1. Ton G. van Leeuwen

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    1. Mentioned In 109 Articles

    2. 3D co-registration algorithm for catheter-based optical coherence tomography

      3D co-registration algorithm for catheter-based optical coherence tomography
      Applications of catheter-based optical coherence tomography (OCT) - originally developed for cardiovascular imaging - have expanded to other organ systems. However, currently available algorithms to co-register 3D OCT data to a second imaging modality were developed for cardiovascular applications and with it, are tailored to small tubular tissue structures. The available algorithms can often not be applied outside the cardiovascular system, e.g. when an OCT probe is introduced into the kidney ...
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    3. Common-path integrated low coherence interferometry system and method therefor

      Common-path integrated low coherence interferometry system and method therefor
      A low coherence interferometry imaging system comprising a common-path interferometer that is at least partially integrated as part of a planar lightwave circuit is disclosed. Imaging systems in accordance with the present invention are implemented in integrated optics without the inclusion of highly wavelength-sensitive components. As a result, they exhibit less wavelength dependence than PLC-based interferometers of the prior art. Further, the common-path interferometer arrangement of the present invention avoids ...
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    4. Comparison of Optical Imaging Techniques to Quantitatively Assess the Perfusion of the Gastric Conduit during Oesophagectomy

      Comparison of Optical Imaging Techniques to Quantitatively Assess the Perfusion of the Gastric Conduit during Oesophagectomy
      In this study, four optical techniquesOptical Coherence Tomography, Sidestream Darkfield Microscopy, Laser Speckle Contrast Imaging, and Fluorescence Angiography (FA)were compared on performing an intraoperative quantitative perfusion assessment of the gastric conduit during oesophagectomy. We hypothesised that the quantitative parameters show decreased perfusion towards the fundus in the gastric conduit and in patients with anastomotic leakage. In a prospective study in patients undergoing oesophagectomy with gastric conduit reconstruction, measurements were ...
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    5. Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation

      Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation
      Significance: Optical coherence tomography (OCT) provides cross-sectional and volumetric images of backscattering from biological tissue that reveal the tissue morphology. The strength of the scattering, characterized by an attenuation coefficient, represents an alternative and complementary tissue optical property, which can be characterized by parametric imaging of the OCT attenuation coefficient. Over the last 15 years, a multitude of studies have been reported seeking to advance methods to determine the OCT ...
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    6. En‐face optical coherence tomography for the detection of cancer in prostatectomy specimens: quantitative analysis in 20 patients

      En‐face optical coherence tomography for the detection of cancer in prostatectomy specimens: quantitative analysis in 20 patients
      The increase histopathological evaluation of prostatectomy specimens rises the workload on pathologists. Automated histopathology systems, preferably directly on unstained specimens, would accelerate the pathology workflow. In this study, we investigate the potential of quantitative analysis of Optical Coherence Tomography (OCT) to separate benign from malignant prostate tissue automatically. Twenty fixated prostates were cut, from which 54 slices were scanned by OCT. Quantitative OCT metrics (attenuation coefficient, residue, goodness‐of‐fit ...
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    7. Computed Tomography–Mediated Registration of Trapeziometacarpal Articular Cartilage Using Intraarticular Optical Coherence Tomography and Cryomicrotome Imaging: A Cadaver Study

      Computed Tomography–Mediated Registration of Trapeziometacarpal Articular Cartilage Using Intraarticular Optical Coherence Tomography and Cryomicrotome Imaging: A Cadaver Study
      Objective Accurate, high-resolution imaging of articular cartilage thickness is an important clinical challenge in patients with osteoarthritis, especially in small joints. In this study, computed tomography (CT) mediated catheter-based optical coherence tomography (OCT) was utilized to create a digital reconstruction of the articular surface of the trapeziometacarpal (TMC) joint and to assess cartilage thickness in comparison to cryomicrotome data. Design Using needle-based introduction of the OCT probe, the articular surface ...
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    8. Simple and robust calibration procedure for k-linearization and dispersion compensation in optical coherence tomography

      Simple and robust calibration procedure for k-linearization and dispersion compensation in optical coherence tomography
      In Fourier-domain optical coherence tomography (FD-OCT), proper signal sampling and dispersion compensation are essential steps to achieve optimal axial resolution. These calibration steps can be performed through numerical signal processing, but require calibration information about the system that may require lengthy and complex measurement protocols. We report a highly robust calibration procedure that can simultaneously determine correction vectors for nonlinear wavenumber sampling and dispersion compensation. The proposed method requires only ...
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    9. The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study

      The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study
      Objective To demonstrate the safety and feasibility of clinical in vivo needle‐based optical coherence tomography (OCT) imaging of the prostate. Materials and Methods Two patients with prostate cancer underwent each two percutaneous in vivo needle‐based OCT measurements before transperineal template mapping biopsy. The OCT probe was introduced via a needle and positioned under ultrasound guidance. To test the safety, adverse events were recorded during and after the procedure ...
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    10. Optical coherence tomography to detect acute esophageal radiation-induced damage in mice: a validation study

