1. Università Vita-Salute San Raffaele

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    1. Mentioned In 127 Articles

    2. Visual Outcomes and OCT Biomarkers of Vision Improvement in Patients with Leber's Hereditary Optic Neuropathy treated with Idebenone

      Visual Outcomes and OCT Biomarkers of Vision Improvement in Patients with Leber's Hereditary Optic Neuropathy treated with Idebenone
      Purpose To assess the relationship of demographics, clinical characteristics and structural optical coherence tomography (OCT) findings to long-term visual outcomes in patients with Leber's hereditary optic neuropathy (LHON) treated with idebenone. Design Retrospective, interventional, non-comparative clinical cohort study. Methods In this study, a total of 17 participants (34 eyes) with LHON treated with idebenone therapy within 1 year after disease onset and 2 years (24 months) of regular follow-ups ...
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    3. Optical Coherence Tomography Angiography Characterization Of Evolving Lesions In Fellow Eyes Of Exudative Type 3 Macular Neovascularization Patients

      Optical Coherence Tomography Angiography Characterization Of Evolving Lesions In Fellow Eyes Of Exudative Type 3 Macular Neovascularization Patients
      Purpose: To investigate fellow eyes of newly diagnosed unilateral exudative Type 3 (T3) macular neovascularization (MNV) patients by assessing the presence and progression of a preclinical neovascular component during a 3-year follow-up. Methods: This is a longitudinal study involving three retinal referral centers. Patients affected by unilateral exudative treatment-naive T3 MNV were enrolled. Results: Twenty-four eyes of 24 patients (79 6 years old) were enrolled. Nine eyes (37%) displayed a ...
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    4. Normative Data and Conversion Equation for Spectral-Domain Optical Coherence Tomography in an International Healthy Control Cohort

      Normative Data and Conversion Equation for Spectral-Domain Optical Coherence Tomography in an International Healthy Control Cohort
      Background: Spectral-domain (SD-) optical coherence tomography (OCT) can reliably measure axonal (peripapillary retinal nerve fiber layer [pRNFL]) and neuronal (macular ganglion cell + inner plexiform layer [GCIPL]) thinning in the retina. Measurements from 2 commonly used SD-OCT devices are often pooled together in multiple sclerosis (MS) studies and clinical trials despite software and segmentation algorithm differences; however, individual pRNFL and GCIPL thickness measurements are not interchangeable between devices. In some circumstances ...
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    5. Comparison of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Thickness Values Using Spectral-Domain and Swept-Source OCT

      Comparison of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Thickness Values Using Spectral-Domain and Swept-Source OCT
      Purpose: To compare peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (mGCIPL) thickness measurements obtained with spectral domain optical coherence tomography (SD-OCT) and swept-source OCT (SS-OCT) using an OCT-angiography scanning protocol, and their ability to distinguish among patients with glaucoma, glaucoma suspects (GS), and healthy controls (HC). Methods: Cross-sectional study of 196 eyes (81 glaucoma, 48 GS, and 67 HC) of 119 participants. Participants underwent peripapillary ...
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    6. The Role of Optical Coherence Tomography Criteria and Machine Learning in Multiple Sclerosis and Optic Neuritis Diagnosis

      The Role of Optical Coherence Tomography Criteria and Machine Learning in Multiple Sclerosis and Optic Neuritis Diagnosis
      Background and objectives: Recent studies have suggested that inter-eye differences (IEDs) in peripapillary retinal nerve fiber layer (pRNFL) or ganglion cell+inner plexiform (GCIPL) thickness by spectral-domain optical coherence tomography (SD-OCT) may identify people with a history of unilateral optic neuritis (ON). However, this requires further validation. Machine learning classification may be useful for validating thresholds for OCT IEDs and for examining added utility for visual function tests, such as ...
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    7. Assessment of Diabetic Choroidopathy Using Ultra-Widefield Optical Coherence Tomography

