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    1. Mentioned In 257 Articles

    2. A Framework for Multiscale Quantitation of Relationships Between Choriocapillaris Flow Impairment and Geographic Atrophy Growth

      Explore American Journal of Ophthalmology Ophthalmology
      A Framework for Multiscale Quantitation of Relationships Between Choriocapillaris Flow Impairment and Geographic Atrophy Growth
      Purpose To develop a multiscale analysis framework for investigating the relationships between geographic atrophy (GA) growth rate and choriocapillaris (CC) blood flow impairment using optical coherence tomography (OCT) and OCT angiography (OCTA). Design Retrospective case series. Methods We developed an OCT/OCTA analysis framework that quantitatively measures GA growth rates at global and local scales, and CC impairment at global, zonal, and local scales. A geometric GA growth model was ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Jay S. Duker

    3. Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography

      Explore IOVS Journal Ophthalmology
      Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography
      Purpose : Swept-source optical coherence tomography angiography (SS-OCTA) was used to investigate if the clinical stage of dry age-related macular degeneration (AMD) was correlated with global and regional macular choriocapillaris (CC) perfusion. Methods : In this retrospective, cross-sectional study, 6 6-mm SS-OCTA images from eyes with early, intermediate, and advanced dry AMD (56 eyes, 41 patients) were analyzed using algorithms described in the literature to assess regional flow deficit percentage (FD%) and ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Andre J. Witkin

    4. Association Between Perifoveal Drusen Burden Determined by OCT and Genetic Risk in Early and Intermediate Age-Related Macular Degeneration

      Explore IOVS Journal Ophthalmology
      Association Between Perifoveal Drusen Burden Determined by OCT and Genetic Risk in Early and Intermediate Age-Related Macular Degeneration
      Purpose : The purpose of this study was to determine associations between macular drusen parameters derived from an automatic optical coherence tomography (OCT) algorithm, nonadvanced age-related macular degeneration (AMD) stage, and genetic variants. Methods : Eyes classified as early or intermediate AMD with OCT imaging and genetic data were selected ( n = 239 eyes). Drusen area and volume measurements were estimated using the Zeiss Cirrus advanced retinal pigment epithelium analysis algorithm in a ...
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      Mentions: Harvard University Tufts University

    5. Retinal Nonperfusion Relationship to Arteries or Veins Observed on Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy

      Explore IOVS Journal Ophthalmology
      Retinal Nonperfusion Relationship to Arteries or Veins Observed on Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy
      Purpose : To evaluate whether retinal capillary nonperfusion is found predominantly adjacent to arteries or veins in eyes with diabetic retinopathy (DR). Methods : Sixty-three eyes from 44 patients with proliferative DR (PDR) or non-PDR (NPDR) were included. Images (12 12-mm) foveal-centered optical coherence tomography (OCT) angiography (OCTA) images were taken using the Zeiss Plex Elite 9000. In 37 eyes, widefield montages with five fixation points were also obtained. A semiautomatic algorithm ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Andre J. Witkin

    6. DISTINGUISHING INTRARETINAL MICROVASCULAR ABNORMALITIES FROM RETINAL NEOVASCULARIZATION USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Explore LWW Online Ophthalmology
      DISTINGUISHING INTRARETINAL MICROVASCULAR ABNORMALITIES FROM RETINAL NEOVASCULARIZATION USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
      Purpose: With the increasing prevalence of diabetes, fast, noninvasive identification of proliferative diabetic retinopathy ( PDR ) becomes essential. This study evaluated the utility of optical coherence tomography angiography ( OCTA ) to characterize intraretinal microvascular abnormalities ( IRMA ) and retinal neovascularization (NV). Methods: Patients with severe non- PDR or PDR were imaged with fluorescein angiography and widefield swept-source OCTA (Zeiss Plex Elite 9000; Carl Zeiss Meditec, Dublin, CA). Regions suspicious for IRMA or retinal ...
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      Mentions: Jay S. Duker Tufts University Nadia K. Waheed

    7. Reply to Correspondence: Impact of Binarization Thresholding and Brightness/Contrast Adjustment Methodology on Optical Coherence Tomography Angiography Image Quantification

