1. UCLA

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    1. Mentioned In 234 Articles

    2. Concerns about the interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication

      Concerns about the interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication
      We read with great interest the correspondence in Lancet by Marinho et al. [ 1 ] describing purported retinal manifestations of coronavirus disease (COVID-19). While there is great interest to understand potential ocular complications of COVID-19 during this pandemic, we have some concerns regarding the interpretation of the fundus and optical coherence tomography (OCT) findings. Marinho et al. examined 12 COVID-19 patients (all confirmed by PCR or antibody testing) with typical systemic ...
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    3. Frequency-doubled FDML-MOPA laser in the visible

      Frequency-doubled FDML-MOPA laser in the visible
      Wavelength-swept lasers enable high-speed measurements in absorption spectroscopy, Raman spectroscopy, nonlinear Raman hyperspectral microscopy, rapid confocal microscopy, short impulse generation, and most importantly for high-speed optical coherence tomography, with speeds up to video-rate volumetric imaging. Recently, we introduced a pulsed wavelength-swept laser based on the Fourier domain mode-locked (FDML) laser principle combined with a master-oscillator power amplifier (MOPA) architecture. The high peak powers reached with this laser enabled rapid two-photon ...
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    4. Optical coherence tomography angiography for detection of macular neovascularization associated with atrophy in age-related macular degeneration

      Optical coherence tomography angiography for detection of macular neovascularization associated with atrophy in age-related macular degeneration
      Purpose To evaluate the ability of optical coherence tomography angiography (OCTA) to detect macular neovascularization (MNV) in eyes with atrophy compared with fluorescein angiography (FA), indocyanine green angiography (ICGA), and optical coherence tomography (OCT). Methods In this prospective study, eyes with MNV and atrophy (termed macular atrophy or MA) secondary to age-related macular degeneration (AMD), and AMD eyes with geographic atrophy (GA) without MNV underwent multimodal imaging with FA, ICGA ...
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    5. Association of Intravitreal Aflibercept With Optical Coherence Tomography Angiography Vessel Density in Patients With Proliferative Diabetic Retinopathy: A Secondary Analysis of a Randomized Clinical Trial

      Association of Intravitreal Aflibercept With Optical Coherence Tomography Angiography Vessel Density in Patients With Proliferative Diabetic Retinopathy: A Secondary Analysis of a Randomized Clinical Trial
      Importance Although previous studies have evaluated the association between antivascular endothelial growth factor therapy and macular vessel density, they were confounded by the presence of macular edema, which may be associated with artifacts and segmentation errors in optical coherence tomography angiography (OCTA). Objective To evaluate the association of intravitreal aflibercept with changes in macular vascular density using OCTA in patients with proliferative diabetic retinopathy without diabetic macular edema. Design, Setting ...
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    6. Evaluation of retinal vessel quantity within individual retinal structural layers using optical coherence tomography angiography

      Evaluation of retinal vessel quantity within individual retinal structural layers using optical coherence tomography angiography
      Purpose To evaluate retinal vessel quantity within various retinal structural layers using optical coherence tomography angiography (OCTA). Methods In this IRB-approved study, 22 normal eyes (from 22 subjects) were imaged using the Spectralis OCT2, with a 15 15 degree OCTA scan centered on fovea and two additional 15 5 degree OCTA scans, displaced temporally and nasally by 15 degrees along the fovea-Bruchs membrane opening (BMO) axis. Following projection artifact removal ...
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    7. Automated Retinal Layer Segmentation Using Graph-based Algorithm Incorporating Deep-learning-derived Information

      Automated Retinal Layer Segmentation Using Graph-based Algorithm Incorporating Deep-learning-derived Information
      Regular drusen, an accumulation of material below the retinal pigment epithelium (RPE), have long been established as a hallmark early feature of nonneovascular age-related macular degeneration (AMD). Advances in imaging have expanded the phenotype of AMD to include another extracellular deposit, reticular pseudodrusen (RPD) (also termed subretinal drusenoid deposits, SDD), which are located above the RPE. We developed an approach to automatically segment retinal layers associated with regular drusen and ...
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    8. Subtype-differentiated impacts of subretinal drusenoid deposits on photoreceptors revealed by adaptive optics scanning laser ophthalmoscopy

      Subtype-differentiated impacts of subretinal drusenoid deposits on photoreceptors revealed by adaptive optics scanning laser ophthalmoscopy
      Purpose To examine the structure of photoreceptors surrounding two subtypes of subretinal drusenoid deposits (SDD), namely, dot and ribbon SDD, using multimodal imaging including adaptive optics scanning laser ophthalmoscopy (AOSLO) and spectral-domain optical coherence tomography (SD-OCT). Methods Twenty-six eyes of 13 patients with age-related macular degeneration (AMD) and SDD and 16 eyes of 8 subjects in normal chorioretinal health were studied. SDD presence, stage, and subtype were determined using color ...
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    9. Anterior segment optical coherence tomography imaging in peripheral ulcerative keratitis, a corneal structural description

      Anterior segment optical coherence tomography imaging in peripheral ulcerative keratitis, a corneal structural description
      Background Anterior segment optical coherence tomography (AS OCT) is a helpful tool used to diagnose and manage many corneal conditions, but its use has not been reported in case of peripheral ulcerative keratitis (PUK). The aim of this study is to describe AS OCT findings in cases of PUK. Methods Retrospective observational case series of six eyes presenting with a PUK and proven systemic vasculitis. Clinical course, slit lamp photographs ...
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      Mentions: UCLA
    10. Thresholding strategies to measure vessel density by optical coherence tomography angiography

