1. UC Davis

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    1. Mentioned In 211 Articles

    2. Extraction of phase-based optoretinograms (ORG) from serial B-scans acquired over tens of seconds by mouse retinal raster scanning OCT system

      Extraction of phase-based optoretinograms (ORG) from serial B-scans acquired over tens of seconds by mouse retinal raster scanning OCT system
      Several specialized retinal optical coherence tomography (OCT) acquisition and processing methods have been recently developed to allow in vivo probing of light-evoked photoreceptors function, focusing on measurements in individual photoreceptors (rods and cones). Recent OCT investigations in humans and experimental animals have shown that the outer segments in dark-adapted rods and cones elongate in response to the visible optical stimuli that bleach fractions of their visual photopigment. We have previously ...
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    3. Proactive spectrometer matching for excess noise suppression in balanced visible light optical coherence tomography (OCT)

      Proactive spectrometer matching for excess noise suppression in balanced visible light optical coherence tomography (OCT)
      Supercontinuum sources for visible light spectral domain OCT (SDOCT) are noisy and often expensive. Balanced detection can reduce excess noise, but is rarely used in SDOCT. Here, we show that balanced detection can achieve effective excess noise cancellation across all depths if two linear array spectrometers are spectrally well-matched. We propose excess noise correlation matrices as tools to achieve such precise spectral matching. Using optomechanical adjustments, while monitoring noise correlations ...
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    4. Investigating the causes of stimulus-evoked changes in cone reflectance using a combined adaptive optics SLO-OCT system

      Investigating the causes of stimulus-evoked changes in cone reflectance using a combined adaptive optics SLO-OCT system
      In vivo functional imaging of human photoreceptors is an emerging field, with compelling potential applications in basic science, translational research, and clinical management of ophthalmic disease. Measurements of light-evoked changes in the photoreceptors has been successfully demonstrated using adaptive optics (AO) coherent flood illumination (CFI), AO scanning light ophthalmoscopy (SLO), AO optical coherence tomography (OCT), and full-field OCT with digital AO (dAO). While the optical principles and data processing of ...
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      Mentions: UC Davis
    5. Heinrich Müller (1820-1864) and the entoptic discovery of the site in the retina where vision is initiated

      Heinrich Müller (1820-1864) and the entoptic discovery of the site in the retina where vision is initiated
      Heinrich Mller was a nineteenth-century German retinal anatomist who, during his short career, was one of the discoverers of the rod photopigment rhodopsin and neuroglia in the retina, now known as Mller cells. He also described the ocular muscles and double foveae of some birds. An important, but largely neglected, insight by Mller was to combine careful psychophysical measurements and geometrical optics to find the location of the photosensitive layer ...
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      Mentions: UC Davis
    6. Utility of IOLMaster 700 Swept-Source Optical Coherence Tomography in Detecting Macular Disease for Preoperative Cataract Surgery Patients

      Utility of IOLMaster 700 Swept-Source Optical Coherence Tomography in Detecting Macular Disease for Preoperative Cataract Surgery Patients
      Purpose: To assess the efficacy of IOLMaster 700 (IOLM) biometer swept-source optical coherence tomography (SS-OCT) in detecting macular pathology before cataract surgery and to compare IOLM SS-OCT characteristics of foveal pathology with a widely used spectral-domain OCT (SD-OCT) system. Patients and Methods: Retrospective analysis of 1156 consecutive eyes with IOLMaster 700 SS-OCT undergoing cataract surgery from January to June 2017 was performed. Approximately a third of these eyes (327 eyes ...
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    7. Real-time needle guidance for venipuncture based on optical coherence tomography

      Real-time needle guidance for venipuncture based on optical coherence tomography
      An algorithm for realtime venipuncture needle guidance is described, using an optical coherence tomography (OCT) probe that emits light pulses at fixed angular intervals along a cone, giving accurate distance measurements to points on the blood vessel. Using this data, a method is developed to visually display the blood vessel for needle guidance. A leastsquares fit to a general quadric surface, specified by a symmetric matrix, is performed. For a ...
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      Mentions: UC Davis
    8. 1700 nm optical coherence microscopy enables minimally invasive, label-free, in vivo optical biopsy deep in the mouse brain

      1700 nm optical coherence microscopy enables minimally invasive, label-free, in vivo optical biopsy deep in the mouse brain
      In vivo, minimally invasive microscopy in deep cortical and sub-cortical regions of the mouse brain has been challenging. To address this challenge, we present an in vivo high numerical aperture optical coherence microscopy (OCM) approach that fully utilizes the water absorption window around 1700nm, where ballistic attenuation in the brain is minimized. Key issues, including detector noise, excess light source noise, chromatic dispersion, and the resolution-speckle tradeoff, are analyzed and ...
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      Mentions: UC Davis
    9. Polarization properties of retinal blood vessel walls measured with polarization sensitive optical coherence tomography

