1. Università Vita-Salute San Raffaele

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    1. Mentioned In 103 Articles

    2. OCTA-guided navigated laser therapy for advanced macula neovascularization secondary to age related macular degeneration

      OCTA-guided navigated laser therapy for advanced macula neovascularization secondary to age related macular degeneration
      Introduction: To evaluate the effects of the Navilas system guided by optical coherence tomography angiography for advanced macular neovascularization (MNV) secondary to age-related macular degeneration (AMD). Methods: Prospective case-series including nine eyes presenting with advanced MNV with persistence of exudative signs, no longer responding to anti-VEGF therapy, best-corrected visual acuity at least of 1.3logMar. All patients were treated with Navilas guided by overlaid optical coherence tomography angiography (OCTA) images ...
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    3. Using three-dimensional OCTA metrics improves repeatability on quantification of ischemia in eyes with diabetic macular edema

      Using three-dimensional OCTA metrics improves repeatability on quantification of ischemia in eyes with diabetic macular edema
      Purpose: Two-dimensional (2D) optical coherence tomography angiography (OCTA) is known to be prone to segmentation errors, especially in pathologic eyes. Therefore, our aim was to systematically compare intra-session repeatability between repeated scans for 2D and three-dimensional (3D) OCTA metrics in quantifying retinal perfusion in eyes with diabetic macular edema (DME). Methods: Diabetic patients with diabetic retinopathy (DR) and DME who had two consecutive OCTA imaging scans obtained during the same ...
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    4. Quantitative OCTA parameter variations after treatment of macular neovascularization secondary to age-related macular degeneration

      Quantitative OCTA parameter variations after treatment of macular neovascularization secondary to age-related macular degeneration
      Purpose: Macular neovascularization (MNV) secondary to age-related macular degeneration (AMD) can be characterized by quantitative optical coherence tomography angiography (OCTA). The aim of the study was to assess the evolution of quantitative OCTA parameters after one-year of anti-VEGF injections. Methods: Nave AMD-related MNV eyes were prospectively recruited to analyze OCT and OCTA parameters, including MNV vessel tortuosity (VT) and reflectivity, at baseline and at the end of the follow-up. MNV ...
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    5. Optical Coherence Tomography Angiography in Intermediate and Late Age-Related Macular Degeneration: Review of Current Technical Aspects and Applications

      Optical Coherence Tomography Angiography in Intermediate and Late Age-Related Macular Degeneration: Review of Current Technical Aspects and Applications
      Optical coherence tomography angiography (OCTA) is a non-invasive diagnostic instrument that has become indispensable for the management of age-related macular degeneration (AMD). OCTA allows quickly visualizing retinal and choroidal microvasculature, and in the last years, its use has increased in clinical practice as well as for research into the pathophysiology of AMD. This review provides a discussion of new technology and application of OCTA in intermediate and late AMD.
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    6. Choroidal vascularization and adrenergic innervation qualitative findings obtained with induced fluorescence preparations and optical coherence tomography angiography: possible correlations and perspectives

      Choroidal vascularization and adrenergic innervation qualitative findings obtained with induced fluorescence preparations and optical coherence tomography angiography: possible correlations and perspectives
      Background Recent advances in optical coherence tomography (OCT) technology allow a more accurate choroidal visualization. The aim of this study is to provide histochemical analysis with induced fluorescence images of the choroidal stromal, vascular and nerve network, highlighting possible correspondences with OCT and OCT angiography (OCT-A) analysis. Methods The material examined with a histochemical process of induced fluorescence through condensation of biologically active monoamines with glyoxylic acid was obtained from ...
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    7. Quantitative deep vascular complex analysis of different AMD stages on optical coherence tomography angiography

      Quantitative deep vascular complex analysis of different AMD stages on optical coherence tomography angiography
      Aims: To investigate alterations in deep retinal vascular complex (DVC) in patients with non-neovascular intermediate AMD (iAMD), treatment-nave quiescent macular neovascularization (qMNV), exudative AMD (eAMD) by means of OCT angiography (OCTA). Methods: Patients with iAMD, qMNV, eAMD and healthy controls presenting in the Department of Ophthalmology of the Centre Hospitalier Intercommunal de Crteil between January 2016 and January 2018, were retrospectively included. 3 3-mm OCTA (AngioVue RTVue XR Avanti) perfusion ...
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    8. Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders

      Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders
      Purpose Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD. Here we summarise the profile of the Collaborative OCT in NMOSD repository as the initial effort in establishing this platform ...
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    9. Spontaneous resolution of optic pit maculopathy: an OCT report

      Spontaneous resolution of optic pit maculopathy: an OCT report
      The separation of the vitreous from the optic nerve head and the macula plays a primary role in the spontaneous resolution of optic disc pit (ODP) maculopathy. Optical coherence tomography (OCT) helps in the non-invasive monitoring of this condition, when treated conservatively. The aim of this report was to describe a pediatric case of spontaneously resolved ODP maculopathy, managed conservatively and monitored by means of spectral domain (SD)-OCT. A ...
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    10. Clear subretinal fluid in a case of non-neovascular early-onset drusen: Swept-source imaging evaluation