      Assessment of Diabetic Choroidopathy Using Ultra-Widefield Optical Coherence Tomography
      Purpose: The purpose of this study was to investigate a confocal scanning laser ophthalmoscopy (cSLO) ultra-widefield (UWF) swept-source optical coherence tomography (S-SOCT) in assessment of diabetic choroidopathy and to evaluate the agreement of measurements with a spectral-domain OCT (SD-OCT) instrument. Methods: We conducted a cross-sectional study of patients with diabetes evaluating the choroidal vascularity index (CVI) in the nasal, temporal, and central macula segments of a UWF SS-OCT scan centered ...
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    8. Optical Coherence Tomography Findings in Infectious Posterior Uveitis

      Optical Coherence Tomography Findings in Infectious Posterior Uveitis
      Purpose To describe and illustrate the main optical coherence tomography (OCT) findings of infectious uveitis. Methods Narrative review. Results Posterior segment OCT in patients with infectious uveitis reveals posterior hyaloid face precipitates, superficial retinal precipitates and infiltrates, foveolitis, retinitis, neuro-retinitis, choroidal granulomas, and choroiditis as main imaging biomarkers. Some of these features are specific to the underlying causing etiology and may support the diagnosis and the initiation of treatment. Some ...
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    9. Optical coherence tomography predictors of 3-year visual outcome for type 3 macular neovascularization

      Optical coherence tomography predictors of 3-year visual outcome for type 3 macular neovascularization
      Purpose: To identify baseline optical coherence tomography (OCT) predictors of the 3-year visual outcome for type 3 (T3) macular neovascularization (MNV) secondary to age-related macular degeneration (AMD) treated by anti-vascular endothelial growth factor (VEGF) therapy. Design: Retrospective longitudinal study. Participants: Forty eyes of 30 patients affected by exudative treatment-nave T3 MNV were enrolled. Methods: Baseline best-corrected visual acuity (BCVA) and several baseline OCT features were assessed and included in the ...
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    10. Recommendations for OCTA reporting in retinal vascular disease: A Delphi approach by International Experts

      Recommendations for OCTA reporting in retinal vascular disease: A Delphi approach by International Experts
      Purpose: To develop a consensus nomenclature for reporting optical coherence tomography angiography (OCTA) findings in retinal vascular disease (e.g., diabetic retinopathy, retinal vein occlusion) by international experts. Design: Delphi-based survey SUBJECTS, PARTICIPANTS AND/OR CONTROLS: Twenty-five retinal vascular disease and OCTA imaging experts METHODS, INTERVENTION, OR TESTING: A Delphi method of consensus development was used, comprising two rounds of online questionnaires, followed by a face-to-face meeting conducted virtually. Twenty-five ...
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    11. Discerning Between Macular Hemorrhages Due to Macular Neovascularization or Due to Spontaneous Bruch’s Membrane Rupture in High Myopia: A Comparative Analysis Between OCTA and Fluorescein Angiography

      Discerning Between Macular Hemorrhages Due to Macular Neovascularization or Due to Spontaneous Bruch’s Membrane Rupture in High Myopia: A Comparative Analysis Between OCTA and Fluorescein Angiography
      Introduction: To evaluate the sensitivity and specificity of optical coherence tomography angiography (OCTA) in comparison to fluorescein angiography (FA) in discerning between macular hemorrhages due to myopic macular neovascularization (m-MNV) and idiopathic macular hemorrhage (IMH) in patients with high myopia (HM). Methods: In this retrospective study, 14 eyes of 14 patients (mean age 60 16 years) affected by macular hemorrhage due to HM were included. All patients underwent OCTA and ...
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    12. Advanced retinal imaging and applications for clinical practice: A consensus review

