1. UK National Physical Laboratory

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    1. Mentioned In 39 Articles

    2. Methods to assess sensitivity of optical coherence tomography systems

      Methods to assess sensitivity of optical coherence tomography systems
      Measuring the sensitivity of an optical coherence tomography (OCT) system determines the minimum sample reflectivity it can detect and provides a figure of merit for system optimization and comparison. The published literature lacks a detailed description of OCT sensitivity measurement procedures. Here we describe a commonly-used measurement method and introduce two new phantom-based methods, which also offer a means to directly visualize low reflectivity conditions relevant to biological tissue. We ...
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    3. Multi-system comparison of optical coherence tomography performance with point spread function phantoms

      Multi-system comparison of optical coherence tomography performance with point spread function phantoms
      Point spread function (PSF) phantoms based on unstructured distributions of sub-resolution particles in a transparent matrix have proven effective for evaluating resolution and its spatial variation in optical coherence tomography (OCT) systems. Measurements based on PSF phantoms have the potential to become a standard test method for consistent, objective and quantitative inter-comparison of OCT system performance. Towards this end, we have evaluated three PSF phantoms and investigated their ability to ...
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    4. Plasma treatment as a method for functionalising and improving dispersion of carbon nanotubes in epoxy resins

      Plasma treatment as a method for functionalising and improving dispersion of carbon nanotubes in epoxy resins
      This study reports on the results of plasma-treated carbon nanotubes (CNTs) in the presence of oxygen and ammonia which can be scaled up for relatively large quantities of nanomaterials. The plasma treatment has been shown to change the surface chemistry and energy as well as the morphology of the carbon nanotubes. X-ray photoelectron spectroscopy analysis shows increases in oxygen and nitrogen groups on the oxygen- and ammonia-treated CNTs, respectively. Titration ...
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    5. Fabrication of high quality optical coherence tomography (OCT) calibration artefacts using femtosecond inscription

      Fabrication of high quality optical coherence tomography (OCT) calibration artefacts using femtosecond inscription
      Optical coherence tomography (OCT) is a non-invasive three-dimensional imaging system that is capable of producing high resolution in-vivo images. OCT is approved for use in clinical trials in Japan, USA and Europe. For OCT to be used effectively in a clinical diagnosis, a method of standardisation is required to assess the performance across different systems. This standardisation can be implemented using highly accurate and reproducible artefacts for calibration at both ...
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    6. Three-dimensional calibration targets for optical coherence tomography

      Three-dimensional calibration targets for optical coherence tomography
      The recent expansion of clinical applications for optical coherence tomography (OCT) is driving the development of approaches for consistent image acquisition. There is a simultaneous need for time-stable, easy-to-use imaging targets for calibration and standardization of OCT devices. We present calibration targets consisting of three-dimensional structures etched into nanoparticle-embedded resin. Spherical iron oxide nanoparticles with a predominant particle diameter of 400 nm were homogeneously dispersed in a two part polyurethane ...
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    7. Feature Of The Week 1/8/12: Ultrafast Processing and Rendering of OCT Data using a GPU

      Feature Of The Week 1/8/12: Ultrafast Processing and Rendering of OCT Data using a GPU
      Processing of the large volumetric data is the bottleneck of the current FD-OCT systems. Solving this issue enables real time visualisation. Various groups have applied utilising the full power of GPU for OCT data processing allows to realise the full potential of OCT. GPU based data processing to OCT. Here we present a GPU-CPU based processing methodology as well evaluates the performance of various GPUs.In standard processing, interference data ...
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    8. Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues

      Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues
      Selecting the most representative site for biopsy is crucial in establishing a definitive diagnosis of oral epithelial dysplasia. The current process involves clinical examination that can be subjective and prone to sampling errors. The aim of this study was therefore to investigate the use of optical coherence tomography (OCT) for differentiation of normal and dysplastic oral epithelial samples, with a view to developing an objective and reproducible approach for biopsy ...
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    9. Screening cervical and oesophageal tissues using optical coherence tomography

      Screening cervical and oesophageal tissues using optical coherence tomography
      Optical Coherence Tomography (OCT) is a technique that allows imaging tissue in three spatial dimensions. Such a technique makes it possible to examine the subsurface of the tissue. The depth of penetration into the tissue can be tailored by tuning the wavelength of the light source. While in some cases it is desirable to obtain deep penetration of the sample, when scanning for cancerous changes, it may only be necessary ...
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    10. Seeing is Believing: Materials scientists at NPL are developing optical techniques for measuring the content and distribution of nanoparticles in materials.

      Seeing is Believing: Materials scientists at NPL are developing optical techniques for measuring the content and distribution of nanoparticles in materials.
      ...nd out more about NPL's work on Composites. Find out more about NPL's work on Advanced Materials. Source: UK National Physical Laboratory (NPL) Even tiny concentrations of nanoparticles can have a very large effect o...
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    11. Novel non-contact optical characterisation methods of polymeric nanocomposite structures based on their particle loading and dispersion profile

      Novel non-contact optical characterisation methods of polymeric nanocomposite structures based on their particle loading and dispersion profile
      Current methods to characterise specific properties of polymeric nanocomposites (PNCs), such as particle loading and dispersion profile, rely on a number of techniques that require special sample preparation and treatment, are very expensive, require long measurement times and quite often produce ambiguous results that are difficult to evaluate and interpret. In addition, given their complexity, they are not entirely suited for in-situ industrial environments. This paper presents alternative techniques based ...
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  2. About UK National Physical Laboratory

    UK National Physical Laboratory

    National Physical Laboratory (NPL) is the UK’s National Measurement Institute and is a world-leading centre of excellence in developing and applying the most accurate measurement standards, science and technology available to man. For more than a century NPL has developed and maintained the nation’s primary measurement standards. These standards underpin an infrastructure of traceability throughout the UK and the world that ensures accuracy and consistency of measurement.  NPL ensures that cutting edge measurement science and technology have a positive impact in the real world. NPL delivers world-leading measurement solutions that are critical to commercial research and development, and support business success across the UK and the globe.  Good measurement improves productivity and quality; it underpins consumer confidence and trade and is vital to innovation. We undertake research and share our expertise with government, business and society to help enhance economic performance and the quality of life.   NPL’s measurements help to save lives, protect the environment, enable citizens to feel safe and secure, as well as supporting international trade and companies to innovation. Support in areas such as the development of advanced medical treatments and environmental monitoring helps secure a better quality of life for all.