      Clear subretinal fluid in a case of non-neovascular early-onset drusen: Swept-source imaging evaluation
      A 50-year-old male presented with recent metamorphopsia in the right eye. Fundus examination revealed bilateral multiple cuticular drusen along with few large colloid drusen (phenotype 3 cuticular drusen). No vitelliform material was evident in the macula in either eye. Fluorescein angiography (FA), indocyanine green angiography (ICGA) did not demonstrate a macular neovascularization (MNV) in either eye. Swept-source optical coherence tomography (SS-OCT) revealed sub-retinal pigment epithelial (RPE) drusen and a clear ...
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    11. Quantitative Optical Coherence Tomography Angiography Parameters in Type 1 Macular Neovascularization Secondary to Age-Related Macular Degeneration

      Quantitative Optical Coherence Tomography Angiography Parameters in Type 1 Macular Neovascularization Secondary to Age-Related Macular Degeneration
      Purpose : The purpose of this paper was to study type 1 macular neovascularization (MNV) quantitative optical coherence tomography (OCT) angiography (OCTA) features by means of advanced postprocessing analyses. Methods : We recruited patients affected by nave type 1 MNV secondary to age-related macular degeneration (AMD) and age-matched controls. All patients underwent ophthalmologic examination and multimodal imaging. They were treated with pro-re-nata anti-VEGF injections. The ensuing follow-up lasted 24 months. Quantitative OCT ...
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    12. Extrafoveal müller cells detection in vivo in the human retina: A pilot study based on optical coherence tomography

      Extrafoveal müller cells detection in vivo in the human retina: A pilot study based on optical coherence tomography
      Mller cells (MC) represent a key element for the metabolic and functional regulation of the vertebrate retina. The aim of the present study was to test the feasibility of a new method for the in-vivo detection and quantification of extrafoveal MC in human retina. We developed a new approach to isolate and analyse extrafoveal MC in vivo, starting from structural optical coherence tomography data. Our pilot investigation was based on ...
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    13. Guidelines on Optical Coherence Tomography Angiography Imaging: 2020 Focused Update

      Guidelines on Optical Coherence Tomography Angiography Imaging: 2020 Focused Update
      Optical coherence tomography angiography (OCTA) has significantly expanded our knowledge of the ocular vasculature. In this review, we provide a discussion of the fundamental principles of OCTA and the application of this imaging modality to study the retinal and choroidal vessels. These guidelines are focused on 2020, and include updates since the 2019 publication. Importantly, we will comment on recent findings on OCTA technology with a special focus on the ...
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    14. Choroidal Rift: A New OCT Finding in Eyes with Central Serous Chorioretinopathy

      Choroidal Rift: A New OCT Finding in Eyes with Central Serous Chorioretinopathy
      Central serous chorioretinopathy (CSC) is a complex and not entirely understood retinal disease. The aim of our research was to describe a novel optical coherence tomography (OCT) finding named choroidal rift, which may be identified in the choroid of eyes with CSC. We collected data from 357 patients (488 eyes) with CSC who had structural OCT and OCT angiography (OCTA) scans obtained. Choroidal rifts were identified as polygonal (and not ...
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    15. Optical Coherence Tomography Angiography Quantitative Assessment of Macular Neovascularization in Best Vitelliform Macular Dystrophy

      Optical Coherence Tomography Angiography Quantitative Assessment of Macular Neovascularization in Best Vitelliform Macular Dystrophy
      Purpose : To describe quantitative characteristics of macular neovascularization (MNV) in vitelliform macular dystrophy (VMD) patients by means of optical coherence tomography angiography (OCTA). Methods : The study design was a prospective case series. All patients underwent complete ophthalmologic assessment, optical coherence tomography, and OCTA. The quantitative OCTA parameters examined included vessel tortuosity and vessel dispersion of the MNV. The primary outcome was OCTA characterization of MNV in VMD. Secondary outcomes included ...
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    16. An anomalous foveal OCT-sign after posterior capsule rupture in cataract surgery: Complicated cataract surgery maculopathy

      An anomalous foveal OCT-sign after posterior capsule rupture in cataract surgery: Complicated cataract surgery maculopathy
      Purpose: To report a series of novel optical coherence tomography (SD-OCT) foveal abnormalities, that we called T-sign, that were noticed after a complicated cataract surgery with posterior capsule rupture and vitreous loss. Methods: Retrospective case series of persistent foveal changes that incurred after anteroposterior vitreo-foveal traction secondary to phacoemulsification in presence of posterior capsule rupture. Results: The study included three eyes of three patients that incurred in complicated cataract surgery ...
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  2. About Università Vita-Salute San Raffaele

    Università Vita-Salute San Raffaele

    Università Vita-Salute San Raffaele is a vibrant and acclaimed University in Milan, Italy.  Its campus, which converges with the San Raffaele Hospital site, is overseen by an 8-metre statue of San Raffaele that crowns the central dome of the University’s new and resplendent Headquarters. Inspired by Jesus’ invitation in the Gospel to “go forth, teach and heal”, Don Luigi Verzé, the founder, foresaw a natural progression from his seedling hospital to a renowned health care provider and to an international biomedical research and teaching centre. His vision duly came to fruition with the respective inaugurations of DIBIT, a substantial complex of research laboratories, in 1992, and of the Università Vita-Salute San Raffaele in 1996. The University opened with the Faculty of Psychology. Two years later, in 1998, the Faculty of Medicine was added, and the current triumvirate was completed with the creation, in 2002, of  the Faculty of Philosophy.