1. UC Irvine

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    1. Mentioned In 362 Articles

    2. Optical coherence tomography for cancer screening and triage

      Optical coherence tomography for cancer screening and triage
      A device for cancer screening and triage using an optical coherence tomography (OCT) imaging system integrated with optical imaging probe is provided. Endoscopic OCT images are generated using the OCT system having a helical probe. The images are further analyzed to generate a depth resolved intensity OCT signal to classify the region of tissue into variable grades of dysplasia to guide the physician's biopsy or resection.
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      Mentions: UC Irvine
    3. First interobserver agreement of optical coherence tomography in the bile duct: A multicenter collaborative study

      First interobserver agreement of optical coherence tomography in the bile duct: A multicenter collaborative study
      Background and study aims Optical coherence tomography (OCT) is a new technology available for evaluation of indeterminate biliary strictures. It allows under-the-surface visualization and preliminary studies have confirmed standardized characteristics associated with malignancy. The aim of this study is to evaluate the first interobserver agreement in identifying previously agreed upon OCT criteria and diagnosing of malignant versus benign disease. Patients and methods Fourteen endoscopists were asked to review an atlas ...
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    4. Central Macular Topographic and Volumetric Measures: New Biomarkers for Detection of Glaucoma

      Central Macular Topographic and Volumetric Measures: New Biomarkers for Detection of Glaucoma
      Purpose : To test the hypothesis that newly developed shape measures using optical coherence tomography (OCT) macular volume scans can discriminate patients with perimetric glaucoma from healthy subjects. Methods : OCT structural measures defining macular topography and volume were recently developed based on cubic Bzier curves. We exported macular volume scans from 135 eyes with glaucoma (133 patients) and 155 healthy eyes (85 subjects) and estimated global and quadrant-based measures. The best ...
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      Mentions: UC Irvine UCLA
    5. OCT Evaluation of Vaginal Epithelial Thickness during CO2 Laser Treatment: A Pilot Study

      OCT Evaluation of Vaginal Epithelial Thickness during CO2 Laser Treatment: A Pilot Study
      Genitourinary syndrome of menopause (GSM) negatively affects more than half of postmenopausal women. Energy-based therapy has been explored as a minimally invasive treatment for GSM; however, its mechanism of action and efficacy is controversial. Here, we report on a pilot imaging study conducted on a small group of menopause patients undergoing laser treatment. Intravaginal optical coherence tomography (OCT) endoscope was used to quantitatively monitor the changes in the vaginal epithelial ...
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      Mentions: UC Irvine
    6. Visualization of ex vivo rabbit olfactory mucosa and foramina with three-dimensional optical coherence tomography

      Visualization of ex vivo rabbit olfactory mucosa and foramina with three-dimensional optical coherence tomography
      There is increasing interest in developing a minimally invasive imaging modality to safely evaluate dynamic microscopic changes of the olfactory mucosa and cribriform foramina. Herein, we utilized three-dimensional (3D) optical coherence tomography (OCT) to characterize the ex vivo stratified substructure of olfactory mucosa in rabbits and create 3D reconstructed images of olfactory foramina. Olfactory mucosa and cribriform plates from four New Zealand White rabbits were dissected and imaged using two ...
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      Mentions: UC Irvine
    7. The Role of Optical Coherence Tomography Criteria and Machine Learning in Multiple Sclerosis and Optic Neuritis Diagnosis

      The Role of Optical Coherence Tomography Criteria and Machine Learning in Multiple Sclerosis and Optic Neuritis Diagnosis
      Background and objectives: Recent studies have suggested that inter-eye differences (IEDs) in peripapillary retinal nerve fiber layer (pRNFL) or ganglion cell+inner plexiform (GCIPL) thickness by spectral-domain optical coherence tomography (SD-OCT) may identify people with a history of unilateral optic neuritis (ON). However, this requires further validation. Machine learning classification may be useful for validating thresholds for OCT IEDs and for examining added utility for visual function tests, such as ...
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    8. Intravascular polarization-sensitive optical coherence tomography based on polarization mode delay

      Intravascular polarization-sensitive optical coherence tomography based on polarization mode delay
      Intravascular polarization-sensitive optical coherence tomography (IV-PSOCT) provides depth-resolved tissue birefringence which can be used to evaluate the mechanical stability of a plaque. In our previous study, we reported a new strategy to construct polarization-sensitive optical coherence tomography in a microscope platform. Here, we demonstrated that this technology can be implemented in an endoscope platform, which has many clinical applications. A conventional intravascular OCT system can be modified for IV-PSOCT by ...
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      Mentions: UC Irvine
    9. Research Techniques Made Simple: Emerging Imaging Technologies for Noninvasive Optical Biopsy of Human Skin

