1. UCLA

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    1. Mentioned In 240 Articles

    2. Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Neuroretinal Rim Thickness Using Spectral-Domain Optical Coherence Tomography

      Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Neuroretinal Rim Thickness Using Spectral-Domain Optical Coherence Tomography
      Purpose : To compare the rates of clinically significant artifacts for two-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness versus three-dimensional (3D) neuroretinal rim thickness using spectral-domain optical coherence tomography (SD-OCT). Methods : Only one eye per patient was used for analysis of 120 glaucoma patients and 114 normal patients. For RNFL scans and optic nerve scans, 15 artifact types were calculated per B-scan and per eye. Neuroretinal rim tissue was quantified ...
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    3. Detection of Glaucoma Deterioration in The Macular Region with Optical Coherence Tomography: Challenges and Solutions

      Detection of Glaucoma Deterioration in The Macular Region with Optical Coherence Tomography: Challenges and Solutions
      Purpose Macular imaging with optical coherence tomography (OCT) measures the most critical retinal ganglion cells (RGC) in the human eye. The goal of this perspective is to review the challenges to detection of glaucoma progression with macular OCT imaging and propose ways to enhance its performance. Design Perspective with review of relevant literature. Methods Review of challenges and issues related to detection of change on macular OCT images in glaucoma ...
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      Mentions: UCLA
    4. Classification of advanced and early stages of diabetic retinopathy from non-diabetic subjects by an ordinary least squares modeling method applied to OCTA images

      Classification of advanced and early stages of diabetic retinopathy from non-diabetic subjects by an ordinary least squares modeling method applied to OCTA images
      As the prevalence of diabetic retinopathy (DR) continues to rise, there is a need to develop computer-aided screening methods. The current study reports and validates an ordinary least squares (OLS) method to model optical coherence tomography angiography (OCTA) images and derive OLS parameters for classifying proliferative DR (PDR) and no/mild non-proliferative DR (NPDR) from non-diabetic subjects. OLS parameters were correlated with vessel metrics quantified from OCTA images and were ...
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      Mentions: UCLA
    5. OCT Angiography to Predict Geographic Atrophy Progression using Choriocapillaris Flow Void as a Biomarker

      OCT Angiography to Predict Geographic Atrophy Progression using Choriocapillaris Flow Void as a Biomarker
      Purpose : To investigate the relationship between choriocapillaris (CC) flow void (FV) percentage and geographic atrophy (GA) growth rate, and study how variations in FV percentage surrounding GA predict regional GA growth. Methods : This prospective, longitudinal study enrolled subjects with GA secondary to nonexudative age-related macular degeneration. Optical coherence tomography angiography imaged the CC and FV percentage was evaluated using a validated algorithm. GA growth rate was measured as the difference ...
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    6. Impact of Scan Tilt on Quantitative Assessments Using Optical Coherence Tomography Angiography

      Impact of Scan Tilt on Quantitative Assessments Using Optical Coherence Tomography Angiography
      Purpose : To investigate the impact of scan tilt on quantitative assessments using swept-source optical coherence tomography angiography (SS-OCTA) in healthy participants. Methods : Healthy participants were imaged with a SS-OCTA system (PLEX Elite 9000; Carl Zeiss Meditec, Inc, Dublin, CA). After a standard scan was obtained, tilted scans were obtained by moving the optical coherence tomography beam entrance position horizontally. The tilting angle was measured from the B-scan image, and the ...
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    7. Comparison of Rates of Progression of Macular OCT Measures in Glaucoma

      Comparison of Rates of Progression of Macular OCT Measures in Glaucoma
      Purpose : The purpose of this study was to compare rates of change of various macular thickness measures and evaluate the influence of baseline damage on macular rates of change. Methods : One hundred twelve eyes (112 patients) with 2 years of follow-up and 5 macular optical coherence tomography (OCT) images and 10-2 visual field (VF) tests were included. OCT measures of interests were full macular thickness (FMT), ganglion cell complex (GCC ...
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      Mentions: UCLA
    8. Concerns about the interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication

      Concerns about the interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication
      We read with great interest the correspondence in Lancet by Marinho et al. [ 1 ] describing purported retinal manifestations of coronavirus disease (COVID-19). While there is great interest to understand potential ocular complications of COVID-19 during this pandemic, we have some concerns regarding the interpretation of the fundus and optical coherence tomography (OCT) findings. Marinho et al. examined 12 COVID-19 patients (all confirmed by PCR or antibody testing) with typical systemic ...
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    9. Frequency-doubled FDML-MOPA laser in the visible

      Frequency-doubled FDML-MOPA laser in the visible
      Wavelength-swept lasers enable high-speed measurements in absorption spectroscopy, Raman spectroscopy, nonlinear Raman hyperspectral microscopy, rapid confocal microscopy, short impulse generation, and most importantly for high-speed optical coherence tomography, with speeds up to video-rate volumetric imaging. Recently, we introduced a pulsed wavelength-swept laser based on the Fourier domain mode-locked (FDML) laser principle combined with a master-oscillator power amplifier (MOPA) architecture. The high peak powers reached with this laser enabled rapid two-photon ...
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    10. Optical coherence tomography angiography for detection of macular neovascularization associated with atrophy in age-related macular degeneration

