1. UC Irvine

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    1. Mentioned In 355 Articles

    2. Intravascular polarization-sensitive optical coherence tomography based on polarization mode delay

      Intravascular polarization-sensitive optical coherence tomography based on polarization mode delay
      Intravascular polarization-sensitive optical coherence tomography (IV-PSOCT) provides depth-resolved tissue birefringence which can be used to evaluate the mechanical stability of a plaque. In our previous study, we reported a new strategy to construct polarization-sensitive optical coherence tomography in a microscope platform. Here, we demonstrated that this technology can be implemented in an endoscope platform, which has many clinical applications. A conventional intravascular OCT system can be modified for IV-PSOCT by ...
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      Mentions: UC Irvine
    3. Research Techniques Made Simple: Emerging Imaging Technologies for Noninvasive Optical Biopsy of Human Skin

      Research Techniques Made Simple: Emerging Imaging Technologies for Noninvasive Optical Biopsy of Human Skin
      Over the past few years, high-resolution optical imaging technologies such as optical coherence tomography (OCT), reflectance confocal microscopy (RCM), and multiphoton microscopy (MPM) have advanced significantly as new methodologies for clinical research and for real-time detection, diagnosis, and therapy monitoring of skin diseases. Implementation of these technologies into clinical research and practice requires clinicians to have an understanding of their capabilities, benefits, and limitations. This concise review provides insights on ...
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    4. Enhance the delivery of light energy ultra-deep into turbid medium by controlling multiple scattering photons to travel in open channels

      Enhance the delivery of light energy ultra-deep into turbid medium by controlling multiple scattering photons to travel in open channels
      Multiple light scattering is considered as the major limitation for deep imaging and focusing in turbid media. In this paper, we present an innovative method to overcome this limitation and enhance the delivery of light energy ultra-deep into turbid media with significant improvement in focusing. Our method is based on a wide-field reflection matrix optical coherence tomography (RM-OCT). The time-reversal decomposition of the RM is calibrated with the Tikhonov regularization ...
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      Mentions: UC Irvine
    5. Rapid chemically selective 3D imaging in the mid-infrared

      Rapid chemically selective 3D imaging in the mid-infrared
      The emerging technique of mid-infrared optical coherence tomography (MIR-OCT) takes advantage of the reduced scattering of MIR light in various materials and devices, enabling tomographic imaging at deeper penetration depths. Because of challenges in MIR detection technology, the image acquisition time is, however, significantly longer than for tomographic imaging methods in the visible/near-infrared. Here we demonstrate an alternative approach to MIR tomography with high-speed imaging capabilities. Through femtosecond nondegenerate ...
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      Mentions: UC Irvine
    6. Optical coherence tomography device for characterization of atherosclerosis with a 1.7 micron swept laser source

      Optical coherence tomography device for characterization of atherosclerosis with a 1.7 micron swept laser source
      An OCT system with a swept light source centered around 1.7 .mu.m for identifying atherosclerotic plaque and visualization of large lipid pool is provided. Advantages for using the 1.7 .mu.m swept source laser include higher contrast between lipid and normal tissue and deeper penetration of the optical signals from the 1.7 .mu.m swept source laser into the tissue. With deeper penetration into the tissue ...
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      Mentions: UC Irvine
    7. Systematic dispersion compensation for spectral domain optical coherence tomography using time-frequency analysis and iterative optimization for iridocorneal angle imaging

      Systematic dispersion compensation for spectral domain optical coherence tomography using time-frequency analysis  and iterative optimization for iridocorneal angle imaging
      Dispersion is a common phenomenon in optics due to the frequency dependence of the refrac tive index in polychromatic light. This issue, if left untreated in optical coherence tomography (OCT) imaging, leads to signal broadening of the coherence length and deterioration of the axial resolution. We report a new numeric method for the systemati c dispersion compensation in a spectral - domain (SD) OCT for imaging the iridocorneal angle of human ...
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      Mentions: UC Irvine
    8. Evaluation of Device-Based Cutaneous Channels Using Optical Coherence Tomography: Impact for Topical Drug Delivery

      Evaluation of Device-Based Cutaneous Channels Using Optical Coherence Tomography: Impact for Topical Drug Delivery
      Background: Topical medications play a large role in the management of cutaneous diseases, but penetration is limited. Device-assisted drug delivery using mechanical destruction, lasers, and other energy-based modalities can increase penetration and absorption through creation of transcutaneous channels. Objective: To examine real-time, in vivo cutaneous changes in response to various devices used to improve topical drug delivery through optical coherence tomography (OCT) imaging. Methods and materials: Treatment was performed with ...
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      Mentions: UC Irvine
    9. Analysis of port-wine birthmark vascular characteristics by location: Utility of optical coherence tomography mapping

