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    1. Mentioned In 107 Articles

    2. Post-Doc Position for biomedical engineer / vision scientist in small animal High-Resolution Retinal Imaging Group at University of California, Davis

      Post-Doc Position for biomedical engineer / vision scientist in small animal High-Resolution Retinal Imaging Group at University of California, Davis
      ...he UC Davis EyePod Small Animal Imaging Laboratory in the Department of Cell Biology and Human Anatomy at the UC Davis Main Campus. The goal of our research is to develop the next generation in vivo small animal cellular...
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    3. Optical Coherence Tomography angiography reveals laminar microvascular hemodynamics in the rat somatosensory cortex during activation

      Optical Coherence Tomography angiography reveals laminar microvascular hemodynamics in the rat somatosensory cortex during activation

      The BOLD (blood-oxygen-level dependent) fMRI (functional Magnetic Resonance Imaging) signal is shaped, in part, by changes in red blood cell (RBC) content and flow across vascular compartments over time. These complex dynamics have been challenging to characterize directly due to a lack of appropriate imaging modalities. In this study, making use of infrared light scattering from RBCs, depth-resolved Optical Coherence Tomography (OCT) angiography was applied to image laminar functional hyperemia in the rat somatosensory cortex. After defining and validating depth-specific metrics for changes in RBC content and speed, laminar hemodynamic responses in microvasculature up to cortical depths of > 1 mm ...

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    4. Two research scientist positions are available in the Vision Science and Advanced Retinal Imaging Laboratory at the University of California, Davis

      Two research scientist positions are available in the Vision Science and Advanced Retinal Imaging Laboratory at the University of California, Davis

      Two research scientist positions are available in the Vision Science and Advanced Retinal Imaging Laboratory at the University of California, Davis. One position will be filled by someone with background in vision science while the other will be for a person with experience in a high-resolution imaging modality such as OCT, adaptive optics or scanning laser ophthalmoscope. Strong skills in programming or image processing would be an asset. The positions will be open until filled. Salary will be based on experience and salary scales of the UC. The University of California is committed to diversity. Minorities, women, veterans and persons ...

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    5. Precision-Guided Epidurals and Better Blood Monitors

      Precision-Guided Epidurals and Better Blood Monitors

      The march of modern medicine is often driven by revolutions in medical imaging. When technology advances, doctors are better able to peer deeply into human tissues, and thus able to detect, diagnose and treat human diseases more effectively. Now, researchers have taken an established imaging technology called “optical coherence tomography,” or OCT, and integrated it with other instruments to bring about the next revolution in imaging by helping doctors provide safer, less painful and more effective care for women in labor and people with diabetic retinopathy and glaucoma. Their research will be presented at CLEO: 2014 being held June 8-13 ...

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    6. Spectral domain optical coherence tomography imaging of spectacular ecdysis in the royal python (Python regius)

      Spectral domain optical coherence tomography imaging of spectacular ecdysis in the royal python (Python regius)

      Objective To describe using spectral domain optical coherence tomography (SD-OCT), digital slit-lamp biomicroscopy, and external photography, changes in the ophidian cuticle, spectacle, and cornea during ecdysis. Animals Studied Four normal royal pythons ( Python regius) . Procedures Snakes were assessed once daily throughout a complete shed cycle using nasal, axial, and temporal SD-OCT images, digital slit-lamp biomicroscopy, and external photography. Results Spectral domain optical coherence tomography (SD-OCT) images reliably showed the spectacular cuticle and stroma, subcuticular space (SCS), cornea, anterior chamber, iris, and Schlemm's canal. When visible, the subspectacular space (SSS) was more distended peripherally than axially. Ocular surface changes throughout ...

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      Mentions: UC Davis
    7. Maximum Likelihood Doppler Frequency Estimation under Decorrelation Noise for Quantifying Flow in Optical Coherence Tomography

      Maximum Likelihood Doppler Frequency Estimation under Decorrelation Noise for Quantifying Flow in Optical Coherence Tomography

      Recent hardware advances in optical coherence tomography (OCT) have led to ever higher A-scan rates. However, the estimation of blood flow axial velocities is limited by the presence and type of noise. Higher acquisition rates alone do not necessarily enable precise quantification of Doppler velocities, particularly if the estimator is sub-optimal. In previous work, we have shown that the Kasai autocorrelation estimator is statistically sub-optimal under conditions of additive white Gaussian noise. In addition, for practical OCT measurements of flow, decorrelation noise affects Doppler frequency estimation by broadening the signal spectrum. Here we derive a general maximum likelihood estimator (MLE ...