      Research Techniques Made Simple: Emerging Imaging Technologies for Noninvasive Optical Biopsy of Human Skin
      Over the past few years, high-resolution optical imaging technologies such as optical coherence tomography (OCT), reflectance confocal microscopy (RCM), and multiphoton microscopy (MPM) have advanced significantly as new methodologies for clinical research and for real-time detection, diagnosis, and therapy monitoring of skin diseases. Implementation of these technologies into clinical research and practice requires clinicians to have an understanding of their capabilities, benefits, and limitations. This concise review provides insights on ...
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    10. Enhance the delivery of light energy ultra-deep into turbid medium by controlling multiple scattering photons to travel in open channels

      Enhance the delivery of light energy ultra-deep into turbid medium by controlling multiple scattering photons to travel in open channels
      Multiple light scattering is considered as the major limitation for deep imaging and focusing in turbid media. In this paper, we present an innovative method to overcome this limitation and enhance the delivery of light energy ultra-deep into turbid media with significant improvement in focusing. Our method is based on a wide-field reflection matrix optical coherence tomography (RM-OCT). The time-reversal decomposition of the RM is calibrated with the Tikhonov regularization ...
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      Mentions: UC Irvine
    11. Rapid chemically selective 3D imaging in the mid-infrared

      Rapid chemically selective 3D imaging in the mid-infrared
      The emerging technique of mid-infrared optical coherence tomography (MIR-OCT) takes advantage of the reduced scattering of MIR light in various materials and devices, enabling tomographic imaging at deeper penetration depths. Because of challenges in MIR detection technology, the image acquisition time is, however, significantly longer than for tomographic imaging methods in the visible/near-infrared. Here we demonstrate an alternative approach to MIR tomography with high-speed imaging capabilities. Through femtosecond nondegenerate ...
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      Mentions: UC Irvine
    12. Optical coherence tomography device for characterization of atherosclerosis with a 1.7 micron swept laser source

      Optical coherence tomography device for characterization of atherosclerosis with a 1.7 micron swept laser source
      An OCT system with a swept light source centered around 1.7 .mu.m for identifying atherosclerotic plaque and visualization of large lipid pool is provided. Advantages for using the 1.7 .mu.m swept source laser include higher contrast between lipid and normal tissue and deeper penetration of the optical signals from the 1.7 .mu.m swept source laser into the tissue. With deeper penetration into the tissue ...
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      Mentions: UC Irvine
    13. Systematic dispersion compensation for spectral domain optical coherence tomography using time-frequency analysis and iterative optimization for iridocorneal angle imaging

      Systematic dispersion compensation for spectral domain optical coherence tomography using time-frequency analysis  and iterative optimization for iridocorneal angle imaging
      Dispersion is a common phenomenon in optics due to the frequency dependence of the refrac tive index in polychromatic light. This issue, if left untreated in optical coherence tomography (OCT) imaging, leads to signal broadening of the coherence length and deterioration of the axial resolution. We report a new numeric method for the systemati c dispersion compensation in a spectral - domain (SD) OCT for imaging the iridocorneal angle of human ...
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      Mentions: UC Irvine
    14. Evaluation of Device-Based Cutaneous Channels Using Optical Coherence Tomography: Impact for Topical Drug Delivery

      Evaluation of Device-Based Cutaneous Channels Using Optical Coherence Tomography: Impact for Topical Drug Delivery
      Background: Topical medications play a large role in the management of cutaneous diseases, but penetration is limited. Device-assisted drug delivery using mechanical destruction, lasers, and other energy-based modalities can increase penetration and absorption through creation of transcutaneous channels. Objective: To examine real-time, in vivo cutaneous changes in response to various devices used to improve topical drug delivery through optical coherence tomography (OCT) imaging. Methods and materials: Treatment was performed with ...
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      Mentions: UC Irvine
    15. Analysis of port-wine birthmark vascular characteristics by location: Utility of optical coherence tomography mapping

      Analysis of port-wine birthmark vascular characteristics by location: Utility of optical coherence tomography mapping
      Introduction: Port-wine birthmarks (PWBs) are congenital capillary malformations that can be located on any area of the body. Vascular features include vessel size, depth, and density, which can greatly differ between patients, individual lesions, and even sites within the same lesion. Previous studies have determined that the location of PWB lesions has impacted their clinical response to laser treatment. Objective: We utilized dynamic optical coherence tomography (D-OCT) to measure in ...
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  2. About UC Irvine

    UC Irvine

    The University of California at Irvine is a public research university situated in Irvine, California. Founded in 1965, it is the second-youngest University of California campus.   Beckman Laser Institute at the University of California in Irvine. The BLI mission is to serve as the world's leading interdisciplinary center for Biomedical Optics.