1. UC Irvine

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    1. Mentioned In 330 Articles

    2. Imaging of in vivo pseudoxanthoma elasticum via multiphoton microscopy and optical coherence tomography

      Imaging of in vivo pseudoxanthoma elasticum via multiphoton microscopy and optical coherence tomography
      Pseudoxanthoma elasticum (PXE) is an autosomal recessive disorder of abnormal elastic tissue deposition and calcification. 1 PXE primarily affects the elastic fibers in the dermis of the skin, Bruch membrane of the eye, and the media and intima of mid-sized arteries. The skin findings may present as small yellow, orange, or cream-colored papules, resembling plucked-chicken skin or cobblestone. The skin on the neck and skin flexures may be lax and ...
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      Mentions: UC Irvine
    3. Coupling Pressure Sensing with Optical Coherence Tomography to Evaluate the Internal Nasal Valve

      Coupling Pressure Sensing with Optical Coherence Tomography to Evaluate the Internal Nasal Valve
      Purpose: To evaluate endoscopic long-range optical coherence tomography system combined with a pressure sensor to concurrently measure internal nasal valve cross-sectional area and intraluminal pressure. Methods: A pressure sensor was constructed using an Arduino platform and calibrated using a limiter-controlled vacuum system and industrial absolute pressure gauge. Long-range optical coherence tomography imaging and pressure transduction were performed concurrently in the naris of eight healthy adult subjects during normal respiration and ...
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    4. UC Irvine Receives a 2020 NIH Grant for In Vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology

      UC Irvine Receives a 2020 NIH Grant for In Vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology
      ...tart the developments in pharmacotherapy, devices, and surgical intervention.

      University of California at Irvine Receives a 2020 NIH Grant for $593,557 for In Vivo Imaging and Quantificati...

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    5. UC Irvine Receives a 2020 NIH Grant for Phased Resolved ARF Optical Coherence Elastography for Intravascular Imaging

      UC Irvine Receives a 2020 NIH Grant for Phased Resolved ARF Optical Coherence Elastography for Intravascular Imaging
      ...powerful tool that provides a quantitative means to benchmark and evaluate new medical devices and therapies. University of California at Irvine Receives a 2020 NIH Grant for $698,188 for Phased Resolved ARF Optical Cohe...
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    6. Ultrahigh-sensitive optical coherence elastography

      Ultrahigh-sensitive optical coherence elastography
      The phase stability of an optical coherence elastography (OCE) system is the key determining factor for achieving a precise elasticity measurement, and it can be affected by the signal-to-noise ratio (SNR), timing jitters in the signal acquisition process, and fluctuations in the optical path difference (OPD) between the sample and reference arms. In this study, we developed an OCE system based on swept-source optical coherence tomography (SS-OCT) with a common-path ...
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    7. Optical Coherence Tomography in the Evaluation of the Scalp and Hair: Common Features and Clinical Utility

      Optical Coherence Tomography in the Evaluation of the Scalp and Hair: Common Features and Clinical Utility
      Background and Objective Early diagnosis and treatment of hair loss disorders is vital in providing patients with improved psychological outcomes. Non‐invasive imaging with optical coherence tomography (OCT) may be useful in characterizing and managing alopecia. Despite expanding clinical applications of OCT in dermatology, guidelines demonstrating in vivo features of normal and alopecic scalp images remain scant. This pilot study aims to provide an atlas of OCT findings of healthy ...
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      Mentions: UC Irvine
    8. Skin Imaging to Inform Laser Treatments

      Skin Imaging to Inform Laser Treatments
      The purpose of this study is to obtain information (such as lesion depth, depth of the most superficial part of the lesion, and the size and density of blood vessels) with the assistance of an imaging device, and use this information to assist in selection of laser settings for the treatment of skin conditions. The imaging modality is called Optical Coherence Tomography (OCT). Multiple laser modalities will be used, including ...
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      Mentions: UC Irvine
    9. Beating Cancer - One Patient at a Time

      Beating Cancer - One Patient at a Time
      Like most people, John Gifford wasn't looking forward to a colonoscopy when he arrived on the UCI Medical Center campus in Orange in 2018. The Riverside man, 65, was concerned about his family history of colorectal cancer and had dutifully scheduled an appointment with UCI Health gastroenterologist Dr. William Karnes. The exam turned out to be intriguing and enlightening - a far cry from what one expects during a colonoscopy ...
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    10. Optical Vaginal Biopsy Using Optical Coherence Tomography

