1. UC Riverside

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    1. Mentioned In 30 Articles

    2. The optoretinogram reveals the primary steps of phototransduction in the living human eye

      The optoretinogram reveals the primary steps of phototransduction in the living human eye
      Photoreceptors initiate vision by converting photons to electrical activity. The onset of the phototransduction cascade is marked by the isomerization of photopigments upon light capture. We revealed that the onset of phototransduction is accompanied by a rapid (5 ms), nanometer-scale electromechanical deformation in individual human cone photoreceptors. Characterizing this biophysical phenomenon associated with phototransduction in vivo was enabled by high-speed phase-resolved optical coherence tomography in a line-field configuration that allowed ...
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    3. Integrated multimodality intravascular imaging system that combines optical coherence tomography, ultrasound imaging, and acoustic radiation force optical coherence elastography

      Integrated multimodality intravascular imaging system that combines optical coherence tomography, ultrasound imaging, and acoustic radiation force optical coherence elastography
      An integrated intraluminal imaging system includes an optical coherence tomography interferometer (OCT), an ultrasound subsystem (US) and a phase resolved acoustic radiation force optical coherence elastography subsystem (PR-RAF-OCE). The steps include performing OCT to generate a returned optical signal, performing US imaging to generate a returned ultrasound signal, performing PRARF-OCE to generate a returned PR-ARF-OCE signal by generating a amplitude modulated ultrasound beam or chirped amplitude modulated ultrasound beam to ...
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    4. Hyperspectral Imaging Using Visible-Light Optical Coherence Tomography (HIS-OCT) for Retina Imaging and Oximetry (Thesis)

      Hyperspectral Imaging Using Visible-Light Optical Coherence Tomography (HIS-OCT) for Retina Imaging and Oximetry (Thesis)
      Optical coherence tomography (OCT) is a diverse imaging modality that has been used to image the retina and diagnose various eye related disease due to its high resolution, fast acquisition speeds, and non-invasive properties [1] [2] [3] [4]. OCT has been increasingly used in a clinical setting since it was first introduced in 1991 [2] [5]; since that time, OCT has been able to improve how we diagnose and view ...
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      Mentions: UC Riverside
    5. University of California at Berkeley Receives NIH Grant for Interferometric Optophysiology of the Human Retina

      University of California at Berkeley Receives NIH Grant for Interferometric Optophysiology of the Human Retina
      ...combining and validating two new approaches. First, interferometry (including phase-resolved OCT; Park Lab at UC Riverside) can, in principle, be used to measure nanometer-scale distortions in the membranes of cells that...
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    6. OCT intensity and phase fluctuations correlated with activity-dependent neuronal calcium dynamics in the Drosophila CNS [Invited]

      OCT intensity and phase fluctuations correlated with activity-dependent neuronal calcium dynamics in the Drosophila CNS [Invited]
      Phase-resolved OCT and fluorescence microscopy were used simultaneously to examine stereotypic patterns of neural activity in the isolated Drosophila central nervous system. Both imaging modalities were focused on individually identified bursicon neurons known to be involved in a fixed action pattern initiated by ecdysis-triggering hormone. We observed clear correspondence of OCT intensity, phase fluctuations, and activity-dependent calcium-induced fluorescence.
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    7. University of California at Berkely Receives NIH Grant for Interferometric Optophysiology of the Human Retina

      University of California at Berkely Receives NIH Grant for Interferometric Optophysiology of the Human Retina
      ...combining and validating two new approaches. First, interferometry (including phase-resolved OCT; Park Lab at UC Riverside) can, in principle, be used to measure nanometer-scale distortions in the membranes of cells that...
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    8. Visualizing Cortical Tissue Optical Changes During Seizure Activity with Optical Coherence Tomography

      Visualizing Cortical Tissue Optical Changes During Seizure Activity with Optical Coherence Tomography
      Optical coherence tomography (OCT) is a label-free, high resolution, minimally invasive imaging tool, which can produce millimeter depth-resolved cross-sectional images. We identified changes in the backscattered intensity of infrared light, which occurred during the development of induced seizures in vivo in mice. In a large region of interest, we observed significant decreases in the OCT intensity from cerebral cortex tissue preceding and during generalized tonic-clonic seizures induced with pentylenetetrazol (PTZ ...
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    9. In vivo optical microscopy of peripheral nerve myelination with polarization sensitive-optical coherence tomography

      In vivo optical microscopy of peripheral nerve myelination with polarization sensitive-optical coherence tomography
      Assessing nerve integrity and myelination after injury is necessary to provide insight for treatment strategies aimed at restoring neuromuscular function. Currently, this is largely done with electrical analysis, which lacks direct quantitative information. In vivo optical imaging with sufficient imaging depth and resolution could be used to assess the nerve microarchitecture. In this study, we examine the use of polarization sensitive-optical coherence tomography (PS-OCT) to quantitatively assess the sciatic nerve ...
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    10. Decreased light attenuation in cerebral cortex during cerebral edema detected using optical coherence tomography

      Decreased light attenuation in cerebral cortex during cerebral edema detected using optical coherence tomography
      Cerebral edema develops in response to a variety of conditions, including traumatic brain injury and stroke, and contributes to the poor prognosis associated with these injuries. This study examines the use of optical coherence tomography (OCT) for detecting cerebral edema in vivo . Three-dimensional imaging of an in vivo water intoxication model in mice was performed using a spectral-domain OCT system centered at 1300 nm. The change in attenuation coefficient was ...
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  2. About UC Riverside

    UC Riverside

    University of California at Riverside is one of 10 universities within the prestigious University of California system, and the only UC located in Inland Southern California.  Widely recognized as one of the most ethnically diverse research universities in the nation, UCR's current enrollment is 17,187 students, with a goal of 21,000 students by 2010. The campus is in the midst of a tremendous growth spurt with new and remodeled facilities coming on-line on a regular basis.  We are located approximately 50 miles east of downtown Los Angeles. UCR is also within easy driving distance of dozens of major cultural and recreational sites, as well as desert, mountain and coastal destinations.