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Tufts University
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Mentioned In 239 Articles
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A Joint Probabilistic Model for Speckle Variance, Amplitude Decorrelation and Interframe Variance (IFV) Optical Coherence Tomography Angiography
Optical Coherence Tomography Angiography (OCTA) is a general method to visualize blood flow in biological tissue. Despite its good results in practice, the commonly used Amplitude Decorrelation OCTA (AD-OCTA) measure suffers from a well-understood objective function, which makes it challenging to mathematically model post processing tasks like, e.g., denoising. In this paper, a probabilistic model is developed for the three OCTA measures Speckle Variance OCTA, ADOCTA and the newly ...Read Full Article -
Microscope-Integrated Intraoperative Ultrahigh-Speed Swept-Source Optical Coherence Tomography for Widefield Retinal and Anterior Segment Imaging
BACKGROUND AND OBJECTIVE: To demonstrate the feasibility of retinal and anterior segment intraoperative widefield imaging using an ultrahigh-speed, swept-source optical coherence tomography (SS-OCT) surgical microscope attachment. PATIENTS AND METHODS: A prototype post-objective SS-OCT using a 1,050-nm wavelength, 400 kHz A-scan rate, vertical cavity surface-emitting laser (VCSEL) light source was integrated to a commercial ophthalmic surgical microscope after the objective. Each widefield OCT data set was acquired in 3 seconds ...Read Full Article -
Long-term Progression of Type 1 Neovascularization in Age-related Macular Degeneration Using Optical Coherence Tomography Angiography
Purpose To analyze the long-term growth patterns of type 1 neovascularization (NV) in eyes with age-related macular degeneration (AMD) receiving anti-vascular endothelial growth factor (VEGF) therapy. Design : Retrospective cohort study. Methods Patients were enrolled from two eye centers and underwent optical coherence tomography angiography (OCTA) imaging with follow-up greater than 1 year. Choroidal neovascularization (CNV) was manually segmented on OCTA images and compared between time points. CNV growth was sub-divided ...Read Full Article -
Quantitative Analysis of Three Distinct Retinal Capillary Plexuses in Healthy Eyes Using Optical Coherence Tomography Angiography
Purpose : To identify and quantify the three distinct retinal capillary plexuses and the foveal avascular zone (FAZ) in healthy subjects according to age using optical coherence tomography angiography (OCTA) with novel projection artifact removal (PAR) software and improved segmentation. Methods : All eyes in this cross-sectional study underwent OCTA imaging using RTVue XR Avanti with novel PAR AngioVue software. OCTA scans were analyzed and the three main parafoveal retinal capillary plexuses ...Read Full Article -
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY TO DETECT MACULAR CAPILLARY ISCHEMIA IN PATIENTS WITH INNER RETINAL CHANGES AFTER RESOLVED DIABETIC MACULAR EDEMA
To compare foveal vascular anatomy between patients with and without disorganization of retinal inner layers (DRILs) after resolved diabetic macular edema using optical coherence tomography angiography (OCTA). Methods: Twenty-four eyes of 21 age- and sex-matched patients with resolved diabetic macular edema were included in this retrospective, cross-sectional study. All eyes were imaged with enhanced high-definition line or cross-line structural B scans and 3 3-mm OCTA scans. Optical coherence tomography B ...Read Full Article -
Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis
Purpose : To use a novel optical coherence tomography angiography (OCTA) algorithm termed variable interscan time analysis (VISTA) to evaluate relative blood flow speeds in polypoidal choroidal vasculopathy (PCV). Methods : Prospective cross-sectional study enrolling patients with confirmed diagnosis of PCV. OCTA of the retina and choroid was obtained with a prototype swept-source OCT system. The acquired OCT volumes were centered on the branching vascular network (BVN) and polyps as determined by ...Read Full Article -
Image Averaging, a Powerful Tool in Optical Coherence Tomography and OCT Angiography
In an elegantly conducted study, Uji et al 1 describe the association of averaging multiple en face images with the quality of the optical coherence tomography angiography (OCTA) images of the choroidal microvasculature. They demonstrate that the resulting vascular images approximate much more closely the structure of the choriocapillaris as visualized histopathologically. This is an interesting and potentially important advance in the ability of OCTA to image the choriocapillaris in ...Read Full Article -
Optical Coherence Tomography Angiography of the Eye (Textbook)
