1. Tom Pfeiffer

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    1. Mentioned In 22 Articles

    2. Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging

      Explore OSA | OSA Publishing Tunable Sources
      Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging
      In order to realize adjustable A-scan rates of fast optical coherence tomography (OCT) systems, we investigate averaging of OCT image data acquired with a MHz-OCT system based on a Fourier Domain Mode Locked (FDML) laser. Increased system sensitivity and image quality can be achieved with the same system at the cost of lower imaging speed. Effectively, the A-scan rate can be reduced in software by a freely selectable factor. We ...
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      Mentions: Robert A. Huber University of Lübeck Tom Pfeiffer

    3. Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography

      Explore IEEE Xplore Cardiology
      Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography
      We demonstrate three-dimensional intravascular flow imaging compatible with routine clinical image acquisition workflow by means of megahertz (MHz) intravascular Doppler Optical Coherence Tomography (OCT). The OCT system relies on a 1.1 mm diameter motorized imaging catheter and a 1.5 MHz Fourier Domain Mode Locked (FDML) laser. Using a post processing method to compensate the drift of the FDML laser output, we can resolve the Doppler phase shift between ...
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      Mentions: Robert A. Huber Gijs van Soest Anton F. W. van der Steen

    4. High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography

      Explore OSA | OSA Publishing Probes
      High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography
      We present a forward-viewing fiber scanning endoscope (FSE) for high-speed volumetric optical coherence tomography (OCT). The reduction in size of the probe was achieved by substituting the focusing optics by an all-fiber-based imaging system which consists of a combination of scanning single-mode fibers, a glass spacer, made from a step-index multi-mode fiber, and a gradient-index fiber. A lateral resolution of 11 m was achieved at a working distance of 1 ...
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      Mentions: Robert A. Huber Gereon Hüttmann University of Lübeck

    5. Ultra low noise Fourier domain mode locked laser for high quality megahertz optical coherence tomography

      Explore OSA | OSA Publishing Tunable Sources
      Ultra low noise Fourier domain mode locked laser for high quality megahertz optical coherence tomography
      We investigate the origin of high frequency noise in Fourier domain mode locked (FDML) lasers and present an extremely well dispersion compensated setup which virtually eliminates intensity noise and dramatically improves coherence properties. We show optical coherence tomography (OCT) imaging at 3.2 MHz A-scan rate and demonstrate the positive impact of the described improvements on the image quality. Especially in highly scattering samples, at specular reflections and for strong ...
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      Mentions: Robert A. Huber University of Lübeck Technical University of Munich

    6. High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates

      Explore OSA | OSA Publishing Ophthalmology , Tunable Sources
      High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates
      We present a new 1060 nm Fourier domain mode locked laser (FDML laser) with a record 143 nm sweep bandwidth at 2∙ 417 kHz = 834 kHz and 120 nm at 1.67 MHz, respectively. We show that not only the bandwidth alone, but also the shape of the spectrum is critical for the resulting axial resolution, because of the specific wavelength-dependent absorption of the vitreous. The theoretical limit of our ...
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      Mentions: Robert A. Huber University of Lübeck Tom Pfeiffer

    8. Thermo-elastic optical coherence tomography

      Explore OSA | OSA Publishing
      Thermo-elastic optical coherence tomography
      The absorption of nanosecond laser pulses induces rapid thermo-elastic deformation in tissue. A sub-micrometer scale displacement occurs within a few microseconds after the pulse arrival. In this Letter, we investigate the laser-induced thermo-elastic deformation using a 1.5 MHz phase-sensitive optical coherence tomography (OCT) system. A displacement image can be reconstructed, which enables a new modality of phase-sensitive OCT, called thermo-elastic OCT. An analysis of the results shows that the ...
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      Mentions: Robert A. Huber Delft University of Technology Chinese Academy of Sciences

    9. Feature tracking for automated volume of interest stabilization on 4D-OCT images

      Explore Conference Proceedings
      Feature tracking for automated volume of interest stabilization on 4D-OCT images
      A common representation of volumetric medical image data is the triplanar view (TV), in which the surgeon manually selects slices showing the anatomical structure of interest. In addition to common medical imaging such as MRI or computed tomography, recent advances in the field of optical coherence tomography (OCT) have enabled live processing and volumetric rendering of four-dimensional images of the human body. Due to the region of interest undergoing motion ...
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      Mentions: Robert A. Huber University of Lübeck University of Hannover

