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    1. Mentioned In 135 Articles

    2. An iterative closest point approach for the registration of volumetric human retina image data obtained by optical coherence tomography

      An iterative closest point approach for the registration of volumetric human retina image data obtained by optical coherence tomography
      This paper introduces an improved approach for the volume data registration of human retina. Volume data registration refers to calculating out a near-optimal transformation between two volumes with overlapping region and stitching them together. Iterative closest point (ICP) algorithm is a registration method that deals with registration between points. Classical ICP is time consuming and often traps in local minimum when the overlapping region is not big enough. Optical Coherence ...
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    3. Comparison of amplitude-decorrelation, speckle-variance and phase-variance OCT angiography methods for imaging the human retina and choroid

      Comparison of amplitude-decorrelation, speckle-variance and phase-variance OCT angiography methods for imaging the human retina and choroid
      We compared the performance of three OCT angiography (OCTA) methods: speckle variance, amplitude decorrelation and phase variance for imaging of the human retina and choroid. Two averaging methods, split spectrum and volume averaging, were compared to assess the quality of the OCTA vascular images. All data were acquired using a swept-source OCT system at 1040 nm central wavelength, operating at 100,000 A-scans/s. We performed a quantitative comparison using ...
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    4. Imaging and graphing of cortical vasculature using dynamically focused optical coherence microscopy angiography

      Imaging and graphing of cortical vasculature using dynamically focused optical coherence microscopy angiography
      Recently, optical coherence tomography (OCT) angiography has enabled label-free imaging of vasculature based on dynamic scattering in vessels. However, quantitative volumetric analysis of the vascular networks depicted in OCT angiography data has remained challenging. Multiple-scattering tails (artifacts specific to the imaging geometry) make automated assessment of vascular morphology problematic. We demonstrate that dynamically focused optical coherence microscopy (OCM) angiography with a high numerical aperture, chosen so the scattering length greatly ...
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    5. Post-Doc Position for biomedical engineer / vision scientist in the UC Davis EyePod - Small Animal Retinal Imaging Laboratory at University of California, Davis

      Post-Doc Position for biomedical engineer / vision scientist in the UC Davis EyePod - Small Animal Retinal Imaging Laboratory at University of California, Davis
      ...he UC Davis EyePod Small Animal Imaging Laboratory in the Department of Cell Biology and Human Anatomy at the UC Davis Main Campus. The goal of our research is to develop and translate the next generation in vivo Read Full Article
    6. University of California at Davis Receives NIH Grant for Properties of Photoreceptors and Muller Cells Investigated with AO-OCT

      University of California at Davis Receives NIH Grant for Properties of Photoreceptors and Muller Cells Investigated with AO-OCT
      ... laboratory of John S. Werner where AO-OCT instrumentation has been pioneered and conveniently located in the UC Davis Eye Center. One AO-OCT system is available for the candidate's modification and exclusive use. Traini...
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    7. In vivo wide-field multispectral scanning laser ophthalmoscopy–optical coherence tomography mouse retinal imager: longitudinal imaging of ganglion cells, microglia, and Müller glia, and mapping of the mouse retinal and choroidal vasculature

      In vivo wide-field multispectral scanning laser ophthalmoscopy–optical coherence tomography mouse retinal imager: longitudinal imaging of ganglion cells, microglia, and Müller glia, and mapping of the mouse retinal and choroidal vasculature
      Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) provide complementary views of the retina, with the former collecting fluorescence data with good lateral but relatively low-axial resolution, and the latter collecting label-free backscattering data with comparable lateral but much higher axial resolution. To take maximal advantage of the information of both modalities in mouse retinal imaging, we have constructed a compact, four-channel, wide-field ( 50 deg ) system that simultaneously acquires ...
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    8. Noninvasive, in vivo imaging of subcortical mouse brain regions with 1.7  μm optical coherence tomography

      Noninvasive, in vivo imaging of subcortical mouse brain regions with 1.7  μm optical coherence tomography
      A spectral/Fourier domain optical coherence tomography (OCT) intravital microscope using a supercontinuum light source at 1.7 m was developed to study subcortical structures noninvasively in the living mouse brain. The benefits of 1.7 m for deep tissue brain imaging are demonstrated by quantitatively comparing OCT signal attenuation characteristics of cortical tissue across visible and near-infrared wavelengths. Imaging of hippocampal tissue architecture and white matter microvasculature are demonstrated ...
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    9. Laminar microvascular transit time distribution in the mouse somatosensory cortex revealed by Dynamic Contrast Optical Coherence Tomography