Optical coherence tomography (OCT) angiography is an important new imaging modality that is already being used by ophthalmologists in retina centers worldwide. It uses motion as intrinsic contrast, thus obviating the need to inject any intravenous dye. It uses infrared light that is invisible to the patient, and only requires few seconds per scan. This makes it both easier to use and much better tolerated by patients than traditional dye-based ...Read Full Article -
Atlas of Retinal OCT: Optical Coherence Tomography (Textbook)
Optical Coherence Tomography has revolutionized todays eye care. This remarkable non-invasive scanning technology is unparalleled for aiding diagnosis of retinal disease and recording disease progression. Atlas of Retinal OCT: Optical Coherence Tomography provides expert guidance in this rapidly evolving area with high-quality, oversized images that show precise detail and assist with rapid, accurate clinical decision making.Read Full Article -
Diagnosing Choroidal Neovascularization in Asymptomatic Individuals Using Optical Coherence Tomography Angiography
Optical coherence tomography angiography (OCTA) is a noninvasive, rapid imaging technique that generates angiographic images without intravenous dye injections. Cross-sectional studies have described the presence of asymptomatic choroidal neovascularization (CNV) in patients with intermediate age-related macular degeneration (AMD). This case report describes the OCT features on longitudinal follow-up of a patient who started with unilateral asymptomatic CNV and eventually developed symptomatic exudative AMD.Read Full Article -
Optical Coherence Tomography Features Preceding the Onset of Advanced Age-Related Macular Degeneration
Purpose : Age-related macular degeneration (AMD) is a progressive disease with multifactorial etiology. There is a need to identify clinical features that are harbingers of advanced disease. We evaluated morphologic features of the retina and choroid on optical coherence tomography (OCT) to determine if they predict progression to advanced disease. Methods : Progressors transitioned from early or intermediate AMD to advanced disease ( n = 40 eyes), and were matched on baseline AMD grade ...Read Full Article -
Visualization of changes in the foveal avascular zone in both observed and treated diabetic macular edema using optical coherence tomography angiography
Background Central vision loss in diabetic retinopathy is commonly related to diabetic macular edema (DME). The objective of this study was to describe changes between consecutive visits on optical coherence tomography angiography (OCTA) of the foveal avascular zone (FAZ) in eyes with DME. Methods 20 eyes from 14 patients with DME were imaged on 2 successive clinic visits separated by at least 1 month. The mean interval between visits was ...Read Full Article -
Analysis Of AGE-RELATED Choroidal Layers Thinning In Healthy Eyes Using SWEPT-SOURCE Optical Coherence Tomography
Purpose: To study the changes in the choroidal layers thickness with age in a healthy population using swept-source optical coherence tomography. Methods: Retrospective data analysis of a subgroup of eyes from a previous single-center, prospective, cross-sectional, noninterventional study. One hundred and sixty-nine healthy eyes were evaluated using swept-source optical coherence tomography. Inclusion criteria were best-corrected visual acuity between 20/20 and 20/25, spherical equivalent between 3 diopters, and no ...Read Full Article -
OCT Technology: Will We Be “Swept” Away?
A look at the differences between spectral-domain and swept-source OCT, and the potential clinical benefits of swept-source. As is sometimes the case with technology, just when we get comfortable using a device and begin to understand its secrets, limitations and how to best put it to use in our practices, a shiny new instrument arrives and demands our attention. Though this imaging modality has been around for some time, swept-source ...Read Full Article
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About Tufts University
Tufts University is one of the premier universities in the United States. Tufts enjoys a global reputation for academic excellence and for preparing students as leaders in a wide range of professions.
Tufts University School of Medicine is one of the eight schools that comprise Tufts University. The New England Eye Center is a local, national and international referral and consultation facility, providing the most current and comprehensive services in tertiary care ophthalmology. It is a complete clinical and technical center for the testing and treatment of all types of eye diseases and visual problems. Our staff ophthalmologists hold teaching appointments at Tufts University School of Medicine. The New England Eye Center is part of Tufts Medical Center, a major academic medical center in downtown Boston, Massachusetts. Tufts Medical Center offers comprehensive inpatient and outpatient care for adults and children.