1. UK National Physical Laboratory

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    1. Mentioned In 39 Articles

    2. Spatially deconvolved optical coherence tomography

      Spatially deconvolved optical coherence tomography
      In this paper we present spatially mapped point-spread function (PSF) measurements of an optical coherence tomography (OCT) instrument and subsequent spatial deconvolution. The OCT B-scan image plane was divided into 2400 subimages, for which PSFs were determined from OCT measurements of a specially designed phantom. Each PSF was deconvolved from its corresponding subimage of the phantom using the Lucy-Richardson algorithm. Following deconvolution, all of the subimages were reassembled to form ...
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    3. Contrast phantoms for optical coherence tomography

      Contrast phantoms for optical coherence tomography
      In this work we present contrast measurement phantoms for optical coherence tomography. In this initial study, contrast has been evaluated from OCT images of a USAF-1951 bar target, buried beneath scattering layers of different density. Preliminary results indicate that scattering does not degrade imaging contrast significantly, however further work is required to verify these findings. This work has important implications from a quality control perspective as well for OCT inter-comparisons ...
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    4. Spotting the signs: Improving resolution of systems used to image human tissue could help early identification of life-threatening diseases

      Spotting the signs: Improving resolution of systems used to image human tissue could help early identification of life-threatening diseases
      ...le for detecting changes in tissue structure that can indicate the early stages of cancer. Researchers at the National Physical Laboratory (NPL) have developed a new means to ensure that a screening technique using Optic...
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    5. Report on Optical Tissue Phantoms from National Physical Laboratory in UK

      Report on Optical Tissue Phantoms from National Physical Laboratory in UK
      The key figures of merit for Optical Coherence Tomography (OCT) systems are sensitivity and resolution. These parameters can be used to determine the suitability of instruments for purpose and to gauge the practical improvements to instruments afforded by modifications to the design. Therefore, NPL is developing reproducible and stable phantoms for depth resolved sensitivity and three-dimensional resolution or point-spread-function (PSF
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    6. OCT aims for industrial application

      OCT aims for industrial application
      The speed, precision, and cost benefits of optical coherence tomography are beginning to attract the interest of industrial end users. For detailed subsurface imaging of small, semiopaque 2-D surface areas or 3-D structures, OCT is just the thing. When optical coherence tomography (OCT) was introduced in the early 1990s, it was immediately recognized for its ability to produce high-resolution, depth-resolved imagery of biological tissue. Its impact on ophthalmology is evident ...
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    7. Michelson Diagnostics Diversifies into Non-Medical Market

      Michelson Diagnostics Diversifies into Non-Medical Market
      ...gh fly larva Fly larva hidden layers MEMS device, showing ability of OCT to see hidden layers. Image courtesy National Physical Laboratory. pearl Pearl, showing outer nacre layer Ex1301 Microscope EX1301 OCT microscope i...
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  2. About UK National Physical Laboratory

    UK National Physical Laboratory

    National Physical Laboratory (NPL) is the UK’s National Measurement Institute and is a world-leading centre of excellence in developing and applying the most accurate measurement standards, science and technology available to man. For more than a century NPL has developed and maintained the nation’s primary measurement standards. These standards underpin an infrastructure of traceability throughout the UK and the world that ensures accuracy and consistency of measurement.  NPL ensures that cutting edge measurement science and technology have a positive impact in the real world. NPL delivers world-leading measurement solutions that are critical to commercial research and development, and support business success across the UK and the globe.  Good measurement improves productivity and quality; it underpins consumer confidence and trade and is vital to innovation. We undertake research and share our expertise with government, business and society to help enhance economic performance and the quality of life.   NPL’s measurements help to save lives, protect the environment, enable citizens to feel safe and secure, as well as supporting international trade and companies to innovation. Support in areas such as the development of advanced medical treatments and environmental monitoring helps secure a better quality of life for all.