tomography angiography for early detection and objective evaluation of proliferative diabetic retinopathy
  
  Explore BJO Online Mar 24 2020 Ophthalmology
  
  Purpose To evaluate the utility of widefield optical coherence tomography angiography (WF-OCTA) compared with clinical examination in grading diabetic retinopathy in patients diagnosed clinically with proliferative diabetic retinopathy (PDR) or severe non-proliferative diabetic retinopathy (NPDR). Design This retrospective observational case series included patients diagnosed clinically with PDR or severe NPDR. Patients underwent standard clinical examination and WF-OCTA imaging (PLEX Elite 9000, Carl Zeiss Meditec AG) using 1212 montage scans between ...
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  Mentions: University College London Carl Zeiss Meditec Praveen J. Patel
9. Automated Pupillometry using a Prototype Binocular Optical Coherence Tomography System
  
  Explore American Journal of Ophthalmology Feb 27 2020 Ophthalmology
  
  Purpose To determine the test-retest reliability and diagnostic accuracy of a binocular optical coherence tomography (OCT) prototype (Envision Diagnostics, USA) for pupillometry. Design Assessment of diagnostic reliability and accuracy. Methods Fifty participants with RAPD confirmed using the swinging flashlight method (mean age 49.6 years) and 50 healthy controls (mean age 31.3 years) were examined. Participants twice underwent an automated pupillometry exam using a binocular OCT system that presents ...
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  Mentions: University College London Axel Petzold Pearse A. Keane
10. The Use of Optical Coherence Tomography as a Diagnostic Tool for Dental Caries (Thesis)
  
  Explore UCL Discovery Dec 17 2019 Dentistry , Student Theses
  
  Dental caries is one of the most common human diseases, 60-90% of school children worldwide have dental cavities. Severity can vary, from early demineralisation, which preventive measures can improve, to cavitation, leading to fillings. Different diagnostic tools are available, such as clinical examination, radiographic investigation and Enhanced Visual examination/International Caries Detection and Assessment System (ICDAS). To date, there is no universal diagnostic tool that can be used to detect ...
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  Mentions: University College London
11. KU Leuven leads €6 million research project on heart disease and dementia
  
  Explore KU Leuven nieuws Dec 13 2019 Cardiology , Neurology
  
  ...large and varied population of patients, at the Academic Hospital Maastricht, the Universidad de Navarra, and University College London. Doctors who are routinely scanning patients' hearts will be asked to examine their ...
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  Mentions: University College London Academic Hospital Maastricht K. U. Leuven
12. Optical coherence tomography in the assessment of cutaneous cancer margins of the face: an immediate ex vivo study
  
  Explore ScienceDirect Dec 8 2019 Dermatology , Oncology
  
  Background The assessment of cutaneous cancer margins intra-operatively or in the immediate postoperative phase can guide the operator into achieving clearer margins. Achieving a clear (tumour-free) margins following surgery is an essential factor that can reduce morbidity and disfigurement. The aim of present study was to determine the accuracy of optical coherence tomography in assessing cutaneous cancer margins of the face. Materials and Methods The excised tissue specimens that were ...
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  Mentions: University College London Colin Hopper
13. The Relationship Between Ambient Atmospheric Fine Particulate Matter (PM2.5) and Glaucoma in a Large Community Cohort
  
  Explore IOVS Journal Nov 27 2019 Ophthalmology
  
  Purpose : Glaucoma is more common in urban populations than in others. Ninety percent of the world's population are exposed to air pollution above World Health Organization (WHO) recommended limits. Few studies have examined the association between air pollution and glaucoma. Methods : Questionnaire data, ophthalmic measures, and ambient residential area air quality data for 111,370 UK Biobank participants were analyzed. Particulate matter with an aerodynamic diameter 2.5 m ...
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  Mentions: University College London World Health Organization Praveen J. Patel
14. Subclinical Macular Changes And Disease Laterality In Pediatric Coats Disease Determined By Quantitative Optical Coherence Tomography Angiography
  
  Explore LWW Online Nov 26 2019 Ophthalmology
  
  Purpose: To determine vascular change at the macula in both eyes in unilateral pediatric Coats disease using optical coherence tomography angiography. Methods: Retrospective case-series. Thirteen eyes of pediatric patients with a diagnosis of unilateral Coats disease of various stages were compared with 13 fellow eyes. Optical coherence tomography angiography images were acquired using the RTVue XR Avanti. Scans were analyzed with novel projection artifact removal software and improved segmentation. Vascular ...
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  Mentions: Optovue University College London Pearse A. Keane
15. Efficacy and Reproducibility of Attenuation-Compensated Optical Coherence Tomography for Assessing External Elastic Membrane Border and Plaque Composition in Native and Stented Segments ― An In Vivo and Histology-Based Study ―
  
  Explore jstage.jst.go.jp Nov 21 2019 Cardiology
  
  Background: Attenuation-compensated (AC) technique was recently introduced to improve the plaque characterization of optical coherence tomography (OCT). Histological validation demonstrated promising results but the efficacy and reproducibility of this technique for assessing in-vivo tissue composition remains unclear. Methods and Results: OCT images portraying native (n=200) and stented (n=200) segments and 31 histological cross-sections were analyzed. AC-OCT appeared superior to conventional (C)-OCT in detecting the external elastic lamina ...
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  Mentions: Imperial College London Leiden University University College London
16. Correspondence: Trends in Retina Specialist Imaging Utilization From 2012 to 2016 in the United States Medicare Fee-for-Service Population
  
  Explore American Journal of Ophthalmology Nov 14 2019 Ophthalmology
  
  We read with great interest the recent report by Wibbelsman and associates titled Trends in Retina Specialist Imaging Utilization from 2012 to 2016 in the USA Medicare fee-for-service Population.1 Despite the prominent role of optical coherence tomography (OCT) in ophthalmic practice, there is a surprising scarcity of published literature on the frequency of its application.
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  Mentions: University College London Pearse A. Keane
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