      Laminar microvascular transit time distribution in the mouse somatosensory cortex revealed by Dynamic Contrast Optical Coherence Tomography
      The transit time distribution of blood through the cerebral microvasculature both constrains oxygen delivery and governs the kinetics of neuroimaging signals such as blood-oxygen-level-dependent functional Magnetic Resonance Imaging (BOLD fMRI). However, in spite of its importance, capillary transit time distribution has been challenging to quantify comprehensively and efficiently at the microscopic level. Here, we introduce a method, called Dynamic Contrast Optical Coherence Tomography (DyC-OCT), based on dynamic cross-sectional OCT imaging ...
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    10. Cerebral metabolic rate of oxygen (CMRO2) assessed by combined Doppler and spectroscopic OCT

      Cerebral metabolic rate of oxygen (CMRO2) assessed by combined Doppler and spectroscopic OCT
      A method of measuring cortical oxygen metabolism in the mouse brain that uses independent quantitative measurements of three key parameters: cerebral blood flow (CBF), arteriovenous oxygen extraction (OE), and hemoglobin concentration ([HbT]) is presented. Measurements were performed using a single visible light spectral/Fourier domain OCT microscope, with Doppler and spectroscopic capabilities, through a thinned-skull cranial window in the mouse brain. Baseline metabolic measurements in mice are shown to be ...
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    11. University of California at Davis Receives 2015 NIH Grant for Imaging Neuronal and Capillary Dysfunction Deep in the Rodent Brain In Vivo using 1700nm Optical Coherence Microscopy and Tracer-Based Kinetics

      University of California at Davis Receives 2015 NIH Grant for Imaging Neuronal and Capillary Dysfunction Deep in the Rodent Brain In Vivo using 1700nm Optical Coherence Microscopy and Tracer-Based Kinetics
      ...ad adoption of these novel techniques to study subcortical pathophysiology non-invasively in the mouse brain. University of California at Davis Receives a 2015 NIH Grant for $286,607 for Imaging Neuronal and Capillary Dy...
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    12. Mapping the 3D Connectivity of the Rat Inner Retinal Vascular Network Using OCT Angiography

      Mapping the 3D Connectivity of the Rat Inner Retinal Vascular Network Using OCT Angiography
      Purpose : The purpose of this study is to demonstrate three-dimensional (3D) graphing based on optical coherence tomography (OCT) angiography for characterization of the inner retinal vascular architecture and determination of its topologic principles. Methods : Rat eyes ( N = 3) were imaged with a 1300-nm spectral/Fourier domain OCT microscope. A topologic model of the inner retinal vascular network was obtained from OCT angiography data using a combination of automated and manually-guided ...
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    13. En face projection imaging of the human choroidal layers with tracking SLO and swept source OCT angiography methods

      En face projection imaging of the human choroidal layers with tracking SLO and swept source OCT angiography methods
      We tested and compared the capability of multiple optical coherence tomography (OCT) angiography methods: phase variance, amplitude decorrelation and speckle variance, with application of the split spectrum technique, to image the choroiretinal complex of the human eye. To test the possibility of OCT imaging stability improvement we utilized a real-time tracking scanning laser ophthalmoscopy (TSLO) system combined with a swept source OCT setup. In addition, we implemented a post- processing ...
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  2. About UC Davis

    UC Davis

    University of California at Davis is a public university located in the city of Davis, California and is one of the ten campuses of the University of California. Vision Science and Advanced Retinal Imaging Laboratory is at the University of California, Davis and is concerned with understanding the functional and structural basis of early stage mechanisms of human vision. Center for Biophotonics, Science and Technology at The University of California at Davis.  The Center for Biophotonics, Science and Technology (CBST) was conceived in response to the NRC recommendations. UC Davis Medical Center is a major research hospital located in Sacramento, California and is the primary teaching hospital of UC Davis School of Medicine. Researchers and specialists at the 577 licensed bed medical center work in over 150 areas of specialty. The UC Davis hospital has been ranked among the top 50 hospitals in the nation in the 2004 survey of US News and World Report. Particularly respected are its programs in heart surgery and ear, nose, and throat treatment. It is also a Level I trauma center for both adults and pediatrics.