1. Tufts University

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    1. Mentioned In 306 Articles

    2. A deep learning model for automated segmentation of geographic atrophy imaged with swept-source optical coherence tomography images

      A deep learning model for automated segmentation of geographic atrophy imaged with swept-source optical coherence tomography images
      Purpose: To present a deep-learning algorithm for the segmentation of geographic atrophy (GA) using en face swept-source optical coherence tomography (SS-OCT) images that is accurate and reproducible for the assessment of GA growth over time. Design: Retrospective review of images obtained as part of a prospective natural history study Subjects: Patients with GA (90), early/intermediate AMD (32), healthy controls (16) METHODS: An automated algorithm utilizing scan volume data to ...
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    3. Automated Image Threshold Method Comparison for Conjunctival Vessel Quantification on Optical Coherence Tomography Angiography

      Automated Image Threshold Method Comparison for Conjunctival Vessel Quantification on Optical Coherence Tomography Angiography
      Purpose : To determine the impact of image binarization and the best thresholding method for conjunctival optical coherence tomography angiography (OCTA). Methods : Vessel density (VD) of 14 OCTA conjunctival images (nine nasal and five temporal conjunctivas, and eight right and six left eyes) from normal subjects was analyzed. The binarization of gold-standard images, created by removing pixels that do not represent vessels on ImageJ software, was assessed by three masked graders ...
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      Mentions: Tufts University
    4. Prospective, longitudinal study: daily self-imaging with home OCT in neovascular age-related macular degeneration

      Prospective, longitudinal study: daily self-imaging with home OCT in neovascular age-related macular degeneration
      Objective To validate the performance of the Notal Vision Home OCT (NVHO) system for daily self-imaging at home, and to characterize retinal fluid dynamics in neovascular age-related macular degeneration (nAMD). Design Prospective observational study Subjects Fifteen participants who have at least one eye with nAMD undergoing anti-vascular endothelial growth factor (VEGF) treatments. Methods The participants performed daily self-imaging at home with NVHO for 3 months. Scans were uploaded to the ...
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    5. Recommendations for OCTA reporting in retinal vascular disease: A Delphi approach by International Experts

      Recommendations for OCTA reporting in retinal vascular disease: A Delphi approach by International Experts
      Purpose: To develop a consensus nomenclature for reporting optical coherence tomography angiography (OCTA) findings in retinal vascular disease (e.g., diabetic retinopathy, retinal vein occlusion) by international experts. Design: Delphi-based survey SUBJECTS, PARTICIPANTS AND/OR CONTROLS: Twenty-five retinal vascular disease and OCTA imaging experts METHODS, INTERVENTION, OR TESTING: A Delphi method of consensus development was used, comprising two rounds of online questionnaires, followed by a face-to-face meeting conducted virtually. Twenty-five ...
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    6. Advanced retinal imaging and applications for clinical practice: A consensus review

      Advanced retinal imaging and applications for clinical practice: A consensus review
      Imaging is an integral part of the evaluation and management of retinal disorders. Each imaging modality has its own unique capabilities and can show a different aspect or perspective of disease. Multimodal retinal imaging provides a wealth of substantive and insightful information; however, the integration of all this complex data can be overwhelming. We discuss the applications and the strengths and limitations of the many different retinal imaging tools that ...
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    7. Optical Coherence Tomography Angiography Biomarkers Predict Anatomical Response to Bevacizumab in Diabetic Macular Edema

      Optical Coherence Tomography Angiography Biomarkers Predict Anatomical Response to Bevacizumab in Diabetic Macular Edema
      Purpose: To identify biomarkers that may predict an early anatomical response to the treatment of diabetic macular edema (DME) with intravitreal bevacizumab (IVB) by means of optical coherence tomography angiography (OCTA). Methods: This study is a retrospective study of treatment-nave patients with DME who underwent 6 6 mm OCTA imaging of the macula at baseline and after three monthly IVB injections. Thirty-six eyes of 23 patients were included. Eyes that ...
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    8. Diagnosing Persistent Hyper-Transmission Defects on En Face OCT Imaging of Age-Related Macular Degeneration

      Diagnosing Persistent Hyper-Transmission Defects on En Face OCT Imaging of Age-Related Macular Degeneration
      Purpose: A training exercise was performed to study the ability of graders to reliably identify precursor lesions to geographic atrophy (GA), known as persistent choroidal hyper-transmission defects (hyperTDs), using en face optical coherence tomography (OCT) images from eyes with non-exudative age-related macular degeneration (AMD). Design: Intergrader agreement study PARTICIPANTS: Eleven graders participated in this exercise. Methods: Formal training on how to identify persistent hyperTDs on en face OCT images was ...
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    9. OCT Angiography-based Evaluation of the Choriocapillaris in Neovascular Age-related Macular Degeneration