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    8. Improved in vivo imaging of human blood circulation in the chorioretinal complex using phase variance method with new phase stabilized 1 μm swept-source optical coherence tomography (pv-SSOCT)

      Improved in vivo imaging of human blood circulation in the chorioretinal complex using phase variance method with new phase stabilized 1 μm swept-source optical coherence tomography (pv-SSOCT)

      We demonstrate the feasibility of our newly developed phase stabilized high-speed (100 kHz A-scans/s) 1 μm sweptsource optical coherence tomography (SSOCT) system with the phase-variance based motion contrast method for visualization of human chorioretinal complex microcirculation. Compared to our previously reported spectral domain (spectrometer based) phase-variance (pv)-SDOCT system it has advantages of higher sensitivity, reduced fringe washout for high blood flow speeds and deeper penetration in choroid. High phase stability SSOCT imaging was achieved by using a computationally efficient phase stabilization approach. This process does not require additional calibration hardware and complex numerical procedures. Our phase stabilization method ...

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    9. The Dose-Dependent Macular Thickness Changes Assessed By FD-OCT in Patients With Retinitis Pigmentosa Treated With Ciliary Neurotrophic Factor

      The Dose-Dependent Macular Thickness Changes Assessed By FD-OCT in Patients With Retinitis Pigmentosa Treated With Ciliary Neurotrophic Factor

      Purpose: To evaluate the effect of intravitreal ciliary neurotrophic factor (CNTF) implant on mean macular thickness (MMT) in eyes with retinitis pigmentosa using high-resolution Fourier domain optical coherence tomography imaging. Methods: A cohort of 8 patients (CNTF-3: n = 5; CNTF-4: n = 3) enrolled in Neurotech sponsored Phase 2 clinical trial underwent Fourier domain optical coherence tomography imaging. A >=3% change in MMT from baseline or fellow eye was considered as a measurable change. Results: Two patients enrolled in the CNTF-3 study received low-dose implant. At 18 months, a change in MMT from -4.47 [mu]m to 6 [mu]m ...

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    10. Progress on Developing Adaptive Optics–Optical Coherence Tomography for In Vivo Retinal Imaging: Monitoring and Correction of Eye Motion Artifacts

      Progress on Developing Adaptive Optics–Optical Coherence Tomography for In Vivo Retinal Imaging: Monitoring and Correction of Eye Motion Artifacts

      Recent progress in retinal image acquisition techniques, including optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO), combined with improved performance of adaptive optics (AO) instrumentation, has resulted in improvement in the quality of in vivo images of cellular structures in the human retina. Here, we present a short review of progress on developing AO-OCT instruments. Despite significant progress in imaging speed and resolution, eye movements present during acquisition of a retinal image with OCT introduce motion artifacts into the image, complicating analysis and registration. This effect is especially pronounced in high-resolution datasets acquired with AO-OCT instruments. Several retinal tracking ...

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    11. Research Scientist Positions in the Vision Science and Advanced Retinal Imaging Laboratory at the University of California, Davis

      Research Scientist Positions in the Vision Science and Advanced Retinal Imaging Laboratory at the University of California, Davis

      Two research scientist positions are available in the Vision Science and Advanced Retinal Imaging Laboratory at the University of California, Davis. One position will be filled by someone with background in vision science while the other will be for a person with experience in a high-resolution imaging modality such as OCT, adaptive optics or scanning laser ophthalmoscope. Strong skills in programming or image processing would be an asset. The positions will be open until filled. Salary will be based on experience and salary scales of the UC. The University of California is committed to diversity. Minorities, women, veterans and persons ...

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  2. About UC Davis

    UC Davis

    University of California at Davis  is a public university located in the city of Davis, California and is one of the ten campuses of the University of California. Vision Science and Advanced Retinal Imaging Laboratory is at the University of California, Davis and is concerned with understanding the functional and structural basis of early stage mechanisms of human vision. Center for Biophotonics, Science and Technology at The University of California at Davis.  The Center for Biophotonics, Science and Technology (CBST) was conceived in response to the NRC recommendations. UC Davis Medical Center is a major research hospital located in Sacramento, California and is the primary teaching hospital of UC Davis School of Medicine. Researchers and specialists at the 577 licensed bed medical center work in over 150 areas of specialty. The UC Davis hospital has been ranked among the top 50 hospitals in the nation in the 2004 survey of US News and World Report. Particularly respected are its programs in heart surgery and ear, nose, and throat treatment. It is also a Level I trauma center for both adults and pediatrics.