      Optical coherence tomography to detect acute esophageal radiation-induced damage in mice: a validation study
      Radiation therapy for patients with non-small-cell lung cancer is hampered by acute radiation-induced toxicity in the esophagus. This study aims to validate that optical coherence tomography (OCT), a minimally invasive imaging technique with high resolution (~10 m), is able to visualize and monitor acute radiation-induced esophageal damage (ARIED) in mice. We compare our findings with histopathology as the gold standard. Irradiated mice receive a single dose of 40 Gy at ...
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    11. Decreasing the Size of a Spectral Domain Optical Coherence Tomography System With Cascaded ...

      Decreasing the Size of a Spectral Domain Optical Coherence Tomography System With Cascaded ...
      This paper describes a proof-of-concept of a miniaturized spectral-domain optical coherence tomography system, based on photonic integrated circuit (PIC) technology. The integrated optics 512-channel spectrometer consists of cascaded arrayed waveguide gratings (AWG) with the output waveguides directly attached to a CCD detector. The spectrometer has a center wavelength of 850 nm and a spectral sampling interval of 0.22 nm. The PIC has a footprint of 2.0 2.7 ...
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    12. From sample structure to optical properties and back : A theoretical framework for quantitative OCT and its clinical application (Thesis)

      From sample structure to optical properties and back : A theoretical framework for quantitative OCT and its clinical application (Thesis)
      The aim of this thesis is to provide a methodology to extract quantitative parameters from optical coherence tomography (OCT) images and to relate these parameters to sample properties such as structure, organization and flow. OCT uses near-infrared light to acquire 3D images of biological tissue, with a resolution around 5-15 m and an imaging depth of approximately 2 mm. OCT can be a useful clinical tool for minimally-invasive, high-resolution imaging ...
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    13. Optical Coherence Tomography in Urologic Oncology: a Comprehensive Review

      Optical Coherence Tomography in Urologic Oncology: a Comprehensive Review
      Introduction Optical coherence tomography (OCT) is being investigated in urologic oncology for optical diagnosis. This comprehensive review analyzes the current state of development of OCT for bladder, upper urinary tract, kidney, prostate, testis, and penis cancer. Also, the potential role of OCT with regard to the current diagnostic pathways is critically appraised to guide future developments. Methods Embase and Pubmed were systematically searched for English and German articles on OCT ...
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    14. One‐to‐one registration of en‐face optical coherence tomography attenuation coefficients with histology of a prostatectomy specimen

      One‐to‐one registration of en‐face optical coherence tomography attenuation coefficients with histology of a prostatectomy specimen
      Optical coherence tomography (OCT), enables high‐resolution 3D imaging of the morphology of light scattering tissues. From the OCT signal, parameters can be extracted and related to tissue structures. One of the quantitative parameters is the attenuation coefficient; the rate at which the intensity of detected light decays in depth. To couple the quantitative parameters with the histology one‐to‐one registration is needed. The primary aim of this study ...
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    15. Decreasing the Size of a Spectral Domain Optical Coherence Tomography System with Cascaded Arrayed Waveguide Gratings in a Photonic Integrated Circuit

      Decreasing the Size of a Spectral Domain Optical Coherence Tomography System with Cascaded Arrayed Waveguide Gratings in a Photonic Integrated Circuit
      This paper describes a proof-of-concept of a miniaturized spectral-domain optical coherence tomography system, based on photonic integrated circuit (PIC) technology. The integrated optics 512-channel spectrometer consists of cascaded arrayed waveguide gratings (AWG) with the output waveguides directly attached to a CCD detector. The spectrometer has a center wavelength of 850 nm and a spectral sampling interval of 0.22 nm. The PIC has a footprint of 2.0x2.7 cm2 ...
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  2. About Ton G. van Leeuwen

    Ton G. van Leeuwen

    Ton G. van Leeuwen studied physics at the University of Amsterdam and received his Ph.D. degree in 1993 from the Laboratory of Experimental Cardiology, University of Utrecht, The Netherlands. Currently, he is head of the department of Biomedical Engineering & Physics, Academic Medical Center, University of Amsterdam, and Professor at the Biomedical Photonic Imaging group, University of Twente. His current research interests include the clinical application of biomedical optics.

  3. Quotes

    1. OCT is the ‘work horse’ of the biomedical photonics research field ...“Integrating the components in photonics chips will further increase both the technical and the clinical capabilities of OCT. Furthermore, PIC-based OCT will not only make the current applications cheaper but also broaden its application scope.
      In AMC and LioniX International partner on development of OCT modules