1. Tueng T. Shen

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    1. Mentioned In 19 Articles

    2. University of Washington Receives NIH Grant for Optical Coherence Elastography of Corneal Dyanamics

      University of Washington Receives NIH Grant for Optical Coherence Elastography of Corneal Dyanamics
      University of Washington Receives a 2019 NIH Grant for $560,406 for Optical Coherence Elastography of Corneal Dyanamics. The principal investigator is Sueng Shen. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. The cornea is a highly organized, layered (lamellae) structure of collagen fibrils providing both high tensile strength to protect the eye and 70% of it refractive power. Although physical ...
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    3. The evaluation of spontaneous Descemet’s membrane reattachment using swept-source optical coherence tomography: a case report

      The evaluation of spontaneous Descemet’s membrane reattachment using swept-source optical coherence tomography: a case report
      A 29-year old man presented with a history of facial burn in August of 2017. Slit lamp examination revealed significant central corneal stromal scarring in the right eye. The patient received deep anterior lamellar keratoplasty (DALK) in the right eye. Three weeks post operatively, the patient was found to have recurrent corneal edema on slit lamp exam, and standard anterior segment optical coherence tomography (OCT) revealed a central detachment of ...
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    4. Robust numerical phase stabilization for long-range swept-source optical coherence tomography

      Robust numerical phase stabilization for long-range swept-source optical coherence tomography
      A novel phase stabilization technique is demonstrated with significant improvement in the phase stability of a micro-electromechanical (MEMS) vertical cavity surface-emitting laser (VCSEL) based swept-source optical coherence tomography (SS-OCT) system. Without any requirements of hardware modifications, the new fully numerical phase stabilization technique features high tolerance to acquisition jitter, and significantly reduced budget in computational effort. We demonstrate that when measured with biological tissue, this technique enables a phase sensitivity ...
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    5. University of Washington Received NIH Grant Optical Coherence Elastography of Corneal Dynamics

      University of Washington Received NIH Grant Optical Coherence Elastography of Corneal Dynamics
      The University of Washington Received a 2017 NIH Grant for $529,475 Optical Coherence Elastography of Corneal Dynamics. The principal investigator is Tueng Shen. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. The cornea is a highly organized, layered (lamellae) structure of collagen fibrils providing both high tensile strength to protect the eye and 70% of it refractive power. Although physical ...
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    6. Non-contact rapid optical coherence elastography by high-speed 4D imaging of elastic waves

      Non-contact rapid optical coherence elastography by high-speed 4D imaging of elastic waves
      Shear wave OCE (SW-OCE) uses an OCT system to track propagating mechanical waves, providing the information needed to map the elasticity of the target sample. In this study we demonstrate high speed, 4D imaging to capture transient mechanical wave propagation. Using a high-speed Fourier domain mode-locked (FDML) swept-source OCT (SS-OCT) system operating at ~1.62 MHz A-line rate, the equivalent volume rate of mechanical wave imaging is 16 kvps (kilo-volumes ...
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    7. Acoustic micro-tapping for non-contact 4D imaging of tissue elasticity

      Acoustic micro-tapping for non-contact 4D imaging of tissue elasticity
      Elastography plays a key role in characterizing soft media such as biological tissue. Although this technology has found widespread use in both clinical diagnostics and basic science research, nearly all methods require direct physical contact with the object of interest and can even be invasive. For a number of applications, such as diagnostic measurements on the anterior segment of the eye, physical contact is not desired and may even be ...
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    8. Air-coupled acoustic radiation force for non-contact generation of broadband mechanical waves in soft media

      Air-coupled acoustic radiation force for non-contact generation of broadband mechanical waves in soft media
      A non-contact method for efficient, non-invasive excitation of mechanical waves in soft media is proposed, in which we focus an ultrasound (US) signal through air onto the surface of a medium under study. The US wave reflected from the air/medium interface provides radiation force to the medium surface that launches a transient mechanical wave in the transverse (lateral) direction. The type of mechanical wave is determined by boundary conditions ...
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    9. Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate

      Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate
      We present single-shot phase-sensitive imaging of propagating mechanical waves within tissue, enabled by an ultrafast optical coherence tomography (OCT) system powered by a 1.628MHz Fourier domain mode-locked (FDML) swept laser source. We propose a practical strategy for phase-sensitive measurement by comparing the phases between adjacent OCT B-scans, where the B-scan contains a number of A-scans equaling an integer number of FDML buffers. With this approach, we show that micro-strain ...
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    10. Pulsatile motion of trabecular meshwork in a patient with iris cyst by phase-sensitive optical coherence tomography: a case report

      Pulsatile motion of trabecular meshwork in a patient with iris cyst by phase-sensitive optical coherence tomography: a case report
      ...logy, ^3Department of Bioengineering, University of Washington, Seattle, WA 98104, USA Correspondence to: Dr. Tueng T. Shen, MD, PhD. Department of Ophthalmology, Department of Bioengineering, University of Washington, B...
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    11. Shear wave elastography of ex vivo human corneas using phase-sensitive optical coherence tomography

      Shear wave elastography of ex vivo human corneas using phase-sensitive optical coherence tomography
      Assessing the biomechanical properties of the cornea can provide clinically valuable information in addition to structural images for better management of pathologies (e.g. glaucoma) or refractive surgeries. OCT provides a micron scale and high sensitivity that are ideal for ophthalmic applications. We propose a shear wave elastography (SWE) method for the cornea based on phase-sensitive optical coherence tomography (PhS-OCT). SWE consists in launching a propagating shear wave in tissues ...
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    12. Pulsatile motion of the trabecular meshwork in healthy human subjects quantified by phase-sensitive optical coherence tomography

      Pulsatile motion of the trabecular meshwork in healthy human subjects quantified by phase-sensitive optical coherence tomography
      Aqueous leaves the anterior chamber of eye by passing through the trabecular meshwork (TM), a tissue thought to be responsible for increased outflow resistance in glaucoma. Motion assessment could permit characterization of TM biomechanical properties necessary to maintain intra-ocular pressure (IOP) within a narrow homeostatic range. In this paper, we report the first in vivo identification of TM motion in humans. We use a phase-sensitive optical coherence tomography (PhS-OCT) system ...
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    13. Methods And Systems For Imaging Tissue Motion Using Optical Coherence Tomography

      Methods And Systems For Imaging Tissue Motion Using Optical Coherence Tomography
      A system and method for measuring tissue motion within a living tissue of the anterior segment and aqueous outflow system of the eye in a subject are provided. Tissue movements are extracted from a plurality of images acquired from the living tissue using an optical coherence tomography system. The images may be corrected using motion compensation. To extract the tissue movements from the images, waves from a cardiac pulse or ...
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    14. Phase-sensitive optical coherence tomography characterization of pulse-induced trabecular meshwork displacement in ex vivo nonhuman primate eyes

      Phase-sensitive optical coherence tomography characterization of pulse-induced trabecular meshwork displacement in ex vivo nonhuman primate eyes
      Glaucoma is a blinding disease for which intraocular pressure (IOP) is the only treatable risk factor. The mean IOP is regulated through the aqueous outflow system, which contains the trabecular meshwork (TM). Considerable evidence indicates that trabecular tissue movement regulates the aqueous outflow and becomes abnormal during glaucoma; however, such motion has thus far escaped detection. The purpose of this study is to describe anovel use of a phase-sensitive optical ...
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    15. 1-15 of 19 1 2 »
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  2. About Tueng T. Shen

    Tueng T. Shen

    Tueng T. Shen is at the University of Washington.