      Advanced retinal imaging and applications for clinical practice: A consensus review
      Imaging is an integral part of the evaluation and management of retinal disorders. Each imaging modality has its own unique capabilities and can show a different aspect or perspective of disease. Multimodal retinal imaging provides a wealth of substantive and insightful information; however, the integration of all this complex data can be overwhelming. We discuss the applications and the strengths and limitations of the many different retinal imaging tools that ...
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    13. Retinal vascular impairment in Wolfram syndrome: an optical coherence tomography angiography study

      Retinal vascular impairment in Wolfram syndrome: an optical coherence tomography angiography study
      To evaluate differences in macular and optic disc circulation in patients affected by Wolfram Syndrome (WS) employing optical coherence tomography-angiography (OCTA) imaging. In this retrospective study, 18 eyes from 10 WS patients, 16 eyes of 8 patients affected by type I diabetes and 17 eyes from 17 healthy controls were enrolled. All patients were imaged through OCT and OCTA and vascular parameters, as perfusion density (PD) and vessel length density ...
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    14. Subretinal transient hyporeflectivity in age-related macular degeneration: a spectral-domain optical coherence tomography study

      Subretinal transient hyporeflectivity in age-related macular degeneration: a spectral-domain optical coherence tomography study
      Purpose: To describe and assess the prognostic significance of subretinal transient hyporeflectivity (STHR), a novel spectral-domain optical coherence tomography (SD-OCT) in age-related macular degeneration. Methods: Consecutive patients with AMD presenting STHR, defined as a small, well-defined, round subretinal, hyporeflective lesion on SD-OCT and without exudative signs were included. Clinical examination and SD-OCT (Spectralis, Heidelberg Engineering, Heidelberg, Germany) were analyzed at inclusion, as well as one month prior to inclusion and ...
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    15. Double-kissing nano-crush for bifurcation PCI guided by live OCT imaging: Shedding light on stent positioning

      Double-kissing nano-crush for bifurcation PCI guided by live OCT imaging: Shedding light on stent positioning
      Percutaneous coronary intervention (PCI) of bifurcation lesions poses unique challenges and carries a high risk of adverse events on follow-up, mainly driven by repeat revascularization and stent thrombosis . Several techniques exist to tackle bifurcation lesions. Among those, double kissing (DK) crush has emerged in recent years as a safe and effective approach for complex bifurcations requiring a two-stent strategy. In its most recent iteration, the DK nano-crush, minimal (ideally less ...
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    16. Retinal Optical Coherence Tomography in Neuromyelitis Optica

      Retinal Optical Coherence Tomography in Neuromyelitis Optica
      Background and objectives: To determine optic nerve and retinal damage in aquaporin-4 antibody (AQP4-IgG)-seropositive neuromyelitis optica spectrum disorders (NMOSD) in a large international cohort after previous studies have been limited by small and heterogeneous cohorts. Methods: The cross-sectional Collaborative Retrospective Study on retinal optical coherence tomography (OCT) in neuromyelitis optica collected retrospective data from 22 centers. Of 653 screened participants, we included 283 AQP4-IgG-seropositive patients with NMOSD and 72 ...
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  2. About Università Vita-Salute San Raffaele

    Università Vita-Salute San Raffaele

    Università Vita-Salute San Raffaele is a vibrant and acclaimed University in Milan, Italy.  Its campus, which converges with the San Raffaele Hospital site, is overseen by an 8-metre statue of San Raffaele that crowns the central dome of the University’s new and resplendent Headquarters. Inspired by Jesus’ invitation in the Gospel to “go forth, teach and heal”, Don Luigi Verzé, the founder, foresaw a natural progression from his seedling hospital to a renowned health care provider and to an international biomedical research and teaching centre. His vision duly came to fruition with the respective inaugurations of DIBIT, a substantial complex of research laboratories, in 1992, and of the Università Vita-Salute San Raffaele in 1996. The University opened with the Faculty of Psychology. Two years later, in 1998, the Faculty of Medicine was added, and the current triumvirate was completed with the creation, in 2002, of  the Faculty of Philosophy.