      Explore American Journal of Ophthalmology Ophthalmology
      Reply to Correspondence: Impact of Binarization Thresholding and Brightness/Contrast Adjustment Methodology on Optical Coherence Tomography Angiography Image Quantification
      We thank Dr Rabiolo and associates for their interest in our work and their correspondence.1 We also applaud them for their valuable study that examined the effect of binarization thresholding on vessel area density (VAD) in retinal vascular optical coherence tomography angiography (OCTA) images.2 In their correspondence, they highlight several points regarding our results and conclusions compared with their own findings.
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      Mentions: Tufts University Nadia K. Waheed

    8. Volumetric Analysis of Vascularized Serous Pigment Epithelial Detachment Progression in Neovascular Age-Related Macular Degeneration Using Optical Coherence Tomography Angiography

      Explore IOVS Journal Ophthalmology
      Volumetric Analysis of Vascularized Serous Pigment Epithelial Detachment Progression in Neovascular Age-Related Macular Degeneration Using Optical Coherence Tomography Angiography
      Purpose : To analyze the evolution of type 1 neovascularization associated with vascularized serous pigment epithelial detachment (vsPED) using three-dimensional, volumetric, en face optical coherence tomography angiography (OCTA). Methods : This was a retrospective case series from four tertiary medical centers. OCTA images were analyzed at baseline and at the 3-, 6-, 12-, 18-, and 24-month follow-up visit when available. Visual acuity, number of injections, PED maximal height and PED area and ...
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      Mentions: Tufts University Srinivas R. Sadda Giuseppe Querques

    9. Controlling for Artifacts in Widefield Optical Coherence Tomography Angiography Measurements of Non-Perfusion Area

      Explore Nature Publishing Group Ophthalmology
      Controlling for Artifacts in Widefield Optical Coherence Tomography Angiography Measurements of Non-Perfusion Area
      The recent clinical adoption of optical coherence tomography (OCT) angiography (OCTA) has enabled non-invasive, volumetric visualization of ocular vasculature at micron-scale resolutions. Initially limited to 3mm3mm and 6mm6mm fields-of-view (FOV), commercial OCTA systems now offer 12mm12mm, or larger, imaging fields. While larger FOVs promise a more complete visualization of retinal disease, they also introduce new challenges to the accurate and reliable interpretation of OCTA data. In particular, because of vignetting ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Andre J. Witkin

    10. Effect of total anti-VEGF treatment exposure on patterns of choroidal neovascularisation assessed by optical coherence tomography angiography in age-related macular degeneration: a retrospective case series

      Explore Home | BMJ Open Ophthalmology Ophthalmology
      Effect of total anti-VEGF treatment exposure on patterns of choroidal neovascularisation assessed by optical coherence tomography angiography in age-related macular degeneration: a retrospective case series
      Objective To compare clinical characteristics of patients suffering from neovascular age-related macular degeneration (nAMD) with mature and immature choroidal neovascularisation (CNV) as assessed by optical coherence tomography angiography (OCTA). To explore the effect of total anti-vascular endothelial growth factor exposure on the occurrence of mature CNV when correcting for potential confounders. Methods and analysis In this retrospective case series, we included 40 eyes of 36 patients with nAMD with CNV ...
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      Mentions: Tufts University Praveen J. Patel Nadia K. Waheed

    11. COmbined multimodal analysis of Peripheral Retinal and mAcular circulation in Diabetic Retinopathy (COPRA Study)

      Explore ScienceDirect Ophthalmology
      COmbined multimodal analysis of Peripheral Retinal and mAcular circulation in Diabetic Retinopathy (COPRA Study)
      Importance The relationship between peripheral retinal capillary non-perfusion with central NP is non-linear. Objective To systematically examine the relationships between the microvascular indices that are measured on OCTA and the presence and extent of peripheral non-perfusion in persons with diabetic retinopathy Design Retrospective cross-sectional study of patients with varying degrees of diabetic retinopathy ; Setting: Two large tertiary referral retina clinics Participants Eighty-two eyes of forty-five patients with varying degrees of ...
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      Mentions: Tufts University Nadia K. Waheed Usha Chakravarthy

