Purpose: To describe the vitreoretinal interface of the asymptomatic fellow eyes of patients with acute unilateral posterior vitreous detachment (PVD) based on biomicroscopic examination and spectral domain optical coherence tomography. Methods: Sixty-five eyes of 65 consecutive patients with acute unilateral PVD were examined by slit-lamp, indirect ophthalmoscopy, and spectral domain optical coherence tomography. The state of PVD in different retinal locations and premacular pocket were assessed and graded using spectral domain optical coherence tomography. Results: Nine eyes (13.85%) had no PVD, 15 (23.08%) had extrafoveal vitreous separation (Stage 1), 18 (27.69%) had partial foveal vitreous separation (Stage ...
Small animal models of human diseases serve as a vital component in modern medical research, including eye-related research, where they facilitate the understanding of the underlying biological processes of human disorders, and development of novel therapies against vision-robbing diseases. Non-invasive ophthalmic imaging modalities such as optical coherence tomography have become an important tool for small animal vision research programs and has greatly accelerated numerous preclinical studies. OCT offers the ability to perform longitudinal in vivo studies which are not feasible with more invasive imaging techniques such as immunohistology. However, to better visualize the retinal cellular microstructure and understand the molecular ...
Purpose: To report the results of imaging using high-resolution, Fourier domain anterior segment optical coherence tomography (AS-OCT) to evaluate patients with a type 1 Boston Keratoprosthesis (KPro). Methods: We performed a retrospective comparative study of patients in whom we implanted the Boston KPro. A total of 26 eyes of 23 patients from the Cornea Service at the University of California Davis Eye Center were included. Subjects were evaluated with the Spectralis AS-OCT (Heidelberg Engineering GmbH). Results: Preoperative diagnoses for KPro surgery included failed corneal transplant (69%), chemical burn (23%), and aniridia (8%). The average age of patients was 63.2 ...
Purpose: To evaluate the safety of oral fluorescein angiography (FA) and to compare its efficacy in detection of macular edema (ME) with spectral-domain optical coherence tomography (SD-OCT). Methods: Results of imaging studies for 1,928 eyes of 1,019 patients who had simultaneously undergone both oral FA and SD-OCT by a confocal laser ophthalmoscope were reviewed. Sensitivity in detecting ME, discrepancy rate, and "kappa" agreement were determined for both the techniques and with eyes stratified by disease diagnosis. Results: No allergic reactions occurred after oral FA. Mild gastric discomfort was noted in <1% of the patients; 1,840 eyes (95 ...
Purpose. To study retinal structure in choroideremia patients and carriers using high-resolution imaging techniques. Methods. Subjects from four families (six female carriers and five affected males) with choroideremia (CHM) were characterized with best-corrected visual acuity (BCVA), kinetic and static perimetry, full-field electroretinography, and fundus autofluorescence (FAF). High-resolution macular images were obtained with adaptive optics scanning laser ophthalmoscopy (AOSLO) and spectral domain optical coherence tomography (SD-OCT). Coding regions of the CHM gene were sequenced. Results. Molecular analysis of the CHM gene identified a deletion of exons 9 to 15 in family A, a splice site mutation at position 79+1 of ...
Purpose: Correlating spectral domain optical coherence tomography characteristics with final best-corrected visual acuity (BCVA) in eyes with subfoveal scarring after treatment for wet age-related macular degeneration. Methods: Seventy-nine eyes from 64 subjects, who developed subfoveal scarring after treatment of wet age-related macular degeneration, were retrospectively studied. Spectral domain optical coherence tomography characteristics were analyzed, including percentage disruption of inner segment/outer segment junction and external limiting membrane, central macular thickness, subfoveal scar thickness, subretinal scar area, and proximity of retina with intact outer structures to the fovea. A multivariate stepwise regression analysis was performed with the final BCVA logarithm of ...
Purpose: To evaluate and compare the diagnostic abilities of the speckle noise-reduced spectral-domain optical coherence tomography (SD-OCT; Spectralis OCT) and time-domain optical coherence tomography (TD-OCT; Stratus OCT) to detect localized retinal nerve fiber layer (RNFL) defects in patients with preperimetric open-angle glaucoma. Methods: Thirty-five eyes of 35 preperimetric glaucoma patients with localized RNFL defects and 72 normal control eyes were scanned using SD-OCT and TD-OCT. Areas under the receiver-operating characteristic curves (AUROCs), and the sensitivity and specificity for detecting localized RNFL defects based on the internal normative database of each device were calculated and compared. Results: The AUROC for the ...
Three-dimensional reconstruction of optical coherence tomography (OCT) images is a modern technique that helps interpret the images and understand the underlying disease. However, the 3D reconstruction displayed on commercial devices is of limited quality: images are shown on 2D screens and it is difficult or impossible to adjust the view point and capture the data set from a meaningful perspective. We did a preliminary study to evaluate the applicability of a novel, 3D TV-based virtual reality system with interactive volume rendering software to clinical diagnostics and present a workflow, which can incorporate virtual reality technology at various levels of immersion ...
University of California at San Diego (UCSD) is a public research university in San Diego, California. UCSD is one of ten University of California campuses and was founded in 1955 around the pre-existing Scripps Institution of Oceanography.