      Polarization properties of retinal blood vessel walls measured with polarization sensitive optical coherence tomography
      A new method based on polarization-sensitive optical coherence tomography (PS-OCT) is introduced to determine the polarization properties of human retinal vessel walls, in vivo . Measurements were obtained near the optic nerve head of three healthy human subjects. The double pass phase retardation per unit depth (DPPR/UD), which is proportional to the birefringence, is higher in artery walls, presumably because of the presence of muscle tissue. Measurements in surrounding retinal ...
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    10. In vivo Morphometry of Inner Plexiform Layer (IPL) Stratification in the Human Retina With Visible Light Optical Coherence Tomography

      In vivo Morphometry of Inner Plexiform Layer (IPL) Stratification in the Human Retina With Visible Light Optical Coherence Tomography
      From the bipolar cells to higher brain visual centers, signals in the vertebrate visual system are transmitted along parallel on and off pathways. These two pathways are spatially segregated along the depth axis of the retina. Yet, to our knowledge, there is no way to directly assess this anatomical stratification in vivo . Here, employing ultrahigh resolution visible light Optical Coherence Tomography (OCT) imaging in humans, we report a stereotyped reflectivity ...
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    11. Functional regulation of an outer retina hyporeflective band on optical coherence tomography images

      Functional regulation of an outer retina hyporeflective band on optical coherence tomography images
      Human and animal retinal optical coherence tomography (OCT) images show a hyporeflective band (HB) between the photoreceptor tip and retinal pigment epithelium layers whose mechanisms are unclear. In mice, HB magnitude and the external limiting membrane-retinal pigment epithelium (ELM-RPE) thickness appear to be dependent on light exposure, which is known to alter photoreceptor mitochondria respiration. Here, we test the hypothesis that these two OCT biomarkers are linked to metabolic activity ...
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    12. Visible Light Optical Coherence Tomography (OCT) Quantifies Subcellular Contributions to Outer Retinal Band 4

      Visible Light Optical Coherence Tomography (OCT) Quantifies Subcellular Contributions to Outer Retinal Band 4
      Purpose : To use visible light optical coherence tomography (OCT) to investigate subcellular reflectivity contributions to the outermost (4th) of the retinal hyperreflective bands visualized by current clinical near-infrared (NIR) OCT. Methods : Visible light OCT, with 1.0 m axial resolution, was performed in 28 eyes of 19 human subjects (2157 years old) without history of ocular pathology. Two foveal and three extrafoveal hyperreflective zones were consistently depicted within band 4 ...
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    13. Postdoc Position for Biomedical Engineer / Vision Scientist in the UC Davis EyePod - Small Animal Ocular Imaging Laboratory at University of California, Davis

      Postdoc Position for Biomedical Engineer / Vision Scientist in the UC Davis EyePod - Small Animal Ocular Imaging Laboratory at University of California, Davis
      ... laboratory collaborates closely with UC Davis Eye Center Vision Science and Advanced Retinal Imaging (VSRI). UC Davis has a large, active community of ~45 NIH-funded vision scientists with interests ranging from molecul...
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      Mentions: UC Davis
    14. Kilohertz retinal FF-SS-OCT and flood imaging with hardware-based adaptive optics

      Kilohertz retinal FF-SS-OCT and flood imaging with hardware-based adaptive optics
      A retinal imaging system was designed for full-field (FF) swept-source (SS) optical coherence tomography (OCT) with cellular resolution. The system incorporates a real-time adaptive optics (AO) subsystem and a very high-speed CMOS sensor, and is capable of acquiring volumetric images of the retina at rates up to 1 kHz. While digital aberration correction (DAC) is an attractive potential alternative to AO, it has not yet been shown to provide resolution ...
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      Mentions: UC Davis
    15. Visible light OCT improves imaging through a highly scattering retinal pigment epithelial wall

      Visible light OCT improves imaging through a highly scattering retinal pigment epithelial wall
      Here we provide a counter-example to the conventional wisdom in biomedical optics that longer wavelengths aid deeper imaging in tissue. Specifically, we investigate visible light optical coherence tomography of Bruchs membrane (BM) in the non-pathologic eyes of humans and two mouse strains. Surprisingly, we find that shorter visible wavelengths improve the visualization of BM in pigmented eyes, where it is located behind a highly scattering layer of melanosomes in the ...
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      Mentions: UC Davis
    16. 1-15 of 211 1 2 3 4 ... 12 13 14 »
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  2. About UC Davis

    UC Davis

    University of California at Davis is a public university located in the city of Davis, California and is one of the ten campuses of the University of California. Vision Science and Advanced Retinal Imaging Laboratory is at the University of California, Davis and is concerned with understanding the functional and structural basis of early stage mechanisms of human vision. Center for Biophotonics, Science and Technology at The University of California at Davis.  The Center for Biophotonics, Science and Technology (CBST) was conceived in response to the NRC recommendations. UC Davis Medical Center is a major research hospital located in Sacramento, California and is the primary teaching hospital of UC Davis School of Medicine. Researchers and specialists at the 577 licensed bed medical center work in over 150 areas of specialty. The UC Davis hospital has been ranked among the top 50 hospitals in the nation in the 2004 survey of US News and World Report. Particularly respected are its programs in heart surgery and ear, nose, and throat treatment. It is also a Level I trauma center for both adults and pediatrics.