    12. Impact of Binarization Thresholding and Brightness/Contrast Adjustment Methodology on Optical Coherence Tomography Angiography Image Quantification

      Explore American Journal of Ophthalmology Ophthalmology
      Impact of Binarization Thresholding and Brightness/Contrast Adjustment Methodology on Optical Coherence Tomography Angiography Image Quantification
      Purpose Binarization is a critical technique in OCTA image analysis, but there is no consistency in the method used in published OCTA studies. This study assessed whether differences in OCTA binarization and brightness/contrast adjustments affect quantification metrics. Design Prospective cross-sectional validity study Methods This was a single-center study examining 21 eyes of 11 healthy individuals. All eyes were imaged using the Carl Zeiss PLEX Elite 9000 swept source-OCTA, and ...
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      Mentions: Jay S. Duker Tufts University Nadia K. Waheed

    13. Early hydroxychloroquine retinopathy: optical coherence tomography abnormalities preceding Humphrey visual field defects

      Explore BJO Online Ophthalmology
      Early hydroxychloroquine retinopathy: optical coherence tomography abnormalities preceding Humphrey visual field defects
      Background/Aims Hydroxychloroquine (HCQ) retinopathy may result in severe and irreversible vision loss, emphasising the importance of screening and early detection. The purpose of this study is to report the novel finding of early optical coherence tomography (OCT) abnormalities due to HCQ toxicity that may develop in the setting of normal Humphrey visual field (HVF) testing. Methods Data from patients with chronic HCQ exposure was obtained from seven tertiary care ...
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      Mentions: Case Western Reserve University Jay S. Duker LuEsther T. Mertz Retinal Research Center

    15. Summary of 6th International Meeting on OCT Angiography & Advances in OCT in Rome December 2018: A Tremendous Success

      Explore Optical Coherence Tomography News
      Summary of 6th International Meeting on OCT Angiography & Advances in OCT in Rome December 2018: A Tremendous Success
      On December 14 and 15 2018, over 1400 ophthalmologists participated in Rome at tha most important meeting on OCT and OCT Angiography. the 6th international meeting on OCT Angiography, advances in OCT . The organizer, Dr Lumbroso has, since he started to organize these meetings, a well-defined objective: informing ophthalmologist in any country on the new clinical possibilities of Ocular imaging. The policy is to invite the best speakers in the ...
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      Mentions: Philip J. Rosenfeld Massachusetts Institute of Technology James G. Fujimoto

    16. QUANTIFICATION OF RETINAL CAPILLARY NONPERFUSION IN DIABETICS USING WIDE-FIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Explore LWW Online Ophthalmology
      QUANTIFICATION OF RETINAL CAPILLARY NONPERFUSION IN DIABETICS USING WIDE-FIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
      Purpose: To combine advances in high-speed, wide-field optical coherence tomography angiography ( OCTA ) with image processing methods for semiautomatic quantitative analysis of capillary nonperfusion in patients with diabetic retinopathy (DR). Methods: Sixty-eight diabetic patients (73 eyes), either without retinopathy or with different degrees of retinopathy, were prospectively recruited for volumetric swept-source OCTA imaging using 12 mm 12 mm fields centered at the fovea. A custom, semiautomatic software algorithm was used to ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Andre J. Witkin
    17. 1-15 of 257 1 2 3 4 ... 15 16 17 »
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  4. About Tufts University

    Tufts University

    Tufts University is one of the premier universities in the United States. Tufts enjoys a global reputation for academic excellence and for preparing students as leaders in a wide range of professions.

    Tufts University School of Medicine is one of the eight schools that comprise Tufts University.   The New England Eye Center is a local, national and international referral and consultation facility, providing the most current and comprehensive services in tertiary care ophthalmology. It is a complete clinical and technical center for the testing and treatment of all types of eye diseases and visual problems. Our staff ophthalmologists hold teaching appointments at Tufts University School of Medicine. The New England Eye Center is part of Tufts Medical Center, a major academic medical center in downtown Boston, Massachusetts. Tufts Medical Center offers comprehensive inpatient and outpatient care for adults and children.

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