      Optical Vaginal Biopsy Using Optical Coherence Tomography
      Objective Optical coherence tomography is a noninvasive technology that visualizes tissue microstructure with high spatial resolution. We designed a novel vaginal system that demonstrates a clear distinction between vaginal tissues planes. In this study, we sought to compare vaginal tomographic images of premenopausal, perimenopausal, and postmenopausal women, demonstrate feasibility of tracking vaginal tissue changes after treatment with fractional-pixel CO 2 laser therapy, and obtain a histologic correlation of these findings ...
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    11. Extended imaging depth of en-face optical coherence tomography based on fast measurement of a reflection matrix by wide-field heterodyne detection

      Extended imaging depth of en-face optical coherence tomography based on fast measurement of a reflection matrix by wide-field heterodyne detection
      Multiple light scattering in biomedical tissue limits the penetration depth of optical imaging systems such as optical coherence tomography. To increase the imaging depth in scattering media, a computational method based on coherent reflection matrix measurement has been developed using low coherence interferometry. The complex reflection matrix is obtained via point-by-point scanning followed by a phase-shifting method; then singular value decomposition is used to retrieve the singly back-scattered light. However ...
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    12. Optical coherence elastography (OCE) method under acoustic radiation force excitation using OCT doppler variance methods and OCT correlation-based methods

      Optical coherence elastography (OCE) method under acoustic radiation force excitation using OCT doppler variance methods and OCT correlation-based methods
      A system for imaging and quantifying shear wave and shear modulus under orthogonal acoustic radiation force (ARF) excitation using the OCT Doppler variance apparatus. The ARF perpendicular or with at least a perpendicular component to the OCT beam is produced by a remote ultrasonic transducer. The OCT Doppler variance apparatus, which is sensitive to the transverse vibration, is used to measure the ARF induced vibration. For analysis of the shear ...
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    13. In vivo evaluation of posterior eye elasticity using shaker-based optical coherence elastography

      In vivo evaluation of posterior eye elasticity using shaker-based optical coherence elastography
      Age-related macular degeneration (AMD) is a progressive retinal disease and becomes the leading cause of blindness. It is well established that early detection is the key to preservation of functional vision. However, it is very difficult to diagnose AMD in very early stages, before structural changes are evident. Consequently, investigating the biomechanical properties of the retina maybe essential for understanding its physiological function. In this study, we present a shear ...
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    14. Spatiotemporal dynamics of pial collateral blood flow following permanent middle cerebral artery occlusion in a rat model of sensory-based protection: a Doppler optical coherence tomography study

      Spatiotemporal dynamics of pial collateral blood flow following permanent middle cerebral artery occlusion in a rat model of sensory-based protection: a Doppler optical coherence tomography study
      There is a growing recognition regarding the importance of pial collateral flow in the protection from impending ischemic stroke both in preclinical and clinical studies. Collateral flow is also a major player in sensory stimulation-based protection from impending ischemic stroke. Doppler optical coherence tomography has been employed to image spatiotemporal patterns of collateral flow within the dorsal branches of the middle cerebral artery (MCA) as it provides a powerful tool ...
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    15. The Use of Optical Coherence Tomography and Convolutional Neural Networks to Distinguish Normal and Abnormal Oral Mucosa

      The Use of Optical Coherence Tomography and Convolutional Neural Networks to Distinguish Normal and Abnormal Oral Mucosa
      Incomplete surgical resection of head and neck squamous cell carcinoma (HNSCC) is the most common cause of local HNSCC recurrence. Currently, surgeons rely on pre‐operative imaging, direct visualization, palpation, and frozen section to determine the extent of tissue resection. It has been demonstrated that optical coherence tomography (OCT), a minimally invasive, non‐ionizing near infrared mesoscopic imaging modality can resolve subsurface differences between normal and abnormal head and neck ...
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    16. Automatic three-dimensional segmentation method for OCT and doppler OCT angiography

      Automatic three-dimensional segmentation method for OCT and doppler OCT angiography
      A three-dimensional (three dimensional) segmentation method with intensity-based Doppler variance (IBDV) based on swept-source OCT. The automatic three dimensional segmentation method is used to obtain seven surfaces of intra-retinal layers. The microvascular network of the retina, which is acquired by the IBDV method, can be divided into six layers. The microvascular network of the six individual layers are visualized, and the morphology and contrast images can be improved by using ...
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  2. About UC Irvine

    UC Irvine

    The University of California at Irvine is a public research university situated in Irvine, California. Founded in 1965, it is the second-youngest University of California campus.   Beckman Laser Institute at the University of California in Irvine. The BLI mission is to serve as the world's leading interdisciplinary center for Biomedical Optics.