    10. Analysis of FDML lasers with meter range coherence

      Explore Conference Proceedings Tunable Sources
      Analysis of FDML lasers with meter range coherence
      FDML lasers provide sweep rates in the MHz range at wide optical bandwidths, making them ideal sources for high speed OCT. Recently, at lower speed, ultralong-range swept-source OCT has been demonstrated using a tunable vertical cavity surface emitting laser (VCSEL) and also using a Vernier-tunable laser. These sources provide relatively high sweep rates and meter range coherence lengths. In order to achieve similar coherence, we developed an extremely well dispersion ...
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      Mentions: Robert A. Huber Wolfgang Wieser University of Lübeck

    11. Heartbeat OCT and Motion-Free 3D In Vivo Coronary Artery Microscopy

      Explore imaging.onlinejacc.org Cardiology
      Heartbeat OCT and Motion-Free 3D In Vivo Coronary Artery Microscopy
      Intravascular optical coherence tomography (IV-OCT) has gained widespread use over the past few years, offering highly detailed images of coronary artery pathologies and interventions (1) . In contrast to the cross-sectional view, longitudinal sections and 3-dimensional (3D) renderings are affected by cardiac motion artifacts and undersampling, complicating interpretation and measurements (2) . We developed Heartbeat OCT, a new OCT method that achieves up to 4,000 frames/s imaging speed for isotropically ...
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      Mentions: Robert A. Huber Evelyn Regar Gijs van Soest

    12. Flexible A-scan rate MHz OCT: computational downscaling by coherent averaging

      Explore Conference Proceedings
      Flexible A-scan rate MHz OCT: computational downscaling by coherent averaging
      In order to realize fast OCT-systems with adjustable line rate, we investigate averaging of image data from an FDML based MHz-OCT-system. The line rate can be reduced in software and traded in for increased system sensitivity and image quality. We compare coherent and incoherent averaging to effectively scale down the system speed of a 3.2 MHz FDML OCT system to around 100 kHz in postprocessing. We demonstrate that coherent ...
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      Mentions: Robert A. Huber Wolfgang Wieser University of Lübeck

    13. Feature Of The Week 12/06/2015: Heartbeat Optical Coherence Tomography

      Explore Optical Coherence Tomography News Cardiology
      Feature Of The Week 12/06/2015: Heartbeat Optical Coherence Tomography
      Intravascular optical coherence tomography (IV-OCT) has gained widespread use over the past few years, offering highly detailed images of the coronary artery pathologies and interventions. In contrast to the cross-sectional view, longitudinal sections and three-dimensional (3D) renderings are affected by cardiac motion artifacts and undersampling, complicating interpretation and measurements. We developed Heartbeat OCT, a new OCT method that overcomes these issues. This study aims to demonstrate in vivo Heartbeat OCT ...
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      Mentions: Robert A. Huber Evelyn Regar Delft University of Technology

    14. Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography

      Explore OSA | OSA Publishing
      Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography
      Cardiac motion artifacts, non-uniform rotational distortion and undersampling affect the image quality and the diagnostic impact of intravascular optical coherence tomography (IV-OCT). In this study we demonstrate how these limitations of IV-OCT can be addressed by using an imaging system that we called Heartbeat OCT, combining a fast Fourier Domain Mode Locked laser, fast pullback, and a micromotor actuated catheter, designed to examine a coronary vessel in less than one ...
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      Mentions: Robert A. Huber Evelyn Regar Delft University of Technology

    16. Optical coherence tomography guided laser cochleostomy: towards the accuracy on tens of micrometer scale

      Explore Hindawi Publishing Corporation Otolaryngology
      Optical coherence tomography guided laser cochleostomy: towards the accuracy on tens of micrometer scale
      Lasers have been proven to be precise tools for bone ablation. Applying no mechanical stress to the patient, they are potentially very suitable for microsurgery on fragile structures such as the inner ear. However, it remains challenging to control the laser-bone ablation without injuring embedded soft tissue. In this work, we demonstrate a closed-loop control of a short-pulsed CO 2 laser to perform laser cochleostomy under the monitoring of an ...
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      Mentions: Robert A. Huber Wolfgang Wieser University of Lübeck
    17. 1-15 of 22 1 2 »
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  4. About Tom Pfeiffer

    Tom Pfeiffer

    Tom Pfeiffer studied physics at the LMU Munich in Germany. He joined the Emmy Noether / ERC StG group of Robert Huber at the chair for BioMolecular Optics at the LMU as a PhD student in 2011. Recently, he moved with the group of Robert Huber to the Institute of Biomedical imaging to Universität zu Lübeck.

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