COMPUTATIONAL OPHTHALMOLOGY MODULE OVERVIEW At UCSD, structural imaging instruments such as the spectral domain optical coherence tomography (SD-OCT) and fun...
Purpose: To compare laser photocoagulation plans for diabetic macular edema (DME) using fluorescein angiography (FA) versus optical coherence tomography (OCT) thickness map superimposed on the retina. Methods: Fourteen eyes with DME undergoing navigated laser photocoagulation with navigated photocoagulator had FA taken using the same instrument. Optical coherence tomography central retinal thickness map was imported to the photocoagulator and with same magnification aligned onto the retina. Three retina specialists placed laser spot marks separately on FA and OCT image in a masked fashion. The spots placed by each physician were compared between FA and OCT and among physicians. The area of ...
Optical coherence tomography is an imaging modality that is broadly used in ophthalmic diagnostics. The current generation of OCT systems enables reliable acquisition of volumetric scans containing information about the thicknesses of the various retinal layers. Thus, monitoring layer thickness changes is the main quantitative analysis performed by commercial instruments. In principle, measurements of the OCT signal intensity could also provide information on the health status of the retinal tissue. Unfortunately quantitative measurements and interpretation of scattering changes in retinal OCT is very limited due to variation in overall brightness of the OCT B-scans between imaging sessions. These changes might ...
Glaucoma is an ocular disease characterized by distinctive changes in the optic nerve head (ONH) and visual field. Glaucoma can strike without symptoms and causes blindness if it remains without treatment. Therefore, early disease detection is important so that treatment can be initiated and blindness prevented. In this context, important advances in technology for non-invasive imaging of the eye have been made providing quantitative tools to measure structural changes in ONH topography, an essential element for glaucoma detection and monitoring. 3D spectral domain optical coherence tomography (SD-OCT), an optical imaging technique, has been commonly used to discriminate glaucomatous from healthy ...
Background: Optic nerve head drusen (ONHD) are calcific deposits buried or at the surface of the optic disc. Although ONHD may be associated with progressive visual field defects, the mechanism of drusen-related field loss is poorly understood. Methods for detecting and imaging disc drusen include B-scan ultrasonography, fundus autofluorescence, and optical coherence tomography (OCT). These modalities are useful for drusen detection but are limited by low resolution or poor penetration of deep structures. This review was designed to assess the potential role of new OCT technologies in imaging ONHD. Evidence Acquisition: Critical appraisal of published literature and comparison of new ...
Purpose: To describe the vitreoretinal interface of the asymptomatic fellow eyes of patients with acute unilateral posterior vitreous detachment (PVD) based on biomicroscopic examination and spectral domain optical coherence tomography. Methods: Sixty-five eyes of 65 consecutive patients with acute unilateral PVD were examined by slit-lamp, indirect ophthalmoscopy, and spectral domain optical coherence tomography. The state of PVD in different retinal locations and premacular pocket were assessed and graded using spectral domain optical coherence tomography. Results: Nine eyes (13.85%) had no PVD, 15 (23.08%) had extrafoveal vitreous separation (Stage 1), 18 (27.69%) had partial foveal vitreous separation (Stage ...
Small animal models of human diseases serve as a vital component in modern medical research, including eye-related research, where they facilitate the understanding of the underlying biological processes of human disorders, and development of novel therapies against vision-robbing diseases. Non-invasive ophthalmic imaging modalities such as optical coherence tomography have become an important tool for small animal vision research programs and has greatly accelerated numerous preclinical studies. OCT offers the ability to perform longitudinal in vivo studies which are not feasible with more invasive imaging techniques such as immunohistology. However, to better visualize the retinal cellular microstructure and understand the molecular ...
University of California at San Diego (UCSD) is a public research university in San Diego, California. UCSD is one of ten University of California campuses and was founded in 1955 around the pre-existing Scripps Institution of Oceanography.