      Optical coherence tomography angiography for detection of macular neovascularization associated with atrophy in age-related macular degeneration
      Purpose To evaluate the ability of optical coherence tomography angiography (OCTA) to detect macular neovascularization (MNV) in eyes with atrophy compared with fluorescein angiography (FA), indocyanine green angiography (ICGA), and optical coherence tomography (OCT). Methods In this prospective study, eyes with MNV and atrophy (termed macular atrophy or MA) secondary to age-related macular degeneration (AMD), and AMD eyes with geographic atrophy (GA) without MNV underwent multimodal imaging with FA, ICGA ...
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    11. Association of Intravitreal Aflibercept With Optical Coherence Tomography Angiography Vessel Density in Patients With Proliferative Diabetic Retinopathy: A Secondary Analysis of a Randomized Clinical Trial

      Association of Intravitreal Aflibercept With Optical Coherence Tomography Angiography Vessel Density in Patients With Proliferative Diabetic Retinopathy: A Secondary Analysis of a Randomized Clinical Trial
      Importance Although previous studies have evaluated the association between antivascular endothelial growth factor therapy and macular vessel density, they were confounded by the presence of macular edema, which may be associated with artifacts and segmentation errors in optical coherence tomography angiography (OCTA). Objective To evaluate the association of intravitreal aflibercept with changes in macular vascular density using OCTA in patients with proliferative diabetic retinopathy without diabetic macular edema. Design, Setting ...
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    12. Evaluation of retinal vessel quantity within individual retinal structural layers using optical coherence tomography angiography

      Evaluation of retinal vessel quantity within individual retinal structural layers using optical coherence tomography angiography
      Purpose To evaluate retinal vessel quantity within various retinal structural layers using optical coherence tomography angiography (OCTA). Methods In this IRB-approved study, 22 normal eyes (from 22 subjects) were imaged using the Spectralis OCT2, with a 15 15 degree OCTA scan centered on fovea and two additional 15 5 degree OCTA scans, displaced temporally and nasally by 15 degrees along the fovea-Bruchs membrane opening (BMO) axis. Following projection artifact removal ...
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    13. Automated Retinal Layer Segmentation Using Graph-based Algorithm Incorporating Deep-learning-derived Information

      Automated Retinal Layer Segmentation Using Graph-based Algorithm Incorporating Deep-learning-derived Information
      Regular drusen, an accumulation of material below the retinal pigment epithelium (RPE), have long been established as a hallmark early feature of nonneovascular age-related macular degeneration (AMD). Advances in imaging have expanded the phenotype of AMD to include another extracellular deposit, reticular pseudodrusen (RPD) (also termed subretinal drusenoid deposits, SDD), which are located above the RPE. We developed an approach to automatically segment retinal layers associated with regular drusen and ...
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    14. Subtype-differentiated impacts of subretinal drusenoid deposits on photoreceptors revealed by adaptive optics scanning laser ophthalmoscopy

      Subtype-differentiated impacts of subretinal drusenoid deposits on photoreceptors revealed by adaptive optics scanning laser ophthalmoscopy
      Purpose To examine the structure of photoreceptors surrounding two subtypes of subretinal drusenoid deposits (SDD), namely, dot and ribbon SDD, using multimodal imaging including adaptive optics scanning laser ophthalmoscopy (AOSLO) and spectral-domain optical coherence tomography (SD-OCT). Methods Twenty-six eyes of 13 patients with age-related macular degeneration (AMD) and SDD and 16 eyes of 8 subjects in normal chorioretinal health were studied. SDD presence, stage, and subtype were determined using color ...
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    15. Anterior segment optical coherence tomography imaging in peripheral ulcerative keratitis, a corneal structural description

      Anterior segment optical coherence tomography imaging in peripheral ulcerative keratitis, a corneal structural description
      Background Anterior segment optical coherence tomography (AS OCT) is a helpful tool used to diagnose and manage many corneal conditions, but its use has not been reported in case of peripheral ulcerative keratitis (PUK). The aim of this study is to describe AS OCT findings in cases of PUK. Methods Retrospective observational case series of six eyes presenting with a PUK and proven systemic vasculitis. Clinical course, slit lamp photographs ...
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      Mentions: UCLA
    16. Thresholding strategies to measure vessel density by optical coherence tomography angiography

      Thresholding strategies to measure vessel density by optical coherence tomography angiography
      Objective A variety of binarization strategies have been used to measure vessel density by optical coherence tomography angiography (OCT-A), but it is uncertain if they produce similar results. The purpose of the study was to evaluate the impact of different thresholding methods and contrast and brightness adjustment on OCT-A vessel density metrics. Design Observational, cross-sectional case series. Participants Consecutive healthy volunteers. Methods Healthy volunteers underwent fovea-centred 3 mm 3 mm ...
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  2. About UCLA

    UCLA

    University of California at Los Angeles (UCLA) is a public research university located in Westwood, Los Angeles, California, United States. It was founded in 1919, making it the second-oldest general-purpose campus in the University of California system. The name was changed in 1927 to the University of California at Los Angeles. UCLA comprises the College of Letters and Science (the primary undergraduate college) as well as undergraduate colleges Arts and Architecture, Herb Alpert School of Music, Henry Samueli School of Engineering and Applied Science, Nursing, and Theater, Film, and Television, seven professional schools, and five professional Health Science schools. Since 2001, UCLA has enrolled over 33,000 total students annually, and that number is steadily rising.