      OCT Angiography-based Evaluation of the Choriocapillaris in Neovascular Age-related Macular Degeneration
      Neovascular age-related macular degeneration (AMD) can lead to rapid, irreversible vision loss in untreated eyes. While the pathogenesis of neovascular AMD remains incompletely understood, the choriocapillaris has been hypothesized as the initial site of injury. Due to limitations of dye-based angiography, in vivo imaging of the choriocapillaris has been a longstanding challenge. However, the clinical introduction of optical coherence tomography angiography (OCTA) has enabled researchers and clinicians to noninvasively image ...
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    10. Multiscale correlation of microvascular changes on optical coherence tomography angiography with retinal sensitivity in diabetic retinopathy

      Multiscale correlation of microvascular changes on optical coherence tomography angiography with retinal sensitivity in diabetic retinopathy
      Purpose: To assess global, zonal, and local correlations between vessel density changes measured by optical coherence tomography angiography (OCTA) and retinal sensitivity measured by microperimetry across diabetic retinopathy severity. Methods: Diabetic patients and non-diabetic controls underwent OCTA imaging and microperimetry testing. Pearson's correlation was used to assess associations between average sensitivity and skeletonized vessel density (SVD) or FAZ area centrally. Linear mixed effects modeling was used to assess relationships ...
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    11. Anterior segment optical coherence tomography angiography in the assessment of ocular surface lesions

      Anterior segment optical coherence tomography angiography in the assessment of ocular surface lesions
      Purpose: Describe the utility of anterior segment optical coherence tomography angiography (AS-OCTA) to assess ocular surface lesions. Methods: Retrospective, case-control study of 10 eyes of 9 patients with malignant lesions and 23 eyes of 22 patients with benign lesions. Lesions included 13 epithelial, 10 pigmented and 10 lymphoid lesions. Graders performed an average of 3 depth and diameter measurements of peri-lesional vessels entering each lesion on AS-OCTA. Statistical models to ...
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      Mentions: Tufts University
    12. Full Thickness Macular Hole Size by Hypertransmission Signal on Spectral-Domain Optical Coherence Tomography

      Full Thickness Macular Hole Size by Hypertransmission Signal on Spectral-Domain Optical Coherence Tomography
      Purpose: To assess the full thickness macular hole (FTMH) size using the choroidal hypertransmission signal on spectral domain optical coherence tomography (SD-OCT), and to compare this method to the standard aperture measurement of the minimum aperture size at the level of the neurosensory retina. Design: Cross-sectional study of retrospective data. Methods: Eyes with FTMH imaged on SD-OCT were included. Two independent masked graders used the device's built-in caliper tool ...
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    13. Optical coherence tomography angiography distortion correction in widefield montage images

      Optical coherence tomography angiography distortion correction in widefield montage images
      Background: Optical coherence tomography (OCT) imaging is inherently susceptible to distortion artifacts due to the natural curvature of the eye. This study proposes a novel model for widefield OCT angiography (OCTA) distortion correction and analyzes the effects of this correction on quantification metrics. Methods: Widefield OCTA images were obtained on normal subjects at five fixation spatial positions. Radial and field distortion correction were applied and images stitched together to form ...
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    14. OCT-OCTA segmentation: combining structural and blood flow information to segment Bruch's membrane

      OCT-OCTA segmentation: combining structural and blood flow information to segment Bruch's membrane
      In this paper we present a fully automated graph-based segmentation algorithm that jointly uses optical coherence tomography (OCT) and OCT angiography (OCTA) data to segment Bruch's membrane (BM). This is especially valuable in cases where the spatial correlation between BM, which is usually not visible on OCT scans, and the retinal pigment epithelium (RPE), which is often used as a surrogate for segmenting BM, is distorted by pathology. We ...
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  2. About Tufts University

    Tufts University

    Tufts University is one of the premier universities in the United States. Tufts enjoys a global reputation for academic excellence and for preparing students as leaders in a wide range of professions.

    Tufts University School of Medicine is one of the eight schools that comprise Tufts University.   The New England Eye Center is a local, national and international referral and consultation facility, providing the most current and comprehensive services in tertiary care ophthalmology. It is a complete clinical and technical center for the testing and treatment of all types of eye diseases and visual problems. Our staff ophthalmologists hold teaching appointments at Tufts University School of Medicine. The New England Eye Center is part of Tufts Medical Center, a major academic medical center in downtown Boston, Massachusetts. Tufts Medical Center offers comprehensive inpatient and outpatient care for adults and children.