      Analysis of port-wine birthmark vascular characteristics by location: Utility of optical coherence tomography mapping
      Introduction: Port-wine birthmarks (PWBs) are congenital capillary malformations that can be located on any area of the body. Vascular features include vessel size, depth, and density, which can greatly differ between patients, individual lesions, and even sites within the same lesion. Previous studies have determined that the location of PWB lesions has impacted their clinical response to laser treatment. Objective: We utilized dynamic optical coherence tomography (D-OCT) to measure in ...
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    10. University of California at Irvine Receives NIH Grant for Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy

      University of California at Irvine Receives NIH Grant for Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy
      ...a significant impact on image-guided laser therapy and the management of GSM.

      University of California at Irvine Receives a 2021 NIH Grant for $1,946,945 for Continuous Monitoring and Mana...

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    11. Modular deep neural networks for automatic quality control of retinal optical coherence tomography scans

      Modular deep neural networks for automatic quality control of retinal optical coherence tomography scans
      Retinal optical coherence tomography (OCT) with intraretinal layer segmentation is increasingly used not only in ophthalmology but also for neurological diseases such as multiple sclerosis (MS). Signal quality influences segmentation results, and high-quality OCT images are needed for accurate segmentation and quantification of subtle intraretinal layer changes. Among others, OCT image quality depends on the ability to focus, patient compliance and operator skills. Current criteria for OCT quality define acceptable ...
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      Mentions: UC Irvine
    12. Retinal Optical Coherence Tomography in Neuromyelitis Optica

      Retinal Optical Coherence Tomography in Neuromyelitis Optica
      Background and objectives: To determine optic nerve and retinal damage in aquaporin-4 antibody (AQP4-IgG)-seropositive neuromyelitis optica spectrum disorders (NMOSD) in a large international cohort after previous studies have been limited by small and heterogeneous cohorts. Methods: The cross-sectional Collaborative Retrospective Study on retinal optical coherence tomography (OCT) in neuromyelitis optica collected retrospective data from 22 centers. Of 653 screened participants, we included 283 AQP4-IgG-seropositive patients with NMOSD and 72 ...
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    13. Surface kinematic and depth-resolved analysis of human vocal folds in vivo during phonation using optical coherence tomography

      Surface kinematic and depth-resolved analysis of human vocal folds in vivo during phonation using optical coherence tomography
      Significance: The human vocal fold (VF) oscillates in multiple vectors and consists of distinct layers with varying viscoelastic properties that contribute to the mucosal wave. Office-based and operative laryngeal endoscopy are limited to diagnostic evaluation of the VF epithelial surface only and are restricted to axial-plane characterization of the horizontal mucosal wave. As such, understanding of the biomechanics of human VF motion remains limited. Aim: Optical coherence tomography (OCT) is ...
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    14. Vascular characteristics of port wine birthmarks as measured by dynamic optical coherence tomography

      Vascular characteristics of port wine birthmarks as measured by dynamic optical coherence tomography
      Background: Port wine birthmarks (PWB) are congenital capillary malformations. Vessel characteristics, such as diameter and depth, may impact presentation and outcomes. They can be imaged using dynamic optical coherence tomography (D-OCT), a high-resolution, non-invasive imaging method. Purpose: We conducted a cross-sectional observational study to measure in-vivo vascular characteristics as a function of PWB color. Methods: Patients undergoing treatment for PWB were recruited from three sites. PWB were classified by color ...
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    15. 1.7-micron Optical Coherence Tomography Angiography for Characterization of Skin Lesions – A Feasibility Study

      1.7-micron Optical Coherence Tomography Angiography for Characterization of Skin Lesions – A Feasibility Study
      Optical coherence tomography (OCT) is a non-invasive diagnostic method that offers real-time visualization of the layered architecture of the skin in vivo. The 1.7-micron OCT system has been applied in cardiology, gynecology and dermatology, demonstrating an improved penetration depth in contrast to conventional 1.3-micron OCT. To further extend the capability, we developed a 1.7-micron OCT/OCT angiography (OCTA) system that allows for a visualization of both morphology ...
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      Mentions: UC Irvine
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  2. About UC Irvine

    UC Irvine

    The University of California at Irvine is a public research university situated in Irvine, California. Founded in 1965, it is the second-youngest University of California campus.   Beckman Laser Institute at the University of California in Irvine. The BLI mission is to serve as the world's leading interdisciplinary center for Biomedical Optics.