      Thresholding strategies to measure vessel density by optical coherence tomography angiography
      Objective A variety of binarization strategies have been used to measure vessel density by optical coherence tomography angiography (OCT-A), but it is uncertain if they produce similar results. The purpose of the study was to evaluate the impact of different thresholding methods and contrast and brightness adjustment on OCT-A vessel density metrics. Design Observational, cross-sectional case series. Participants Consecutive healthy volunteers. Methods Healthy volunteers underwent fovea-centred 3 mm 3 mm ...
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    11. Optimizing the Repeatability of Choriocapillaris Flow Deficit Measurement from Optical Coherence Tomography Angiography

      Optimizing the Repeatability of Choriocapillaris Flow Deficit Measurement from Optical Coherence Tomography Angiography
      Purpose To evaluate impact of processing technique and slab selection on the repeatability of choriocapillaris (CC) flow deficit (FD) measurements as assessed using optical coherence tomography angiography (OCTA) Design: prospective, cross-sectional study Methods Healthy subjects were imaged with four consecutive 3x3mm OCTA using a swept source OCT (PLEX elite 9000, Carl Zeiss Meditec, Dublin, CA). OCTA images were generated using the Max projection, and three 10 m-thick slabs starting 11 ...
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    12. Effect of image averaging on optical coherence tomography angiography data in eyes with branch retinal vein occlusion

      Effect of image averaging on optical coherence tomography angiography data in eyes with branch retinal vein occlusion
      Purpose To investigate the effect of image averaging on qualitative and quantitative assessments of optical coherence tomography angiography (OCTA) images from eyes of patients with branch retinal vein occlusion (BRVO). Methods Macular OCTA images of 33 eyes of 33 patients with BRVO were obtained using the HS100 HR-SD-OCT system (Canon, Inc.). For each eye, five OCTA cube scans were obtained with a 33 mm scan protocol, and the data were ...
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    13. Clinical Corneal Optical Coherence Elastography Measurement Precision: Effect of Heartbeat and Respiration

      Clinical Corneal Optical Coherence Elastography Measurement Precision: Effect of Heartbeat and Respiration
      Purpose : Normal physiological movements (e.g., respiration and heartbeat) induce eye motions during clinical measurements of human corneal biomechanical properties using optical coherence elastography (OCE). We quantified the effects of respiratory and cardiac-induced eye motions on clinical corneal OCE measurement precision and repeatability. Methods : Corneal OCE was performed using low-force, micro-air-pulse tissue stimulation and high-resolution phase-sensitive optical coherence tomography (OCT) imaging. Axial surface displacements of the corneal apex were measured ...
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    14. Reproducibility and agreement of four anterior segment-optical coherence tomography devices for anterior chamber angle measurements

      Reproducibility and agreement of four anterior segment-optical coherence tomography devices for anterior chamber angle measurements
      Purpose To compare the reproducibility and agreement of anterior chamber angle (ACA) parameters and metrics obtained by four different anterior segment-optical coherence tomography (AS-OCT) devices. Methods In this prospective study, 30 eyes from 15 normal subjects underwent anterior segment angle scanning using the Spectralis, Cirrus, and Optovue spectral domain optical coherence tomography (SD-OCT), as well as the Visante time-domain optical coherence tomography (TD-OCT). For each eye, the scan line was ...
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    15. Quantitative assessment of the retinal microvasculature and choriocapillaris in myopic patients using swept-source optical coherence tomography angiography

      Quantitative assessment of the retinal microvasculature and choriocapillaris in myopic patients using swept-source optical coherence tomography angiography
      ...rate myopia (3D, 6D), and age-matched healthy subjects presenting to the Shanghai General Hospital and Doheny-UCLA Eye Centers were enrolled in this prospective, multicenter study. Any subjects with evidence of macular a...
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    16. Arm-mounted Optical Coherence Tomography Angiography in Extremely Low Birth Weight Neonates with Retinopathy of Prematurity

      Arm-mounted Optical Coherence Tomography Angiography in Extremely Low Birth Weight Neonates with Retinopathy of Prematurity
      Purpose To assess the feasibility of imaging extremely low birth weight infants, defined as infants born weighing less than 1000 grams or before 27 weeks of gestational age, with an arm-mounted optical coherence tomography angiography (OCTA) device. Methods Cross-sectional case series conducted at a single site in-patient academic center. Subjects included infants who had been born premature and met ROP screening criteria. Birth history such as gestational age and birth ...
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      Mentions: UCLA
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  2. About UCLA

    UCLA

    University of California at Los Angeles (UCLA) is a public research university located in Westwood, Los Angeles, California, United States. It was founded in 1919, making it the second-oldest general-purpose campus in the University of California system. The name was changed in 1927 to the University of California at Los Angeles. UCLA comprises the College of Letters and Science (the primary undergraduate college) as well as undergraduate colleges Arts and Architecture, Herb Alpert School of Music, Henry Samueli School of Engineering and Applied Science, Nursing, and Theater, Film, and Television, seven professional schools, and five professional Health Science schools. Since 2001, UCLA has enrolled over 33,000 total students annually, and that number is steadily rising.